Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Rora

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes RORA
- Mouse genes Rora
- Rat genes Rora
- Zfish genes roraa,rorab
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rora

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008013	beta-catenin binding	Rora	IPI	UniProtKB:Q02248	Mouse	MGI:MGI:2683830\|PMID:14687547
Molecular Function	GO:0003677	DNA binding	RORA	IDA		Human	PMID:11053433
Molecular Function	GO:0003677	DNA binding	RORA	IDA		Human	PMID:7926749
Molecular Function	GO:0003677	DNA binding	RORA	IDA		Human	PMID:9328355
Molecular Function	GO:0003677	DNA binding	Rora	IDA		Mouse	PMID:7838158
Molecular Function	GO:0003700	DNA-binding transcription factor activity	RORA	IDA		Human	PMID:11053433
Molecular Function	GO:0003700	DNA-binding transcription factor activity	RORA	IDA		Human	PMID:17545671
Molecular Function	GO:0003700	DNA-binding transcription factor activity	RORA	IDA		Human	PMID:18658046
Molecular Function	GO:0003700	DNA-binding transcription factor activity	RORA	IDA		Human	PMID:7926749
Molecular Function	GO:0003700	DNA-binding transcription factor activity	RORA	IDA		Human	PMID:9328355
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Rora	IDA		Mouse	MGI:MGI:5504349\|PMID:22753030
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Rora	IDA		Mouse	PMID:7838156
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Rora	IDA		Mouse	MGI:MGI:3772713\|PMID:18164222
Molecular Function	GO:0098531	ligand-activated transcription factor activity	RORA	IDA		Human	PMID:19965867
Molecular Function	GO:0008142	oxysterol binding	RORA	IDA		Human	PMID:19965867
Molecular Function	GO:0005515	protein binding	RORA	IPI	UniProtKB:P51843	Human	PMID:16713569
Molecular Function	GO:0005515	protein binding	RORA	IPI	UniProtKB:Q16665	Human	PMID:18658046
Molecular Function	GO:0005515	protein binding	RORA	IPI	UniProtKB:P97784	Human	PMID:22170608
Molecular Function	GO:0005515	protein binding	RORA	IPI	UniProtKB:P14136	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RORA	IPI	UniProtKB:P15172	Human	PMID:9862959
Molecular Function	GO:0005515	protein binding	Rora	IPI	UniProtKB:P54254	Mouse	MGI:MGI:3693029\|PMID:17110330
Molecular Function	GO:0005515	protein binding	Rora	IPI	UniProtKB:Q8CBD1	Mouse	MGI:MGI:5586794\|PMID:21628546
Molecular Function	GO:0005515	protein binding	Rora	IPI	UniProtKB:Q9QYH6	Mouse	MGI:MGI:5508569\|PMID:20300063
Molecular Function	GO:0005515	protein binding	Rora	IPI	UniProtKB:P48437	Mouse	MGI:MGI:5582866\|PMID:23723244
Molecular Function	GO:0005515	protein binding	Rora	IPI	UniProtKB:P28033	Mouse	MGI:MGI:3846256\|PMID:19324970
Molecular Function	GO:0005515	protein binding	Rora	IPI	RGD:1305406	Rat	PMID:24615205\|RGD:9586357
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	RORA	IDA		Human	PMID:21628546
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Rora	IDA		Mouse	PMID:15199055
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	RORA	IDA		Human	PMID:19955433
Molecular Function	GO:0043565	sequence-specific DNA binding	RORA	IDA		Human	PMID:11053433
Molecular Function	GO:0043565	sequence-specific DNA binding	Rora	IDA		Mouse	MGI:MGI:5553243\|PMID:18055760
Molecular Function	GO:0001223	transcription coactivator binding	RORA	IPI	UniProtKB:Q15596	Human	PMID:10478845
Molecular Function	GO:0001223	transcription coactivator binding	RORA	IPI	UniProtKB:Q15648	Human	PMID:10478845
Molecular Function	GO:0001223	transcription coactivator binding	RORA	IPI	UniProtKB:Q09472	Human	PMID:9862959
Molecular Function	GO:0001223	transcription coactivator binding	Rora	IPI	UniProtKB:Q61026	Mouse	MGI:MGI:3820385\|PMID:19039140
Molecular Function	GO:0001223	transcription coactivator binding	Rora	IPI	UniProtKB:O70343	Mouse	MGI:MGI:3715412\|PMID:17476214
Molecular Function	GO:0001221	transcription coregulator binding	RORA	IPI	UniProtKB:Q6STE5	Human	PMID:14701856
Molecular Function	GO:0001222	transcription corepressor binding	RORA	IPI	UniProtKB:O75376	Human	PMID:9328355
Cellular Component	GO:0005730	nucleolus	RORA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	RORA	IDA		Human	PMID:18658046
Cellular Component	GO:0005634	nucleus	RORA	IDA		Human	PMID:19965867
Cellular Component	GO:0005634	nucleus	Rora	IDA		Mouse	MGI:MGI:5504349\|PMID:22753030
Cellular Component	GO:0005634	nucleus	Rora	IDA		Mouse	MGI:MGI:5582866\|PMID:23723244
Cellular Component	GO:0005634	nucleus	Rora	IDA		Mouse	MGI:MGI:5553243\|PMID:18055760
Cellular Component	GO:0005634	nucleus	Rora	IDA		Mouse	PMID:19955433
Biological Process	GO:0001525	angiogenesis	RORA	IMP		Human	PMID:18658046
Biological Process	GO:0071456	cellular response to hypoxia	RORA	IMP		Human	PMID:18658046
Biological Process	GO:0071347	cellular response to interleukin-1	Rora	IDA		Mouse	PMID:19955433
Biological Process	GO:0036315	cellular response to sterol	RORA	IMP		Human	PMID:18658046
Biological Process	GO:0036315	cellular response to sterol	RORA	IDA		Human	PMID:19965867
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Rora	IDA		Mouse	PMID:19955433
Biological Process	GO:0021930	cerebellar granule cell precursor proliferation	Rora	IMP	UniProtKB:Q62226	Mouse	MGI:MGI:2683830\|PMID:14687547
Biological Process	GO:0021702	cerebellar Purkinje cell differentiation	Rora	IMP	MGI:MGI:1857035	Mouse	PMID:8996814
Biological Process	GO:0021587	cerebellum morphogenesis	roraa	IMP	ZFIN:ZDB-CRISPR-190429-2	Zfish	PMID:29656859
Biological Process	GO:0046068	cGMP metabolic process	Rora	IMP	MGI:MGI:1857035	Mouse	PMID:7518067
Biological Process	GO:0042632	cholesterol homeostasis	Rora	IMP		Mouse	MGI:MGI:5553243\|PMID:18055760
Biological Process	GO:0032922	circadian regulation of gene expression	Rora	IDA		Mouse	MGI:MGI:5504349\|PMID:22753030
Biological Process	GO:0007623	circadian rhythm	Rora	IEP		Rat	PMID:15781226\|RGD:2325957
Biological Process	GO:0030522	intracellular receptor signaling pathway	RORA	IDA		Human	PMID:19965867
Biological Process	GO:0042692	muscle cell differentiation	RORA	IMP		Human	PMID:9862959
Biological Process	GO:0045599	negative regulation of fat cell differentiation	Rora	IMP		Mouse	MGI:MGI:3846256\|PMID:19324970
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	RORA	IMP		Human	PMID:11252722
Biological Process	GO:0050728	negative regulation of inflammatory response	RORA	IMP		Human	PMID:11252722
Biological Process	GO:0006809	nitric oxide biosynthetic process	Rora	IMP	MGI:MGI:1857035	Mouse	PMID:7518067
Biological Process	GO:0042753	positive regulation of circadian rhythm	Rora	IDA		Mouse	MGI:MGI:5504349\|PMID:22753030
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	RORA	IDA		Human	PMID:7926749
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Rora	IDA		Mouse	MGI:MGI:5586794\|PMID:21628546
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Rora	IDA		Mouse	MGI:MGI:5582866\|PMID:23723244
Biological Process	GO:0010628	positive regulation of gene expression	roraa	IDA		Zfish	PMID:27171500
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	RORA	IDA		Human	PMID:17545671
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	RORA	IDA		Human	PMID:19955433
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Rora	IDA		Mouse	PMID:15199055
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Rora	IGI	MGI:MGI:1276116	Mouse	PMID:15199055
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Rora	IGI	MGI:MGI:1342774	Mouse	PMID:15199055
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	RORA	IMP		Human	PMID:18658046
Biological Process	GO:0042752	regulation of circadian rhythm	Rora	IMP		Mouse	MGI:MGI:5567901\|PMID:23172836
Biological Process	GO:0006355	regulation of DNA-templated transcription	RORA	IDA		Human	PMID:9328355
Biological Process	GO:0006355	regulation of DNA-templated transcription	Rora	IDA		Mouse	MGI:MGI:5553243\|PMID:18055760
Biological Process	GO:0006355	regulation of DNA-templated transcription	Rora	IDA		Mouse	PMID:7838156
Biological Process	GO:0010468	regulation of gene expression	roraa	IGI	ZFIN:ZDB-GENE-050105-1	Zfish	PMID:27171500
Biological Process	GO:0010906	regulation of glucose metabolic process	Rora	IMP		Mouse	MGI:MGI:5545992\|PMID:19965867
Biological Process	GO:0043030	regulation of macrophage activation	Rora	IMP	MGI:MGI:1857035	Mouse	PMID:1565842
Biological Process	GO:0008589	regulation of smoothened signaling pathway	Rora	IMP		Mouse	MGI:MGI:2683830\|PMID:14687547
Biological Process	GO:0019218	regulation of steroid metabolic process	Rora	IMP	UniProtKB:P51450	Mouse	MGI:MGI:5554367\|PMID:17666523
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Rora	IDA		Mouse	MGI:MGI:3772713\|PMID:18164222
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Rora	IMP		Mouse	MGI:MGI:3846256\|PMID:19324970
Biological Process	GO:0072539	T-helper 17 cell differentiation	Rora	IMP		Mouse	MGI:MGI:3772713\|PMID:18164222
Biological Process	GO:0070328	triglyceride homeostasis	RORA	IMP	UniProtKB:P51448	Human	PMID:11053433
Biological Process	GO:0070328	triglyceride homeostasis	Rora	IMP		Mouse	MGI:MGI:3722589\|PMID:11053433
Biological Process	GO:0070328	triglyceride homeostasis	Rora	IMP		Mouse	MGI:MGI:5553243\|PMID:18055760
Biological Process	GO:0006805	xenobiotic metabolic process	Rora	IMP	UniProtKB:P51450	Mouse	MGI:MGI:5554367\|PMID:17666523

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.