Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Rnf8

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes RNF8
- Mouse genes Rnf8
- Rat genes Rnf8
- Zfish genes rnf8
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rnf8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	RNF8	IDA		Human	PMID:18001824
Molecular Function	GO:0003682	chromatin binding	RNF8	IDA		Human	PMID:18001825
Molecular Function	GO:0042393	histone binding	RNF8	IDA		Human	PMID:18001824
Molecular Function	GO:0042393	histone binding	RNF8	IDA		Human	PMID:18001825
Molecular Function	GO:0042393	histone binding	Rnf8	IMP		Mouse	MGI:MGI:3835231\|PMID:19015238
Molecular Function	GO:0042802	identical protein binding	RNF8	IPI	UniProtKB:O76064	Human	PMID:22980979
Molecular Function	GO:0042802	identical protein binding	RNF8	IPI	UniProtKB:O76064	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q9C0F1	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q14676	Human	PMID:18001824
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q14676	Human	PMID:18001825
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:P62837	Human	PMID:19690564
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:O95714	Human	PMID:20023648
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:O00401	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q9UL42	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:O96017	Human	PMID:22266820
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:P13010	Human	PMID:22266820
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:O75164	Human	PMID:22373579
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:O95714	Human	PMID:22508508
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:O00401	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:O43251	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q8IX15-3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q9BSE2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q9UH03	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q9UL42	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q9Y6D9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:V9HW80	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q9BUR4	Human	PMID:25512560
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q99986	Human	PMID:26869104
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q9BUR4	Human	PMID:27715493
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:O00401	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q9BSE2	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q9UH03	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q9Y6D9	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:A1L4K1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:I6L9I8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:O00401	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:O15173	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:O43251-10	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:O75558	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:O95208-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:P20618	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:P28482	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:P49585	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:P49760	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:P49761	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:P50570	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:P60410	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:P61968	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:P62837	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q15025	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q49A88-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q53TS8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q5QJE6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q5T7B8-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q63ZY3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q6P2H3-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q6UXN7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q8IVM0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q8IVP1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q8IZU0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q96CD2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q96D03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q96D09	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q96DT7-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q96IT1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q9BPY3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q9BSE2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q9BYQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q9BYQ4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q9C0F1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q9NRD5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q9NY72	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q9P1Z2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q9UH03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q9UL40	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q9UL42	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q9Y2J4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q9Y3C0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RNF8	IPI	UniProtKB:Q9Y6D9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Rnf8	IPI	UniProtKB:Q9JMB7	Mouse	MGI:MGI:5905675\|PMID:28552346
Molecular Function	GO:0005515	protein binding	Rnf8	IPI	UniProtKB:Q96AP0	Mouse	MGI:MGI:5919331\|PMID:22101936
Molecular Function	GO:0042803	protein homodimerization activity	RNF8	IDA		Human	PMID:22980979
Molecular Function	GO:0061630	ubiquitin protein ligase activity	Rnf8	IMP		Mouse	PMID:19015238
Molecular Function	GO:0031625	ubiquitin protein ligase binding	RNF8	IPI	UniProtKB:P61088	Human	PMID:22266820
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	RNF8	IDA		Human	PMID:18001824
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	RNF8	IDA		Human	PMID:18001825
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	RNF8	IDA		Human	PMID:18948756
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	RNF8	IDA		Human	PMID:21911360
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	RNF8	IDA		Human	PMID:22266820
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	RNF8	IDA		Human	PMID:22373579
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	RNF8	IDA		Human	PMID:22980979
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	Rnf8	IMP		Mouse	MGI:MGI:3835231\|PMID:19015238
Molecular Function	GO:0008270	zinc ion binding	RNF8	IDA		Human	PMID:22980979
Cellular Component	GO:0000781	chromosome, telomeric region	Rnf8	IDA		Mouse	MGI:MGI:5293246\|PMID:21857671
Cellular Component	GO:0005737	cytoplasm	Rnf8	IDA		Mouse	MGI:MGI:5905675\|PMID:28552346
Cellular Component	GO:0005829	cytosol	RNF8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	RNF8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	RNF8	IDA		Human	PMID:18001824
Cellular Component	GO:0005634	nucleus	RNF8	IDA		Human	PMID:18001825
Cellular Component	GO:0005634	nucleus	Rnf8	IDA		Mouse	MGI:MGI:5905675\|PMID:28552346
Cellular Component	GO:0035861	site of double-strand break	RNF8	IDA		Human	PMID:22266820
Cellular Component	GO:0000151	ubiquitin ligase complex	RNF8	IDA		Human	PMID:18001824
Cellular Component	GO:0000151	ubiquitin ligase complex	RNF8	IDA		Human	PMID:18001825
Biological Process	GO:0006974	DNA damage response	RNF8	IDA		Human	PMID:20550933
Biological Process	GO:0006974	DNA damage response	RNF8	IDA		Human	PMID:21911360
Biological Process	GO:0006974	DNA damage response	RNF8	IDA		Human	PMID:22266820
Biological Process	GO:0006974	DNA damage response	RNF8	IDA		Human	PMID:22373579
Biological Process	GO:0006974	DNA damage response	RNF8	IDA		Human	PMID:22980979
Biological Process	GO:0006974	DNA damage response	Rnf8	IDA		Mouse	MGI:MGI:5293246\|PMID:21857671
Biological Process	GO:0006302	double-strand break repair	RNF8	IDA		Human	PMID:18001824
Biological Process	GO:0006302	double-strand break repair	RNF8	IDA		Human	PMID:18001825
Biological Process	GO:0006302	double-strand break repair	RNF8	IDA		Human	PMID:22980979
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	Rnf8	IMP		Mouse	MGI:MGI:5465398\|PMID:22266820
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	Rnf8	IMP		Mouse	MGI:MGI:5293246\|PMID:21857671
Biological Process	GO:0040029	epigenetic regulation of gene expression	RNF8	IMP		Human	PMID:20550933
Biological Process	GO:0070535	histone H2A K63-linked ubiquitination	RNF8	IDA		Human	PMID:22980979
Biological Process	GO:0033522	histone H2A ubiquitination	RNF8	IDA		Human	PMID:18001824
Biological Process	GO:0033522	histone H2A ubiquitination	RNF8	IDA		Human	PMID:18001825
Biological Process	GO:0045190	isotype switching	Rnf8	IMP		Mouse	MGI:MGI:4420833\|PMID:20080757
Biological Process	GO:0034244	negative regulation of transcription elongation by RNA polymerase II	RNF8	IMP		Human	PMID:20550933
Biological Process	GO:0045739	positive regulation of DNA repair	RNF8	IDA		Human	PMID:18001824
Biological Process	GO:0045739	positive regulation of DNA repair	RNF8	IDA		Human	PMID:18001825
Biological Process	GO:0051865	protein autoubiquitination	RNF8	IDA		Human	PMID:22266820
Biological Process	GO:0070936	protein K48-linked ubiquitination	RNF8	IDA		Human	PMID:21911360
Biological Process	GO:0070936	protein K48-linked ubiquitination	RNF8	IDA		Human	PMID:22266820
Biological Process	GO:0070936	protein K48-linked ubiquitination	RNF8	IDA		Human	PMID:22373579
Biological Process	GO:0070534	protein K63-linked ubiquitination	RNF8	IDA		Human	PMID:21911360
Biological Process	GO:0010212	response to ionizing radiation	RNF8	IDA		Human	PMID:18001824
Biological Process	GO:0010212	response to ionizing radiation	RNF8	IDA		Human	PMID:18001825
Biological Process	GO:0042770	signal transduction in response to DNA damage	Rnf8	IMP		Mouse	MGI:MGI:3835231\|PMID:19015238
Biological Process	GO:0035092	sperm DNA condensation	Rnf8	IMP		Mouse	MGI:MGI:5905675\|PMID:28552346
Biological Process	GO:0035092	sperm DNA condensation	Rnf8	IMP		Mouse	MGI:MGI:4441228\|PMID:20153262
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	RNF8	IDA		Human	PMID:22266820
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	RNF8	IDA		Human	PMID:22373579

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.