Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RNF168
  • Mouse genes Rnf168
  • Rat genes Rnf168
  • Zfish genes rnf168
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rnf168

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	RNF168	IDA		Human	PMID:19203578
Molecular Function	GO:0003682	chromatin binding	RNF168	IDA		Human	PMID:19203579
Molecular Function	GO:0003682	chromatin binding	RNF168	IDA		Human	PMID:19500350
Molecular Function	GO:0042393	histone binding	RNF168	IDA		Human	PMID:19203578
Molecular Function	GO:0042393	histone binding	RNF168	IDA		Human	PMID:19203579
Molecular Function	GO:0042393	histone binding	RNF168	IMP		Human	PMID:23760478
Molecular Function	GO:0140858	histone H2AK15 ubiquitin ligase activity	RNF168	IDA		Human	PMID:27153538
Molecular Function	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	RNF168	IDA		Human	PMID:19500350
Molecular Function	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	RNF168	IDA		Human	PMID:21041483
Molecular Function	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	RNF168	IDA		Human	PMID:22742833
Molecular Function	GO:0031491	nucleosome binding	RNF168	IDA		Human	PMID:22742833
Molecular Function	GO:0005515	protein binding	RNF168	IPI	UniProtKB:Q9Y3C5	Human	PMID:15231748
Molecular Function	GO:0005515	protein binding	RNF168	IPI	UniProtKB:P61088	Human	PMID:19203578
Molecular Function	GO:0005515	protein binding	RNF168	IPI	UniProtKB:O75164	Human	PMID:22373579
Molecular Function	GO:0005515	protein binding	RNF168	IPI	UniProtKB:P07305	Human	PMID:26503038
Molecular Function	GO:0005515	protein binding	RNF168	IPI	UniProtKB:P13196	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF168	IPI	UniProtKB:Q9BZR9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF168	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RNF168	IPI	UniProtKB:P37840	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RNF168	IPI	UniProtKB:Q14203-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RNF168	IPI	UniProtKB:Q9Y3C5	Human	PMID:32814053
Molecular Function	GO:0043130	ubiquitin binding	RNF168	IDA		Human	PMID:19203578
Molecular Function	GO:0043130	ubiquitin binding	RNF168	IDA		Human	PMID:19203579
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	RNF168	IDA		Human	PMID:19203578
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	RNF168	IDA		Human	PMID:19203579
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	RNF168	IDA		Human	PMID:19500350
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	RNF168	IDA		Human	PMID:22373579
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	RNF168	IDA		Human	PMID:22980979
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	RNF168	IMP		Human	PMID:23760478
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	RNF168	IDA		Human	PMID:27153538
Cellular Component	GO:0005829	cytosol	RNF168	IDA		Human	GO_REF:0000052
Cellular Component	GO:1990391	DNA repair complex	Rnf168	IDA		Mouse	PMID:24217620
Cellular Component	GO:0005654	nucleoplasm	RNF168	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	RNF168	IDA		Human	PMID:19203578
Cellular Component	GO:0005634	nucleus	RNF168	IDA		Human	PMID:19203579
Cellular Component	GO:0032991	protein-containing complex	RNF168	IDA		Human	PMID:24217620
Cellular Component	GO:0035861	site of double-strand break	RNF168	IDA		Human	PMID:27153538
Cellular Component	GO:0035861	site of double-strand break	RNF168	IDA		Human	PMID:19500350
Cellular Component	GO:0035861	site of double-strand break	RNF168	IDA		Human	PMID:21041483
Cellular Component	GO:0000151	ubiquitin ligase complex	RNF168	IDA		Human	PMID:19203578
Cellular Component	GO:0000151	ubiquitin ligase complex	RNF168	IDA		Human	PMID:19203579
Biological Process	GO:0034644	cellular response to UV	Rnf168	IDA		Mouse	PMID:24217620
Biological Process	GO:0006974	DNA damage response	RNF168	IDA		Human	PMID:19500350
Biological Process	GO:0006974	DNA damage response	RNF168	IDA		Human	PMID:20550933
Biological Process	GO:0006974	DNA damage response	RNF168	IDA		Human	PMID:22373579
Biological Process	GO:0006974	DNA damage response	RNF168	IDA		Human	PMID:22508508
Biological Process	GO:0006974	DNA damage response	RNF168	IDA		Human	PMID:22980979
Biological Process	GO:0006302	double-strand break repair	RNF168	IDA		Human	PMID:19203578
Biological Process	GO:0006302	double-strand break repair	RNF168	IDA		Human	PMID:19203579
Biological Process	GO:0006302	double-strand break repair	RNF168	IDA		Human	PMID:22980979
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	RNF168	IDA		Human	PMID:27153538
Biological Process	GO:0040029	epigenetic regulation of gene expression	RNF168	IMP		Human	PMID:20550933
Biological Process	GO:0070535	histone H2A K63-linked ubiquitination	RNF168	IDA		Human	PMID:19203578
Biological Process	GO:0070535	histone H2A K63-linked ubiquitination	RNF168	IDA		Human	PMID:19203579
Biological Process	GO:0070535	histone H2A K63-linked ubiquitination	RNF168	IDA		Human	PMID:19500350
Biological Process	GO:0035518	histone H2A monoubiquitination	RNF168	IDA		Human	PMID:22980979
Biological Process	GO:0035518	histone H2A monoubiquitination	RNF168	IMP		Human	PMID:23760478
Biological Process	GO:0036351	histone H2A-K13 ubiquitination	RNF168	IDA		Human	PMID:22980979
Biological Process	GO:0036352	histone H2A-K15 ubiquitination	RNF168	IDA		Human	PMID:22980979
Biological Process	GO:0036352	histone H2A-K15 ubiquitination	RNF168	IMP		Human	PMID:23760478
Biological Process	GO:0036352	histone H2A-K15 ubiquitination	RNF168	IDA		Human	PMID:27153538
Biological Process	GO:0045190	isotype switching	Rnf168	IMP		Mouse	MGI:MGI:4420833|PMID:20080757
Biological Process	GO:0034244	negative regulation of transcription elongation by RNA polymerase II	RNF168	IMP		Human	PMID:20550933
Biological Process	GO:0045739	positive regulation of DNA repair	RNF168	IDA		Human	PMID:19203578
Biological Process	GO:0045739	positive regulation of DNA repair	RNF168	IDA		Human	PMID:19203579
Biological Process	GO:0045739	positive regulation of DNA repair	RNF168	IMP		Human	PMID:23760478
Biological Process	GO:0070534	protein K63-linked ubiquitination	RNF168	IDA		Human	PMID:22266820
Biological Process	GO:0016567	protein ubiquitination	RNF168	IDA		Human	PMID:22373579
Biological Process	GO:0032880	regulation of protein localization	Rnf168	IMP		Mouse	PMID:24217620
Biological Process	GO:0010212	response to ionizing radiation	RNF168	IDA		Human	PMID:19203578
Biological Process	GO:0010212	response to ionizing radiation	RNF168	IDA		Human	PMID:19203579
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	RNF168	IDA		Human	PMID:22373579

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern