Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ROBO2
  • Mouse genes Robo2
  • Rat genes Robo2
  • Zfish genes robo2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Robo2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008046	axon guidance receptor activity	Robo2	IDA		Rat	PMID:10102268|RGD:68763
Molecular Function	GO:0042802	identical protein binding	ROBO2	IDA		Human	PMID:12504588
Molecular Function	GO:0005515	protein binding	ROBO2	IPI	UniProtKB:Q9Y6N7	Human	PMID:12504588
Molecular Function	GO:0005515	protein binding	ROBO2	IPI	UniProtKB:O75093	Human	PMID:15207848
Molecular Function	GO:0005515	protein binding	ROBO2	IPI	UniProtKB:O75094	Human	PMID:15207848
Molecular Function	GO:0005515	protein binding	ROBO2	IPI	UniProtKB:O94813	Human	PMID:15207848
Molecular Function	GO:0005515	protein binding	ROBO2	IPI	UniProtKB:Q8TDT2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ROBO2	IPI	UniProtKB:Q96Q45-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	robo2	IPI	UniProtKB:A8BB30	Zfish	PMID:19765300
Molecular Function	GO:0005515	protein binding	robo2	IPI	UniProtKB:A8BBG3	Zfish	PMID:19765300
Cellular Component	GO:0030673	axolemma	Robo2	IDA		Mouse	PMID:15084255
Cellular Component	GO:0009986	cell surface	ROBO2	IDA		Human	PMID:12504588
Cellular Component	GO:0070062	extracellular exosome	ROBO2	HDA		Human	PMID:19056867
Biological Process	GO:0033564	anterior/posterior axon guidance	robo2	IMP	ZFIN:ZDB-GENO-100622-2	Zfish	PMID:19605629
Biological Process	GO:0033564	anterior/posterior axon guidance	robo2	IGI	ZFIN:ZDB-GENO-110803-4	Zfish	PMID:19605629
Biological Process	GO:0035904	aorta development	Robo2	IGI	UniProtKB:O89026	Mouse	MGI:MGI:5913048|PMID:25691540
Biological Process	GO:0003180	aortic valve morphogenesis	Robo2	IGI	UniProtKB:O89026	Mouse	MGI:MGI:5913048|PMID:25691540
Biological Process	GO:0061364	apoptotic process involved in luteolysis	ROBO2	IEP		Human	PMID:18566128
Biological Process	GO:0007411	axon guidance	Robo2	IMP	MGI:MGI:3043127	Mouse	PMID:15091338
Biological Process	GO:0007411	axon guidance	Robo2	IDA		Rat	PMID:10102268|RGD:68763
Biological Process	GO:0007411	axon guidance	robo2	IMP	ZFIN:ZDB-GENO-190108-14	Zfish	PMID:29385124
Biological Process	GO:0007411	axon guidance	robo2	IMP	ZFIN:ZDB-GENO-980202-828	Zfish	PMID:15716341
Biological Process	GO:0007411	axon guidance	robo2	IMP	ZFIN:ZDB-GENO-980202-828	Zfish	PMID:15110042
Biological Process	GO:0007411	axon guidance	robo2	IMP	ZFIN:ZDB-MRPHLNO-080708-10	Zfish	PMID:18061159
Biological Process	GO:0016199	axon midline choice point recognition	Robo2	IGI	UniProtKB:O89026	Mouse	MGI:MGI:3823169|PMID:18986510
Biological Process	GO:0016199	axon midline choice point recognition	robo2	IGI	ZFIN:ZDB-GENO-070412-5,ZFIN:ZDB-MRPHLNO-100622-1,ZFIN:ZDB-MRPHLNO-100622-2	Zfish	PMID:20505109
Biological Process	GO:0016199	axon midline choice point recognition	robo2	IGI	ZFIN:ZDB-GENO-070412-4,ZFIN:ZDB-MRPHLNO-100622-1,ZFIN:ZDB-MRPHLNO-100622-2	Zfish	PMID:20505109
Biological Process	GO:0007413	axonal fasciculation	robo2	IMP	ZFIN:ZDB-GENO-070412-4	Zfish	PMID:17267551
Biological Process	GO:0007413	axonal fasciculation	robo2	IMP	ZFIN:ZDB-GENO-070412-5	Zfish	PMID:17267551
Biological Process	GO:0060385	axonogenesis involved in innervation	robo2	IGI	ZFIN:ZDB-MRPHLNO-171204-1	Zfish	PMID:26733807
Biological Process	GO:0007420	brain development	ROBO2	IEP		Human	PMID:10197527
Biological Process	GO:0007420	brain development	Robo2	IEP		Rat	PMID:11754167|RGD:2314870
Biological Process	GO:0032870	cellular response to hormone stimulus	ROBO2	IEP		Human	PMID:18566128
Biological Process	GO:0021952	central nervous system projection neuron axonogenesis	robo2	IMP	ZFIN:ZDB-MRPHLNO-121016-4	Zfish	PMID:22956848
Biological Process	GO:0021952	central nervous system projection neuron axonogenesis	robo2	IGI	ZFIN:ZDB-MRPHLNO-070328-6,ZFIN:ZDB-MRPHLNO-120604-2,ZFIN:ZDB-MRPHLNO-121016-3	Zfish	PMID:22956848
Biological Process	GO:0021952	central nervous system projection neuron axonogenesis	robo2	IMP	ZFIN:ZDB-MRPHLNO-121016-3	Zfish	PMID:22956848
Biological Process	GO:0021602	cranial nerve morphogenesis	robo2	IMP	ZFIN:ZDB-MRPHLNO-121016-3	Zfish	PMID:25972174
Biological Process	GO:0003272	endocardial cushion formation	Robo2	IGI	UniProtKB:O89026	Mouse	MGI:MGI:5913048|PMID:25691540
Biological Process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	ROBO2	IDA		Human	PMID:12504588
Biological Process	GO:0001656	metanephros development	Robo2	IMP	MGI:MGI:3043127	Mouse	PMID:15130495
Biological Process	GO:0048843	negative regulation of axon extension involved in axon guidance	robo2	IMP	ZFIN:ZDB-GENO-121128-8	Zfish	PMID:22190641
Biological Process	GO:0050925	negative regulation of negative chemotaxis	ROBO2	IDA		Human	PMID:11748139
Biological Process	GO:0021891	olfactory bulb interneuron development	Robo2	IMP		Mouse	MGI:MGI:3702250|PMID:17360927
Biological Process	GO:0003148	outflow tract septum morphogenesis	Robo2	IGI	UniProtKB:O89026	Mouse	MGI:MGI:5913048|PMID:25691540
Biological Process	GO:0050772	positive regulation of axonogenesis	ROBO2	IDA		Human	PMID:12504588
Biological Process	GO:0035481	positive regulation of Notch signaling pathway involved in heart induction	Robo2	IDA		Mouse	MGI:MGI:5913048|PMID:25691540
Biological Process	GO:0003184	pulmonary valve morphogenesis	Robo2	IGI	UniProtKB:O89026	Mouse	MGI:MGI:5913048|PMID:25691540
Biological Process	GO:0048696	regulation of collateral sprouting in absence of injury	robo2	IGI	ZFIN:ZDB-MRPHLNO-081016-1,ZFIN:ZDB-MRPHLNO-101025-4	Zfish	PMID:24385488
Biological Process	GO:0048696	regulation of collateral sprouting in absence of injury	robo2	IGI	ZFIN:ZDB-MRPHLNO-080809-1,ZFIN:ZDB-MRPHLNO-101025-4	Zfish	PMID:24385488
Biological Process	GO:0048696	regulation of collateral sprouting in absence of injury	robo2	IGI	ZFIN:ZDB-MRPHLNO-101025-4,ZFIN:ZDB-MRPHLNO-110406-1	Zfish	PMID:24385488
Biological Process	GO:0031290	retinal ganglion cell axon guidance	Robo2	IMP		Mouse	MGI:MGI:4368044|PMID:19782674
Biological Process	GO:0031290	retinal ganglion cell axon guidance	robo2	IGI	ZFIN:ZDB-GENO-070412-4,ZFIN:ZDB-MRPHLNO-100622-1,ZFIN:ZDB-MRPHLNO-100622-2	Zfish	PMID:20505109
Biological Process	GO:0031290	retinal ganglion cell axon guidance	robo2	IMP	ZFIN:ZDB-GENO-120314-26	Zfish	PMID:9007260
Biological Process	GO:0031290	retinal ganglion cell axon guidance	robo2	IGI	ZFIN:ZDB-GENO-070412-5,ZFIN:ZDB-MRPHLNO-100622-1,ZFIN:ZDB-MRPHLNO-100622-2	Zfish	PMID:20505109
Biological Process	GO:0031290	retinal ganglion cell axon guidance	robo2	IMP	ZFIN:ZDB-GENO-070412-4	Zfish	PMID:17267551
Biological Process	GO:0031290	retinal ganglion cell axon guidance	robo2	IMP	ZFIN:ZDB-GENO-980202-1127	Zfish	PMID:9007260
Biological Process	GO:0031290	retinal ganglion cell axon guidance	robo2	IMP	ZFIN:ZDB-GENO-070412-5	Zfish	PMID:17267551
Biological Process	GO:0050975	sensory perception of touch	robo2	IGI	ZFIN:ZDB-MRPHLNO-171204-1	Zfish	PMID:26733807
Biological Process	GO:0021510	spinal cord development	Robo2	IEP		Rat	PMID:10102268|RGD:68763
Biological Process	GO:0001657	ureteric bud development	ROBO2	IMP		Human	PMID:17357069
Biological Process	GO:0001657	ureteric bud development	Robo2	IMP		Mouse	MGI:MGI:3043010|PMID:15130495
Biological Process	GO:0060412	ventricular septum morphogenesis	Robo2	IGI	UniProtKB:O89026	Mouse	MGI:MGI:5913048|PMID:25691540

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern