Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Ripk2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes RIPK2
- Mouse genes Ripk2
- Rat genes Ripk2
- Zfish genes ripk2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ripk2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0050700	CARD domain binding	RIPK2	IDA		Human	PMID:10329646
Molecular Function	GO:0050700	CARD domain binding	RIPK2	IPI	UniProtKB:Q9HC29	Human	PMID:11087742
Molecular Function	GO:0089720	caspase binding	RIPK2	IPI	UniProtKB:P29466	Human	PMID:11432859
Molecular Function	GO:0089720	caspase binding	RIPK2	IPI	UniProtKB:P29466	Human	PMID:11536016
Molecular Function	GO:0089720	caspase binding	RIPK2	IPI	UniProtKB:P29466	Human	PMID:15383541
Molecular Function	GO:0042802	identical protein binding	RIPK2	IPI	UniProtKB:O43353	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	RIPK2	IPI	UniProtKB:O43353	Human	PMID:32296183
Molecular Function	GO:0030274	LIM domain binding	RIPK2	IPI	UniProtKB:Q15654	Human	PMID:15657077
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	RIPK2	IDA		Human	PMID:16824733
Molecular Function	GO:0005515	protein binding	RIPK2	IPI	UniProtKB:Q5EG05	Human	PMID:11432859
Molecular Function	GO:0005515	protein binding	RIPK2	IPI	UniProtKB:Q5EG05	Human	PMID:11536016
Molecular Function	GO:0005515	protein binding	RIPK2	IPI	UniProtKB:Q5EG05	Human	PMID:15383541
Molecular Function	GO:0005515	protein binding	RIPK2	IPI	UniProtKB:Q9BX69	Human	PMID:16418290
Molecular Function	GO:0005515	protein binding	RIPK2	IPI	UniProtKB:O43353	Human	PMID:19337385
Molecular Function	GO:0005515	protein binding	RIPK2	IPI	UniProtKB:Q9HC29	Human	PMID:19337385
Molecular Function	GO:0005515	protein binding	RIPK2	IPI	UniProtKB:Q9Y239	Human	PMID:19337385
Molecular Function	GO:0005515	protein binding	RIPK2	IPI	UniProtKB:P98170	Human	PMID:19667203
Molecular Function	GO:0005515	protein binding	RIPK2	IPI	UniProtKB:Q92974	Human	PMID:21887730
Molecular Function	GO:0005515	protein binding	RIPK2	IPI	UniProtKB:Q12933	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	RIPK2	IPI	UniProtKB:Q7Z434	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	RIPK2	IPI	UniProtKB:P98170	Human	PMID:21931591
Molecular Function	GO:0005515	protein binding	RIPK2	IPI	UniProtKB:Q13489	Human	PMID:21931591
Molecular Function	GO:0005515	protein binding	RIPK2	IPI	UniProtKB:Q13490	Human	PMID:21931591
Molecular Function	GO:0005515	protein binding	RIPK2	IPI	UniProtKB:Q9HC29	Human	PMID:21931826
Molecular Function	GO:0005515	protein binding	RIPK2	IPI	UniProtKB:Q9HC29	Human	PMID:22829933
Molecular Function	GO:0005515	protein binding	RIPK2	IPI	UniProtKB:Q13114	Human	PMID:23333941
Molecular Function	GO:0005515	protein binding	RIPK2	IPI	UniProtKB:P98170	Human	PMID:23818254
Molecular Function	GO:0005515	protein binding	RIPK2	IPI	UniProtKB:P98170	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RIPK2	IPI	UniProtKB:Q9HC29	Human	PMID:27812135
Molecular Function	GO:0005515	protein binding	RIPK2	IPI	UniProtKB:Q3KP66	Human	PMID:28436939
Molecular Function	GO:0005515	protein binding	RIPK2	IPI	UniProtKB:P98170	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	RIPK2	IPI	UniProtKB:P98170	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	RIPK2	IPI	UniProtKB:Q12933	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	RIPK2	IPI	UniProtKB:Q13114	Human	PMID:32707033
Molecular Function	GO:0042803	protein homodimerization activity	RIPK2	IDA		Human	PMID:19337385
Molecular Function	GO:0005102	signaling receptor binding	RIPK2	IPI	UniProtKB:Q9HC29	Human	PMID:24790089
Cellular Component	GO:0005737	cytoplasm	RIPK2	IDA		Human	PMID:21887730
Cellular Component	GO:0005856	cytoskeleton	RIPK2	IDA		Human	PMID:21887730
Cellular Component	GO:0005829	cytosol	RIPK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0032991	protein-containing complex	RIPK2	IMP		Human	PMID:11432859
Cellular Component	GO:0032991	protein-containing complex	RIPK2	IDA		Human	PMID:11536016
Cellular Component	GO:0032991	protein-containing complex	RIPK2	IDA		Human	PMID:15383541
Cellular Component	GO:0032991	protein-containing complex	RIPK2	IDA		Human	PMID:21887730
Cellular Component	GO:0031982	vesicle	RIPK2	IDA		Human	PMID:21887730
Biological Process	GO:0097202	activation of cysteine-type endopeptidase activity	RIPK2	IDA		Human	PMID:11821383
Biological Process	GO:0002250	adaptive immune response	Ripk2	IMP		Mouse	MGI:MGI:5285496\|PMID:21469090
Biological Process	GO:0140367	antibacterial innate immune response	ripk2	IMP	ZFIN:ZDB-GENO-200310-1	Zfish	PMID:29692779
Biological Process	GO:0035739	CD4-positive, alpha-beta T cell proliferation	Ripk2	IMP	MGI:MGI:2446070	Mouse	PMID:11894097
Biological Process	GO:0035739	CD4-positive, alpha-beta T cell proliferation	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Ripk2	IMP	MGI:MGI:2446070	Mouse	PMID:11894097
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0071223	cellular response to lipoteichoic acid	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0071225	cellular response to muramyl dipeptide	RIPK2	IDA		Human	PMID:21887730
Biological Process	GO:0071224	cellular response to peptidoglycan	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0032602	chemokine production	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Ripk2	IMP	MGI:MGI:2446070	Mouse	PMID:11894097
Biological Process	GO:0042742	defense response to bacterium	ripk2	IDA		Zfish	PMID:27235368
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Ripk2	IMP	MGI:MGI:2446070	Mouse	PMID:11894097
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:18261938
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0051607	defense response to virus	ripk2	IDA		Zfish	PMID:27235368
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Ripk2	IDA		Mouse	PMID:18261938
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Ripk2	IMP		Mouse	MGI:MGI:5285496\|PMID:21469090
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:18261938
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Ripk2	IMP	MGI:MGI:2446070	Mouse	PMID:11894097
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0033080	immature T cell proliferation in thymus	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0045087	innate immune response	RIPK2	IDA		Human	PMID:23806334
Biological Process	GO:0045087	innate immune response	Ripk2	IMP		Mouse	MGI:MGI:5285496\|PMID:21469090
Biological Process	GO:0045087	innate immune response	ripk2	IMP	ZFIN:ZDB-GENO-190205-6	Zfish	PMID:29659823
Biological Process	GO:0045087	innate immune response	ripk2	IMP	ZFIN:ZDB-GENO-190205-7	Zfish	PMID:29659823
Biological Process	GO:0045087	innate immune response	ripk2	IMP	ZFIN:ZDB-GENO-190205-5	Zfish	PMID:29659823
Biological Process	GO:0032623	interleukin-2 production	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0032635	interleukin-6 production	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0032635	interleukin-6 production	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:18261938
Biological Process	GO:0007254	JNK cascade	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:18261938
Biological Process	GO:0007254	JNK cascade	Ripk2	IMP	MGI:MGI:2446070	Mouse	PMID:11894097
Biological Process	GO:0007254	JNK cascade	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0010934	macrophage cytokine production	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0010934	macrophage cytokine production	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:18261938
Biological Process	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	RIPK2	IDA		Human	PMID:16824733
Biological Process	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	RIPK2	IDA		Human	PMID:23806334
Biological Process	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0043065	positive regulation of apoptotic process	Ripk2	IDA		Mouse	PMID:14663141
Biological Process	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	Ripk2	IMP	MGI:MGI:2446070	Mouse	PMID:11894097
Biological Process	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0010942	positive regulation of cell death	RIPK2	IDA		Human	PMID:16920334
Biological Process	GO:0032722	positive regulation of chemokine production	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0001961	positive regulation of cytokine-mediated signaling pathway	Ripk2	IMP	MGI:MGI:2446070	Mouse	PMID:11894097
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Ripk2	IDA		Mouse	PMID:18261938
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	RIPK2	IDA		Human	PMID:10329646
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:18261938
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Ripk2	IMP	MGI:MGI:2446070	Mouse	PMID:11894097
Biological Process	GO:0033092	positive regulation of immature T cell proliferation in thymus	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	RIPK2	IDA		Human	PMID:11432859
Biological Process	GO:0032743	positive regulation of interleukin-2 production	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Ripk2	IMP		Mouse	MGI:MGI:5543891\|PMID:21887730
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:18261938
Biological Process	GO:0046330	positive regulation of JNK cascade	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:18261938
Biological Process	GO:0046330	positive regulation of JNK cascade	Ripk2	IMP	MGI:MGI:2446070	Mouse	PMID:11894097
Biological Process	GO:0046330	positive regulation of JNK cascade	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:18261938
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	RIPK2	IDA		Human	PMID:11821383
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	RIPK2	IMP		Human	PMID:21887730
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	RIPK2	IMP		Human	PMID:21931591
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Ripk2	IMP		Mouse	MGI:MGI:5543891\|PMID:21887730
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Ripk2	IMP	MGI:MGI:2446070	Mouse	PMID:14638696
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	RIPK2	IDA		Human	PMID:21887730
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	RIPK2	IDA		Human	PMID:21887730
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	RIPK2	IDA		Human	PMID:21887730
Biological Process	GO:0032092	positive regulation of protein binding	RIPK2	IMP		Human	PMID:11432859
Biological Process	GO:0031398	positive regulation of protein ubiquitination	RIPK2	IMP		Human	PMID:15620648
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:18261938
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	Ripk2	IMP	MGI:MGI:2446070	Mouse	PMID:11894097
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0045627	positive regulation of T-helper 1 cell differentiation	Ripk2	IMP	MGI:MGI:2446070	Mouse	PMID:11894097
Biological Process	GO:0002827	positive regulation of T-helper 1 type immune response	Ripk2	IMP	MGI:MGI:2446070	Mouse	PMID:11894097
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Ripk2	IMP		Mouse	MGI:MGI:5543891\|PMID:21887730
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:18261938
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0032729	positive regulation of type II interferon production	Ripk2	IMP	MGI:MGI:2446070	Mouse	PMID:11894097
Biological Process	GO:0032729	positive regulation of type II interferon production	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:1904417	positive regulation of xenophagy	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:22033934
Biological Process	GO:0006355	regulation of DNA-templated transcription	ripk2	IDA		Zfish	PMID:27235368
Biological Process	GO:0006355	regulation of DNA-templated transcription	ripk2	IGI	ZFIN:ZDB-GENE-061108-4	Zfish	PMID:27235368
Biological Process	GO:0043330	response to exogenous dsRNA	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0070555	response to interleukin-1	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0070671	response to interleukin-12	Ripk2	IMP	MGI:MGI:2446070	Mouse	PMID:11894097
Biological Process	GO:0070671	response to interleukin-12	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0070673	response to interleukin-18	Ripk2	IMP	MGI:MGI:2446070	Mouse	PMID:11894097
Biological Process	GO:0070673	response to interleukin-18	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0051403	stress-activated MAPK cascade	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:18261938
Biological Process	GO:0051403	stress-activated MAPK cascade	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0051403	stress-activated MAPK cascade	Ripk2	IMP	MGI:MGI:2446070	Mouse	PMID:11894097
Biological Process	GO:0042098	T cell proliferation	Ripk2	IMP	MGI:MGI:2446070	Mouse	PMID:14638696
Biological Process	GO:0050852	T cell receptor signaling pathway	Ripk2	IMP		Mouse	MGI:MGI:5285496\|PMID:21469090
Biological Process	GO:0050852	T cell receptor signaling pathway	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0034134	toll-like receptor 2 signaling pathway	RIPK2	IDA		Human	PMID:11894098
Biological Process	GO:0034142	toll-like receptor 4 signaling pathway	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0032640	tumor necrosis factor production	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:18261938
Biological Process	GO:0032640	tumor necrosis factor production	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0032609	type II interferon production	Ripk2	IMP	MGI:MGI:2446070	Mouse	PMID:11894097
Biological Process	GO:0032609	type II interferon production	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:11894098
Biological Process	GO:0098792	xenophagy	Ripk2	IMP	MGI:MGI:2660793	Mouse	PMID:22033934

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.