Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RNF34
  • Mouse genes Rnf34
  • Rat genes Rnf34
  • Zfish genes rnf34a,rnf34b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rnf34

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0002039	p53 binding	RNF34	IPI	UniProtKB:P04637	Human	PMID:17121812
Molecular Function	GO:0002039	p53 binding	RNF34	IPI	UniProtKB:P04637	Human	PMID:18382127
Molecular Function	GO:1901981	phosphatidylinositol phosphate binding	RNF34	IDA		Human	PMID:15069192
Molecular Function	GO:0005515	protein binding	RNF34	IPI	UniProtKB:Q14790	Human	PMID:15069192
Molecular Function	GO:0005515	protein binding	RNF34	IPI	UniProtKB:Q9UBK2	Human	PMID:22064484
Molecular Function	GO:0005515	protein binding	RNF34	IPI	UniProtKB:Q92624	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RNF34	IPI	UniProtKB:G5E9A7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RNF34	IPI	UniProtKB:O14908-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RNF34	IPI	UniProtKB:P02489	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RNF34	IPI	UniProtKB:Q01658	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RNF34	IPI	UniProtKB:Q53GS7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RNF34	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RNF34	IPI	UniProtKB:Q92876	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RNF34	IPI	UniProtKB:Q9BZ23-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RNF34	IPI	UniProtKB:Q9Y5Q9	Human	PMID:32814053
Molecular Function	GO:0061630	ubiquitin protein ligase activity	RNF34	IDA		Human	PMID:15069192
Molecular Function	GO:0061630	ubiquitin protein ligase activity	RNF34	IDA		Human	PMID:17121812
Molecular Function	GO:0061630	ubiquitin protein ligase activity	RNF34	IMP		Human	PMID:22064484
Molecular Function	GO:0061630	ubiquitin protein ligase activity	Rnf34	IDA		Rat	PMID:25193658|RGD:10047328
Molecular Function	GO:0031625	ubiquitin protein ligase binding	RNF34	IPI	UniProtKB:Q00987	Human	PMID:18382127
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	Rnf34	IDA		Rat	PMID:12859687|RGD:708308
Cellular Component	GO:0005737	cytoplasm	RNF34	IDA		Human	PMID:15069192
Cellular Component	GO:0016604	nuclear body	RNF34	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	RNF34	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	RNF34	IDA		Human	PMID:22064484
Cellular Component	GO:0005886	plasma membrane	RNF34	IDA		Human	PMID:15069192
Biological Process	GO:0070417	cellular response to cold	Rnf34	IMP		Mouse	MGI:MGI:5582154|PMID:22064484
Biological Process	GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	RNF34	IMP		Human	PMID:15069192
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	RNF34	IMP		Human	PMID:15069192
Biological Process	GO:1901797	negative regulation of signal transduction by p53 class mediator	RNF34	IMP		Human	PMID:17121812
Biological Process	GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	RNF34	IMP		Human	PMID:25012219
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	RNF34	IDA		Human	PMID:15069192
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	RNF34	IMP		Human	PMID:22064484
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	RNF34	IMP		Human	PMID:25012219
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Rnf34	IMP		Mouse	MGI:MGI:5582154|PMID:22064484
Biological Process	GO:0070936	protein K48-linked ubiquitination	RNF34	IMP		Human	PMID:25012219
Biological Process	GO:0016567	protein ubiquitination	RNF34	IDA		Human	PMID:15069192
Biological Process	GO:0016567	protein ubiquitination	RNF34	IMP		Human	PMID:22064484
Biological Process	GO:2000374	regulation of oxygen metabolic process	Rnf34	IMP		Mouse	MGI:MGI:5582154|PMID:22064484
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	RNF34	IMP		Human	PMID:22064484
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	Rnf34	IMP		Mouse	MGI:MGI:5582154|PMID:22064484

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern