Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RPS3
  • Mouse genes Rps3
  • Rat genes Rps3
  • Zfish genes rps3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rps3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003684	damaged DNA binding	RPS3	IDA		Human	PMID:14706345
Molecular Function	GO:0003684	damaged DNA binding	RPS3	IDA		Human	PMID:16737853
Molecular Function	GO:0003684	damaged DNA binding	RPS3	IDA		Human	PMID:17560175
Molecular Function	GO:0003684	damaged DNA binding	RPS3	IDA		Human	PMID:18610840
Molecular Function	GO:0003677	DNA binding	RPS3	IDA		Human	PMID:18610840
Molecular Function	GO:0004520	DNA endonuclease activity	RPS3	IDA		Human	PMID:15707971
Molecular Function	GO:0004520	DNA endonuclease activity	RPS3	IDA		Human	PMID:20605787
Molecular Function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	RPS3	IDA		Human	PMID:15707971
Molecular Function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	RPS3	IDA		Human	PMID:16737853
Molecular Function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	RPS3	IDA		Human	PMID:18610840
Molecular Function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	RPS3	IDA		Human	PMID:19059439
Molecular Function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	RPS3	IDA		Human	PMID:7775413
Molecular Function	GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	Rps3	IDA		Mouse	MGI:MGI:3529384|PMID:15707971
Molecular Function	GO:0140297	DNA-binding transcription factor binding	RPS3	IPI	UniProtKB:O09139	Human	PMID:20605787
Molecular Function	GO:0019899	enzyme binding	RPS3	IPI	UniProtKB:O15527	Human	PMID:15518571
Molecular Function	GO:0019899	enzyme binding	RPS3	IPI	UniProtKB:P27695	Human	PMID:15518571
Molecular Function	GO:0019899	enzyme binding	RPS3	IPI	UniProtKB:P13051	Human	PMID:18973764
Molecular Function	GO:0019899	enzyme binding	RPS3	IPI	UniProtKB:Q99873	Human	PMID:19460357
Molecular Function	GO:0030544	Hsp70 protein binding	RPS3	IDA		Human	PMID:23911537
Molecular Function	GO:0051879	Hsp90 protein binding	RPS3	IDA		Human	PMID:23911537
Molecular Function	GO:0019900	kinase binding	RPS3	IPI	UniProtKB:P31749	Human	PMID:20605787
Molecular Function	GO:0019900	kinase binding	Rps3	IPI	UniProtKB:P47196	Rat	PMID:20605787|RGD:10402036
Molecular Function	GO:0008017	microtubule binding	RPS3	IDA		Human	PMID:23131551
Molecular Function	GO:0003729	mRNA binding	RPS3	IDA		Human	PMID:18464793
Molecular Function	GO:0032357	oxidized purine DNA binding	RPS3	IDA		Human	PMID:14706345
Molecular Function	GO:0032358	oxidized pyrimidine DNA binding	RPS3	IDA		Human	PMID:19656744
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:P63104	Human	PMID:15161933
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:P19838	Human	PMID:18045535
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:P25963	Human	PMID:18045535
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:Q04206	Human	PMID:18045535
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:Q15843	Human	PMID:18274552
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:Q05655	Human	PMID:19059439
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:P04637	Human	PMID:19656744
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:Q00987	Human	PMID:19656744
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:A0A0F3UH49	Human	PMID:20041225
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:Q8X831	Human	PMID:20041225
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:Q8XAL6	Human	PMID:20041225
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:P63104	Human	PMID:20618440
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:Q15843	Human	PMID:21145461
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:Q08752	Human	PMID:21146485
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:O14920	Human	PMID:21399639
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:Q04207	Human	PMID:22244329
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:Q13158	Human	PMID:22510408
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:Q15628	Human	PMID:22510408
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:O94826	Human	PMID:23911537
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:Q14103	Human	PMID:24423872
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:P25963	Human	PMID:24457201
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:Q04206	Human	PMID:24457201
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:Q5S007	Human	PMID:24725412
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:P19712:PRO_0000038050	Human	PMID:24965446
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:P19838	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:Q04206	Human	PMID:26526615
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:Q86UK7	Human	PMID:28065601
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:Q86UK7	Human	PMID:28132843
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:Q5S007	Human	PMID:31046837
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:Q96GA3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RPS3	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Rps3	IPI	UniProtKB:P97784	Mouse	MGI:MGI:5009503|PMID:19129230
Molecular Function	GO:0005515	protein binding	Rps3	IPI	UniProtKB:Q9R0N3	Rat	PMID:24882364|RGD:8693368
Molecular Function	GO:0051018	protein kinase A binding	RPS3	IPI	UniProtKB:P15531	Human	PMID:16814409
Molecular Function	GO:0019901	protein kinase binding	RPS3	IPI	UniProtKB:P27361	Human	PMID:15950189
Molecular Function	GO:0019901	protein kinase binding	RPS3	IPI	UniProtKB:P06493	Human	PMID:21871177
Molecular Function	GO:0044877	protein-containing complex binding	RPS3	IMP		Human	PMID:18045535
Molecular Function	GO:0003723	RNA binding	RPS3	IDA		Human	PMID:20217897
Molecular Function	GO:0003723	RNA binding	RPS3	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	RPS3	HDA		Human	PMID:22681889
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	RPS3	IMP		Human	PMID:18045535
Molecular Function	GO:0070181	small ribosomal subunit rRNA binding	RPS3	IDA		Human	PMID:18610840
Molecular Function	GO:0003735	structural constituent of ribosome	RPS3	HDA		Human	PMID:15883184
Molecular Function	GO:0003735	structural constituent of ribosome	RPS3	IDA		Human	PMID:23636399
Molecular Function	GO:0003735	structural constituent of ribosome	Rps3	IDA		Mouse	MGI:MGI:7432473|PMID:36517592
Molecular Function	GO:0097100	supercoiled DNA binding	RPS3	IDA		Human	PMID:15707971
Molecular Function	GO:0015631	tubulin binding	RPS3	IDA		Human	PMID:23131551
Molecular Function	GO:0044390	ubiquitin-like protein conjugating enzyme binding	RPS3	IPI	UniProtKB:P63279	Human	PMID:21968017
Cellular Component	GO:0005737	cytoplasm	RPS3	IDA		Human	PMID:14988002
Cellular Component	GO:0005737	cytoplasm	RPS3	IDA		Human	PMID:19059439
Cellular Component	GO:0005737	cytoplasm	RPS3	IDA		Human	PMID:20217897
Cellular Component	GO:0005737	cytoplasm	RPS3	IMP		Human	PMID:21871177
Cellular Component	GO:0005737	cytoplasm	Rps3	IDA		Mouse	PMID:12388085
Cellular Component	GO:0005829	cytosol	RPS3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	RPS3	IDA		Human	PMID:16814409
Cellular Component	GO:0005829	cytosol	RPS3	IDA		Human	PMID:17560175
Cellular Component	GO:0005829	cytosol	RPS3	IDA		Human	PMID:18045535
Cellular Component	GO:0022626	cytosolic ribosome	RPS3	IDA		Human	PMID:23636399
Cellular Component	GO:0022627	cytosolic small ribosomal subunit	RPS3	HDA		Human	PMID:15883184
Cellular Component	GO:0022627	cytosolic small ribosomal subunit	RPS3	IDA		Human	PMID:8706699
Cellular Component	GO:0022627	cytosolic small ribosomal subunit	Rps3	IDA		Mouse	MGI:MGI:7432473|PMID:36517592
Cellular Component	GO:0022627	cytosolic small ribosomal subunit	Rps3	IDA		Rat	PMID:12876473|RGD:2299084
Cellular Component	GO:0022627	cytosolic small ribosomal subunit	Rps3	IDA		Rat	PMID:2328735|RGD:1599573
Cellular Component	GO:0022627	cytosolic small ribosomal subunit	Rps3	IDA		Rat	PMID:947902|RGD:2300010
Cellular Component	GO:0030425	dendrite	Rps3	IDA		Rat	PMID:12876473|RGD:2299084
Cellular Component	GO:0012505	endomembrane system	Rps3	IDA		Rat	PMID:12876473|RGD:2299084
Cellular Component	GO:0005783	endoplasmic reticulum	RPS3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	RPS3	HDA		Human	PMID:20458337
Cellular Component	GO:0005925	focal adhesion	RPS3	HDA		Human	PMID:21423176
Cellular Component	GO:0016020	membrane	RPS3	HDA		Human	PMID:19946888
Cellular Component	GO:0005743	mitochondrial inner membrane	RPS3	IDA		Human	PMID:23911537
Cellular Component	GO:0005759	mitochondrial matrix	RPS3	IDA		Human	PMID:23911537
Cellular Component	GO:0072686	mitotic spindle	RPS3	IDA		Human	PMID:23131551
Cellular Component	GO:0071159	NF-kappaB complex	RPS3	IDA		Human	PMID:18045535
Cellular Component	GO:0005730	nucleolus	RPS3	IDA		Human	PMID:19460357
Cellular Component	GO:0005634	nucleus	RPS3	IDA		Human	PMID:14988002
Cellular Component	GO:0005634	nucleus	RPS3	IDA		Human	PMID:16814409
Cellular Component	GO:0005634	nucleus	RPS3	IDA		Human	PMID:17560175
Cellular Component	GO:0005634	nucleus	RPS3	IDA		Human	PMID:18045535
Cellular Component	GO:0005634	nucleus	RPS3	IDA		Human	PMID:19059439
Cellular Component	GO:0005634	nucleus	RPS3	IDA		Human	PMID:19460357
Cellular Component	GO:0005634	nucleus	RPS3	IDA		Human	PMID:20041225
Cellular Component	GO:0005634	nucleus	RPS3	IMP		Human	PMID:21399639
Cellular Component	GO:0005634	nucleus	RPS3	IMP		Human	PMID:21871177
Cellular Component	GO:0005634	nucleus	Rps3	IDA		Rat	PMID:20605787|RGD:10402036
Cellular Component	GO:0005886	plasma membrane	RPS3	IDA		Human	PMID:22510408
Cellular Component	GO:0005844	polysome	RPS3	IDA		Human	PMID:19460357
Cellular Component	GO:0005844	polysome	Rps3	IDA		Rat	PMID:23121659|RGD:12792285
Cellular Component	GO:0014069	postsynaptic density	RPS3	EXP		Human	PMID:21170055
Cellular Component	GO:0014069	postsynaptic density	RPS3	IDA		Human	PMID:21170055
Cellular Component	GO:1990904	ribonucleoprotein complex	RPS3	IDA		Human	PMID:17289661
Cellular Component	GO:0005840	ribosome	RPS3	IDA		Human	PMID:19059439
Cellular Component	GO:0005840	ribosome	RPS3	IDA		Human	PMID:19460357
Cellular Component	GO:0005840	ribosome	RPS3	IDA		Human	PMID:20217897
Cellular Component	GO:0032587	ruffle membrane	RPS3	IDA		Human	PMID:16814409
Cellular Component	GO:0045202	synapse	Rps3	EXP		Mouse	PMID:16635246
Cellular Component	GO:0045202	synapse	Rps3	IDA		Mouse	PMID:16635246
Biological Process	GO:0070301	cellular response to hydrogen peroxide	RPS3	IDA		Human	PMID:23911537
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	Rps3	IDA		Rat	PMID:20605787|RGD:10402036
Biological Process	GO:0034614	cellular response to reactive oxygen species	RPS3	IDA		Human	PMID:23911537
Biological Process	GO:0071356	cellular response to tumor necrosis factor	RPS3	IMP		Human	PMID:18045535
Biological Process	GO:0043009	chordate embryonic development	rps3	IMP	ZFIN:ZDB-MRPHLNO-070326-1	Zfish	PMID:17183665
Biological Process	GO:0007059	chromosome segregation	RPS3	IMP		Human	PMID:23131551
Biological Process	GO:0006974	DNA damage response	RPS3	IEP		Human	PMID:17560175
Biological Process	GO:0006974	DNA damage response	Rps3	IDA		Rat	PMID:20605787|RGD:10402036
Biological Process	GO:0006281	DNA repair	RPS3	IMP		Human	PMID:19059439
Biological Process	GO:0030218	erythrocyte differentiation	rps3	IMP	ZFIN:ZDB-MRPHLNO-070126-7,ZFIN:ZDB-MRPHLNO-070326-1	Zfish	PMID:24417973
Biological Process	GO:0045738	negative regulation of DNA repair	RPS3	IMP		Human	PMID:17049931
Biological Process	GO:0031397	negative regulation of protein ubiquitination	RPS3	IDA		Human	PMID:19656744
Biological Process	GO:0017148	negative regulation of translation	RPS3	IDA		Human	PMID:20217897
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	RPS3	IMP		Human	PMID:18045535
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	RPS3	IDA		Human	PMID:14988002
Biological Process	GO:1905053	positive regulation of base-excision repair	RPS3	IDA		Human	PMID:18973764
Biological Process	GO:2001272	positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	RPS3	IMP		Human	PMID:22510408
Biological Process	GO:1902546	positive regulation of DNA N-glycosylase activity	RPS3	IDA		Human	PMID:15518571
Biological Process	GO:0045739	positive regulation of DNA repair	RPS3	IDA		Human	PMID:23911537
Biological Process	GO:0032079	positive regulation of endodeoxyribonuclease activity	RPS3	IDA		Human	PMID:18973764
Biological Process	GO:0010628	positive regulation of gene expression	RPS3	IMP		Human	PMID:20605787
Biological Process	GO:0032743	positive regulation of interleukin-2 production	RPS3	IMP		Human	PMID:18045535
Biological Process	GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	RPS3	IMP		Human	PMID:22510408
Biological Process	GO:0043507	positive regulation of JUN kinase activity	RPS3	IMP		Human	PMID:22510408
Biological Process	GO:0031116	positive regulation of microtubule polymerization	RPS3	IMP		Human	PMID:23131551
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	RPS3	IGI	UniProtKB:Q04206	Human	PMID:18045535
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	RPS3	IMP		Human	PMID:18045535
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Rps3	IMP		Mouse	MGI:MGI:5882887|PMID:18045535
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	RPS3	IDA		Human	PMID:20041225
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly	RPS3	IMP		Human	PMID:18045535
Biological Process	GO:0031334	positive regulation of protein-containing complex assembly	Rps3	IMP		Mouse	MGI:MGI:5882887|PMID:18045535
Biological Process	GO:0050862	positive regulation of T cell receptor signaling pathway	RPS3	IMP		Human	PMID:18045535
Biological Process	GO:0042981	regulation of apoptotic process	RPS3	IMP		Human	PMID:20605787
Biological Process	GO:0042981	regulation of apoptotic process	Rps3	IMP		Rat	PMID:20605787|RGD:10402036
Biological Process	GO:0061481	response to TNF agonist	RPS3	IDA		Human	PMID:20041225
Biological Process	GO:0051225	spindle assembly	RPS3	IMP		Human	PMID:23131551

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern