Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RRM2B
  • Mouse genes Rrm2b
  • Rat genes Rrm2b
  • Zfish genes rrm2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rrm2b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042802	identical protein binding	RRM2B	IPI	UniProtKB:Q7LG56	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	RRM2B	IPI	UniProtKB:Q7LG56	Human	PMID:25502805
Molecular Function	GO:0042802	identical protein binding	RRM2B	IPI	UniProtKB:Q7LG56	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	RRM2B	IPI	UniProtKB:Q00987	Human	PMID:19015526
Molecular Function	GO:0005515	protein binding	RRM2B	IPI	UniProtKB:Q13315	Human	PMID:19015526
Molecular Function	GO:0005515	protein binding	RRM2B	IPI	UniProtKB:O43929	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RRM2B	IPI	UniProtKB:Q9H4P4	Human	PMID:25910212
Molecular Function	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	Rrm2b	IDA		Mouse	PMID:11517226
Cellular Component	GO:0005737	cytoplasm	rrm2b	IDA		Zfish	PMID:21194559
Cellular Component	GO:0005829	cytosol	RRM2B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	RRM2B	IDA		Human	PMID:18997010
Cellular Component	GO:0005654	nucleoplasm	RRM2B	IDA		Human	GO_REF:0000052
Biological Process	GO:0009265	2'-deoxyribonucleotide biosynthetic process	RRM2B	IDA		Human	PMID:16376858
Biological Process	GO:0009200	deoxyribonucleoside triphosphate metabolic process	Rrm2b	IMP	MGI:MGI:2672883	Mouse	PMID:12858174
Biological Process	GO:0009200	deoxyribonucleoside triphosphate metabolic process	Rrm2b	IMP	MGI:MGI:2672883	Mouse	PMID:17486094
Biological Process	GO:0009263	deoxyribonucleotide biosynthetic process	Rrm2b	IDA		Mouse	PMID:11517226
Biological Process	GO:0006974	DNA damage response	rrm2b	IDA		Zfish	PMID:21194559
Biological Process	GO:0006281	DNA repair	RRM2B	IDA		Human	PMID:11719458
Biological Process	GO:0006281	DNA repair	Rrm2b	IMP	MGI:MGI:2672883	Mouse	PMID:12858174
Biological Process	GO:0001822	kidney development	Rrm2b	IMP	MGI:MGI:2672883	Mouse	PMID:12858174
Biological Process	GO:0006264	mitochondrial DNA replication	RRM2B	IMP		Human	PMID:17486094
Biological Process	GO:0006264	mitochondrial DNA replication	Rrm2b	IMP	MGI:MGI:2672883	Mouse	PMID:17486094
Biological Process	GO:0000002	mitochondrial genome maintenance	rrm2b	IMP	ZFIN:ZDB-MRPHLNO-210706-1	Zfish	PMID:32931159
Biological Process	GO:0000002	mitochondrial genome maintenance	rrm2b	IMP	ZFIN:ZDB-MRPHLNO-210706-2	Zfish	PMID:32931159
Biological Process	GO:1902254	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	Rrm2b	IMP	MGI:MGI:2672883	Mouse	PMID:12858174
Biological Process	GO:0070318	positive regulation of G0 to G1 transition	RRM2B	IDA		Human	PMID:11517226
Biological Process	GO:0070318	positive regulation of G0 to G1 transition	Rrm2b	IDA		Mouse	MGI:MGI:2152627|PMID:11517226
Biological Process	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	RRM2B	IDA		Human	PMID:10716435
Biological Process	GO:0003014	renal system process	Rrm2b	IMP	MGI:MGI:2672883	Mouse	PMID:12858174
Biological Process	GO:0014075	response to amine	Rrm2b	IEP		Rat	PMID:14587038|RGD:2291845
Biological Process	GO:0006979	response to oxidative stress	Rrm2b	IMP	MGI:MGI:2672883	Mouse	PMID:12858174
Biological Process	GO:0009185	ribonucleoside diphosphate metabolic process	RRM2B	IDA		Human	PMID:16376858

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern