Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RPL5
  • Mouse genes Rpl5
  • Rat genes Rpl5
  • Zfish genes rpl5a,rpl5b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rpl5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008097	5S rRNA binding	RPL5	IDA		Human	PMID:18560357
Molecular Function	GO:0008097	5S rRNA binding	Rpl5	IDA		Rat	PMID:6430881|RGD:11039444
Molecular Function	GO:0003730	mRNA 3'-UTR binding	RPL5	IDA		Human	PMID:16213212
Molecular Function	GO:0048027	mRNA 5'-UTR binding	RPL5	IDA		Human	PMID:16213212
Molecular Function	GO:0003729	mRNA binding	Rpl5	IDA		Rat	PMID:7338522|RGD:11040966
Molecular Function	GO:0005515	protein binding	RPL5	IPI	UniProtKB:Q53EL6	Human	PMID:12054647
Molecular Function	GO:0005515	protein binding	RPL5	IPI	UniProtKB:P62829,UniProtKB:P62913,UniProtKB:Q00987	Human	PMID:15314173
Molecular Function	GO:0005515	protein binding	RPL5	IPI	UniProtKB:O15381	Human	PMID:15469983
Molecular Function	GO:0005515	protein binding	RPL5	IPI	UniProtKB:P06748	Human	PMID:16648475
Molecular Function	GO:0005515	protein binding	RPL5	IPI	UniProtKB:Q00987	Human	PMID:17110929
Molecular Function	GO:0005515	protein binding	RPL5	IPI	UniProtKB:Q00987	Human	PMID:17373842
Molecular Function	GO:0005515	protein binding	RPL5	IPI	UniProtKB:P62913,UniProtKB:Q00987	Human	PMID:18560357
Molecular Function	GO:0005515	protein binding	RPL5	IPI	UniProtKB:P43146	Human	PMID:20434207
Molecular Function	GO:0005515	protein binding	RPL5	IPI	UniProtKB:Q63155	Human	PMID:20434207
Molecular Function	GO:0005515	protein binding	RPL5	IPI	UniProtKB:Q14684	Human	PMID:20926688
Molecular Function	GO:0005515	protein binding	RPL5	IPI	UniProtKB:Q00987	Human	PMID:21399665
Molecular Function	GO:0005515	protein binding	RPL5	IPI	UniProtKB:P63241	Human	PMID:9465063
Molecular Function	GO:0005515	protein binding	RPL5	IPI	UniProtKB:O42480	Human	PMID:9687515
Molecular Function	GO:0005515	protein binding	RPL5	IPI	UniProtKB:P52297	Human	PMID:9687515
Molecular Function	GO:0005515	protein binding	RPL5	IPI	UniProtKB:Q28CS8	Human	PMID:9687515
Molecular Function	GO:0005515	protein binding	Rpl5	IPI	UniProtKB:P23804	Mouse	MGI:MGI:4830897|PMID:20832751
Molecular Function	GO:0005515	protein binding	Rpl5	IPI	UniProtKB:P23804	Mouse	MGI:MGI:3760347|PMID:17936560
Molecular Function	GO:0005515	protein binding	Rpl5	IPI	UniProtKB:P23804	Mouse	MGI:MGI:5437555|PMID:22789538
Molecular Function	GO:0005515	protein binding	Rpl5	IPI	PR:Q61937	Mouse	PMID:16648475
Molecular Function	GO:0005515	protein binding	Rpl5	IPI	UniProtKB:P62142	Rat	PMID:7649987|RGD:2316860
Molecular Function	GO:0003723	RNA binding	RPL5	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	RPL5	HDA		Human	PMID:22681889
Molecular Function	GO:0003735	structural constituent of ribosome	RPL5	IMP		Human	PMID:18697920
Molecular Function	GO:0003735	structural constituent of ribosome	RPL5	IDA		Human	PMID:23636399
Molecular Function	GO:0003735	structural constituent of ribosome	RPL5	IDA		Human	PMID:32669547
Molecular Function	GO:0003735	structural constituent of ribosome	Rpl5	IDA		Mouse	MGI:MGI:7432473|PMID:36517592
Molecular Function	GO:1990948	ubiquitin ligase inhibitor activity	RPL5	IDA		Human	PMID:18560357
Molecular Function	GO:0031625	ubiquitin protein ligase binding	RPL5	IPI	UniProtKB:Q00987	Human	PMID:18560357
Cellular Component	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	Rpl5	IDA		Rat	PMID:8982850|RGD:2316859
Cellular Component	GO:0005737	cytoplasm	RPL5	IDA		Human	PMID:15314173
Cellular Component	GO:0005737	cytoplasm	RPL5	IDA		Human	PMID:15469983
Cellular Component	GO:0005737	cytoplasm	RPL5	HDA		Human	PMID:16791210
Cellular Component	GO:0005829	cytosol	RPL5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0022625	cytosolic large ribosomal subunit	RPL5	IPI		Human	PMID:25901680
Cellular Component	GO:0022625	cytosolic large ribosomal subunit	RPL5	HDA		Human	PMID:12962325
Cellular Component	GO:0022625	cytosolic large ribosomal subunit	RPL5	IDA		Human	PMID:32669547
Cellular Component	GO:0022625	cytosolic large ribosomal subunit	Rpl5	IPI		Mouse	MGI:MGI:6810796|PMID:25901680
Cellular Component	GO:0022625	cytosolic large ribosomal subunit	Rpl5	IDA		Mouse	MGI:MGI:7432473|PMID:36517592
Cellular Component	GO:0022625	cytosolic large ribosomal subunit	Rpl5	IDA		Rat	PMID:3988767|RGD:11035230
Cellular Component	GO:0022626	cytosolic ribosome	RPL5	IDA		Human	PMID:23636399
Cellular Component	GO:0022626	cytosolic ribosome	Rpl5	IDA		Rat	PMID:3733691|RGD:11035229
Cellular Component	GO:0005783	endoplasmic reticulum	RPL5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	RPL5	HDA		Human	PMID:20458337
Cellular Component	GO:0005925	focal adhesion	RPL5	HDA		Human	PMID:21423176
Cellular Component	GO:0016020	membrane	RPL5	HDA		Human	PMID:19946888
Cellular Component	GO:0005730	nucleolus	RPL5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	RPL5	IDA		Human	PMID:15469983
Cellular Component	GO:0005730	nucleolus	RPL5	HDA		Human	PMID:16791210
Cellular Component	GO:0005730	nucleolus	RPL5	IDA		Human	PMID:24120868
Cellular Component	GO:0005654	nucleoplasm	RPL5	IDA		Human	PMID:24120868
Cellular Component	GO:0005634	nucleus	RPL5	IDA		Human	PMID:9687515
Cellular Component	GO:0014069	postsynaptic density	Rpl5	EXP		Rat	PMID:15020595|RGD:13702264
Cellular Component	GO:0014069	postsynaptic density	Rpl5	IDA		Rat	PMID:15020595|RGD:13702264
Cellular Component	GO:0032991	protein-containing complex	RPL5	IDA		Human	PMID:15314173
Cellular Component	GO:1990904	ribonucleoprotein complex	RPL5	IDA		Human	PMID:18809582
Cellular Component	GO:1990904	ribonucleoprotein complex	Rpl5	IDA		Rat	PMID:8982850|RGD:2316859
Cellular Component	GO:0045202	synapse	Rpl5	IDA		Mouse	PMID:16635246
Cellular Component	GO:0045202	synapse	Rpl5	EXP		Mouse	PMID:16635246
Biological Process	GO:0071241	cellular response to inorganic substance	Rpl5	IEP		Rat	PMID:12930674|RGD:2316858
Biological Process	GO:0043009	chordate embryonic development	rpl5a	IMP	ZFIN:ZDB-MRPHLNO-070327-5	Zfish	PMID:17183665
Biological Process	GO:2000435	negative regulation of protein neddylation	RPL5	IDA		Human	PMID:18560357
Biological Process	GO:1904667	negative regulation of ubiquitin protein ligase activity	RPL5	IDA		Human	PMID:18560357
Biological Process	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	RPL5	IDA		Human	PMID:18560357
Biological Process	GO:0010628	positive regulation of gene expression	RPL5	IDA		Human	PMID:18560357
Biological Process	GO:1905017	positive regulation of isoleucine-tRNA ligase activity	Rpl5	IMP		Rat	PMID:1665486|RGD:11040680
Biological Process	GO:1905020	positive regulation of methionine-tRNA ligase activity	Rpl5	IMP		Rat	PMID:1665486|RGD:11040680
Biological Process	GO:0010922	positive regulation of phosphatase activity	Rpl5	IDA		Rat	PMID:7649987|RGD:2316860
Biological Process	GO:1905023	positive regulation of threonine-tRNA ligase activity	Rpl5	IMP		Rat	PMID:8049265|RGD:1556518
Biological Process	GO:0045727	positive regulation of translation	RPL5	IDA		Human	PMID:16213212
Biological Process	GO:0050821	protein stabilization	RPL5	IMP		Human	PMID:18560357
Biological Process	GO:1901796	regulation of signal transduction by p53 class mediator	RPL5	IMP		Human	PMID:24120868
Biological Process	GO:0000027	ribosomal large subunit assembly	RPL5	IMP		Human	PMID:24120868
Biological Process	GO:0042273	ribosomal large subunit biogenesis	RPL5	IMP		Human	PMID:18697920
Biological Process	GO:0006364	rRNA processing	RPL5	IMP		Human	PMID:18697920

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern