Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RPS6KA2
  • Mouse genes Rps6ka2
  • Rat genes Rps6ka2
  • Zfish genes rps6ka2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rps6ka2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	RPS6KA2	IPI	UniProtKB:P15056	Human	PMID:16810323
Molecular Function	GO:0005515	protein binding	RPS6KA2	IPI	UniProtKB:Q02156	Human	PMID:16810323
Molecular Function	GO:0005515	protein binding	RPS6KA2	IPI	UniProtKB:P28482	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	RPS6KA2	IPI	UniProtKB:P28482	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	RPS6KA2	IPI	UniProtKB:Q14160	Human	PMID:29144123
Molecular Function	GO:0005515	protein binding	RPS6KA2	IPI	UniProtKB:Q14160	Human	PMID:30126976
Molecular Function	GO:0005515	protein binding	RPS6KA2	IPI	UniProtKB:Q9Y566	Human	PMID:30126976
Molecular Function	GO:0005515	protein binding	RPS6KA2	IPI	UniProtKB:P28482	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RPS6KA2	IPI	UniProtKB:P28482	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	RPS6KA2	IPI	UniProtKB:O14901	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RPS6KA2	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Rps6ka2	IPI	PR:Q7TSG3	Mouse	PMID:15526037
Molecular Function	GO:0004672	protein kinase activity	Rps6ka2	IDA		Mouse	PMID:15526037
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Rps6ka2	IDA		Mouse	PMID:7508917
Molecular Function	GO:0004712	protein serine/threonine/tyrosine kinase activity	RPS6KA2	IDA		Human	PMID:22797923
Molecular Function	GO:0004711	ribosomal protein S6 kinase activity	Rps6ka2	IDA		Mouse	PMID:16585392
Cellular Component	GO:0005737	cytoplasm	RPS6KA2	IDA		Human	PMID:16878154
Cellular Component	GO:0005737	cytoplasm	Rps6ka2	IDA		Mouse	PMID:15526037
Cellular Component	GO:0072687	meiotic spindle	Rps6ka2	IDA		Mouse	MGI:MGI:3521521|PMID:15526037
Cellular Component	GO:0005654	nucleoplasm	RPS6KA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	RPS6KA2	IDA		Human	PMID:16878154
Cellular Component	GO:0005819	spindle	Rps6ka2	IDA		Mouse	PMID:15509711
Biological Process	GO:0002035	brain renin-angiotensin system	Rps6ka2	IDA		Mouse	PMID:16585392
Biological Process	GO:0010659	cardiac muscle cell apoptotic process	Rps6ka2	IDA		Mouse	PMID:16585392
Biological Process	GO:0071322	cellular response to carbohydrate stimulus	Rps6ka2	IDA		Mouse	PMID:16585392
Biological Process	GO:0060047	heart contraction	Rps6ka2	IDA		Mouse	PMID:16585392
Biological Process	GO:0007507	heart development	Rps6ka2	IDA		Mouse	PMID:16585392
Biological Process	GO:0045786	negative regulation of cell cycle	RPS6KA2	IDA		Human	PMID:16878154
Biological Process	GO:0008285	negative regulation of cell population proliferation	RPS6KA2	IDA		Human	PMID:16878154
Biological Process	GO:0045835	negative regulation of meiotic nuclear division	Rps6ka2	IDA		Mouse	PMID:15526037
Biological Process	GO:0001556	oocyte maturation	Rps6ka2	IDA		Mouse	PMID:15526037
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Rps6ka2	IDA		Mouse	PMID:7508917
Biological Process	GO:0043065	positive regulation of apoptotic process	RPS6KA2	IDA		Human	PMID:16878154
Biological Process	GO:0010628	positive regulation of gene expression	Rps6ka2	IDA		Mouse	PMID:16585392
Biological Process	GO:0006468	protein phosphorylation	Rps6ka2	IDA		Mouse	PMID:15526037
Biological Process	GO:0070613	regulation of protein processing	Rps6ka2	IMP		Mouse	PMID:16585392

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern