Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RGS8
  • Mouse genes Rgs8
  • Rat genes Rgs8
  • Zfish genes rgs8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rgs8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001965	G-protein alpha-subunit binding	Rgs8	IPI	UniProtKB:P59215	Rat	PMID:9394004|RGD:69963
Molecular Function	GO:0005096	GTPase activator activity	RGS8	IDA		Human	PMID:18434541
Molecular Function	GO:0005096	GTPase activator activity	Rgs8	IDA		Rat	PMID:9394004|RGD:69963
Molecular Function	GO:0005515	protein binding	RGS8	IPI	UniProtKB:Q08379	Human	PMID:25416956
Cellular Component	GO:0030425	dendrite	Rgs8	IDA		Rat	PMID:12880183|RGD:10680094
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	Rgs8	IDA		Rat	PMID:12880183|RGD:10680094
Cellular Component	GO:0032809	neuronal cell body membrane	Rgs8	IDA		Rat	PMID:12880183|RGD:10680094
Cellular Component	GO:0005634	nucleus	Rgs8	IDA		Rat	PMID:12880183|RGD:10680094
Biological Process	GO:0007420	brain development	Rgs8	IEP		Rat	PMID:10092682|RGD:69962
Biological Process	GO:0007213	G protein-coupled acetylcholine receptor signaling pathway	Rgs8	IDA		Rat	PMID:9394004|RGD:69963
Biological Process	GO:0043547	positive regulation of GTPase activity	RGS8	IDA		Human	PMID:18434541
Biological Process	GO:0043547	positive regulation of GTPase activity	Rgs8	IDA		Rat	PMID:9394004|RGD:69963
Biological Process	GO:0060159	regulation of dopamine receptor signaling pathway	Rgs8	IDA		Rat	PMID:9394004|RGD:69963
Biological Process	GO:0001975	response to amphetamine	Rgs8	IEP		Rat	PMID:26321241|RGD:13524514

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern