Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RIF1
  • Mouse genes Rif1
  • Rat genes Rif1
  • Zfish genes rif1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rif1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	RIF1	IPI	UniProtKB:P62136	Human	PMID:22321011
Molecular Function	GO:0005515	protein binding	RIF1	IPI	UniProtKB:Q12888	Human	PMID:23333306
Molecular Function	GO:0005515	protein binding	RIF1	IPI	UniProtKB:P62136	Human	PMID:27173435
Molecular Function	GO:0005515	protein binding	RIF1	IPI	UniProtKB:Q12888	Human	PMID:28241136
Molecular Function	GO:0005515	protein binding	RIF1	IPI	UniProtKB:P62136	Human	PMID:28330616
Molecular Function	GO:0005515	protein binding	RIF1	IPI	UniProtKB:Q03468	Human	PMID:29203878
Molecular Function	GO:0005515	protein binding	RIF1	IPI	UniProtKB:Q86V20	Human	PMID:29789392
Molecular Function	GO:0005515	protein binding	Rif1	IPI	UniProtKB:Q61066|UniProtKB:Q80Z64	Mouse	MGI:MGI:4399017|PMID:17093407
Molecular Function	GO:0005515	protein binding	Rif1	IPI	UniProtKB:P70399	Mouse	MGI:MGI:5468037|PMID:23306437
Molecular Function	GO:0005515	protein binding	Rif1	IPI	UniProtKB:Q61066	Mouse	MGI:MGI:5320277|PMID:20362541
Molecular Function	GO:0005515	protein binding	Rif1	IPI	UniProtKB:O54864|UniProtKB:Q5DW34|UniProtKB:Q61686|UniProtKB:Q62318|UniProtKB:Q9Z148	Mouse	MGI:MGI:5584328|PMID:24735877
Molecular Function	GO:0005515	protein binding	Rif1	IPI	UniProtKB:P70399	Mouse	MGI:MGI:5468036|PMID:23306439
Molecular Function	GO:0005515	protein binding	Rif1	IPI	UniProtKB:P70399	Mouse	MGI:MGI:5476381|PMID:23333305
Cellular Component	GO:0000785	chromatin	Rif1	IMP		Mouse	MGI:MGI:5584328|PMID:24735877
Cellular Component	GO:0000781	chromosome, telomeric region	Rif1	IDA		Mouse	PMID:15042697
Cellular Component	GO:0140445	chromosome, telomeric repeat region	Rif1	IDA		Mouse	MGI:MGI:5584328|PMID:24735877
Cellular Component	GO:0000793	condensed chromosome	RIF1	IDA		Human	PMID:15583028
Cellular Component	GO:0001939	female pronucleus	Rif1	IDA		Mouse	PMID:15042697
Cellular Component	GO:0001940	male pronucleus	Rif1	IDA		Mouse	PMID:15042697
Cellular Component	GO:0031965	nuclear membrane	RIF1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	RIF1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Rif1	IDA		Mouse	PMID:15042697
Cellular Component	GO:0005886	plasma membrane	RIF1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0035861	site of double-strand break	RIF1	IDA		Human	PMID:28241136
Cellular Component	GO:0035861	site of double-strand break	Rif1	IDA		Mouse	MGI:MGI:5468037|PMID:23306437
Cellular Component	GO:0035861	site of double-strand break	Rif1	IDA		Mouse	MGI:MGI:5468036|PMID:23306439
Cellular Component	GO:0035861	site of double-strand break	Rif1	IMP		Mouse	MGI:MGI:5476381|PMID:23333305
Cellular Component	GO:0051233	spindle midzone	RIF1	IDA		Human	PMID:15583028
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Rif1	IEP		Mouse	PMID:20439489
Biological Process	GO:0006974	DNA damage response	RIF1	IDA		Human	PMID:28241136
Biological Process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	RIF1	IDA		Human	PMID:23333306
Biological Process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	Rif1	IMP		Mouse	MGI:MGI:5476381|PMID:23333305
Biological Process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	Rif1	IMP		Mouse	MGI:MGI:5468037|PMID:23306437
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic	Rif1	IDA		Mouse	MGI:MGI:5584328|PMID:24735877
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Rif1	IMP		Mouse	MGI:MGI:5584328|PMID:24735877
Biological Process	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining	RIF1	IDA		Human	PMID:28241136
Biological Process	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining	Rif1	IMP		Mouse	MGI:MGI:5476381|PMID:23333305
Biological Process	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining	Rif1	IMP		Mouse	MGI:MGI:5468037|PMID:23306437
Biological Process	GO:0051574	positive regulation of histone H3-K9 methylation	Rif1	IMP		Mouse	MGI:MGI:5584328|PMID:24735877
Biological Process	GO:0045830	positive regulation of isotype switching	Rif1	IMP		Mouse	MGI:MGI:5476381|PMID:23333305
Biological Process	GO:0045830	positive regulation of isotype switching	Rif1	IMP		Mouse	MGI:MGI:5468036|PMID:23306439
Biological Process	GO:0045830	positive regulation of isotype switching	Rif1	IMP		Mouse	MGI:MGI:5490831|PMID:23333306
Biological Process	GO:0035019	somatic stem cell population maintenance	Rif1	IMP		Mouse	PMID:16518401
Biological Process	GO:0031509	subtelomeric heterochromatin formation	Rif1	IMP		Mouse	MGI:MGI:5584328|PMID:24735877
Biological Process	GO:0000723	telomere maintenance	Rif1	IMP		Mouse	MGI:MGI:5584328|PMID:24735877
Biological Process	GO:0043247	telomere maintenance in response to DNA damage	RIF1	IDA		Human	PMID:15583028

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern