Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RPA2
  • Mouse genes Rpa2
  • Rat genes Rpa2
  • Zfish genes rpa2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rpa2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003684	damaged DNA binding	RPA2	IDA		Human	PMID:27723717
Molecular Function	GO:0003684	damaged DNA binding	RPA2	IDA		Human	PMID:27723720
Molecular Function	GO:0003684	damaged DNA binding	RPA2	IDA		Human	PMID:7700386
Molecular Function	GO:0003677	DNA binding	Rpa2	IDA		Mouse	PMID:1908076
Molecular Function	GO:0019899	enzyme binding	RPA2	IPI	UniProtKB:Q9NZC9	Human	PMID:19793862
Molecular Function	GO:0019899	enzyme binding	RPA2	IPI	UniProtKB:Q9NZC9	Human	PMID:19793863
Molecular Function	GO:0098505	G-rich strand telomeric DNA binding	RPA2	IDA		Human	PMID:24747047
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P35244	Human	PMID:10449415
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P13051	Human	PMID:10982866
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P23025	Human	PMID:10982866
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P35244	Human	PMID:10982866
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:Q9UJW9	Human	PMID:10982866
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P27694	Human	PMID:11927569
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:O00255	Human	PMID:12509449
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P23025	Human	PMID:12527904
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P27694	Human	PMID:12527904
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:Q99638	Human	PMID:15897895
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P27694	Human	PMID:15965237
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P35244	Human	PMID:15965237
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P04406	Human	PMID:16169070
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P43351	Human	PMID:17765923
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P35244	Human	PMID:19338310
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:Q06609	Human	PMID:20154705
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P23025	Human	PMID:20304803
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P49643-1	Human	PMID:20643958
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P23025	Human	PMID:20670893
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P27694	Human	PMID:20811460
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P27694	Human	PMID:2159011
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:O60516	Human	PMID:22684010
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:O75419	Human	PMID:23910567
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P27694	Human	PMID:24126761
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P35244	Human	PMID:24126761
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:Q6PCD5	Human	PMID:24126761
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:Q9BVW5	Human	PMID:24126761
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:Q9NZC9	Human	PMID:24126761
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P13051	Human	PMID:24910198
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:Q9BVW5	Human	PMID:24910198
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:Q9NZC9	Human	PMID:24910198
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P27694	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P35244	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:Q9NZC9	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P27694	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:Q9NY74	Human	PMID:27723717
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:Q9NY74	Human	PMID:27723720
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:Q6PCD5	Human	PMID:28575657
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:Q6PCD5	Human	PMID:28575658
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:Q6PCD5	Human	PMID:28691929
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:Q5TDH0	Human	PMID:29290612
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P23025	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P24863	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P27694	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P27694	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P35244	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P23025	Human	PMID:7700386
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P27694	Human	PMID:7760808
Molecular Function	GO:0005515	protein binding	RPA2	IPI	UniProtKB:P43351	Human	PMID:8702565
Molecular Function	GO:0005515	protein binding	Rpa2	IPI	UniProtKB:Q9D513	Mouse	MGI:MGI:5538413|PMID:24240703
Molecular Function	GO:0005515	protein binding	Rpa2	IPI	PR:Q91WA1	Mouse	PMID:17141802
Molecular Function	GO:0005515	protein binding	Rpa2	IPI	RGD:1316252	Rat	PMID:9045683|RGD:729744
Molecular Function	GO:0019903	protein phosphatase binding	RPA2	IPI	UniProtKB:Q9NY27	Human	PMID:20154705
Molecular Function	GO:0003697	single-stranded DNA binding	RPA2	IDA		Human	PMID:19010961
Molecular Function	GO:0003697	single-stranded DNA binding	Rpa2	IDA		Rat	PMID:8463251|RGD:2307012
Molecular Function	GO:0031625	ubiquitin protein ligase binding	RPA2	IPI	UniProtKB:Q6PCD5	Human	PMID:21504906
Cellular Component	GO:0000785	chromatin	RPA2	IDA		Human	PMID:10336450
Cellular Component	GO:0000781	chromosome, telomeric region	RPA2	IDA		Human	PMID:17959650
Cellular Component	GO:0000781	chromosome, telomeric region	RPA2	HDA		Human	PMID:19135898
Cellular Component	GO:0005662	DNA replication factor A complex	RPA2	IPI		Human	PMID:11927569
Cellular Component	GO:0005662	DNA replication factor A complex	RPA2	IDA		Human	PMID:11927569
Cellular Component	GO:0005662	DNA replication factor A complex	RPA2	IDA		Human	PMID:2406247
Cellular Component	GO:0005662	DNA replication factor A complex	RPA2	IDA		Human	PMID:27723717
Cellular Component	GO:0005662	DNA replication factor A complex	RPA2	IDA		Human	PMID:27723720
Cellular Component	GO:0005662	DNA replication factor A complex	Rpa2	IDA		Rat	PMID:7503737|RGD:2307013
Cellular Component	GO:0005662	DNA replication factor A complex	Rpa2	IDA		Rat	PMID:8463251|RGD:2307012
Cellular Component	GO:0016604	nuclear body	RPA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	RPA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	RPA2	IDA		Human	PMID:10982866
Cellular Component	GO:0016605	PML body	RPA2	IDA		Human	PMID:17959650
Cellular Component	GO:0016605	PML body	RPA2	IDA		Human	PMID:12814551
Cellular Component	GO:0035861	site of double-strand break	RPA2	IDA		Human	PMID:21504906
Biological Process	GO:0006284	base-excision repair	RPA2	IDA		Human	PMID:9765279
Biological Process	GO:0006260	DNA replication	RPA2	IDA		Human	PMID:2406247
Biological Process	GO:0006260	DNA replication	RPA2	IMP		Human	PMID:9430682
Biological Process	GO:0000724	double-strand break repair via homologous recombination	RPA2	IMP		Human	PMID:17765923
Biological Process	GO:0006298	mismatch repair	RPA2	IMP		Human	PMID:9430682
Biological Process	GO:0031571	mitotic G1 DNA damage checkpoint signaling	RPA2	IMP		Human	PMID:21731742
Biological Process	GO:0006289	nucleotide-excision repair	RPA2	IMP		Human	PMID:9430682
Biological Process	GO:0034502	protein localization to chromosome	RPA2	IDA		Human	PMID:27723717
Biological Process	GO:0034502	protein localization to chromosome	RPA2	IDA		Human	PMID:27723720
Biological Process	GO:2000001	regulation of DNA damage checkpoint	RPA2	IMP		Human	PMID:21504906
Biological Process	GO:0010569	regulation of double-strand break repair via homologous recombination	RPA2	IMP		Human	PMID:20154705
Biological Process	GO:0000723	telomere maintenance	RPA2	IMP		Human	PMID:17959650

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern