Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RIGI
  • Mouse genes Rigi
  • Rat genes Rig1
  • Zfish genes rigi
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rigi

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016887	ATP hydrolysis activity	RIGI	IMP		Human	PMID:19211564
Molecular Function	GO:0003690	double-stranded DNA binding	Rigi	IDA		Mouse	PMID:19158679
Molecular Function	GO:0003725	double-stranded RNA binding	RIGI	IMP		Human	PMID:19211564
Molecular Function	GO:0003725	double-stranded RNA binding	RIGI	IDA		Human	PMID:19576794
Molecular Function	GO:0003725	double-stranded RNA binding	Rigi	IDA		Mouse	MGI:MGI:5315798|PMID:22314235
Molecular Function	GO:0003725	double-stranded RNA binding	Rigi	IDA		Mouse	PMID:22745163
Molecular Function	GO:0005525	GTP binding	RIGI	IMP		Human	PMID:21233210
Molecular Function	GO:0042802	identical protein binding	RIGI	IPI	UniProtKB:O95786	Human	PMID:21102435
Molecular Function	GO:0042802	identical protein binding	RIGI	IPI	UniProtKB:O95786	Human	PMID:34544279
Molecular Function	GO:0140677	molecular function activator activity	RIGI	IDA		Human	PMID:25119032
Molecular Function	GO:0038187	pattern recognition receptor activity	RIGI	IDA		Human	PMID:19576794
Molecular Function	GO:0038187	pattern recognition receptor activity	RIGI	IDA		Human	PMID:25119032
Molecular Function	GO:0038187	pattern recognition receptor activity	RIGI	IDA		Human	PMID:35263596
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q7Z434	Human	PMID:16127453
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q7Z434	Human	PMID:16177806
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q14164	Human	PMID:16281057
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q9UHD2	Human	PMID:16281057
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:P03496	Human	PMID:17079289
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q96C10	Human	PMID:17190814
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q96EQ8	Human	PMID:17460044
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q9NQC7	Human	PMID:18636086
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q86WV6	Human	PMID:18724357
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q8IUD6	Human	PMID:19017631
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q7Z434	Human	PMID:19164550
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:P04543	Human	PMID:19193793
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q7Z434	Human	PMID:19193793
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:P59596	Human	PMID:19380580
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:P12931	Human	PMID:19419966
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q6IUF9	Human	PMID:20007272
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q6IVU5	Human	PMID:20007272
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q6UY62	Human	PMID:20007272
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q6UY71	Human	PMID:20007272
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q7Z434	Human	PMID:20007272
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:O00571	Human	PMID:20127681
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q86WI3	Human	PMID:20434986
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q14258	Human	PMID:20818395
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q920D5	Human	PMID:20818395
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q7Z2W4	Human	PMID:21102435
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q7Z2W4-2	Human	PMID:21102435
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q7Z434	Human	PMID:21102435
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q0P5N6	Human	PMID:21233210
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q8IY21	Human	PMID:21791617
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:O14879	Human	PMID:21813773
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q7Z434	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q96S55	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q84940	Human	PMID:22152002
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q99FX5	Human	PMID:22152002
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:P04487	Human	PMID:22301138
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q7Z434	Human	PMID:22301138
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:O75179	Human	PMID:22328336
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q7Z434	Human	PMID:22623778
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:P21699	Human	PMID:23552410
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q92503	Human	PMID:23843640
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:O75569	Human	PMID:23870315
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:P42224	Human	PMID:24360797
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q14258	Human	PMID:24478431
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q7Z434	Human	PMID:24478431
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:P59596	Human	PMID:24509444
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q9NZM5	Human	PMID:27824081
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:O75569	Human	PMID:28591694
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q9NUD5	Human	PMID:30193849
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q13283	Human	PMID:30804210
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q7Z434	Human	PMID:33372174
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:P0DTC9	Human	PMID:33396605
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q7Z434	Human	PMID:33976430
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q14258	Human	PMID:34452305
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:P0DTC9	Human	PMID:34471099
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q14258	Human	PMID:34471099
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:P0DTD1:PRO_0000449623	Human	PMID:34544279
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q7Z434	Human	PMID:34544279
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:P0DTC9	Human	PMID:35075101
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:P0DTD1:PRO_0000449623	Human	PMID:35075101
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q14258	Human	PMID:35075101
Molecular Function	GO:0005515	protein binding	RIGI	IPI	UniProtKB:Q7Z434	Human	PMID:35075101
Molecular Function	GO:0005515	protein binding	Rigi	IPI	UniProtKB:P22682|UniProtKB:Q80ZE3	Mouse	MGI:MGI:5468580|PMID:23374343
Molecular Function	GO:0005515	protein binding	Rigi	IPI	MGI:MGI:2384570	Mouse	PMID:21791617
Molecular Function	GO:0005515	protein binding	rigi	IPI	ZFIN:ZDB-GENE-061108-4	Zfish	PMID:27235368
Molecular Function	GO:0003724	RNA helicase activity	RIGI	IMP		Human	PMID:19211564
Molecular Function	GO:0003727	single-stranded RNA binding	RIGI	IMP		Human	PMID:19211564
Molecular Function	GO:0003727	single-stranded RNA binding	Rigi	IDA		Mouse	MGI:MGI:5315798|PMID:22314235
Molecular Function	GO:0031625	ubiquitin protein ligase binding	RIGI	IPI	UniProtKB:Q14258	Human	PMID:23950712
Molecular Function	GO:0031625	ubiquitin protein ligase binding	RIGI	IPI	UniProtKB:Q8IUD6	Human	PMID:23950712
Molecular Function	GO:0031625	ubiquitin protein ligase binding	RIGI	IPI	UniProtKB:Q96EQ8	Human	PMID:26471729
Molecular Function	GO:0031625	ubiquitin protein ligase binding	RIGI	IPI	UniProtKB:Q8IUD6	Human	PMID:31006531
Molecular Function	GO:0008270	zinc ion binding	RIGI	IDA		Human	PMID:18243112
Cellular Component	GO:0015629	actin cytoskeleton	RIGI	IDA		Human	PMID:19122199
Cellular Component	GO:0005923	bicellular tight junction	RIGI	IDA		Human	PMID:19122199
Cellular Component	GO:0005737	cytoplasm	RIGI	IDA		Human	PMID:15208624
Cellular Component	GO:0005737	cytoplasm	RIGI	IDA		Human	PMID:27807226
Cellular Component	GO:0005737	cytoplasm	RIGI	IDA		Human	PMID:21102435
Cellular Component	GO:0005829	cytosol	rigi	IDA		Zfish	PMID:25524497
Cellular Component	GO:0005634	nucleus	rigi	IDA		Zfish	PMID:25524497
Cellular Component	GO:1990904	ribonucleoprotein complex	RIGI	IDA		Human	PMID:31006531
Cellular Component	GO:0032587	ruffle membrane	RIGI	IDA		Human	PMID:19122199
Biological Process	GO:0140374	antiviral innate immune response	RIGI	IDA		Human	PMID:28469175
Biological Process	GO:0071360	cellular response to exogenous dsRNA	RIGI	IMP		Human	PMID:21957149
Biological Process	GO:0019221	cytokine-mediated signaling pathway	rigi	IDA		Zfish	PMID:25265425
Biological Process	GO:0002753	cytosolic pattern recognition receptor signaling pathway	RIGI	IDA		Human	PMID:19576794
Biological Process	GO:0051607	defense response to virus	RIGI	IDA		Human	PMID:21478870
Biological Process	GO:0051607	defense response to virus	rigi	IDA		Zfish	PMID:25524497
Biological Process	GO:0051607	defense response to virus	rigi	IMP	ZFIN:ZDB-MRPHLNO-150423-1	Zfish	PMID:25634257
Biological Process	GO:0009597	detection of virus	RIGI	IDA		Human	PMID:17079289
Biological Process	GO:0010467	gene expression	Rigi	IMP		Mouse	PMID:31623059
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	rigi	IDA		Zfish	PMID:28555019
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	rigi	IMP	ZFIN:ZDB-MRPHLNO-180129-2	Zfish	PMID:28555019
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	rigi	IDA		Zfish	PMID:25265425
Biological Process	GO:0045087	innate immune response	RIGI	IMP		Human	PMID:19609254
Biological Process	GO:0045087	innate immune response	RIGI	IMP		Human	PMID:19631370
Biological Process	GO:0045087	innate immune response	Rigi	IMP		Mouse	MGI:MGI:5318026|PMID:17942531
Biological Process	GO:0002230	positive regulation of defense response to virus by host	RIGI	IMP		Human	PMID:19609254
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	RIGI	IDA		Human	PMID:17079289
Biological Process	GO:0010628	positive regulation of gene expression	RIGI	IDA		Human	PMID:24409285
Biological Process	GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	RIGI	IDA		Human	PMID:24409285
Biological Process	GO:0032727	positive regulation of interferon-alpha production	RIGI	IDA		Human	PMID:19576794
Biological Process	GO:0032727	positive regulation of interferon-alpha production	RIGI	IMP		Human	PMID:19609254
Biological Process	GO:0032727	positive regulation of interferon-alpha production	RIGI	IMP		Human	PMID:21957149
Biological Process	GO:0032728	positive regulation of interferon-beta production	RIGI	IDA		Human	PMID:17079289
Biological Process	GO:0032728	positive regulation of interferon-beta production	RIGI	IMP		Human	PMID:19609254
Biological Process	GO:0032728	positive regulation of interferon-beta production	RIGI	IMP		Human	PMID:19631370
Biological Process	GO:0032728	positive regulation of interferon-beta production	RIGI	IMP		Human	PMID:21957149
Biological Process	GO:0032728	positive regulation of interferon-beta production	Rigi	IMP		Mouse	MGI:MGI:5318026|PMID:17942531
Biological Process	GO:0032755	positive regulation of interleukin-6 production	RIGI	IMP		Human	PMID:21957149
Biological Process	GO:0032755	positive regulation of interleukin-6 production	RIGI	IDA		Human	PMID:24409285
Biological Process	GO:0032757	positive regulation of interleukin-8 production	RIGI	IDA		Human	PMID:24409285
Biological Process	GO:0002735	positive regulation of myeloid dendritic cell cytokine production	Rigi	IMP		Mouse	MGI:MGI:5050760|PMID:21703541
Biological Process	GO:0060760	positive regulation of response to cytokine stimulus	RIGI	IMP		Human	PMID:21957149
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	RIGI	IDA		Human	PMID:17079289
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	RIGI	IMP		Human	PMID:21957149
Biological Process	GO:0030334	regulation of cell migration	RIGI	IDA		Human	PMID:19122199
Biological Process	GO:0006355	regulation of DNA-templated transcription	rigi	IDA		Zfish	PMID:27235368
Biological Process	GO:0010468	regulation of gene expression	rigi	IDA		Zfish	PMID:28555019
Biological Process	GO:0043330	response to exogenous dsRNA	Rigi	IMP		Mouse	PMID:21703541
Biological Process	GO:0009615	response to virus	Rigi	IMP		Mouse	MGI:MGI:5318026|PMID:17942531
Biological Process	GO:0039529	RIG-I signaling pathway	RIGI	IMP		Human	PMID:19211564
Biological Process	GO:0039529	RIG-I signaling pathway	RIGI	IDA		Human	PMID:28469175
Biological Process	GO:0039529	RIG-I signaling pathway	rigi	IDA		Zfish	PMID:25524497
Biological Process	GO:0060337	type I interferon-mediated signaling pathway	rigi	IMP	ZFIN:ZDB-MRPHLNO-150423-1	Zfish	PMID:25634257
Biological Process	GO:0060333	type II interferon-mediated signaling pathway	rigi	IMP	ZFIN:ZDB-MRPHLNO-180129-1	Zfish	PMID:28555019
Biological Process	GO:0060333	type II interferon-mediated signaling pathway	rigi	IDA		Zfish	PMID:28555019

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern