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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Rps6kb1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rps6kb1
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0005524ATP bindingRps6kb1IDARatPMID:11574531|RGD:1626103
Molecular FunctionGO:0042802identical protein bindingRps6kb1IPIUniProtKB:P67999RatPMID:17446865|RGD:10054081
Molecular FunctionGO:0042802identical protein bindingRps6kb1IPIUniProtKB:P67999RatPMID:21986499|RGD:10054085
Molecular FunctionGO:0030165PDZ domain bindingRps6kb1IPIRGD:632280RatPMID:9653190|RGD:8554053
Molecular FunctionGO:0042277peptide bindingRps6kb1IDARatPMID:11574531|RGD:1626103
Molecular FunctionGO:0005515protein bindingRPS6KB1IPIUniProtKB:Q8N122HumanPMID:12150926
Molecular FunctionGO:0005515protein bindingRPS6KB1IPIUniProtKB:O94763HumanPMID:17936702
Molecular FunctionGO:0005515protein bindingRPS6KB1IPIUniProtKB:P55884HumanPMID:18423201
Molecular FunctionGO:0005515protein bindingRPS6KB1IPIUniProtKB:P35568HumanPMID:18952604
Molecular FunctionGO:0005515protein bindingRPS6KB1IPIUniProtKB:Q00005HumanPMID:21075311
Molecular FunctionGO:0005515protein bindingRPS6KB1IPIUniProtKB:P55884HumanPMID:21986499
Molecular FunctionGO:0005515protein bindingRPS6KB1IPIUniProtKB:P08151HumanPMID:22439934
Molecular FunctionGO:0005515protein bindingRPS6KB1IPIUniProtKB:Q5VY09HumanPMID:26496226
Molecular FunctionGO:0005515protein bindingRPS6KB1IPIUniProtKB:P13051-2HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingRPS6KB1IPIUniProtKB:Q06481-5HumanPMID:32814053
Molecular FunctionGO:0005515protein bindingRps6kb1IPIUniProtKB:P23804MouseMGI:MGI:4822517|PMID:20657550
Molecular FunctionGO:0005515protein bindingRps6kb1IPIUniProtKB:Q8N122RatPMID:12150926|RGD:8553634
Molecular FunctionGO:0005515protein bindingRps6kb1IPIRGD:2623RatPMID:23831253|RGD:11667971
Molecular FunctionGO:0005515protein bindingRps6kb1IPIUniProtKB:O35867RatPMID:9653190|RGD:8554053
Molecular FunctionGO:0004672protein kinase activityRPS6KB1IDAHumanPMID:17936702
Molecular FunctionGO:0004672protein kinase activityRPS6KB1IDAHumanPMID:18952604
Molecular FunctionGO:0004672protein kinase activityRps6kb1IDAMousePMID:15249583
Molecular FunctionGO:0004672protein kinase activityRps6kb1IMPMousePMID:15249583
Molecular FunctionGO:0004672protein kinase activityRps6kb1IDARatPMID:11574531|RGD:1626103
Molecular FunctionGO:0051721protein phosphatase 2A bindingRps6kb1IPIRGD:3380RatPMID:16899564|RGD:9831455
Molecular FunctionGO:0004712protein serine/threonine/tyrosine kinase activityRPS6KB1IDAHumanPMID:22797923
Molecular FunctionGO:0004711ribosomal protein S6 kinase activityRps6kb1IMPRatPMID:11574531|RGD:1626103
Cellular ComponentGO:0009986cell surfaceRps6kb1IDARatPMID:16710051|RGD:1642988
Cellular ComponentGO:0005829cytosolRps6kb1IDARatPMID:9653190|RGD:8554053
Cellular ComponentGO:0098978glutamatergic synapseRps6kb1IDAMousePMID:18174371
Cellular ComponentGO:0098978glutamatergic synapseRps6kb1IMPMousePMID:18174371
Cellular ComponentGO:0005739mitochondrionRPS6KB1IDAHumanPMID:17936702
Cellular ComponentGO:0005739mitochondrionRps6kb1IDAMouseMGI:MGI:4456959|PMID:11493700
Cellular ComponentGO:0005654nucleoplasmRPS6KB1IDAHumanGO_REF:0000052
Cellular ComponentGO:0005634nucleusRps6kb1IDARatPMID:16710051|RGD:1642988
Cellular ComponentGO:0048471perinuclear region of cytoplasmRps6kb1IDARatPMID:16710051|RGD:1642988
Cellular ComponentGO:0098794postsynapseRps6kb1IDARatPMID:14623952|RGD:155230806
Cellular ComponentGO:0045202synapseRps6kb1IDARatPMID:12711090|RGD:10401640
Biological ProcessGO:0007568agingRps6kb1IEPRatPMID:16041621|RGD:1643019
Biological ProcessGO:0001662behavioral fear responseRps6kb1IGIMGI:MGI:2384784MousePMID:24990923
Biological ProcessGO:0001662behavioral fear responseRps6kb1IGIMGI:MGI:95305MousePMID:24990923
Biological ProcessGO:0016477cell migrationRps6kb1IEPRatPMID:16710051|RGD:1642988
Biological ProcessGO:0071549cellular response to dexamethasone stimulusRps6kb1IDAMousePMID:17556672
Biological ProcessGO:0071363cellular response to growth factor stimulusRPS6KB1IDAHumanPMID:17936702
Biological ProcessGO:0032870cellular response to hormone stimulusRps6kb1IEPRatPMID:16717100|RGD:1642987
Biological ProcessGO:0032869cellular response to insulin stimulusRps6kb1IGIMGI:MGI:3619426MousePMID:24349514
Biological ProcessGO:0071407cellular response to organic cyclic compoundRps6kb1IDAMousePMID:24990923
Biological ProcessGO:0071346cellular response to type II interferonRps6kb1IMPMouseMGI:MGI:5913528|PMID:28178239
Biological ProcessGO:0000082G1/S transition of mitotic cell cycleRPS6KB1IMPHumanPMID:14673156
Biological ProcessGO:0007281germ cell developmentRps6kb1IDAMousePMID:12140361
Biological ProcessGO:0044539long-chain fatty acid import into cellRps6kb1IMPMouseMGI:MGI:5913528|PMID:28178239
Biological ProcessGO:0007616long-term memoryRps6kb1IEPRatPMID:16885218|RGD:1642986
Biological ProcessGO:0050804modulation of chemical synaptic transmissionRps6kb1IMPMousePMID:18174371
Biological ProcessGO:0050804modulation of chemical synaptic transmissionRps6kb1IDAMousePMID:18174371
Biological ProcessGO:0043066negative regulation of apoptotic processRPS6KB1IMPHumanPMID:17936702
Biological ProcessGO:0043066negative regulation of apoptotic processRps6kb1IMPMouseMGI:MGI:4456959|PMID:11493700
Biological ProcessGO:2001237negative regulation of extrinsic apoptotic signaling pathwayRps6kb1IMPMousePMID:11493700
Biological ProcessGO:0046627negative regulation of insulin receptor signaling pathwayRPS6KB1IMPHumanPMID:18952604
Biological ProcessGO:0046627negative regulation of insulin receptor signaling pathwayRps6kb1IMPRatPMID:18952604|RGD:8554230
Biological ProcessGO:0018105peptidyl-serine phosphorylationRPS6KB1IMPHumanPMID:28178239
Biological ProcessGO:0018105peptidyl-serine phosphorylationRps6kb1IMPMouseMGI:MGI:5913528|PMID:28178239
Biological ProcessGO:0045931positive regulation of mitotic cell cycleRPS6KB1IMPHumanPMID:14673156
Biological ProcessGO:0048633positive regulation of skeletal muscle tissue growthRps6kb1IMPRatPMID:16408196|RGD:1643018
Biological ProcessGO:0014911positive regulation of smooth muscle cell migrationRps6kb1IMPRatPMID:16148030|RGD:1643021
Biological ProcessGO:0048661positive regulation of smooth muscle cell proliferationRps6kb1IMPRatPMID:16148030|RGD:1643021
Biological ProcessGO:0045727positive regulation of translationRPS6KB1IMPHumanPMID:18423201
Biological ProcessGO:0045948positive regulation of translational initiationRPS6KB1IMPHumanPMID:16763566
Biological ProcessGO:0043491protein kinase B signalingRps6kb1IGIMGI:MGI:102548MousePMID:15249583
Biological ProcessGO:0043491protein kinase B signalingRps6kb1IGIMGI:MGI:87986MousePMID:15249583
Biological ProcessGO:0043491protein kinase B signalingRps6kb1IGIMGI:MGI:99454MousePMID:15249583
Biological ProcessGO:0043491protein kinase B signalingRps6kb1IGIMGI:MGI:1927343MousePMID:15249583
Biological ProcessGO:0006468protein phosphorylationRps6kb1IMPMousePMID:15249583
Biological ProcessGO:0006468protein phosphorylationRps6kb1IDAMousePMID:15249583
Biological ProcessGO:0006468protein phosphorylationRps6kb1IDARatPMID:11574531|RGD:1626103
Biological ProcessGO:0006468protein phosphorylationRps6kb1IMPRatPMID:9653190|RGD:8554053
Biological ProcessGO:0046324regulation of glucose importRps6kb1IMPRatPMID:18952604|RGD:8554230
Biological ProcessGO:0043200response to amino acidRps6kb1IEPRatPMID:10913029|RGD:1642983
Biological ProcessGO:0014878response to electrical stimulus involved in regulation of muscle adaptationRps6kb1IEPRatPMID:15716393|RGD:1643029
Biological ProcessGO:0045471response to ethanolRps6kb1IEPRatPMID:15547464|RGD:1643023
Biological ProcessGO:0033762response to glucagonRps6kb1IEPRatPMID:15494402|RGD:1601392
Biological ProcessGO:0051384response to glucocorticoidRps6kb1IEPRatPMID:14630710|RGD:1642979
Biological ProcessGO:0009749response to glucoseRps6kb1IEPRatPMID:16885218|RGD:1642986
Biological ProcessGO:0009408response to heatRps6kb1IEPRatPMID:14695116|RGD:1643025
Biological ProcessGO:0032868response to insulinRps6kb1IEPRatPMID:15908181|RGD:1643020
Biological ProcessGO:0032868response to insulinRps6kb1IEPRatPMID:16565309|RGD:1642975
Biological ProcessGO:0032868response to insulinRps6kb1IMPRatPMID:18952604|RGD:8554230
Biological ProcessGO:0043201response to leucineRps6kb1IEPRatPMID:16616211|RGD:1643098
Biological ProcessGO:0032496response to lipopolysaccharideRps6kb1IEPRatPMID:15389631|RGD:1643035
Biological ProcessGO:0009612response to mechanical stimulusRps6kb1IEPRatPMID:17526558|RGD:1642985
Biological ProcessGO:0007584response to nutrientRps6kb1IEPRatPMID:10913029|RGD:1642983
Biological ProcessGO:0031667response to nutrient levelsRPS6KB1IDAHumanPMID:29750193
Biological ProcessGO:0014070response to organic cyclic compoundRps6kb1IEPRatPMID:16616211|RGD:1643098
Biological ProcessGO:0010033response to organic substanceRps6kb1IEPRatPMID:16434554|RGD:1642999
Biological ProcessGO:0010243response to organonitrogen compoundRps6kb1IEPRatPMID:15837117|RGD:8694086
Biological ProcessGO:0043434response to peptide hormoneRps6kb1IEPRatPMID:12668683|RGD:1643037
Biological ProcessGO:0033574response to testosteroneRps6kb1IEPRatPMID:15698549|RGD:1643030
Biological ProcessGO:0009636response to toxic substanceRps6kb1IEPRatPMID:15342961|RGD:1643036
Biological ProcessGO:0034612response to tumor necrosis factorRps6kb1IMPRatPMID:18952604|RGD:8554230
Biological ProcessGO:0009611response to woundingRps6kb1IEPRatPMID:16710051|RGD:1642988
Biological ProcessGO:0009410response to xenobiotic stimulusRps6kb1IEPRatPMID:17728140|RGD:1642973
Biological ProcessGO:0014732skeletal muscle atrophyRps6kb1IEPRatPMID:17885021|RGD:1642984
Biological ProcessGO:0003009skeletal muscle contractionRps6kb1IEPRatPMID:15033970|RGD:1643024
Biological ProcessGO:0031929TOR signalingRPS6KB1IDAHumanPMID:12150926
Biological ProcessGO:0031929TOR signalingRPS6KB1IMPHumanPMID:28178239
Biological ProcessGO:0031929TOR signalingRPS6KB1IMPHumanPMID:29750193

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory