Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RFX6
  • Mouse genes Rfx6
  • Rat genes Rfx6
  • Zfish genes rfx6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rfx6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	RFX6	IDA		Human	PMID:20148032
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:P48378	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:Q86UW9	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:P48380	Human	PMID:20148032
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:A5D8V6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:O43559	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:O75716	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:P14678-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:P54646	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:Q08117	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:Q13131	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:Q14511	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:Q494U1	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:Q5TAL4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:Q86UW9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:Q8NEC5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:A0A0S2Z4Q4	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:A0A0S2Z5X4	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:O14964	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:O43559	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:O75177-5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:O75604	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:P14678-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:P21549	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:P33240	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:P48378	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:P56470	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:Q14511-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:Q7L273	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:Q7Z5V6-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:Q8NEC5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:Q8WW24	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:Q96A09	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:Q96E35	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:Q9BXF9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:Q9H596	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:Q9HBE1-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:Q9NQL9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RFX6	IPI	UniProtKB:Q9Y316	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Rfx6	IPI	UniProtKB:P48381	Mouse	MGI:MGI:4422104|PMID:20148032
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	RFX6	IDA		Human	PMID:20148032
Molecular Function	GO:0000976	transcription cis-regulatory region binding	RFX6	IDA		Human	PMID:20148032
Cellular Component	GO:0005634	nucleus	RFX6	IDA		Human	PMID:25497100
Cellular Component	GO:0005634	nucleus	Rfx6	IDA		Mouse	MGI:MGI:4422104|PMID:20148032
Biological Process	GO:0031018	endocrine pancreas development	RFX6	IMP		Human	PMID:20148032
Biological Process	GO:0031018	endocrine pancreas development	rfx6	IMP		Zfish	PMID:20040487|ZFIN:ZDB-PUB-100105-31
Biological Process	GO:0031018	endocrine pancreas development	rfx6	IMP		Zfish	PMID:20040487
Biological Process	GO:0042593	glucose homeostasis	RFX6	IMP		Human	PMID:20148032
Biological Process	GO:0042593	glucose homeostasis	Rfx6	IMP		Mouse	MGI:MGI:4422104|PMID:20148032
Biological Process	GO:0003310	pancreatic A cell differentiation	Rfx6	IMP		Mouse	MGI:MGI:4422104|PMID:20148032
Biological Process	GO:0003311	pancreatic D cell differentiation	Rfx6	IMP		Mouse	MGI:MGI:4422104|PMID:20148032
Biological Process	GO:0090104	pancreatic epsilon cell differentiation	Rfx6	IMP		Mouse	MGI:MGI:4422104|PMID:20148032
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	RFX6	IDA		Human	PMID:20148032
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	RFX6	IMP		Human	PMID:25497100
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	RFX6	IDA		Human	PMID:20148032
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	RFX6	IMP		Human	PMID:25497100
Biological Process	GO:0050796	regulation of insulin secretion	RFX6	IMP		Human	PMID:20148032
Biological Process	GO:0050796	regulation of insulin secretion	Rfx6	IMP		Mouse	MGI:MGI:4422104|PMID:20148032
Biological Process	GO:0003309	type B pancreatic cell differentiation	Rfx6	IMP		Mouse	MGI:MGI:4422104|PMID:20148032

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern