Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Rock1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ROCK1
- Mouse genes Rock1
- Rat genes Rock1
- Zfish genes rock1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rock1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019828	aspartic-type endopeptidase inhibitor activity	ROCK1	IMP		Human	PMID:24305806
Molecular Function	GO:0005515	protein binding	ROCK1	IPI	UniProtKB:P53667	Human	PMID:10652353
Molecular Function	GO:0005515	protein binding	ROCK1	IPI	UniProtKB:P61586	Human	PMID:14660612
Molecular Function	GO:0005515	protein binding	ROCK1	IPI	UniProtKB:Q99816	Human	PMID:17853893
Molecular Function	GO:0005515	protein binding	ROCK1	IPI	UniProtKB:Q9UHD1	Human	PMID:20230755
Molecular Function	GO:0005515	protein binding	ROCK1	IPI	UniProtKB:P61586	Human	PMID:21281639
Molecular Function	GO:0005515	protein binding	ROCK1	IPI	UniProtKB:Q13203	Human	PMID:22085929
Molecular Function	GO:0005515	protein binding	ROCK1	IPI	UniProtKB:O94811	Human	PMID:23093407
Molecular Function	GO:0005515	protein binding	ROCK1	IPI	UniProtKB:O15481	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ROCK1	IPI	UniProtKB:P25791	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ROCK1	IPI	UniProtKB:Q86V42	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ROCK1	IPI	UniProtKB:Q8IYR0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ROCK1	IPI	UniProtKB:Q9BUI4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ROCK1	IPI	UniProtKB:Q7Z6J6	Human	PMID:25448675
Molecular Function	GO:0005515	protein binding	ROCK1	IPI	UniProtKB:Q14457	Human	PMID:27853422
Molecular Function	GO:0005515	protein binding	ROCK1	IPI	UniProtKB:O15481	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	Rock1	IPI	UniProtKB:P61588	Mouse	MGI:MGI:5508588\|PMID:18946488
Molecular Function	GO:0005515	protein binding	Rock1	IPI	UniProtKB:O35671	Mouse	MGI:MGI:5486556\|PMID:16741948
Molecular Function	GO:0005515	protein binding	Rock1	IPI	UniProtKB:O35671	Mouse	MGI:MGI:5486551\|PMID:17654484
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ROCK1	IDA		Human	PMID:10652353
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ROCK1	IDA		Human	PMID:11018042
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ROCK1	IDA		Human	PMID:18694941
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ROCK1	IDA		Human	PMID:19036714
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ROCK1	IDA		Human	PMID:23093407
Molecular Function	GO:0072518	Rho-dependent protein serine/threonine kinase activity	ROCK1	IDA		Human	PMID:18573880
Molecular Function	GO:0031267	small GTPase binding	Rock1	IMP		Rat	PMID:8816443\|RGD:633784
Cellular Component	GO:0010494	cytoplasmic stress granule	Rock1	IDA		Mouse	MGI:MGI:6148443\|PMID:27430620
Cellular Component	GO:0005856	cytoskeleton	Rock1	IDA		Mouse	MGI:MGI:5486556\|PMID:16741948
Cellular Component	GO:0030027	lamellipodium	Rock1	IDA		Mouse	MGI:MGI:5486556\|PMID:16741948
Cellular Component	GO:0005886	plasma membrane	Rock1	IDA		Mouse	MGI:MGI:5486556\|PMID:16741948
Cellular Component	GO:0001726	ruffle	Rock1	IDA		Mouse	MGI:MGI:5486556\|PMID:16741948
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Rock1	IMP		Mouse	PMID:30826947
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Rock1	IDA		Mouse	PMID:30826947
Biological Process	GO:0030036	actin cytoskeleton organization	Rock1	IGI	UniProtKB:P70336	Mouse	MGI:MGI:3513217\|PMID:15464581
Biological Process	GO:0030036	actin cytoskeleton organization	Rock1	IGI	MGI:MGI:107926	Mouse	PMID:16249236
Biological Process	GO:0030036	actin cytoskeleton organization	Rock1	IGI	MGI:MGI:1930780	Mouse	PMID:16249236
Biological Process	GO:0030036	actin cytoskeleton organization	Rock1	IGI	MGI:MGI:1351655	Mouse	PMID:16249236
Biological Process	GO:0003383	apical constriction	Rock1	IGI	MGI:MGI:2442579	Mouse	PMID:21685893
Biological Process	GO:0003383	apical constriction	Rock1	IGI	MGI:MGI:2135608	Mouse	PMID:21685893
Biological Process	GO:0032060	bleb assembly	Rock1	IMP		Mouse	PMID:17135244
Biological Process	GO:0097746	blood vessel diameter maintenance	Rock1	IMP		Mouse	MGI:MGI:6271078\|PMID:29353861
Biological Process	GO:0030866	cortical actin cytoskeleton organization	ROCK1	IGI	UniProtKB:O75116	Human	PMID:25816133
Biological Process	GO:0030866	cortical actin cytoskeleton organization	ROCK1	IMP		Human	PMID:25816133
Biological Process	GO:0007010	cytoskeleton organization	Rock1	IMP		Rat	PMID:8816443\|RGD:633784
Biological Process	GO:0003347	epicardial cell to mesenchymal cell transition	rock1	IMP		Zfish	PMID:20858732\|ZFIN:ZDB-PUB-101004-32
Biological Process	GO:0001837	epithelial to mesenchymal transition	Rock1	IGI	UniProtKB:P70336	Mouse	MGI:MGI:3513217\|PMID:15464581
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	ROCK1	IMP		Human	PMID:25816133
Biological Process	GO:0007159	leukocyte cell-cell adhesion	ROCK1	IDA		Human	PMID:12082081
Biological Process	GO:0050900	leukocyte migration	ROCK1	IDA		Human	PMID:12082081
Biological Process	GO:0050901	leukocyte tethering or rolling	ROCK1	IDA		Human	PMID:12082081
Biological Process	GO:0022614	membrane to membrane docking	ROCK1	IDA		Human	PMID:12082081
Biological Process	GO:0097049	motor neuron apoptotic process	Rock1	IMP		Mouse	PMID:15071095
Biological Process	GO:0061157	mRNA destabilization	Rock1	IMP		Mouse	MGI:MGI:6271078\|PMID:29353861
Biological Process	GO:0051451	myoblast migration	Rock1	IMP		Mouse	MGI:MGI:5486551\|PMID:17654484
Biological Process	GO:1903392	negative regulation of adherens junction organization	rock1	IMP		Zfish	PMID:20858732\|ZFIN:ZDB-PUB-101004-32
Biological Process	GO:1902992	negative regulation of amyloid precursor protein catabolic process	ROCK1	IMP		Human	PMID:24305806
Biological Process	GO:1902992	negative regulation of amyloid precursor protein catabolic process	ROCK1	IMP		Human	PMID:27853422
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	ROCK1	IMP		Human	PMID:24305806
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	ROCK1	IMP		Human	PMID:27853422
Biological Process	GO:0016525	negative regulation of angiogenesis	ROCK1	IMP		Human	PMID:19181962
Biological Process	GO:1903347	negative regulation of bicellular tight junction assembly	ROCK1	IGI	UniProtKB:O75116	Human	PMID:25816133
Biological Process	GO:2000672	negative regulation of motor neuron apoptotic process	Rock1	IMP		Mouse	PMID:15071095
Biological Process	GO:0035509	negative regulation of myosin-light-chain-phosphatase activity	ROCK1	IGI	UniProtKB:O75116	Human	PMID:25816133
Biological Process	GO:0035509	negative regulation of myosin-light-chain-phosphatase activity	ROCK1	IMP		Human	PMID:25816133
Biological Process	GO:0042326	negative regulation of phosphorylation	Rock1	IMP		Mouse	MGI:MGI:6356246\|PMID:30115939
Biological Process	GO:0032091	negative regulation of protein binding	ROCK1	IDA		Human	PMID:18573880
Biological Process	GO:0140058	neuron projection arborization	ROCK1	IGI	UniProtKB:O60890	Human	PMID:27160703
Biological Process	GO:0031175	neuron projection development	ROCK1	IGI	UniProtKB:O60890	Human	PMID:27160703
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ROCK1	IDA		Human	PMID:18573880
Biological Process	GO:0090521	podocyte cell migration	Rock1	IMP		Mouse	MGI:MGI:6356246\|PMID:30115939
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	ROCK1	IGI	UniProtKB:Q14457	Human	PMID:27853422
Biological Process	GO:0010508	positive regulation of autophagy	ROCK1	IGI	UniProtKB:Q14457	Human	PMID:27853422
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	ROCK1	IMP		Human	PMID:28679962
Biological Process	GO:1905205	positive regulation of connective tissue replacement	ROCK1	IMP		Human	PMID:28679962
Biological Process	GO:0035306	positive regulation of dephosphorylation	ROCK1	IMP		Human	PMID:27221467
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	Rock1	IMP		Mouse	MGI:MGI:5486551\|PMID:17654484
Biological Process	GO:0010628	positive regulation of gene expression	ROCK1	IMP		Human	PMID:27853422
Biological Process	GO:0010628	positive regulation of gene expression	ROCK1	IMP		Human	PMID:28679962
Biological Process	GO:0010628	positive regulation of gene expression	Rock1	IMP		Rat	PMID:28679962\|RGD:13601991
Biological Process	GO:0043410	positive regulation of MAPK cascade	ROCK1	IMP		Human	PMID:28679962
Biological Process	GO:0010922	positive regulation of phosphatase activity	ROCK1	IMP		Human	PMID:27221467
Biological Process	GO:0051496	positive regulation of stress fiber assembly	rock1	IMP		Zfish	PMID:20858732\|ZFIN:ZDB-PUB-101004-32
Biological Process	GO:0072659	protein localization to plasma membrane	ROCK1	IGI	UniProtKB:O75116	Human	PMID:25816133
Biological Process	GO:0072659	protein localization to plasma membrane	ROCK1	IMP		Human	PMID:25816133
Biological Process	GO:0006468	protein phosphorylation	ROCK1	IDA		Human	PMID:23093407
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	ROCK1	IDA		Human	PMID:25911094
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	Rock1	IMP		Mouse	MGI:MGI:6356246\|PMID:30115939
Biological Process	GO:0032970	regulation of actin filament-based process	Rock1	IGI	MGI:MGI:2442579	Mouse	PMID:21685893
Biological Process	GO:0032970	regulation of actin filament-based process	Rock1	IGI	MGI:MGI:2135608	Mouse	PMID:21685893
Biological Process	GO:0110061	regulation of angiotensin-activated signaling pathway	ROCK1	IMP		Human	PMID:28679962
Biological Process	GO:0030334	regulation of cell migration	ROCK1	IDA		Human	PMID:23093407
Biological Process	GO:0051493	regulation of cytoskeleton organization	rock1	IMP		Zfish	PMID:23213468
Biological Process	GO:1903140	regulation of establishment of endothelial barrier	ROCK1	IGI	UniProtKB:O75116	Human	PMID:25816133
Biological Process	GO:1903140	regulation of establishment of endothelial barrier	ROCK1	IMP		Human	PMID:25816133
Biological Process	GO:0045616	regulation of keratinocyte differentiation	ROCK1	IMP		Human	PMID:19997641
Biological Process	GO:0070507	regulation of microtubule cytoskeleton organization	ROCK1	IDA		Human	PMID:23093407
Biological Process	GO:0045664	regulation of neuron differentiation	ROCK1	IGI	UniProtKB:O60890	Human	PMID:27160703
Biological Process	GO:0090128	regulation of synapse maturation	Rock1	IDA		Mouse	PMID:30826947
Biological Process	GO:0090128	regulation of synapse maturation	Rock1	IMP		Mouse	PMID:30826947
Biological Process	GO:1900242	regulation of synaptic vesicle endocytosis	ROCK1	IGI	UniProtKB:O60890	Human	PMID:27160703
Biological Process	GO:1990776	response to angiotensin	Rock1	IGI	UniProtKB:P70336	Mouse	MGI:MGI:6158813\|PMID:28679962
Biological Process	GO:0071559	response to transforming growth factor beta	Rock1	IGI	UniProtKB:P70336	Mouse	MGI:MGI:6158813\|PMID:28679962
Biological Process	GO:0071559	response to transforming growth factor beta	Rock1	IGI	UniProtKB:Q62868	Rat	PMID:28679962\|RGD:13601991
Biological Process	GO:0007266	Rho protein signal transduction	ROCK1	IGI	UniProtKB:O60890	Human	PMID:27160703
Biological Process	GO:0007266	Rho protein signal transduction	Rock1	IMP		Rat	PMID:18332105\|RGD:8554725

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.