Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RIMS2
  • Mouse genes Rims2
  • Rat genes Rims2
  • Zfish genes rims2a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rims2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140677	molecular function activator activity	Rims2	IDA		Mouse	PMID:11056535
Molecular Function	GO:0005515	protein binding	RIMS2	IPI	UniProtKB:P16333	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	Rims2	IPI	PR:Q69ZP3	Mouse	PMID:25730884
Molecular Function	GO:0005515	protein binding	Rims2	IPI	PR:Q9QYX7	Mouse	PMID:12401793
Molecular Function	GO:0005515	protein binding	Rims2	IPI	PR:P55258	Mouse	PMID:12578829
Molecular Function	GO:0005515	protein binding	Rims2	IPI	PR:P35276	Mouse	PMID:12578829
Molecular Function	GO:0005515	protein binding	Rims2	IPI	MGI:MGI:1914545	Mouse	PMID:12578829
Molecular Function	GO:0005515	protein binding	Rims2	IPI	PR:P63011	Mouse	PMID:11056535
Molecular Function	GO:0005515	protein binding	Rims2	IPI	PR:Q9EQZ6	Mouse	PMID:12401793
Molecular Function	GO:0005515	protein binding	Rims2	IPI	PR:Q9CZT8	Mouse	PMID:12578829
Molecular Function	GO:0005515	protein binding	Rims2	IPI	PR:P63011	Mouse	PMID:12578829
Molecular Function	GO:0005515	protein binding	Rims2	IPI	RGD:620054	Rat	PMID:11797009|RGD:633666
Molecular Function	GO:0005515	protein binding	Rims2	IPI	UniProtKB:Q62768	Rat	PMID:16732694|RGD:2311136
Molecular Function	GO:0019904	protein domain specific binding	Rims2	IDA		Rat	PMID:16732694|RGD:2311136
Molecular Function	GO:0044877	protein-containing complex binding	Rims2	IDA		Rat	PMID:16732694|RGD:2311136
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	Rims2	IDA		Mouse	PMID:11056535
Molecular Function	GO:0098882	structural constituent of presynaptic active zone	Rims2	IDA		Mouse	PMID:21241895
Molecular Function	GO:0098882	structural constituent of presynaptic active zone	Rims2	IMP		Mouse	PMID:21241895
Molecular Function	GO:0098882	structural constituent of presynaptic active zone	Rims2	IEP		Mouse	PMID:27537483
Molecular Function	GO:0098882	structural constituent of presynaptic active zone	Rims2	IDA		Mouse	PMID:27537483
Molecular Function	GO:0098882	structural constituent of presynaptic active zone	Rims2	IMP		Mouse	PMID:27537483
Molecular Function	GO:0044325	transmembrane transporter binding	Rims2	IDA		Mouse	PMID:20452978
Cellular Component	GO:0070062	extracellular exosome	RIMS2	HDA		Human	PMID:18570454
Cellular Component	GO:0098982	GABA-ergic synapse	Rims2	IDA		Mouse	PMID:22753485
Cellular Component	GO:0098982	GABA-ergic synapse	Rims2	IMP		Mouse	PMID:22753485
Cellular Component	GO:0098982	GABA-ergic synapse	Rims2	IDA		Mouse	PMID:21262469
Cellular Component	GO:0098982	GABA-ergic synapse	Rims2	IMP		Mouse	PMID:21262469
Cellular Component	GO:0098978	glutamatergic synapse	Rims2	IDA		Mouse	PMID:21241895
Cellular Component	GO:0098978	glutamatergic synapse	Rims2	IMP		Mouse	PMID:21241895
Cellular Component	GO:0098978	glutamatergic synapse	Rims2	IDA		Mouse	PMID:21262469
Cellular Component	GO:0098978	glutamatergic synapse	Rims2	IMP		Mouse	PMID:21262469
Cellular Component	GO:0060077	inhibitory synapse	Rims2	IMP		Mouse	MGI:MGI:5432438|PMID:22753485
Cellular Component	GO:0098684	photoreceptor ribbon synapse	Rims2	IDA		Rat	PMID:9252191|RGD:633897
Cellular Component	GO:0098831	presynaptic active zone cytoplasmic component	Rims2	IDA		Rat	PMID:9252191|RGD:633897
Cellular Component	GO:0032991	protein-containing complex	Rims2	IDA		Rat	PMID:16732694|RGD:2311136
Cellular Component	GO:0045202	synapse	Rims2	IDA		Rat	PMID:12871946|RGD:1302925
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	Rims2	IDA		Mouse	PMID:11598134
Biological Process	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter	Rims2	IGI	MGI:MGI:2152971	Mouse	PMID:17124501
Biological Process	GO:0017156	calcium-ion regulated exocytosis	Rims2	IDA		Mouse	PMID:11056535
Biological Process	GO:0051649	establishment of localization in cell	Rims2	IMP		Mouse	PMID:11598134
Biological Process	GO:0030073	insulin secretion	Rims2	IMP		Mouse	PMID:11598134
Biological Process	GO:0030073	insulin secretion	Rims2	IDA		Mouse	PMID:11598134
Biological Process	GO:0048790	maintenance of presynaptic active zone structure	Rims2	IEP		Mouse	MGI:MGI:6189473|PMID:27537483
Biological Process	GO:0007269	neurotransmitter secretion	Rims2	IGI	MGI:MGI:1930773	Mouse	PMID:25730884
Biological Process	GO:1903861	positive regulation of dendrite extension	RIMS2	IDA		Human	PMID:23999003
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	Rims2	IGI	UniProtKB:Q99NE5|UniProtKB:Q9EQZ7	Mouse	MGI:MGI:4887275|PMID:21262469
Biological Process	GO:0010628	positive regulation of gene expression	Rims2	IGI	UniProtKB:Q99NE5	Mouse	MGI:MGI:4887275|PMID:21262469
Biological Process	GO:0097151	positive regulation of inhibitory postsynaptic potential	Rims2	IGI	UniProtKB:Q99NE5|UniProtKB:Q9EQZ7	Mouse	MGI:MGI:4887275|PMID:21262469
Biological Process	GO:0150037	regulation of calcium-dependent activation of synaptic vesicle fusion	Rims2	IDA		Mouse	PMID:21241895
Biological Process	GO:0150037	regulation of calcium-dependent activation of synaptic vesicle fusion	Rims2	IMP		Mouse	PMID:21241895
Biological Process	GO:0017157	regulation of exocytosis	Rims2	IMP	MGI:MGI:4838195	Mouse	PMID:20674857
Biological Process	GO:0042391	regulation of membrane potential	Rims2	IDA		Mouse	PMID:20452978
Biological Process	GO:0061669	spontaneous neurotransmitter secretion	Rims2	IGI	UniProtKB:Q99NE5|UniProtKB:Q9EQZ7	Mouse	MGI:MGI:4887275|PMID:21262469
Biological Process	GO:0016081	synaptic vesicle docking	Rims2	IDA		Mouse	PMID:21241895
Biological Process	GO:0016081	synaptic vesicle docking	Rims2	IMP		Mouse	PMID:21241895
Biological Process	GO:0016082	synaptic vesicle priming	Rims2	IDA		Mouse	PMID:22753485
Biological Process	GO:0016082	synaptic vesicle priming	Rims2	IMP		Mouse	PMID:22753485
Biological Process	GO:0016082	synaptic vesicle priming	Rims2	IDA		Mouse	PMID:21262469
Biological Process	GO:0016082	synaptic vesicle priming	Rims2	IMP		Mouse	PMID:21262469

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern