Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RGN
  • Mouse genes Rgn
  • Rat genes Rgn
  • Zfish genes rgn
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rgn

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	RGN	IDA		Human	PMID:20329768
Molecular Function	GO:0005509	calcium ion binding	Rgn	IDA		Rat	PMID:699201|RGD:8554242
Molecular Function	GO:0004341	gluconolactonase activity	RGN	IDA		Human	PMID:20329768
Molecular Function	GO:0004341	gluconolactonase activity	RGN	IDA		Human	PMID:23349732
Molecular Function	GO:0004341	gluconolactonase activity	Rgn	IDA		Mouse	MGI:MGI:5486063|PMID:23349732
Molecular Function	GO:0004341	gluconolactonase activity	Rgn	IMP	MGI:MGI:2670511	Mouse	PMID:16585534
Molecular Function	GO:0004341	gluconolactonase activity	Rgn	IDA		Rat	PMID:16585534|RGD:9590200
Molecular Function	GO:0008270	zinc ion binding	RGN	IDA		Human	PMID:20329768
Cellular Component	GO:0005737	cytoplasm	Rgn	IDA		Mouse	PMID:12368201
Cellular Component	GO:0005829	cytosol	Rgn	IDA		Rat	PMID:10922512|RGD:9590172
Cellular Component	GO:0005634	nucleus	Rgn	IDA		Mouse	PMID:12368201
Cellular Component	GO:0005634	nucleus	Rgn	IDA		Rat	PMID:10536367|RGD:9590203
Cellular Component	GO:0005634	nucleus	Rgn	IDA		Rat	PMID:18425353|RGD:9590204
Biological Process	GO:0007568	aging	Rgn	IEP		Rat	PMID:8794449|RGD:9590212
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Rgn	IDA		Rat	PMID:16786169|RGD:8554108
Biological Process	GO:0001822	kidney development	Rgn	IEP		Rat	PMID:8794449|RGD:9590212
Biological Process	GO:0019853	L-ascorbic acid biosynthetic process	Rgn	IDA		Mouse	MGI:MGI:5486063|PMID:23349732
Biological Process	GO:0019853	L-ascorbic acid biosynthetic process	Rgn	IMP	MGI:MGI:2670511	Mouse	PMID:16585534
Biological Process	GO:0001889	liver development	Rgn	IEP		Rat	PMID:8794449|RGD:9590212
Biological Process	GO:0001889	liver development	Rgn	IEP		Rat	PMID:9546611|RGD:9590173
Biological Process	GO:0097421	liver regeneration	Rgn	IEP		Rat	PMID:7759556|RGD:9590197
Biological Process	GO:0043066	negative regulation of apoptotic process	Rgn	IDA		Rat	PMID:15806309|RGD:9590227
Biological Process	GO:0043066	negative regulation of apoptotic process	Rgn	IDA		Rat	PMID:16167335|RGD:9590214
Biological Process	GO:1903011	negative regulation of bone development	Rgn	IMP		Rat	PMID:11129957|RGD:9590179
Biological Process	GO:1903011	negative regulation of bone development	Rgn	IDA		Rat	PMID:12239582|RGD:9681003
Biological Process	GO:1903611	negative regulation of calcium-dependent ATPase activity	Rgn	IMP		Rat	PMID:10861851|RGD:9590176
Biological Process	GO:0051344	negative regulation of cyclic-nucleotide phosphodiesterase activity	Rgn	IDA		Rat	PMID:1656206|RGD:9590243
Biological Process	GO:2000279	negative regulation of DNA biosynthetic process	Rgn	IMP		Rat	PMID:11500948|RGD:9590199
Biological Process	GO:1903625	negative regulation of DNA catabolic process	Rgn	IDA		Rat	PMID:2001740|RGD:9590215
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Rgn	IDA		Rat	PMID:16142398|RGD:9590223
Biological Process	GO:1901318	negative regulation of flagellated sperm motility	Rgn	IDA		Rat	PMID:23615721|RGD:9590208
Biological Process	GO:0034260	negative regulation of GTPase activity	Rgn	IMP		Rat	PMID:11510494|RGD:9590205
Biological Process	GO:1903634	negative regulation of leucine-tRNA ligase activity	Rgn	IDA		Rat	PMID:2280766|RGD:9590217
Biological Process	GO:0045019	negative regulation of nitric oxide biosynthetic process	Rgn	IMP		Rat	PMID:12686401|RGD:9590175
Biological Process	GO:0032515	negative regulation of phosphoprotein phosphatase activity	Rgn	IMP		Rat	PMID:10922512|RGD:9590172
Biological Process	GO:0006469	negative regulation of protein kinase activity	Rgn	IMP		Rat	PMID:11455566|RGD:9590207
Biological Process	GO:0001933	negative regulation of protein phosphorylation	Rgn	IMP		Rat	PMID:9827702|RGD:9590180
Biological Process	GO:1902679	negative regulation of RNA biosynthetic process	Rgn	IMP		Rat	PMID:12397604|RGD:1566573
Biological Process	GO:0032781	positive regulation of ATP-dependent activity	Rgn	IDA		Rat	PMID:16786169|RGD:8554108
Biological Process	GO:1901896	positive regulation of ATPase-coupled calcium transmembrane transporter activity	Rgn	IDA		Rat	PMID:10797571|RGD:9590178
Biological Process	GO:1903629	positive regulation of dUTP diphosphatase activity	Rgn	IDA		Rat	PMID:1315924|RGD:2301218
Biological Process	GO:0045723	positive regulation of fatty acid biosynthetic process	Rgn	IDA		Rat	PMID:16817230|RGD:9590221
Biological Process	GO:0010907	positive regulation of glucose metabolic process	Rgn	IDA		Rat	PMID:16817230|RGD:9590221
Biological Process	GO:0043547	positive regulation of GTPase activity	Rgn	IDA		Rat	PMID:11693188|RGD:9590216
Biological Process	GO:0010922	positive regulation of phosphatase activity	Rgn	IMP		Rat	PMID:9671264|RGD:9590174
Biological Process	GO:1903052	positive regulation of proteolysis involved in protein catabolic process	Rgn	IDA		Rat	PMID:1513338|RGD:9590188
Biological Process	GO:1901671	positive regulation of superoxide dismutase activity	Rgn	IDA		Rat	PMID:15375603|RGD:9590277
Biological Process	GO:0010867	positive regulation of triglyceride biosynthetic process	Rgn	IDA		Rat	PMID:16817230|RGD:9590221
Biological Process	GO:0050848	regulation of calcium-mediated signaling	Rgn	IDA		Rat	PMID:16786169|RGD:8554108
Biological Process	GO:0007283	spermatogenesis	Rgn	IDA		Rat	PMID:23615721|RGD:9590208

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern