Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RPE65
  • Mouse genes Rpe65
  • Rat genes Rpe65
  • Zfish genes rpe65a,rpe65b,rpe65c
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rpe65

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0052885	all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity	Rpe65	IMP		Rat	PMID:21785167|RGD:6893661
Molecular Function	GO:0052884	all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity	RPE65	IDA		Human	PMID:25112876
Molecular Function	GO:0016853	isomerase activity	RPE65	IDA		Human	PMID:28874556
Molecular Function	GO:0005515	protein binding	Rpe65	IPI	UniProtKB:P97479	Mouse	MGI:MGI:5050344|PMID:21493626
Molecular Function	GO:0050251	retinol isomerase activity	rpe65c	IDA		Zfish	PMID:21676174
Cellular Component	GO:0044297	cell body	Rpe65	IDA		Rat	PMID:19180257|RGD:6893662
Cellular Component	GO:0005737	cytoplasm	Rpe65	IDA		Mouse	MGI:MGI:6219868|PMID:26404741
Cellular Component	GO:0005829	cytosol	rpe65c	IDA		Zfish	PMID:21676174
Cellular Component	GO:0005789	endoplasmic reticulum membrane	RPE65	IDA		Human	PMID:29659842
Cellular Component	GO:0016020	membrane	rpe65c	IDA		Zfish	PMID:21676174
Cellular Component	GO:0005634	nucleus	Rpe65	IDA		Mouse	MGI:MGI:6219868|PMID:26404741
Cellular Component	GO:0005886	plasma membrane	Rpe65	IDA		Mouse	MGI:MGI:6219868|PMID:26404741
Biological Process	GO:0043010	camera-type eye development	Rpe65	IEP		Rat	PMID:9512345|RGD:633787
Biological Process	GO:0071257	cellular response to electrical stimulus	Rpe65	IMP		Mouse	PMID:21052544
Biological Process	GO:0007623	circadian rhythm	Rpe65	IEP		Rat	PMID:12742352|RGD:9585648
Biological Process	GO:0050908	detection of light stimulus involved in visual perception	RPE65	IMP		Human	PMID:15557452
Biological Process	GO:0008286	insulin receptor signaling pathway	Rpe65	IMP	MGI:MGI:2181399	Mouse	PMID:17272282
Biological Process	GO:0003407	neural retina development	Rpe65	IDA		Rat	PMID:2631392|RGD:9585660
Biological Process	GO:0010468	regulation of gene expression	Rpe65	IMP	MGI:MGI:2181399	Mouse	PMID:11897783
Biological Process	GO:0009416	response to light stimulus	Rpe65	IEP		Rat	PMID:17389522|RGD:9585654
Biological Process	GO:0060041	retina development in camera-type eye	Rpe65	IMP		Mouse	PMID:21052544
Biological Process	GO:0001895	retina homeostasis	RPE65	IMP		Human	PMID:15557452
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	Rpe65	IMP		Mouse	PMID:21052544
Biological Process	GO:0042574	retinal metabolic process	Rpe65	IMP	MGI:MGI:2181399	Mouse	PMID:11897783
Biological Process	GO:0042574	retinal metabolic process	Rpe65	IMP		Rat	PMID:21785167|RGD:6893661
Biological Process	GO:0001523	retinoid metabolic process	RPE65	IDA		Human	PMID:25112876
Biological Process	GO:0042572	retinol metabolic process	Rpe65	IDA		Rat	PMID:3603006|RGD:9585656
Biological Process	GO:0007601	visual perception	Rpe65	IMP	MGI:MGI:2181399	Mouse	PMID:11897783
Biological Process	GO:1901827	zeaxanthin biosynthetic process	RPE65	IDA		Human	PMID:28874556

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern