Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RPS6KA1
  • Mouse genes Rps6ka1
  • Rat genes Rps6ka1
  • Zfish genes rps6ka1,rps6ka3a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rps6ka1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	RPS6KA1	IDA		Human	PMID:18402937
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Rps6ka1	IPI	UniProtKB:P28033	Mouse	MGI:MGI:3778721|PMID:10635333
Molecular Function	GO:0016301	kinase activity	Rps6ka1	IDA		Mouse	MGI:MGI:3778721|PMID:10635333
Molecular Function	GO:0005515	protein binding	RPS6KA1	IPI	UniProtKB:P46527	Human	PMID:19470470
Molecular Function	GO:0005515	protein binding	RPS6KA1	IPI	UniProtKB:P50552	Human	PMID:21423205
Molecular Function	GO:0005515	protein binding	RPS6KA1	IPI	UniProtKB:O43823	Human	PMID:22130794
Molecular Function	GO:0005515	protein binding	RPS6KA1	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	RPS6KA1	IPI	UniProtKB:P08238	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	RPS6KA1	IPI	UniProtKB:P28482	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	RPS6KA1	IPI	UniProtKB:P28482	Human	PMID:23519423
Molecular Function	GO:0005515	protein binding	RPS6KA1	IPI	UniProtKB:A1JU68	Human	PMID:25513777
Molecular Function	GO:0005515	protein binding	RPS6KA1	IPI	UniProtKB:P28482	Human	PMID:29997244
Molecular Function	GO:0005515	protein binding	RPS6KA1	IPI	UniProtKB:Q14160	Human	PMID:30126976
Molecular Function	GO:0005515	protein binding	RPS6KA1	IPI	UniProtKB:P04271	Human	PMID:31837246
Molecular Function	GO:0005515	protein binding	RPS6KA1	IPI	UniProtKB:P08238	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	RPS6KA1	IPI	UniProtKB:P28482	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	RPS6KA1	IPI	UniProtKB:P28482	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Rps6ka1	IPI	RGD:620713	Rat	PMID:15117958|RGD:10402046
Molecular Function	GO:0004674	protein serine/threonine kinase activity	RPS6KA1	IDA		Human	PMID:10679322
Molecular Function	GO:0004674	protein serine/threonine kinase activity	RPS6KA1	IDA		Human	PMID:22357623
Molecular Function	GO:0004712	protein serine/threonine/tyrosine kinase activity	RPS6KA1	IDA		Human	PMID:22797923
Cellular Component	GO:0005737	cytoplasm	Rps6ka1	IDA		Rat	PMID:15117958|RGD:10402046
Cellular Component	GO:0005829	cytosol	RPS6KA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	RPS6KA1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Rps6ka1	IDA		Rat	PMID:15117958|RGD:10402046
Cellular Component	GO:0005819	spindle	Rps6ka1	IDA		Mouse	PMID:15509711
Cellular Component	GO:0045202	synapse	Rps6ka1	EXP		Mouse	PMID:25211037
Cellular Component	GO:0045202	synapse	Rps6ka1	IDA		Mouse	PMID:25211037
Biological Process	GO:0048565	digestive tract development	rps6ka3a	IMP	ZFIN:ZDB-MRPHLNO-070629-1	Zfish	PMID:17222402
Biological Process	GO:0072574	hepatocyte proliferation	Rps6ka1	IDA		Mouse	MGI:MGI:3778721|PMID:10635333
Biological Process	GO:0043066	negative regulation of apoptotic process	RPS6KA1	IMP		Human	PMID:11684016
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	RPS6KA1	IDA		Human	PMID:18402937
Biological Process	GO:0032007	negative regulation of TOR signaling	RPS6KA1	IMP		Human	PMID:35772404
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Rps6ka1	IDA		Rat	PMID:12213813|RGD:727422
Biological Process	GO:2000491	positive regulation of hepatic stellate cell activation	RPS6KA1	IMP		Human	PMID:10679322
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	RPS6KA1	IMP		Human	PMID:22065586
Biological Process	GO:0006468	protein phosphorylation	RPS6KA1	IMP		Human	PMID:35772404
Biological Process	GO:0006468	protein phosphorylation	Rps6ka1	IDA		Rat	PMID:12213813|RGD:727422
Biological Process	GO:0043588	skin development	rps6ka3a	IGI	ZFIN:ZDB-GENO-121005-3,ZFIN:ZDB-MRPHLNO-070629-1,ZFIN:ZDB-MRPHLNO-070629-3	Zfish	PMID:22623957
Biological Process	GO:0043588	skin development	rps6ka3a	IGI	ZFIN:ZDB-GENO-121005-3,ZFIN:ZDB-MRPHLNO-070629-1	Zfish	PMID:22623957

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern