Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RGS2
  • Mouse genes Rgs2
  • Rat genes Rgs2
  • Zfish genes rgs2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rgs2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0010855	adenylate cyclase inhibitor activity	Rgs2	IMP		Mouse	PMID:21164481
Molecular Function	GO:0048487	beta-tubulin binding	Rgs2	IPI	RGD:628596	Rat	PMID:16820281|RGD:7207368
Molecular Function	GO:0001965	G-protein alpha-subunit binding	RGS2	IPI	UniProtKB:P21279	Human	PMID:19478087
Molecular Function	GO:0005096	GTPase activator activity	RGS2	IMP		Human	PMID:19478087
Molecular Function	GO:0005515	protein binding	RGS2	IPI	UniProtKB:Q13976-1	Human	PMID:14608379
Molecular Function	GO:0005515	protein binding	RGS2	IPI	UniProtKB:Q9ULJ8	Human	PMID:17464283
Molecular Function	GO:0005515	protein binding	RGS2	IPI	UniProtKB:Q5S007	Human	PMID:24794857
Molecular Function	GO:0005515	protein binding	RGS2	IPI	UniProtKB:Q5JR59	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RGS2	IPI	UniProtKB:Q5JR59-3	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	RGS2	IPI	UniProtKB:O76071	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RGS2	IPI	UniProtKB:O60260-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Rgs2	IPI	PR:Q8BK26	Mouse	PMID:25970626
Molecular Function	GO:0005515	protein binding	Rgs2	IPI	PR:Q6R891	Mouse	PMID:17464283
Cellular Component	GO:0005737	cytoplasm	RGS2	IDA		Human	PMID:11278586
Cellular Component	GO:0005737	cytoplasm	Rgs2	IDA		Rat	PMID:15946253|RGD:13524578
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	Rgs2	IDA		Mouse	MGI:MGI:5009116|PMID:21291891
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	Rgs2	IDA		Rat	PMID:21291891|RGD:8554116
Cellular Component	GO:0005829	cytosol	RGS2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Rgs2	IMP		Mouse	MGI:MGI:3836877|PMID:19127022
Cellular Component	GO:0043005	neuron projection	Rgs2	IDA		Rat	PMID:16820281|RGD:7207368
Cellular Component	GO:0005634	nucleus	RGS2	IDA		Human	PMID:11278586
Cellular Component	GO:0005634	nucleus	RGS2	IDA		Human	PMID:10791963
Cellular Component	GO:0005886	plasma membrane	RGS2	IDA		Human	PMID:11278586
Cellular Component	GO:0005886	plasma membrane	Rgs2	IMP		Mouse	MGI:MGI:3836877|PMID:19127022
Biological Process	GO:0007420	brain development	Rgs2	IEP		Rat	PMID:11906535|RGD:13524541
Biological Process	GO:0050873	brown fat cell differentiation	Rgs2	IDA		Mouse	PMID:18492766
Biological Process	GO:0060135	maternal process involved in female pregnancy	Rgs2	IEP		Rat	PMID:12712095|RGD:13524580
Biological Process	GO:0140194	negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process	Rgs2	IMP		Mouse	MGI:MGI:5009116|PMID:21291891
Biological Process	GO:0010614	negative regulation of cardiac muscle hypertrophy	Rgs2	IMP		Mouse	MGI:MGI:3836877|PMID:19127022
Biological Process	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development	Rgs2	IMP		Rat	PMID:16380388|RGD:13524577
Biological Process	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	Rgs2	IMP		Mouse	MGI:MGI:3836877|PMID:19127022
Biological Process	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	Rgs2	IEP		Rat	PMID:11968023|RGD:633858
Biological Process	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	Rgs2	IMP		Rat	PMID:21798518|RGD:7207364
Biological Process	GO:1900924	negative regulation of glycine import across plasma membrane	Rgs2	IMP		Rat	PMID:21798518|RGD:7207364
Biological Process	GO:0043407	negative regulation of MAP kinase activity	Rgs2	IMP		Mouse	MGI:MGI:3836877|PMID:19127022
Biological Process	GO:0090301	negative regulation of neural crest formation	rgs2	IMP	ZFIN:ZDB-MRPHLNO-170320-2	Zfish	PMID:27979767
Biological Process	GO:0010519	negative regulation of phospholipase activity	Rgs2	IMP		Mouse	MGI:MGI:3836877|PMID:19127022
Biological Process	GO:0017148	negative regulation of translation	Rgs2	IMP		Rat	PMID:24576550|RGD:13524571
Biological Process	GO:0014032	neural crest cell development	rgs2	IGI	ZFIN:ZDB-GENE-990415-212	Zfish	PMID:27979767
Biological Process	GO:0030728	ovulation	Rgs2	IEP		Rat	PMID:11058559|RGD:13524582
Biological Process	GO:0060452	positive regulation of cardiac muscle contraction	Rgs2	IMP		Mouse	MGI:MGI:5009116|PMID:21291891
Biological Process	GO:0060452	positive regulation of cardiac muscle contraction	Rgs2	IMP		Mouse	MGI:MGI:3836877|PMID:19127022
Biological Process	GO:0010976	positive regulation of neuron projection development	Rgs2	IMP		Rat	PMID:16820281|RGD:7207368
Biological Process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	RGS2	IMP		Human	PMID:19478087
Biological Process	GO:0055119	relaxation of cardiac muscle	Rgs2	IMP		Mouse	MGI:MGI:3836877|PMID:19127022
Biological Process	GO:0060087	relaxation of vascular associated smooth muscle	Rgs2	IMP		Mouse	MGI:MGI:2682081|PMID:14608379
Biological Process	GO:0001975	response to amphetamine	Rgs2	IEP		Rat	PMID:26321241|RGD:13524514
Biological Process	GO:0045471	response to ethanol	Rgs2	IEP		Rat	PMID:28736108|RGD:13524510
Biological Process	GO:0007283	spermatogenesis	Rgs2	IEP		Mouse	MGI:MGI:2679461|PMID:14581517

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern