Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RPS6KA3
  • Mouse genes Rps6ka3
  • Rat genes Rps6ka3
  • Zfish genes rps6ka3a,rps6ka3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rps6ka3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	RPS6KA3	IDA		Human	PMID:18402937
Molecular Function	GO:0005515	protein binding	RPS6KA3	IPI	UniProtKB:P67870	Human	PMID:10094392
Molecular Function	GO:0005515	protein binding	RPS6KA3	IPI	UniProtKB:P28482	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	RPS6KA3	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	RPS6KA3	IPI	UniProtKB:P28482	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	RPS6KA3	IPI	UniProtKB:P28482	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	RPS6KA3	IPI	UniProtKB:A1JU68	Human	PMID:25513777
Molecular Function	GO:0005515	protein binding	RPS6KA3	IPI	UniProtKB:Q7Z698	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	RPS6KA3	IPI	UniProtKB:P08238	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	RPS6KA3	IPI	UniProtKB:P28482	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	RPS6KA3	IPI	UniProtKB:P67870	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	RPS6KA3	IPI	UniProtKB:P28482	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	RPS6KA3	IPI	UniProtKB:P67870	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	RPS6KA3	IPI	UniProtKB:O14901	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RPS6KA3	IPI	UniProtKB:P09471	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RPS6KA3	IPI	UniProtKB:P27986-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RPS6KA3	IPI	UniProtKB:P46379-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RPS6KA3	IPI	UniProtKB:Q6P4D5-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RPS6KA3	IPI	UniProtKB:Q7Z698	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RPS6KA3	IPI	UniProtKB:Q9HC98-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Rps6ka3	IPI	UniProtKB:P30309	Mouse	MGI:MGI:5918230|PMID:21041626
Molecular Function	GO:0005515	protein binding	Rps6ka3	IPI	UniProtKB:Q06507	Mouse	MGI:MGI:3040115|PMID:15109498
Molecular Function	GO:0005515	protein binding	Rps6ka3	IPI	UniProtKB:P28223-1	Mouse	MGI:MGI:3621613|PMID:16537434
Molecular Function	GO:0019901	protein kinase binding	Rps6ka3	IPI	UniProtKB:P49138	Mouse	MGI:MGI:3761050|PMID:17906627
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Rps6ka3	IDA		Mouse	PMID:12016217
Cellular Component	GO:0005829	cytosol	RPS6KA3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	RPS6KA3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	RPS6KA3	IDA		Human	GO_REF:0000052
Biological Process	GO:0048565	digestive tract development	rps6ka3a	IMP	ZFIN:ZDB-MRPHLNO-070629-1	Zfish	PMID:17222402
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	RPS6KA3	IDA		Human	PMID:18402937
Biological Process	GO:0001503	ossification	rps6ka3b	IGI	ZFIN:ZDB-MRPHLNO-181127-1	Zfish	PMID:30032135
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	RPS6KA3	IMP		Human	PMID:22065586
Biological Process	GO:0032496	response to lipopolysaccharide	Rps6ka3	IMP		Mouse	MGI:MGI:3761050|PMID:17906627
Biological Process	GO:0043588	skin development	rps6ka3a	IGI	ZFIN:ZDB-GENO-121005-3,ZFIN:ZDB-MRPHLNO-070629-1,ZFIN:ZDB-MRPHLNO-070629-3	Zfish	PMID:22623957
Biological Process	GO:0043588	skin development	rps6ka3a	IGI	ZFIN:ZDB-GENO-121005-3,ZFIN:ZDB-MRPHLNO-070629-1	Zfish	PMID:22623957
Biological Process	GO:0002224	toll-like receptor signaling pathway	Rps6ka3	IMP		Mouse	MGI:MGI:3761050|PMID:17906627

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern