Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RSPO1
  • Mouse genes Rspo1
  • Rat genes Rspo1
  • Zfish genes rspo1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rspo1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001664	G protein-coupled receptor binding	RSPO1	IPI	UniProtKB:O75473	Human	PMID:21727895
Molecular Function	GO:0001664	G protein-coupled receptor binding	RSPO1	IPI	UniProtKB:Q9BXB1	Human	PMID:21727895
Molecular Function	GO:0001664	G protein-coupled receptor binding	RSPO1	IPI	UniProtKB:Q9HBX8	Human	PMID:21727895
Molecular Function	GO:0008201	heparin binding	Rspo1	IDA		Mouse	PMID:16543246
Molecular Function	GO:0005515	protein binding	RSPO1	IPI	UniProtKB:Q96MU8	Human	PMID:17804805
Molecular Function	GO:0005515	protein binding	RSPO1	IPI	UniProtKB:Q9ULT6	Human	PMID:22575959
Molecular Function	GO:0005515	protein binding	RSPO1	IPI	UniProtKB:O75473	Human	PMID:22815884
Molecular Function	GO:0005515	protein binding	RSPO1	IPI	UniProtKB:Q9BXB1	Human	PMID:22815884
Molecular Function	GO:0005515	protein binding	RSPO1	IPI	UniProtKB:B0BLW3	Human	PMID:23891289
Molecular Function	GO:0005515	protein binding	RSPO1	IPI	UniProtKB:Q9ULT6	Human	PMID:24165923
Molecular Function	GO:0005515	protein binding	RSPO1	IPI	UniProtKB:Q5SSZ7	Human	PMID:24349440
Molecular Function	GO:0005515	protein binding	RSPO1	IPI	UniProtKB:P21964-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Rspo1	IPI	UniProtKB:O75473	Mouse	MGI:MGI:5499719|PMID:21693646
Molecular Function	GO:0005515	protein binding	Rspo1	IPI	UniProtKB:A2ARI4	Mouse	MGI:MGI:5499719|PMID:21693646
Molecular Function	GO:0005102	signaling receptor binding	RSPO1	IPI	UniProtKB:Q9HBX8	Human	PMID:22615920
Molecular Function	GO:0005102	signaling receptor binding	Rspo1	IPI	UniProtKB:Q14114	Mouse	PMID:16543246
Cellular Component	GO:0005829	cytosol	rspo1	IDA		Zfish	PMID:20349143
Cellular Component	GO:0005615	extracellular space	Rspo1	IDA		Mouse	PMID:14732490
Cellular Component	GO:0005615	extracellular space	Rspo1	IDA		Mouse	PMID:16543246
Cellular Component	GO:0005794	Golgi apparatus	rspo1	IDA		Zfish	PMID:20349143
Cellular Component	GO:0005634	nucleus	Rspo1	IDA		Mouse	PMID:14732490
Biological Process	GO:0001525	angiogenesis	rspo1	IGI	ZFIN:ZDB-MRPHLNO-111104-11,ZFIN:ZDB-MRPHLNO-111104-5	Zfish	PMID:22007135
Biological Process	GO:0001525	angiogenesis	rspo1	IGI	ZFIN:ZDB-MRPHLNO-051212-2,ZFIN:ZDB-MRPHLNO-111104-5	Zfish	PMID:22007135
Biological Process	GO:0001525	angiogenesis	rspo1	IGI	ZFIN:ZDB-MRPHLNO-060515-1,ZFIN:ZDB-MRPHLNO-111104-5	Zfish	PMID:22007135
Biological Process	GO:0001525	angiogenesis	rspo1	IGI	ZFIN:ZDB-MRPHLNO-060824-3,ZFIN:ZDB-MRPHLNO-111104-5	Zfish	PMID:22007135
Biological Process	GO:0001525	angiogenesis	rspo1	IMP	ZFIN:ZDB-GENO-111221-27	Zfish	PMID:22007135
Biological Process	GO:0060218	hematopoietic stem cell differentiation	rspo1	IMP	ZFIN:ZDB-GENO-190321-1	Zfish	PMID:28087636
Biological Process	GO:0060218	hematopoietic stem cell differentiation	rspo1	IMP	ZFIN:ZDB-MRPHLNO-111104-5	Zfish	PMID:28087636
Biological Process	GO:0007140	male meiotic nuclear division	Rspo1	IMP	MGI:MGI:3784976	Mouse	PMID:21991325
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	RSPO1	IDA		Human	PMID:17804805
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	RSPO1	IDA		Human	PMID:22815884
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	Rspo1	IDA		Mouse	MGI:MGI:5499719|PMID:21693646
Biological Process	GO:2000052	positive regulation of non-canonical Wnt signaling pathway	Rspo1	IMP	MGI:MGI:3784976	Mouse	PMID:21991325
Biological Process	GO:0001934	positive regulation of protein phosphorylation	RSPO1	IDA		Human	PMID:22615920
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	RSPO1	IDA		Human	PMID:22575959
Biological Process	GO:0030177	positive regulation of Wnt signaling pathway	RSPO1	IDA		Human	PMID:29769720
Biological Process	GO:0010468	regulation of gene expression	Rspo1	IMP	MGI:MGI:3784976	Mouse	PMID:21991325
Biological Process	GO:2000254	regulation of male germ cell proliferation	Rspo1	IMP	MGI:MGI:3784976	Mouse	PMID:21991325
Biological Process	GO:0002090	regulation of receptor internalization	RSPO1	IDA		Human	PMID:17804805
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	rspo1	IGI	ZFIN:ZDB-MRPHLNO-051212-2,ZFIN:ZDB-MRPHLNO-111104-5	Zfish	PMID:22007135
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	rspo1	IGI	ZFIN:ZDB-MRPHLNO-060515-1,ZFIN:ZDB-MRPHLNO-111104-5	Zfish	PMID:22007135

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern