Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RFFL
  • Mouse genes Rffl
  • Rat genes Rffl
  • Zfish genes rffl,zgc:171740
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rffl

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0002039	p53 binding	RFFL	IPI	UniProtKB:P04637	Human	PMID:17121812
Molecular Function	GO:0002039	p53 binding	RFFL	IPI	UniProtKB:P04637	Human	PMID:18382127
Molecular Function	GO:0002020	protease binding	RFFL	IPI	UniProtKB:Q14790	Human	PMID:15069192
Molecular Function	GO:0002020	protease binding	RFFL	IPI	UniProtKB:Q92851	Human	PMID:15069192
Molecular Function	GO:0005515	protein binding	RFFL	IPI	UniProtKB:Q6MZQ0	Human	PMID:22609986
Molecular Function	GO:0019901	protein kinase binding	RFFL	IPI	UniProtKB:Q13546	Human	PMID:18450452
Molecular Function	GO:0061630	ubiquitin protein ligase activity	RFFL	IDA		Human	PMID:17121812
Molecular Function	GO:0061630	ubiquitin protein ligase activity	RFFL	IDA		Human	PMID:22609986
Molecular Function	GO:0031625	ubiquitin protein ligase binding	RFFL	IPI	UniProtKB:Q00987	Human	PMID:18382127
Cellular Component	GO:0005737	cytoplasm	RFFL	IDA		Human	PMID:15069192
Cellular Component	GO:0031410	cytoplasmic vesicle	Rffl	IDA		Mouse	PMID:15229288
Cellular Component	GO:0010008	endosome membrane	RFFL	IDA		Human	PMID:18450452
Cellular Component	GO:0016020	membrane	RFFL	HDA		Human	PMID:19946888
Cellular Component	GO:0005886	plasma membrane	RFFL	IDA		Human	PMID:15069192
Biological Process	GO:0006886	intracellular protein transport	Rffl	IDA		Mouse	PMID:15229288
Biological Process	GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	RFFL	IMP		Human	PMID:15069192
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	RFFL	IMP		Human	PMID:15069192
Biological Process	GO:1901797	negative regulation of signal transduction by p53 class mediator	RFFL	IMP		Human	PMID:17121812
Biological Process	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	RFFL	IMP		Human	PMID:18450452
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	RFFL	IMP		Human	PMID:18382127
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	RFFL	IMP		Human	PMID:22609986
Biological Process	GO:0070936	protein K48-linked ubiquitination	RFFL	IDA		Human	PMID:18450452
Biological Process	GO:0070936	protein K48-linked ubiquitination	RFFL	IDA		Human	PMID:22609986
Biological Process	GO:0010762	regulation of fibroblast migration	Rffl	IMP		Mouse	MGI:MGI:5448916|PMID:22609986
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	RFFL	IDA		Human	PMID:15069192
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	RFFL	IMP		Human	PMID:18450452
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	RFFL	IMP		Human	PMID:22609986

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern