Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RHEB
  • Mouse genes Rheb
  • Rat genes Rheb
  • Zfish genes rheb,rhebl1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rheb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019003	GDP binding	RHEB	IMP		Human	PMID:15728574
Molecular Function	GO:0019003	GDP binding	Rheb	IDA		Rat	PMID:16354680|RGD:1625606
Molecular Function	GO:0005525	GTP binding	RHEB	IMP		Human	PMID:15728574
Molecular Function	GO:0005525	GTP binding	Rheb	IDA		Mouse	MGI:MGI:5306547|PMID:21336308
Molecular Function	GO:0005525	GTP binding	Rheb	IDA		Rat	PMID:16354680|RGD:1625606
Molecular Function	GO:0003924	GTPase activity	Rheb	IDA		Rat	PMID:16354680|RGD:1625606
Molecular Function	GO:0000287	magnesium ion binding	RHEB	IMP		Human	PMID:15728574
Molecular Function	GO:0005515	protein binding	RHEB	IPI	UniProtKB:P13693	Human	PMID:17301792
Molecular Function	GO:0005515	protein binding	RHEB	IPI	UniProtKB:P42345	Human	PMID:18550814
Molecular Function	GO:0005515	protein binding	RHEB	IPI	UniProtKB:Q13393	Human	PMID:18550814
Molecular Function	GO:0005515	protein binding	RHEB	IPI	UniProtKB:P13473-2	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	RHEB	IPI	UniProtKB:Q92624	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RHEB	IPI	UniProtKB:O00291	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RHEB	IPI	UniProtKB:O75400-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RHEB	IPI	UniProtKB:P06307	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RHEB	IPI	UniProtKB:P13473-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RHEB	IPI	UniProtKB:P22607	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RHEB	IPI	UniProtKB:P55212	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RHEB	IPI	UniProtKB:P62826	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RHEB	IPI	UniProtKB:Q14957	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RHEB	IPI	UniProtKB:Q9UMX0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RHEB	IPI	UniProtKB:Q9Y649	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Rheb	IPI	RGD:619908	Rat	PMID:15150271|RGD:1580097
Molecular Function	GO:0019901	protein kinase binding	Rheb	IPI	UniProtKB:O54992	Mouse	MGI:MGI:5306547|PMID:21336308
Cellular Component	GO:0030425	dendrite	Rheb	IDA		Rat	PMID:15525761|RGD:2307416
Cellular Component	GO:0070062	extracellular exosome	RHEB	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	RHEB	HDA		Human	PMID:20458337
Cellular Component	GO:0098978	glutamatergic synapse	Rheb	IDA		Rat	PMID:24889507|RGD:13702223
Cellular Component	GO:0098978	glutamatergic synapse	Rheb	IMP		Rat	PMID:24889507|RGD:13702223
Cellular Component	GO:0043025	neuronal cell body	Rheb	IDA		Rat	PMID:15525761|RGD:2307416
Cellular Component	GO:0014069	postsynaptic density	RHEB	EXP		Human	PMID:27898073
Cellular Component	GO:0014069	postsynaptic density	RHEB	IDA		Human	PMID:27898073
Cellular Component	GO:0005681	spliceosomal complex	Rheb	IDA		Mouse	PMID:11555636
Cellular Component	GO:0045202	synapse	Rheb	EXP		Mouse	PMID:25211037
Cellular Component	GO:0045202	synapse	Rheb	IDA		Mouse	PMID:25211037
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	Rheb	IMP		Mouse	MGI:MGI:5924677|PMID:28242620
Biological Process	GO:0048709	oligodendrocyte differentiation	Rheb	IMP	MGI:MGI:2179311,MGI:MGI:3850507	Mouse	PMID:25411504
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	Rheb	IMP	MGI:MGI:2179311,MGI:MGI:3850507	Mouse	PMID:25411504
Biological Process	GO:0032008	positive regulation of TOR signaling	RHEB	IMP		Human	PMID:20381137
Biological Process	GO:0032008	positive regulation of TOR signaling	Rheb	IDA		Mouse	MGI:MGI:5306547|PMID:21336308
Biological Process	GO:0099175	regulation of postsynapse organization	Rheb	IDA		Rat	PMID:24889507|RGD:13702223
Biological Process	GO:0099175	regulation of postsynapse organization	Rheb	IMP		Rat	PMID:24889507|RGD:13702223
Biological Process	GO:0032006	regulation of TOR signaling	Rheb	IMP		Mouse	MGI:MGI:4367675|PMID:19258434
Biological Process	GO:2000074	regulation of type B pancreatic cell development	RHEB	IMP		Human	PMID:19258434
Biological Process	GO:0007264	small GTPase mediated signal transduction	Rheb	IDA		Rat	PMID:16354680|RGD:1625606

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern