Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RGCC
  • Mouse genes Rgcc
  • Rat genes Rgcc
  • Zfish genes rgcc
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rgcc

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	RGCC	IPI	UniProtKB:P31749	Human	PMID:19162005
Molecular Function	GO:0005515	protein binding	Rgcc	IPI	UniProtKB:Q8BUN5	Mouse	MGI:MGI:5317995|PMID:21990365
Molecular Function	GO:0005515	protein binding	Rgcc	IPI	PR:P11440	Mouse	PMID:11687586
Molecular Function	GO:0030295	protein kinase activator activity	RGCC	IDA		Human	PMID:11687586
Molecular Function	GO:0019901	protein kinase binding	RGCC	IPI	UniProtKB:P06493	Human	PMID:11687586
Molecular Function	GO:0019901	protein kinase binding	RGCC	IPI	UniProtKB:P53350	Human	PMID:17146433
Molecular Function	GO:0019901	protein kinase binding	Rgcc	IPI	UniProtKB:P39951	Rat	PMID:9756947|RGD:633887
Molecular Function	GO:0070412	R-SMAD binding	RGCC	IPI	UniProtKB:P84022	Human	PMID:21307346
Cellular Component	GO:0005813	centrosome	RGCC	IDA		Human	PMID:17146433
Cellular Component	GO:0005737	cytoplasm	RGCC	IDA		Human	PMID:11687586
Cellular Component	GO:0005737	cytoplasm	RGCC	IDA		Human	PMID:17146433
Cellular Component	GO:0005737	cytoplasm	Rgcc	IDA		Rat	PMID:9756947|RGD:633887
Cellular Component	GO:0005730	nucleolus	RGCC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	RGCC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	RGCC	IDA		Human	PMID:11687586
Biological Process	GO:0071456	cellular response to hypoxia	RGCC	IMP		Human	PMID:19652095
Biological Process	GO:0006956	complement activation	RGCC	IMP		Human	PMID:19162005
Biological Process	GO:0072537	fibroblast activation	Rgcc	IMP		Mouse	MGI:MGI:5317995|PMID:21990365
Biological Process	GO:0016525	negative regulation of angiogenesis	RGCC	IDA		Human	PMID:19652095
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	RGCC	IDA		Human	PMID:19652095
Biological Process	GO:0008285	negative regulation of cell population proliferation	RGCC	IMP		Human	PMID:17146433
Biological Process	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin	RGCC	IDA		Human	PMID:19158077
Biological Process	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin	RGCC	IDA		Human	PMID:21307346
Biological Process	GO:0001818	negative regulation of cytokine production	RGCC	IMP		Human	PMID:19162005
Biological Process	GO:0001937	negative regulation of endothelial cell proliferation	RGCC	IDA		Human	PMID:19652095
Biological Process	GO:0001100	negative regulation of exit from mitosis	RGCC	IDA		Human	PMID:17146433
Biological Process	GO:0090272	negative regulation of fibroblast growth factor production	RGCC	IDA		Human	PMID:19652095
Biological Process	GO:1901991	negative regulation of mitotic cell cycle phase transition	RGCC	IDA		Human	PMID:17146433
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	RGCC	IDA		Human	PMID:19158077
Biological Process	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	RGCC	IDA		Human	PMID:11687586
Biological Process	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	RGCC	IMP		Human	PMID:19162005
Biological Process	GO:0001819	positive regulation of cytokine production	RGCC	IMP		Human	PMID:19162005
Biological Process	GO:2000573	positive regulation of DNA biosynthetic process	Rgcc	IDA		Rat	PMID:9756947|RGD:633887
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	RGCC	IMP		Human	PMID:19158077
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	RGCC	IDA		Human	PMID:19652095
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	RGCC	IMP		Human	PMID:19158077
Biological Process	GO:0010718	positive regulation of epithelial to mesenchymal transition	RGCC	IDA		Human	PMID:21307346
Biological Process	GO:1901203	positive regulation of extracellular matrix assembly	RGCC	IDA		Human	PMID:21307346
Biological Process	GO:0003331	positive regulation of extracellular matrix constituent secretion	RGCC	IDA		Human	PMID:19158077
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	RGCC	IMP		Human	PMID:19162005
Biological Process	GO:0010628	positive regulation of gene expression	RGCC	IDA		Human	PMID:21307346
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	RGCC	IMP		Human	PMID:19162005
Biological Process	GO:0051496	positive regulation of stress fiber assembly	RGCC	IDA		Human	PMID:19158077
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	RGCC	IMP		Human	PMID:19158077

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern