Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Rps6kb1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes RPS6KB1
- Mouse genes Rps6kb1
- Rat genes Rps6kb1
- Zfish genes rps6kb1a,rps6kb1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rps6kb1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Rps6kb1	IDA		Rat	PMID:11574531\|RGD:1626103
Molecular Function	GO:0042802	identical protein binding	Rps6kb1	IPI	UniProtKB:P67999	Rat	PMID:17446865\|RGD:10054081
Molecular Function	GO:0042802	identical protein binding	Rps6kb1	IPI	UniProtKB:P67999	Rat	PMID:21986499\|RGD:10054085
Molecular Function	GO:0030165	PDZ domain binding	Rps6kb1	IPI	RGD:632280	Rat	PMID:9653190\|RGD:8554053
Molecular Function	GO:0042277	peptide binding	Rps6kb1	IDA		Rat	PMID:11574531\|RGD:1626103
Molecular Function	GO:0005515	protein binding	RPS6KB1	IPI	UniProtKB:Q8N122	Human	PMID:12150926
Molecular Function	GO:0005515	protein binding	RPS6KB1	IPI	UniProtKB:O94763	Human	PMID:17936702
Molecular Function	GO:0005515	protein binding	RPS6KB1	IPI	UniProtKB:P55884	Human	PMID:18423201
Molecular Function	GO:0005515	protein binding	RPS6KB1	IPI	UniProtKB:P35568	Human	PMID:18952604
Molecular Function	GO:0005515	protein binding	RPS6KB1	IPI	UniProtKB:Q00005	Human	PMID:21075311
Molecular Function	GO:0005515	protein binding	RPS6KB1	IPI	UniProtKB:P55884	Human	PMID:21986499
Molecular Function	GO:0005515	protein binding	RPS6KB1	IPI	UniProtKB:P08151	Human	PMID:22439934
Molecular Function	GO:0005515	protein binding	RPS6KB1	IPI	UniProtKB:Q5VY09	Human	PMID:26496226
Molecular Function	GO:0005515	protein binding	RPS6KB1	IPI	UniProtKB:P13051-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	RPS6KB1	IPI	UniProtKB:Q06481-5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Rps6kb1	IPI	UniProtKB:P23804	Mouse	MGI:MGI:4822517\|PMID:20657550
Molecular Function	GO:0005515	protein binding	Rps6kb1	IPI	UniProtKB:Q8N122	Rat	PMID:12150926\|RGD:8553634
Molecular Function	GO:0005515	protein binding	Rps6kb1	IPI	RGD:2623	Rat	PMID:23831253\|RGD:11667971
Molecular Function	GO:0005515	protein binding	Rps6kb1	IPI	UniProtKB:O35867	Rat	PMID:9653190\|RGD:8554053
Molecular Function	GO:0004672	protein kinase activity	RPS6KB1	IDA		Human	PMID:17936702
Molecular Function	GO:0004672	protein kinase activity	RPS6KB1	IDA		Human	PMID:18952604
Molecular Function	GO:0004672	protein kinase activity	Rps6kb1	IDA		Mouse	PMID:15249583
Molecular Function	GO:0004672	protein kinase activity	Rps6kb1	IMP		Mouse	PMID:15249583
Molecular Function	GO:0004672	protein kinase activity	Rps6kb1	IDA		Rat	PMID:11574531\|RGD:1626103
Molecular Function	GO:0051721	protein phosphatase 2A binding	Rps6kb1	IPI	RGD:3380	Rat	PMID:16899564\|RGD:9831455
Molecular Function	GO:0004712	protein serine/threonine/tyrosine kinase activity	RPS6KB1	IDA		Human	PMID:22797923
Molecular Function	GO:0004711	ribosomal protein S6 kinase activity	Rps6kb1	IMP		Rat	PMID:11574531\|RGD:1626103
Cellular Component	GO:0009986	cell surface	Rps6kb1	IDA		Rat	PMID:16710051\|RGD:1642988
Cellular Component	GO:0005829	cytosol	Rps6kb1	IDA		Rat	PMID:9653190\|RGD:8554053
Cellular Component	GO:0098978	glutamatergic synapse	Rps6kb1	IDA		Mouse	PMID:18174371
Cellular Component	GO:0098978	glutamatergic synapse	Rps6kb1	IMP		Mouse	PMID:18174371
Cellular Component	GO:0005739	mitochondrion	RPS6KB1	IDA		Human	PMID:17936702
Cellular Component	GO:0005739	mitochondrion	Rps6kb1	IDA		Mouse	MGI:MGI:4456959\|PMID:11493700
Cellular Component	GO:0005654	nucleoplasm	RPS6KB1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Rps6kb1	IDA		Rat	PMID:16710051\|RGD:1642988
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Rps6kb1	IDA		Rat	PMID:16710051\|RGD:1642988
Cellular Component	GO:0098794	postsynapse	Rps6kb1	IDA		Rat	PMID:14623952\|RGD:155230806
Cellular Component	GO:0045202	synapse	Rps6kb1	IDA		Rat	PMID:12711090\|RGD:10401640
Biological Process	GO:0007568	aging	Rps6kb1	IEP		Rat	PMID:16041621\|RGD:1643019
Biological Process	GO:0001662	behavioral fear response	Rps6kb1	IGI	MGI:MGI:2384784	Mouse	PMID:24990923
Biological Process	GO:0001662	behavioral fear response	Rps6kb1	IGI	MGI:MGI:95305	Mouse	PMID:24990923
Biological Process	GO:0016477	cell migration	Rps6kb1	IEP		Rat	PMID:16710051\|RGD:1642988
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Rps6kb1	IDA		Mouse	PMID:17556672
Biological Process	GO:0071363	cellular response to growth factor stimulus	RPS6KB1	IDA		Human	PMID:17936702
Biological Process	GO:0032870	cellular response to hormone stimulus	Rps6kb1	IEP		Rat	PMID:16717100\|RGD:1642987
Biological Process	GO:0032869	cellular response to insulin stimulus	Rps6kb1	IGI	MGI:MGI:3619426	Mouse	PMID:24349514
Biological Process	GO:0071407	cellular response to organic cyclic compound	Rps6kb1	IDA		Mouse	PMID:24990923
Biological Process	GO:0071346	cellular response to type II interferon	Rps6kb1	IMP		Mouse	MGI:MGI:5913528\|PMID:28178239
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	RPS6KB1	IMP		Human	PMID:14673156
Biological Process	GO:0007281	germ cell development	Rps6kb1	IDA		Mouse	PMID:12140361
Biological Process	GO:0044539	long-chain fatty acid import into cell	Rps6kb1	IMP		Mouse	MGI:MGI:5913528\|PMID:28178239
Biological Process	GO:0007616	long-term memory	Rps6kb1	IEP		Rat	PMID:16885218\|RGD:1642986
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Rps6kb1	IMP		Mouse	PMID:18174371
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Rps6kb1	IDA		Mouse	PMID:18174371
Biological Process	GO:0043066	negative regulation of apoptotic process	RPS6KB1	IMP		Human	PMID:17936702
Biological Process	GO:0043066	negative regulation of apoptotic process	Rps6kb1	IMP		Mouse	MGI:MGI:4456959\|PMID:11493700
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	Rps6kb1	IMP		Mouse	PMID:11493700
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	RPS6KB1	IMP		Human	PMID:18952604
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	Rps6kb1	IMP		Rat	PMID:18952604\|RGD:8554230
Biological Process	GO:0018105	peptidyl-serine phosphorylation	RPS6KB1	IMP		Human	PMID:28178239
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Rps6kb1	IMP		Mouse	MGI:MGI:5913528\|PMID:28178239
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	RPS6KB1	IMP		Human	PMID:14673156
Biological Process	GO:0048633	positive regulation of skeletal muscle tissue growth	Rps6kb1	IMP		Rat	PMID:16408196\|RGD:1643018
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	Rps6kb1	IMP		Rat	PMID:16148030\|RGD:1643021
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Rps6kb1	IMP		Rat	PMID:16148030\|RGD:1643021
Biological Process	GO:0045727	positive regulation of translation	RPS6KB1	IMP		Human	PMID:18423201
Biological Process	GO:0045948	positive regulation of translational initiation	RPS6KB1	IMP		Human	PMID:16763566
Biological Process	GO:0043491	protein kinase B signaling	Rps6kb1	IGI	MGI:MGI:102548	Mouse	PMID:15249583
Biological Process	GO:0043491	protein kinase B signaling	Rps6kb1	IGI	MGI:MGI:87986	Mouse	PMID:15249583
Biological Process	GO:0043491	protein kinase B signaling	Rps6kb1	IGI	MGI:MGI:99454	Mouse	PMID:15249583
Biological Process	GO:0043491	protein kinase B signaling	Rps6kb1	IGI	MGI:MGI:1927343	Mouse	PMID:15249583
Biological Process	GO:0006468	protein phosphorylation	Rps6kb1	IMP		Mouse	PMID:15249583
Biological Process	GO:0006468	protein phosphorylation	Rps6kb1	IDA		Mouse	PMID:15249583
Biological Process	GO:0006468	protein phosphorylation	Rps6kb1	IDA		Rat	PMID:11574531\|RGD:1626103
Biological Process	GO:0006468	protein phosphorylation	Rps6kb1	IMP		Rat	PMID:9653190\|RGD:8554053
Biological Process	GO:0046324	regulation of glucose import	Rps6kb1	IMP		Rat	PMID:18952604\|RGD:8554230
Biological Process	GO:0043200	response to amino acid	Rps6kb1	IEP		Rat	PMID:10913029\|RGD:1642983
Biological Process	GO:0014878	response to electrical stimulus involved in regulation of muscle adaptation	Rps6kb1	IEP		Rat	PMID:15716393\|RGD:1643029
Biological Process	GO:0045471	response to ethanol	Rps6kb1	IEP		Rat	PMID:15547464\|RGD:1643023
Biological Process	GO:0033762	response to glucagon	Rps6kb1	IEP		Rat	PMID:15494402\|RGD:1601392
Biological Process	GO:0051384	response to glucocorticoid	Rps6kb1	IEP		Rat	PMID:14630710\|RGD:1642979
Biological Process	GO:0009749	response to glucose	Rps6kb1	IEP		Rat	PMID:16885218\|RGD:1642986
Biological Process	GO:0009408	response to heat	Rps6kb1	IEP		Rat	PMID:14695116\|RGD:1643025
Biological Process	GO:0032868	response to insulin	Rps6kb1	IEP		Rat	PMID:15908181\|RGD:1643020
Biological Process	GO:0032868	response to insulin	Rps6kb1	IEP		Rat	PMID:16565309\|RGD:1642975
Biological Process	GO:0032868	response to insulin	Rps6kb1	IMP		Rat	PMID:18952604\|RGD:8554230
Biological Process	GO:0043201	response to leucine	Rps6kb1	IEP		Rat	PMID:16616211\|RGD:1643098
Biological Process	GO:0032496	response to lipopolysaccharide	Rps6kb1	IEP		Rat	PMID:15389631\|RGD:1643035
Biological Process	GO:0009612	response to mechanical stimulus	Rps6kb1	IEP		Rat	PMID:17526558\|RGD:1642985
Biological Process	GO:0007584	response to nutrient	Rps6kb1	IEP		Rat	PMID:10913029\|RGD:1642983
Biological Process	GO:0031667	response to nutrient levels	RPS6KB1	IDA		Human	PMID:29750193
Biological Process	GO:0014070	response to organic cyclic compound	Rps6kb1	IEP		Rat	PMID:16616211\|RGD:1643098
Biological Process	GO:0010033	response to organic substance	Rps6kb1	IEP		Rat	PMID:16434554\|RGD:1642999
Biological Process	GO:0010243	response to organonitrogen compound	Rps6kb1	IEP		Rat	PMID:15837117\|RGD:8694086
Biological Process	GO:0043434	response to peptide hormone	Rps6kb1	IEP		Rat	PMID:12668683\|RGD:1643037
Biological Process	GO:0033574	response to testosterone	Rps6kb1	IEP		Rat	PMID:15698549\|RGD:1643030
Biological Process	GO:0009636	response to toxic substance	Rps6kb1	IEP		Rat	PMID:15342961\|RGD:1643036
Biological Process	GO:0034612	response to tumor necrosis factor	Rps6kb1	IMP		Rat	PMID:18952604\|RGD:8554230
Biological Process	GO:0009611	response to wounding	Rps6kb1	IEP		Rat	PMID:16710051\|RGD:1642988
Biological Process	GO:0009410	response to xenobiotic stimulus	Rps6kb1	IEP		Rat	PMID:17728140\|RGD:1642973
Biological Process	GO:0014732	skeletal muscle atrophy	Rps6kb1	IEP		Rat	PMID:17885021\|RGD:1642984
Biological Process	GO:0003009	skeletal muscle contraction	Rps6kb1	IEP		Rat	PMID:15033970\|RGD:1643024
Biological Process	GO:0031929	TOR signaling	RPS6KB1	IDA		Human	PMID:12150926
Biological Process	GO:0031929	TOR signaling	RPS6KB1	IMP		Human	PMID:28178239
Biological Process	GO:0031929	TOR signaling	RPS6KB1	IMP		Human	PMID:29750193

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.