Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes REST
  • Mouse genes Rest
  • Rat genes Rest
  • Zfish genes rest
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rest

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Rest	IDA		Mouse	PMID:16684532
Molecular Function	GO:0003682	chromatin binding	Rest	IDA		Mouse	PMID:22780989
Molecular Function	GO:0003677	DNA binding	Rest	IDA		Mouse	PMID:15240883
Molecular Function	GO:0003677	DNA binding	Rest	IDA		Rat	PMID:9454838|RGD:633753
Molecular Function	GO:0003700	DNA-binding transcription factor activity	REST	IDA		Human	PMID:19342457
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Rest	IDA		Rat	PMID:19342457|RGD:4891166
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	REST	IDA		Human	PMID:10449787
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	REST	IDA		Human	PMID:10734093
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	REST	IDA		Human	PMID:21284946
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	REST	IMP		Human	PMID:33108349
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Rest	IDA		Mouse	MGI:MGI:5009400|PMID:17130167
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Rest	IDA		Rat	PMID:17130167|RGD:8553999
Molecular Function	GO:0042802	identical protein binding	Rest	IPI	UniProtKB:Q8VIG1-2	Mouse	MGI:MGI:6294387|PMID:11039732
Molecular Function	GO:0005515	protein binding	REST	IPI	UniProtKB:Q9UKL0	Human	PMID:10449787
Molecular Function	GO:0005515	protein binding	REST	IPI	UniProtKB:Q60520	Human	PMID:10734093
Molecular Function	GO:0005515	protein binding	REST	IPI	UniProtKB:P51532	Human	PMID:12192000
Molecular Function	GO:0005515	protein binding	REST	IPI	UniProtKB:Q96MT3	Human	PMID:16417580
Molecular Function	GO:0005515	protein binding	REST	IPI	UniProtKB:Q96MT3	Human	PMID:16442230
Molecular Function	GO:0005515	protein binding	REST	IPI	UniProtKB:P41229	Human	PMID:17468742
Molecular Function	GO:0005515	protein binding	REST	IPI	UniProtKB:P51531	Human	PMID:17984088
Molecular Function	GO:0005515	protein binding	REST	IPI	UniProtKB:P51532	Human	PMID:17984088
Molecular Function	GO:0005515	protein binding	REST	IPI	UniProtKB:Q92769	Human	PMID:17984088
Molecular Function	GO:0005515	protein binding	REST	IPI	UniProtKB:Q9UKB1	Human	PMID:18354482
Molecular Function	GO:0005515	protein binding	REST	IPI	UniProtKB:Q9Y297	Human	PMID:18354482
Molecular Function	GO:0005515	protein binding	REST	IPI	UniProtKB:Q9UKB1	Human	PMID:18354483
Molecular Function	GO:0005515	protein binding	REST	IPI	UniProtKB:Q9Y297	Human	PMID:18354483
Molecular Function	GO:0005515	protein binding	REST	IPI	UniProtKB:Q9Y232	Human	PMID:19061646
Molecular Function	GO:0005515	protein binding	REST	IPI	UniProtKB:Q93009	Human	PMID:21258371
Molecular Function	GO:0005515	protein binding	REST	IPI	UniProtKB:Q61967	Human	PMID:21284946
Molecular Function	GO:0005515	protein binding	REST	IPI	UniProtKB:P07900	Human	PMID:31361762
Molecular Function	GO:0005515	protein binding	Rest	IPI	UniProtKB:Q3U5C7	Mouse	MGI:MGI:6854464|PMID:34597683
Molecular Function	GO:0005515	protein binding	Rest	IPI	UniProtKB:Q71QF9|UniProtKB:Q96MT3|UniProtKB:Q71QF9|UniProtKB:Q96MT3	Mouse	MGI:MGI:5009175|PMID:14645515
Molecular Function	GO:0005515	protein binding	Rest	IPI	UniProtKB:Q8VIG1-2|UniProtKB:Q8VIG1	Mouse	MGI:MGI:6294407|PMID:10490617
Molecular Function	GO:0005515	protein binding	Rest	IPI	UniProtKB:Q96MT3	Mouse	MGI:MGI:5009175|PMID:14645515
Molecular Function	GO:0005515	protein binding	Rest	IPI	UniProtKB:Q96MT3	Mouse	MGI:MGI:3828923|PMID:18976727
Molecular Function	GO:0005515	protein binding	Rest	IPI	PR:Q09XV5	Mouse	PMID:27602517
Molecular Function	GO:0005515	protein binding	Rest	IPI	PR:Q8C796	Mouse	PMID:10734093
Molecular Function	GO:0005515	protein binding	Rest	IPI	UniProtKB:Q61967	Rat	PMID:21284946|RGD:8554463
Molecular Function	GO:0044877	protein-containing complex binding	Rest	IDA		Rat	PMID:10491605|RGD:2306469
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	REST	IDA		Human	PMID:17984088
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	REST	IMP		Human	PMID:33108349
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	REST	IDA		Human	PMID:8568247
Molecular Function	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	Rest	IDA		Mouse	PMID:29024663
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	REST	IPI	UniProtKB:Q02447	Human	PMID:17130167
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Rest	IPI	UniProtKB:O70494	Mouse	MGI:MGI:5009400|PMID:17130167
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Rest	IPI	UniProtKB:A0A0G2K5M1	Rat	PMID:17130167|RGD:8553999
Molecular Function	GO:0043565	sequence-specific DNA binding	Rest	IDA		Mouse	MGI:MGI:6294387|PMID:11039732
Molecular Function	GO:0043565	sequence-specific DNA binding	Rest	IDA		Mouse	MGI:MGI:6294407|PMID:10490617
Molecular Function	GO:0043565	sequence-specific DNA binding	Rest	IDA		Rat	PMID:10490617|RGD:14397572
Molecular Function	GO:0000976	transcription cis-regulatory region binding	REST	IDA		Human	PMID:17555596
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Rest	IDA		Mouse	MGI:MGI:3580760|PMID:15907476
Cellular Component	GO:0000785	chromatin	Rest	IDA		Rat	PMID:11516394|RGD:2306452
Cellular Component	GO:0005737	cytoplasm	REST	IDA		Human	PMID:24670762
Cellular Component	GO:0005737	cytoplasm	REST	IDA		Human	PMID:27531581
Cellular Component	GO:0005737	cytoplasm	REST	IDA		Human	PMID:30684677
Cellular Component	GO:0005829	cytosol	REST	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Rest	IDA		Mouse	MGI:MGI:5009770|PMID:21199191
Cellular Component	GO:0005654	nucleoplasm	REST	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	REST	IDA		Human	PMID:10734093
Cellular Component	GO:0005634	nucleus	REST	IDA		Human	PMID:16417580
Cellular Component	GO:0005634	nucleus	REST	IDA		Human	PMID:16442230
Cellular Component	GO:0005634	nucleus	REST	IMP		Human	PMID:16442230
Cellular Component	GO:0005634	nucleus	REST	IDA		Human	PMID:17984088
Cellular Component	GO:0005634	nucleus	REST	IDA		Human	PMID:19342457
Cellular Component	GO:0005634	nucleus	REST	IDA		Human	PMID:21258371
Cellular Component	GO:0005634	nucleus	REST	IDA		Human	PMID:21284946
Cellular Component	GO:0005634	nucleus	REST	IDA		Human	PMID:24670762
Cellular Component	GO:0005634	nucleus	REST	IDA		Human	PMID:27531581
Cellular Component	GO:0005634	nucleus	REST	IDA		Human	PMID:30684677
Cellular Component	GO:0005634	nucleus	REST	IDA		Human	PMID:7697725
Cellular Component	GO:0005634	nucleus	Rest	IDA		Mouse	MGI:MGI:6294407|PMID:10490617
Cellular Component	GO:0005634	nucleus	Rest	IDA		Mouse	MGI:MGI:3580760|PMID:15907476
Cellular Component	GO:0005634	nucleus	Rest	IDA		Mouse	MGI:MGI:5009770|PMID:21199191
Cellular Component	GO:0005634	nucleus	Rest	IDA		Mouse	MGI:MGI:5009175|PMID:14645515
Cellular Component	GO:0005634	nucleus	Rest	IDA		Rat	PMID:10490617|RGD:14397572
Cellular Component	GO:0005634	nucleus	Rest	IDA		Rat	PMID:12657670|RGD:1299303
Cellular Component	GO:0005634	nucleus	Rest	IDA		Rat	PMID:19342457|RGD:4891166
Cellular Component	GO:0005634	nucleus	Rest	IDA		Rat	PMID:21536750|RGD:8554180
Cellular Component	GO:0005634	nucleus	Rest	IDA		Rat	PMID:7697725|RGD:8554025
Cellular Component	GO:0032991	protein-containing complex	Rest	IDA		Rat	PMID:10491605|RGD:2306469
Cellular Component	GO:0017053	transcription repressor complex	REST	IDA		Human	PMID:10734093
Cellular Component	GO:0017053	transcription repressor complex	Rest	IDA		Mouse	MGI:MGI:5009400|PMID:17130167
Cellular Component	GO:0017053	transcription repressor complex	Rest	IDA		Rat	PMID:17130167|RGD:8553999
Biological Process	GO:0060088	auditory receptor cell stereocilium organization	Rest	IMP		Mouse	MGI:MGI:6193260|PMID:29961578
Biological Process	GO:0021785	branchiomotor neuron axon guidance	rest	IMP	ZFIN:ZDB-GENO-121106-3	Zfish	PMID:22951640
Biological Process	GO:0060379	cardiac muscle cell myoblast differentiation	Rest	IDA		Mouse	MGI:MGI:5009770|PMID:21199191
Biological Process	GO:0071257	cellular response to electrical stimulus	REST	IMP		Human	PMID:18570921
Biological Process	GO:0071385	cellular response to glucocorticoid stimulus	REST	IDA		Human	PMID:17984088
Biological Process	GO:0033554	cellular response to stress	Rest	IDA		Mouse	PMID:29024663
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	REST	IMP		Human	PMID:20564196
Biological Process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	Rest	IMP		Mouse	MGI:MGI:6193260|PMID:29961578
Biological Process	GO:0021610	facial nerve morphogenesis	rest	IMP	ZFIN:ZDB-GENO-121120-2	Zfish	PMID:22951640
Biological Process	GO:0021610	facial nerve morphogenesis	rest	IMP	ZFIN:ZDB-GENO-121106-3	Zfish	PMID:22951640
Biological Process	GO:0021610	facial nerve morphogenesis	rest	IMP	ZFIN:ZDB-GENO-121121-3	Zfish	PMID:22951640
Biological Process	GO:0021754	facial nucleus development	rest	IMP	ZFIN:ZDB-GENO-170816-4	Zfish	PMID:25769695
Biological Process	GO:0021754	facial nucleus development	rest	IGI	ZFIN:ZDB-GENE-050208-34	Zfish	PMID:25769695
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	Rest	IMP		Mouse	PMID:24029230
Biological Process	GO:0007626	locomotory behavior	rest	IMP	ZFIN:ZDB-GENO-121106-6	Zfish	PMID:27605615
Biological Process	GO:0099563	modification of synaptic structure	Rest	IMP		Rat	PMID:22960932|RGD:14397585
Biological Process	GO:0097475	motor neuron migration	rest	IMP	ZFIN:ZDB-GENO-170816-4	Zfish	PMID:25769695
Biological Process	GO:0043922	negative regulation by host of viral transcription	REST	IDA		Human	PMID:17555596
Biological Process	GO:0032348	negative regulation of aldosterone biosynthetic process	REST	IMP		Human	PMID:19342457
Biological Process	GO:0032348	negative regulation of aldosterone biosynthetic process	Rest	IMP		Rat	PMID:19342457|RGD:4891166
Biological Process	GO:2000798	negative regulation of amniotic stem cell differentiation	REST	IMP		Human	PMID:20942606
Biological Process	GO:0045955	negative regulation of calcium ion-dependent exocytosis	Rest	IMP		Rat	PMID:21536750|RGD:8554180
Biological Process	GO:0008285	negative regulation of cell population proliferation	REST	IMP		Human	PMID:20564196
Biological Process	GO:2000065	negative regulation of cortisol biosynthetic process	REST	IMP		Human	PMID:19342457
Biological Process	GO:2000065	negative regulation of cortisol biosynthetic process	Rest	IMP		Rat	PMID:19342457|RGD:4891166
Biological Process	GO:2000706	negative regulation of dense core granule biogenesis	Rest	IMP		Rat	PMID:21536750|RGD:8554180
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	REST	IDA		Human	PMID:10449787
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	REST	IDA		Human	PMID:10734093
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	REST	IDA		Human	PMID:11741002
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	REST	IDA		Human	PMID:11779185
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	REST	IDA		Human	PMID:17984088
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	REST	IMP		Human	PMID:18570921
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	REST	IDA		Human	PMID:19342457
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	REST	IMP		Human	PMID:20942606
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	REST	IMP		Human	PMID:27531581
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	REST	IDA		Human	PMID:7697725
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Rest	IDA		Mouse	MGI:MGI:5009400|PMID:17130167
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Rest	IMP		Mouse	MGI:MGI:6201823|PMID:21884984
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Rest	IDA		Mouse	PMID:15240883
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Rest	IMP		Rat	PMID:11516394|RGD:2306452
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Rest	IDA		Rat	PMID:17130167|RGD:8553999
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Rest	IDA		Rat	PMID:19342457|RGD:4891166
Biological Process	GO:0010629	negative regulation of gene expression	REST	IMP		Human	PMID:20564196
Biological Process	GO:0010629	negative regulation of gene expression	Rest	IDA		Mouse	MGI:MGI:3580760|PMID:15907476
Biological Process	GO:0010629	negative regulation of gene expression	Rest	IMP		Mouse	MGI:MGI:1289984|PMID:9771705
Biological Process	GO:0010629	negative regulation of gene expression	Rest	IDA		Mouse	MGI:MGI:6294387|PMID:11039732
Biological Process	GO:0010629	negative regulation of gene expression	Rest	IMP		Rat	PMID:25108103|RGD:14397584
Biological Process	GO:0010629	negative regulation of gene expression	rest	IMP	ZFIN:ZDB-GENO-121106-3	Zfish	PMID:22951640
Biological Process	GO:0046676	negative regulation of insulin secretion	REST	IMP		Human	PMID:20942606
Biological Process	GO:2000740	negative regulation of mesenchymal stem cell differentiation	REST	IMP		Human	PMID:18570921
Biological Process	GO:1902894	negative regulation of miRNA transcription	REST	IMP		Human	PMID:33108349
Biological Process	GO:0050768	negative regulation of neurogenesis	Rest	IGI	MGI:MGI:2654470	Mouse	PMID:17403776
Biological Process	GO:0045665	negative regulation of neuron differentiation	REST	IMP		Human	PMID:18570921
Biological Process	GO:0045665	negative regulation of neuron differentiation	REST	IDA		Human	PMID:21258371
Biological Process	GO:0045665	negative regulation of neuron differentiation	Rest	IDA		Mouse	MGI:MGI:3580760|PMID:15907476
Biological Process	GO:0045665	negative regulation of neuron differentiation	Rest	IMP		Mouse	MGI:MGI:5906102|PMID:27819263
Biological Process	GO:0045665	negative regulation of neuron differentiation	Rest	IMP		Rat	PMID:12657670|RGD:1299303
Biological Process	GO:0014043	negative regulation of neuron maturation	rest	IMP	ZFIN:ZDB-GENO-170816-4	Zfish	PMID:25769695
Biological Process	GO:1903204	negative regulation of oxidative stress-induced neuron death	REST	IMP		Human	PMID:24670762
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	rest	IMP	ZFIN:ZDB-MRPHLNO-100614-4	Zfish	PMID:20122919
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	REST	IDA		Human	PMID:21284946
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	REST	IDA		Human	PMID:8568247
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Rest	IMP		Rat	PMID:22960932|RGD:14397585
Biological Process	GO:2000678	negative regulation of transcription regulatory region DNA binding	Rest	IDA		Mouse	MGI:MGI:6294407|PMID:10490617
Biological Process	GO:0050885	neuromuscular process controlling balance	Rest	IMP		Mouse	MGI:MGI:6193260|PMID:29961578
Biological Process	GO:0030182	neuron differentiation	Rest	IEP		Rat	PMID:24841827|RGD:11570515
Biological Process	GO:0042551	neuron maturation	rest	IGI	ZFIN:ZDB-GENE-050208-34	Zfish	PMID:25769695
Biological Process	GO:0001764	neuron migration	rest	IGI	ZFIN:ZDB-MRPHLNO-071221-3,ZFIN:ZDB-MRPHLNO-100614-4	Zfish	PMID:21521740
Biological Process	GO:0001764	neuron migration	rest	IMP	ZFIN:ZDB-MRPHLNO-100614-4	Zfish	PMID:21521740
Biological Process	GO:0097150	neuronal stem cell population maintenance	Rest	IMP		Mouse	MGI:MGI:5906102|PMID:27819263
Biological Process	GO:0043065	positive regulation of apoptotic process	REST	IMP		Human	PMID:20564196
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	REST	IMP		Human	PMID:20564196
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	REST	IDA		Human	PMID:17984088
Biological Process	GO:0010628	positive regulation of gene expression	Rest	IMP		Mouse	MGI:MGI:6193260|PMID:29961578
Biological Process	GO:0010628	positive regulation of gene expression	Rest	IDA		Mouse	MGI:MGI:6294407|PMID:10490617
Biological Process	GO:0010628	positive regulation of gene expression	Rest	IDA		Mouse	MGI:MGI:6294387|PMID:11039732
Biological Process	GO:0045666	positive regulation of neuron differentiation	Rest	IMP		Mouse	MGI:MGI:6201823|PMID:21884984
Biological Process	GO:1903223	positive regulation of oxidative stress-induced neuron death	Rest	IMP		Rat	PMID:22371606|RGD:14397566
Biological Process	GO:1902459	positive regulation of stem cell population maintenance	REST	IDA		Human	PMID:21258371
Biological Process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome	Rest	IMP		Mouse	MGI:MGI:6201823|PMID:21884984
Biological Process	GO:0010468	regulation of gene expression	Rest	IDA		Mouse	PMID:29024663
Biological Process	GO:0045667	regulation of osteoblast differentiation	Rest	IMP		Mouse	MGI:MGI:5641106|PMID:25838543
Biological Process	GO:1903203	regulation of oxidative stress-induced neuron death	Rest	IMP		Rat	PMID:12657670|RGD:1299303
Biological Process	GO:0001666	response to hypoxia	REST	IDA		Human	PMID:27531581
Biological Process	GO:0002931	response to ischemia	Rest	IEP		Rat	PMID:12657670|RGD:1299303
Biological Process	GO:0002931	response to ischemia	Rest	IDA		Rat	PMID:22371606|RGD:14397566
Biological Process	GO:0002931	response to ischemia	Rest	IDA		Rat	PMID:25108103|RGD:14397584
Biological Process	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning	rest	IMP	ZFIN:ZDB-MRPHLNO-100614-4	Zfish	PMID:20122919
Biological Process	GO:0035019	somatic stem cell population maintenance	Rest	IMP		Mouse	MGI:MGI:5906102|PMID:27819263

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern