Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RFX4
  • Mouse genes Rfx4
  • Rat genes Rfx4
  • Zfish genes rfx4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rfx4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	RFX4	IDA		Human	PMID:16893423
Molecular Function	GO:0005515	protein binding	RFX4	IPI	UniProtKB:P14079	Human	PMID:22458338
Molecular Function	GO:0005515	protein binding	Rfx4	IPI	MGI:MGI:1096584	Mouse	PMID:18218630
Molecular Function	GO:0005515	protein binding	Rfx4	IPI	MGI:MGI:1353554	Mouse	PMID:18218630
Molecular Function	GO:0005515	protein binding	Rfx4	IPI	PR:Q91VL9	Mouse	PMID:18218630
Molecular Function	GO:0005515	protein binding	Rfx4	IPI	PR:A2A870	Mouse	PMID:18218630
Molecular Function	GO:0005515	protein binding	Rfx4	IPI	MGI:MGI:1891751	Mouse	PMID:18218630
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	RFX4	IDA		Human	PMID:16893423
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	RFX4	IDA		Human	PMID:28473536
Cellular Component	GO:0005634	nucleus	Rfx4	IDA		Mouse	PMID:18218630
Biological Process	GO:0060271	cilium assembly	Rfx4	IMP	MGI:MGI:3799278	Mouse	PMID:19887680
Biological Process	GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning	Rfx4	IMP	MGI:MGI:3799278	Mouse	PMID:19887680
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	RFX4	IDA		Human	PMID:16893423
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Rfx4	IDA		Mouse	PMID:18218630
Biological Process	GO:0070613	regulation of protein processing	Rfx4	IMP	MGI:MGI:3799278	Mouse	PMID:19887680
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Rfx4	IDA		Mouse	PMID:18218630
Biological Process	GO:0021537	telencephalon development	Rfx4	IMP	MGI:MGI:3799278	Mouse	PMID:19887680
Biological Process	GO:0007418	ventral midline development	rfx4	IMP	ZFIN:ZDB-GENO-180802-21	Zfish	PMID:29243319

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern