Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RORC
  • Mouse genes Rorc
  • Rat genes Rorc
  • Zfish genes rorc,rorca,rorcb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rorc

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Rorc	IDA		Mouse	MGI:MGI:5504349|PMID:22753030
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Rorc	IDA		Mouse	MGI:MGI:5545969|PMID:21853531
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Rorc	IDA		Mouse	MGI:MGI:3772713|PMID:18164222
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	RORC	IDA		Human	PMID:20427770
Molecular Function	GO:0098531	ligand-activated transcription factor activity	RORC	IDA		Human	PMID:19965867
Molecular Function	GO:0008142	oxysterol binding	RORC	IDA		Human	PMID:19965867
Molecular Function	GO:0005515	protein binding	RORC	IPI	UniProtKB:Q9BZS1	Human	PMID:18368049
Molecular Function	GO:0005515	protein binding	RORC	IPI	UniProtKB:Q15788	Human	PMID:20203100
Molecular Function	GO:0005515	protein binding	RORC	IPI	UniProtKB:P97784	Human	PMID:22170608
Molecular Function	GO:0005515	protein binding	RORC	IPI	UniProtKB:O08785	Human	PMID:23555304
Molecular Function	GO:0005515	protein binding	RORC	IPI	UniProtKB:Q9WTL8	Human	PMID:23555304
Molecular Function	GO:0005515	protein binding	RORC	IPI	UniProtKB:P62195	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Rorc	IPI	UniProtKB:Q62227	Mouse	MGI:MGI:6275703|PMID:25212631
Molecular Function	GO:0005515	protein binding	Rorc	IPI	UniProtKB:P48437	Mouse	MGI:MGI:5582866|PMID:23723244
Molecular Function	GO:0005515	protein binding	Rorc	IPI	UniProtKB:Q9R1E0	Mouse	MGI:MGI:5688829|PMID:23467085
Molecular Function	GO:0005515	protein binding	Rorc	IPI	UniProtKB:Q16665|UniProtKB:Q61221	Mouse	MGI:MGI:5289736|PMID:21871655
Molecular Function	GO:0005515	protein binding	Rorc	IPI	UniProtKB:Q99JB6	Mouse	MGI:MGI:3795336|PMID:18368049
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	RORC	IDA		Human	PMID:20427770
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	RORC	IDA		Human	PMID:28473536
Molecular Function	GO:0001223	transcription coactivator binding	Rorc	IPI	UniProtKB:P70365|UniProtKB:Q61026	Mouse	MGI:MGI:3694879|PMID:16148126
Molecular Function	GO:0001223	transcription coactivator binding	Rorc	IPI	UniProtKB:O70343	Mouse	MGI:MGI:3715412|PMID:17476214
Cellular Component	GO:0009897	external side of plasma membrane	Rorc	IDA		Mouse	PMID:23034280
Cellular Component	GO:0016604	nuclear body	RORC	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	RORC	IDA		Human	PMID:19965867
Cellular Component	GO:0005634	nucleus	Rorc	IDA		Mouse	MGI:MGI:3795336|PMID:18368049
Cellular Component	GO:0005634	nucleus	Rorc	IDA		Mouse	MGI:MGI:5504349|PMID:22753030
Cellular Component	GO:0005634	nucleus	Rorc	IDA		Mouse	MGI:MGI:5582866|PMID:23723244
Biological Process	GO:0060612	adipose tissue development	Rorc	IMP		Mouse	MGI:MGI:5545969|PMID:21853531
Biological Process	GO:0046632	alpha-beta T cell differentiation	Rorc	IMP	MGI:MGI:3026635	Mouse	PMID:15247480
Biological Process	GO:0030154	cell differentiation	Rorc	IMP	MGI:MGI:3026635	Mouse	PMID:14691482
Biological Process	GO:0036315	cellular response to sterol	RORC	IDA		Human	PMID:19965867
Biological Process	GO:0032922	circadian regulation of gene expression	Rorc	IMP		Mouse	MGI:MGI:5504349|PMID:22753030
Biological Process	GO:0032922	circadian regulation of gene expression	Rorc	IMP		Mouse	MGI:MGI:5582866|PMID:23723244
Biological Process	GO:0007623	circadian rhythm	Rorc	IEP		Rat	PMID:15781226|RGD:2325957
Biological Process	GO:0048535	lymph node development	Rorc	IMP	MGI:MGI:3026635	Mouse	PMID:14691482
Biological Process	GO:0048537	mucosa-associated lymphoid tissue development	Rorc	IMP	MGI:MGI:3026635	Mouse	PMID:15247480
Biological Process	GO:0070244	negative regulation of thymocyte apoptotic process	Rorc	IMP		Mouse	MGI:MGI:3694879|PMID:16148126
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	RORC	IDA		Human	PMID:20427770
Biological Process	GO:0048541	Peyer's patch development	Rorc	IMP		Mouse	MGI:MGI:2686818|PMID:14691482
Biological Process	GO:0042753	positive regulation of circadian rhythm	Rorc	IDA		Mouse	MGI:MGI:5504349|PMID:22753030
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Rorc	IDA		Mouse	MGI:MGI:5586794|PMID:21628546
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Rorc	IDA		Mouse	MGI:MGI:5582866|PMID:23723244
Biological Process	GO:0006468	protein phosphorylation	Rorc	IMP		Mouse	PMID:15010863
Biological Process	GO:0045598	regulation of fat cell differentiation	Rorc	IMP		Mouse	MGI:MGI:5545969|PMID:21853531
Biological Process	GO:0045586	regulation of gamma-delta T cell differentiation	Rorc	IDA		Mouse	PMID:21737317
Biological Process	GO:0010906	regulation of glucose metabolic process	Rorc	IMP		Mouse	MGI:MGI:5545992|PMID:19965867
Biological Process	GO:0019218	regulation of steroid metabolic process	Rorc	IMP	UniProtKB:P51448	Mouse	MGI:MGI:5554367|PMID:17666523
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Rorc	IDA		Mouse	MGI:MGI:3772713|PMID:18164222
Biological Process	GO:0033077	T cell differentiation in thymus	Rorc	IMP	MGI:MGI:3026635	Mouse	PMID:15247480
Biological Process	GO:0072539	T-helper 17 cell differentiation	Rorc	IMP		Mouse	MGI:MGI:3692468|PMID:16990136
Biological Process	GO:0072539	T-helper 17 cell differentiation	Rorc	IMP		Mouse	MGI:MGI:3772713|PMID:18164222
Biological Process	GO:0072539	T-helper 17 cell differentiation	Rorc	IMP	MGI:MGI:2386114	Mouse	PMID:20383124
Biological Process	GO:0072539	T-helper 17 cell differentiation	Rorc	IDA		Mouse	PMID:18792410
Biological Process	GO:0042093	T-helper cell differentiation	Rorc	IMP		Mouse	MGI:MGI:2686818|PMID:14691482
Biological Process	GO:0006805	xenobiotic metabolic process	Rorc	IMP	UniProtKB:P51448	Mouse	MGI:MGI:5554367|PMID:17666523

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern