Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RRM1
  • Mouse genes Rrm1
  • Rat genes Rrm1
  • Zfish genes rrm1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rrm1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0097718	disordered domain specific binding	Rrm1	IPI	UniProtKB:P11157	Mouse	MGI:MGI:5888982|PMID:8130196
Molecular Function	GO:0042802	identical protein binding	RRM1	IPI	UniProtKB:P23921	Human	PMID:17726094
Molecular Function	GO:0042802	identical protein binding	RRM1	IPI	UniProtKB:P23921	Human	PMID:21336276
Molecular Function	GO:0042802	identical protein binding	RRM1	IPI	UniProtKB:P23921	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RRM1	IPI	UniProtKB:P31350	Human	PMID:17726094
Molecular Function	GO:0005515	protein binding	RRM1	IPI	UniProtKB:P31350	Human	PMID:21336276
Molecular Function	GO:0005515	protein binding	RRM1	IPI	UniProtKB:P31350	Human	PMID:22632967
Molecular Function	GO:0005515	protein binding	RRM1	IPI	UniProtKB:P31350	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	RRM1	IPI	UniProtKB:Q8N720	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Rrm1	IPI	PR:P11157	Mouse	PMID:16829694
Molecular Function	GO:0005515	protein binding	Rrm1	IPI	PR:P11157	Mouse	PMID:16861739
Molecular Function	GO:0017076	purine nucleotide binding	Rrm1	IDA		Mouse	PMID:16861739
Molecular Function	GO:0061731	ribonucleoside-diphosphate reductase activity	RRM1	IMP		Human	PMID:21336276
Molecular Function	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	Rrm1	IDA		Mouse	MGI:MGI:3846285|PMID:19176520
Molecular Function	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	Rrm1	IDA		Mouse	PMID:16861739
Cellular Component	GO:0042995	cell projection	Rrm1	IDA		Rat	PMID:15725396|RGD:5133692
Cellular Component	GO:0005737	cytoplasm	Rrm1	IDA		Rat	PMID:15725396|RGD:5133692
Cellular Component	GO:0005829	cytosol	RRM1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	RRM1	IDA		Human	PMID:18997010
Cellular Component	GO:0043025	neuronal cell body	Rrm1	IDA		Rat	PMID:12834878|RGD:5133694
Cellular Component	GO:0005635	nuclear envelope	Rrm1	IDA		Rat	PMID:2205248|RGD:5133697
Cellular Component	GO:0005971	ribonucleoside-diphosphate reductase complex	RRM1	IPI		Human	PMID:22632967
Cellular Component	GO:0005971	ribonucleoside-diphosphate reductase complex	Rrm1	IMP		Mouse	MGI:MGI:5888982|PMID:8130196
Cellular Component	GO:0005971	ribonucleoside-diphosphate reductase complex	Rrm1	IDA		Mouse	PMID:19176520
Biological Process	GO:0009265	2'-deoxyribonucleotide biosynthetic process	RRM1	IDA		Human	PMID:16376858
Biological Process	GO:0009265	2'-deoxyribonucleotide biosynthetic process	Rrm1	IDA		Mouse	MGI:MGI:6810812|PMID:12578384
Biological Process	GO:0021846	cell proliferation in forebrain	Rrm1	IEP		Rat	PMID:12834878|RGD:5133694
Biological Process	GO:0009263	deoxyribonucleotide biosynthetic process	Rrm1	IDA		Mouse	MGI:MGI:3846285|PMID:19176520
Biological Process	GO:0006281	DNA repair	RRM1	IDA		Human	PMID:11719458
Biological Process	GO:0008584	male gonad development	Rrm1	IEP		Rat	PMID:2775821|RGD:5133698
Biological Process	GO:0006264	mitochondrial DNA replication	RRM1	IMP		Human	PMID:17486094
Biological Process	GO:0006264	mitochondrial DNA replication	Rrm1	IMP		Mouse	MGI:MGI:3714223|PMID:17486094
Biological Process	GO:0000278	mitotic cell cycle	Rrm1	IEP		Rat	PMID:6388757|RGD:5133709
Biological Process	GO:0070318	positive regulation of G0 to G1 transition	RRM1	IDA		Human	PMID:11517226
Biological Process	GO:0070318	positive regulation of G0 to G1 transition	Rrm1	IDA		Mouse	MGI:MGI:2152627|PMID:11517226
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	RRM1	IDA		Human	PMID:24253041
Biological Process	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	RRM1	IDA		Human	PMID:10716435
Biological Process	GO:0051290	protein heterotetramerization	Rrm1	IPI	UniProtKB:P11157	Mouse	MGI:MGI:3846285|PMID:19176520
Biological Process	GO:0006206	pyrimidine nucleobase metabolic process	Rrm1	IEP		Rat	PMID:10204803|RGD:5133695
Biological Process	GO:0010212	response to ionizing radiation	Rrm1	IEP		Rat	PMID:19444910|RGD:2314410
Biological Process	GO:0060041	retina development in camera-type eye	Rrm1	IEP		Rat	PMID:2647502|RGD:5133699
Biological Process	GO:0009185	ribonucleoside diphosphate metabolic process	RRM1	IDA		Human	PMID:16376858
Biological Process	GO:0009185	ribonucleoside diphosphate metabolic process	Rrm1	IDA		Mouse	MGI:MGI:6810812|PMID:12578384

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern