Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Robo1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ROBO1
- Mouse genes Robo1
- Rat genes Robo1
- Zfish genes robo1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Robo1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008046	axon guidance receptor activity	Robo1	IDA		Rat	PMID:9458045\|RGD:61733
Molecular Function	GO:0042802	identical protein binding	ROBO1	IDA		Human	PMID:12504588
Molecular Function	GO:0030275	LRR domain binding	ROBO1	IPI	UniProtKB:O94813	Human	PMID:17848514
Molecular Function	GO:0005515	protein binding	ROBO1	IPI	UniProtKB:Q9HCK4	Human	PMID:12504588
Molecular Function	GO:0005515	protein binding	ROBO1	IPI	UniProtKB:O75093	Human	PMID:15207848
Molecular Function	GO:0005515	protein binding	ROBO1	IPI	UniProtKB:O75094	Human	PMID:15207848
Molecular Function	GO:0005515	protein binding	ROBO1	IPI	UniProtKB:O94813	Human	PMID:15207848
Molecular Function	GO:0005515	protein binding	ROBO1	IPI	UniProtKB:O94813	Human	PMID:17848514
Molecular Function	GO:0005515	protein binding	ROBO1	IPI	UniProtKB:O75044	Human	PMID:26365803
Molecular Function	GO:0005515	protein binding	ROBO1	IPI	UniProtKB:Q13459	Human	PMID:26529257
Molecular Function	GO:0005515	protein binding	Robo1	IPI	UniProtKB:Q8R5K2	Mouse	MGI:MGI:4418596\|PMID:19706539
Molecular Function	GO:0005515	protein binding	Robo1	IPI	PR:Q8R5K2	Mouse	PMID:19684588
Molecular Function	GO:0005515	protein binding	Robo1	IPI	UniProtKB:O94813	Rat	PMID:10102268\|RGD:68763
Molecular Function	GO:0005515	protein binding	Robo1	IPI	UniProtKB:Q63155	Rat	PMID:21215373\|RGD:8554092
Cellular Component	GO:0030673	axolemma	Robo1	IDA		Mouse	PMID:15084255
Cellular Component	GO:0030424	axon	Robo1	IDA		Rat	PMID:18986510\|RGD:2314842
Cellular Component	GO:0009986	cell surface	ROBO1	IDA		Human	PMID:12504588
Cellular Component	GO:0005737	cytoplasm	ROBO1	IDA		Human	PMID:18566128
Cellular Component	GO:0043025	neuronal cell body	Robo1	IDA		Rat	PMID:18986510\|RGD:2314842
Cellular Component	GO:0005886	plasma membrane	ROBO1	IDA		Human	GO_REF:0000052
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ROBO1	IMP		Human	PMID:18566128
Biological Process	GO:0035904	aorta development	Robo1	IGI	UniProtKB:Q7TPD3	Mouse	MGI:MGI:5913048\|PMID:25691540
Biological Process	GO:0003180	aortic valve morphogenesis	Robo1	IGI	UniProtKB:Q7TPD3	Mouse	MGI:MGI:5913048\|PMID:25691540
Biological Process	GO:0007411	axon guidance	Robo1	IMP	MGI:MGI:3043142	Mouse	PMID:15091338
Biological Process	GO:0007411	axon guidance	Robo1	IMP		Mouse	PMID:15084255
Biological Process	GO:0007411	axon guidance	Robo1	IDA		Rat	PMID:9458045\|RGD:61733
Biological Process	GO:0007411	axon guidance	robo1	IGI	ZFIN:ZDB-MRPHLNO-080708-11,ZFIN:ZDB-MRPHLNO-080708-13,ZFIN:ZDB-MRPHLNO-080708-7	Zfish	PMID:18061159
Biological Process	GO:0007411	axon guidance	robo1	IMP	ZFIN:ZDB-MRPHLNO-080708-7	Zfish	PMID:18061159
Biological Process	GO:0016199	axon midline choice point recognition	Robo1	IGI	UniProtKB:Q7TPD3	Mouse	MGI:MGI:3823169\|PMID:18986510
Biological Process	GO:0016199	axon midline choice point recognition	Robo1	IEP		Rat	PMID:18986510\|RGD:2314842
Biological Process	GO:0002042	cell migration involved in sprouting angiogenesis	ROBO1	IMP	UniProtKB:Q9UQL6	Human	PMID:19351956
Biological Process	GO:0007417	central nervous system development	Robo1	IEP		Rat	PMID:11754167\|RGD:2314870
Biological Process	GO:0021836	chemorepulsion involved in postnatal olfactory bulb interneuron migration	ROBO1	IDA		Human	PMID:15207848
Biological Process	GO:0060976	coronary vasculature development	Robo1	IMP		Mouse	PMID:25807483
Biological Process	GO:0003272	endocardial cushion formation	Robo1	IGI	UniProtKB:Q7TPD3	Mouse	MGI:MGI:5913048\|PMID:25691540
Biological Process	GO:0003262	endocardial progenitor cell migration to the midline involved in heart field formation	robo1	IGI	ZFIN:ZDB-MRPHLNO-051212-1,ZFIN:ZDB-MRPHLNO-080708-7,ZFIN:ZDB-MRPHLNO-110628-2,ZFIN:ZDB-MRPHLNO-110628-4	Zfish	PMID:21385766
Biological Process	GO:0007507	heart development	Robo1	IMP		Mouse	PMID:25807483
Biological Process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	ROBO1	IDA		Human	PMID:12504588
Biological Process	GO:0001822	kidney development	Robo1	IMP	MGI:MGI:5496051	Mouse	PMID:27002738
Biological Process	GO:0060763	mammary duct terminal end bud growth	Robo1	IMP	MGI:MGI:3043142	Mouse	PMID:16439476
Biological Process	GO:0030336	negative regulation of cell migration	ROBO1	IMP		Human	PMID:26529257
Biological Process	GO:0008285	negative regulation of cell population proliferation	Robo1	IMP	MGI:MGI:3043142	Mouse	PMID:18829537
Biological Process	GO:0070100	negative regulation of chemokine-mediated signaling pathway	ROBO1	IMP		Human	PMID:18829537
Biological Process	GO:0010629	negative regulation of gene expression	Robo1	IDA		Mouse	MGI:MGI:5913048\|PMID:25691540
Biological Process	GO:0033600	negative regulation of mammary gland epithelial cell proliferation	ROBO1	IMP		Human	PMID:18829537
Biological Process	GO:0050925	negative regulation of negative chemotaxis	ROBO1	IDA		Human	PMID:11748139
Biological Process	GO:0021891	olfactory bulb interneuron development	Robo1	IGI	UniProtKB:Q7TPD3	Mouse	MGI:MGI:3702250\|PMID:17360927
Biological Process	GO:0003148	outflow tract septum morphogenesis	Robo1	IGI	UniProtKB:Q7TPD3	Mouse	MGI:MGI:5913048\|PMID:25691540
Biological Process	GO:0050772	positive regulation of axonogenesis	ROBO1	IDA		Human	PMID:12504588
Biological Process	GO:0010628	positive regulation of gene expression	Robo1	IDA		Mouse	MGI:MGI:5913048\|PMID:25691540
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ROBO1	IMP		Human	PMID:21385766
Biological Process	GO:0035481	positive regulation of Notch signaling pathway involved in heart induction	Robo1	IDA		Mouse	MGI:MGI:5913048\|PMID:25691540
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction	ROBO1	IMP		Human	PMID:26529257
Biological Process	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway	ROBO1	IMP		Human	PMID:21385766
Biological Process	GO:0003184	pulmonary valve morphogenesis	Robo1	IGI	UniProtKB:Q7TPD3	Mouse	MGI:MGI:5913048\|PMID:25691540
Biological Process	GO:0048814	regulation of dendrite morphogenesis	Robo1	IMP		Rat	PMID:11779479\|RGD:8553750
Biological Process	GO:0035385	Roundabout signaling pathway	ROBO1	IMP		Human	PMID:18829537
Biological Process	GO:0035385	Roundabout signaling pathway	ROBO1	IMP		Human	PMID:26529257
Biological Process	GO:0021510	spinal cord development	Robo1	IEP		Rat	PMID:10102268\|RGD:68763
Biological Process	GO:0003281	ventricular septum development	Robo1	IMP		Mouse	PMID:25807483
Biological Process	GO:0060412	ventricular septum morphogenesis	Robo1	IGI	UniProtKB:Q7TPD3	Mouse	MGI:MGI:5913048\|PMID:25691540

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.