Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RGS12
  • Mouse genes Rgs12
  • Rat genes Rgs12
  • Zfish genes rgs12a,rgs12b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rgs12

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001965	G-protein alpha-subunit binding	Rgs12	IPI	RGD:2714	Rat	PMID:11387333|RGD:7207387
Molecular Function	GO:0005096	GTPase activator activity	Rgs12	IDA		Rat	PMID:9651375|RGD:69959
Molecular Function	GO:0030695	GTPase regulator activity	RGS12	IDA		Human	PMID:9651375
Molecular Function	GO:0005515	protein binding	RGS12	IPI	UniProtKB:Q8IYS1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Rgs12	IPI	UniProtKB:P15056|UniProtKB:Q63932	Mouse	MGI:MGI:5508605|PMID:17380122
Molecular Function	GO:0005515	protein binding	Rgs12	IPI	UniProtKB:P04897	Rat	PMID:11387333|RGD:7207387
Molecular Function	GO:0005515	protein binding	Rgs12	IPI	UniProtKB:P08753	Rat	PMID:11387333|RGD:7207387
Molecular Function	GO:0005515	protein binding	Rgs12	IPI	UniProtKB:P10824	Rat	PMID:11387333|RGD:7207387
Cellular Component	GO:0097440	apical dendrite	Rgs12	IDA		Rat	PMID:16819986|RGD:7207381
Cellular Component	GO:0005737	cytoplasm	Rgs12	IDA		Rat	PMID:16819986|RGD:7207381
Cellular Component	GO:0005829	cytosol	RGS12	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Rgs12	IDA		Rat	PMID:17380122|RGD:7207398
Cellular Component	GO:0030425	dendrite	Rgs12	IDA		Rat	PMID:16819986|RGD:7207381
Cellular Component	GO:0043025	neuronal cell body	Rgs12	IDA		Rat	PMID:16819986|RGD:7207381
Cellular Component	GO:0005730	nucleolus	RGS12	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	RGS12	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Rgs12	IDA		Rat	PMID:16819986|RGD:7207381
Cellular Component	GO:0005634	nucleus	Rgs12	IDA		Rat	PMID:17380122|RGD:7207398
Cellular Component	GO:0005886	plasma membrane	Rgs12	IDA		Rat	PMID:17380122|RGD:7207398
Cellular Component	GO:0032991	protein-containing complex	Rgs12	IDA		Rat	PMID:17380122|RGD:7207398
Cellular Component	GO:0045202	synapse	Rgs12	IDA		Rat	PMID:16819986|RGD:7207381
Biological Process	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	Rgs12	IEP		Rat	PMID:9651375|RGD:69959
Biological Process	GO:0038032	termination of G protein-coupled receptor signaling pathway	Rgs12	IDA		Rat	PMID:11130074|RGD:7207399

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern