Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RGS4
  • Mouse genes Rgs4
  • Rat genes Rgs4
  • Zfish genes rgs4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rgs4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001965	G-protein alpha-subunit binding	Rgs4	IPI	RGD:628732	Rat	PMID:20530129|RGD:7207369
Molecular Function	GO:0001965	G-protein alpha-subunit binding	Rgs4	IDA		Rat	PMID:28115169|RGD:13524512
Molecular Function	GO:0001965	G-protein alpha-subunit binding	Rgs4	IDA		Rat	PMID:9108480|RGD:7207370
Molecular Function	GO:0005096	GTPase activator activity	Rgs4	IDA		Rat	PMID:10942773|RGD:13524554
Molecular Function	GO:0005096	GTPase activator activity	Rgs4	IMP		Rat	PMID:20530129|RGD:7207369
Molecular Function	GO:0005096	GTPase activator activity	Rgs4	IMP		Rat	PMID:9430692|RGD:7207375
Molecular Function	GO:0019901	protein kinase binding	Rgs4	IPI	RGD:62004	Rat	PMID:17084383|RGD:2326120
Cellular Component	GO:0005737	cytoplasm	RGS4	IDA		Human	PMID:10791963
Cellular Component	GO:0005737	cytoplasm	Rgs4	IDA		Rat	PMID:21896332|RGD:13524519
Cellular Component	GO:0005737	cytoplasm	Rgs4	IDA		Rat	PMID:9918533|RGD:7207376
Cellular Component	GO:0005829	cytosol	Rgs4	IDA		Rat	PMID:11738086|RGD:2312641
Cellular Component	GO:0005829	cytosol	Rgs4	IDA		Rat	PMID:14534355|RGD:1601365
Cellular Component	GO:0016020	membrane	Rgs4	IDA		Rat	PMID:11738086|RGD:2312641
Cellular Component	GO:0016020	membrane	Rgs4	IDA		Rat	PMID:17084383|RGD:2326120
Cellular Component	GO:0005634	nucleus	RGS4	IDA		Human	PMID:10791963
Cellular Component	GO:0005634	nucleus	Rgs4	IDA		Rat	PMID:21896332|RGD:13524519
Cellular Component	GO:0005886	plasma membrane	Rgs4	IDA		Rat	PMID:14534355|RGD:1601365
Cellular Component	GO:0005886	plasma membrane	Rgs4	IDA		Rat	PMID:9918533|RGD:7207376
Cellular Component	GO:0032991	protein-containing complex	Rgs4	IDA		Rat	PMID:9108480|RGD:7207370
Biological Process	GO:0007409	axonogenesis	rgs4	IMP	ZFIN:ZDB-MRPHLNO-130321-2	Zfish	PMID:23052218
Biological Process	GO:0007420	brain development	Rgs4	IEP		Rat	PMID:11906535|RGD:13524541
Biological Process	GO:1990791	dorsal root ganglion development	Rgs4	IEP		Rat	PMID:14550772|RGD:13524539
Biological Process	GO:0031018	endocrine pancreas development	rgs4	IMP	ZFIN:ZDB-MRPHLNO-111116-2	Zfish	PMID:21911471
Biological Process	GO:0031018	endocrine pancreas development	rgs4	IMP	ZFIN:ZDB-MRPHLNO-111116-1	Zfish	PMID:21911471
Biological Process	GO:0007626	locomotory behavior	rgs4	IMP	ZFIN:ZDB-MRPHLNO-130321-2	Zfish	PMID:23052218
Biological Process	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development	Rgs4	IDA		Rat	PMID:9918533|RGD:7207376
Biological Process	GO:0060160	negative regulation of dopamine receptor signaling pathway	Rgs4	IDA		Rat	PMID:21896332|RGD:13524519
Biological Process	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	Rgs4	IMP		Rat	PMID:21798518|RGD:7207364
Biological Process	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	Rgs4	IMP		Rat	PMID:9918533|RGD:7207376
Biological Process	GO:1900924	negative regulation of glycine import across plasma membrane	Rgs4	IMP		Rat	PMID:21798518|RGD:7207364
Biological Process	GO:1901380	negative regulation of potassium ion transmembrane transport	Rgs4	IDA		Rat	PMID:24421355|RGD:11064811
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	Rgs4	IMP		Rat	PMID:17220354|RGD:13524537
Biological Process	GO:0043547	positive regulation of GTPase activity	Rgs4	IMP		Rat	PMID:20530129|RGD:7207369
Biological Process	GO:0043547	positive regulation of GTPase activity	Rgs4	IMP		Rat	PMID:9430692|RGD:7207375
Biological Process	GO:0010460	positive regulation of heart rate	Rgs4	IMP		Rat	PMID:25844489|RGD:13524517
Biological Process	GO:0110053	regulation of actin filament organization	Rgs4	IDA		Rat	PMID:9918533|RGD:7207376
Biological Process	GO:0051924	regulation of calcium ion transport	Rgs4	IDA		Rat	PMID:16699510|RGD:13524538
Biological Process	GO:1901379	regulation of potassium ion transmembrane transport	Rgs4	IDA		Rat	PMID:11906535|RGD:13524541
Biological Process	GO:0001975	response to amphetamine	Rgs4	IEP		Rat	PMID:26321241|RGD:13524514
Biological Process	GO:0042220	response to cocaine	Rgs4	IEP		Rat	PMID:17632279|RGD:13524536
Biological Process	GO:0045471	response to ethanol	Rgs4	IEP		Rat	PMID:28736108|RGD:13524510
Biological Process	GO:0043278	response to morphine	Rgs4	IEP		Rat	PMID:12653973|RGD:13524581
Biological Process	GO:0043278	response to morphine	Rgs4	IEP		Rat	PMID:22056472|RGD:13524518

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern