Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RFX5
  • Mouse genes Rfx5
  • Rat genes Rfx5
  • Zfish genes rfx5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rfx5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	RFX5	IDA		Human	PMID:10586057
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	RFX5	IGI	UniProtKB:O14593,UniProtKB:P48382	Human	PMID:9806546
Molecular Function	GO:0005515	protein binding	RFX5	IPI	UniProtKB:O00287	Human	PMID:10938133
Molecular Function	GO:0005515	protein binding	RFX5	IPI	UniProtKB:O14593	Human	PMID:10938133
Molecular Function	GO:0005515	protein binding	RFX5	IPI	UniProtKB:P33076	Human	PMID:10938133
Molecular Function	GO:0005515	protein binding	RFX5	IPI	UniProtKB:Q92769	Human	PMID:16464847
Molecular Function	GO:0005515	protein binding	RFX5	IPI	UniProtKB:O14593	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	RFX5	IPI	UniProtKB:O00287	Human	PMID:20732328
Molecular Function	GO:0005515	protein binding	RFX5	IPI	UniProtKB:O14593	Human	PMID:25752541
Molecular Function	GO:0005515	protein binding	RFX5	IPI	UniProtKB:O00287	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	RFX5	IPI	UniProtKB:O00287	Human	PMID:28514442
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	RFX5	IDA		Human	PMID:9806546
Molecular Function	GO:0043565	sequence-specific DNA binding	RFX5	IDA		Human	PMID:23332764
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	RFX5	IDA		Human	PMID:28473536
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	RFX5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	RFX5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	RFX5	IDA		Human	PMID:10938133
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	RFX5	IPI		Human	PMID:10938133
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	RFX5	IPI	UniProtKB:O00287|UniProtKB:O14593	Human	PMID:9806546
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Rfx5	IMP	MGI:MGI:1857456	Mouse	PMID:16254146
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Rfx5	IMP	MGI:MGI:2386501	Mouse	PMID:16254146
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	RFX5	IDA		Human	PMID:10586057
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	RFX5	IDA		Human	PMID:10938133
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	RFX5	IDA		Human	PMID:9806546

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern