Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RTEL1
  • Mouse genes Rtel1
  • Rat genes Rtel1
  • Zfish genes rtel1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rtel1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	RTEL1	IMP		Human	PMID:18957201
Molecular Function	GO:0003678	DNA helicase activity	RTEL1	IMP		Human	PMID:18957201
Molecular Function	GO:0003678	DNA helicase activity	Rtel1	IDA		Mouse	MGI:MGI:5522574|PMID:24115439
Molecular Function	GO:0070182	DNA polymerase binding	Rtel1	IPI	UniProtKB:P52431	Mouse	MGI:MGI:5522574|PMID:24115439
Molecular Function	GO:0005515	protein binding	RTEL1	IPI	UniProtKB:Q96T76	Human	PMID:23585563
Molecular Function	GO:0005515	protein binding	RTEL1	IPI	UniProtKB:P54274	Human	PMID:23959892
Molecular Function	GO:0005515	protein binding	RTEL1	IPI	UniProtKB:O35144	Human	PMID:25620558
Molecular Function	GO:0005515	protein binding	RTEL1	IPI	UniProtKB:Q15554	Human	PMID:25620558
Molecular Function	GO:0005515	protein binding	RTEL1	IPI	UniProtKB:Q9NYB0	Human	PMID:25620558
Molecular Function	GO:0005515	protein binding	RTEL1	IPI	UniProtKB:Q96T76	Human	PMID:28178521
Molecular Function	GO:0005515	protein binding	Rtel1	IPI	UniProtKB:P12004|UniProtKB:P17918|UniProtKB:P97310|UniProtKB:Q0VBD2|UniProtKB:Q99J62|UniProtKB:Q9D071|UniProtKB:Q9D0F6|UniProtKB:Q9WUK4	Mouse	MGI:MGI:5522574|PMID:24115439
Cellular Component	GO:0000781	chromosome, telomeric region	Rtel1	IDA		Mouse	MGI:MGI:5645200|PMID:22579284
Cellular Component	GO:0031965	nuclear membrane	RTEL1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016607	nuclear speck	RTEL1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	RTEL1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	RTEL1	IDA		Human	PMID:23585563
Cellular Component	GO:0005634	nucleus	Rtel1	IDA		Mouse	PMID:15210109
Biological Process	GO:0032508	DNA duplex unwinding	Rtel1	IDA		Mouse	MGI:MGI:5522574|PMID:24115439
Biological Process	GO:1902990	mitotic telomere maintenance via semi-conservative replication	Rtel1	IDA		Mouse	MGI:MGI:5522574|PMID:24115439
Biological Process	GO:0045910	negative regulation of DNA recombination	Rtel1	IDA		Mouse	MGI:MGI:5645200|PMID:22579284
Biological Process	GO:1904430	negative regulation of t-circle formation	RTEL1	IMP		Human	PMID:25620558
Biological Process	GO:1904430	negative regulation of t-circle formation	Rtel1	IMP		Mouse	MGI:MGI:5522574|PMID:24115439
Biological Process	GO:1904430	negative regulation of t-circle formation	Rtel1	IMP		Mouse	MGI:MGI:5645200|PMID:22579284
Biological Process	GO:1904506	negative regulation of telomere maintenance in response to DNA damage	Rtel1	IMP		Mouse	MGI:MGI:5645200|PMID:22579284
Biological Process	GO:1904355	positive regulation of telomere capping	RTEL1	IMP		Human	PMID:23959892
Biological Process	GO:0032206	positive regulation of telomere maintenance	Rtel1	IMP		Mouse	MGI:MGI:5645200|PMID:22579284
Biological Process	GO:1904358	positive regulation of telomere maintenance via telomere lengthening	RTEL1	IMP		Human	PMID:23959892
Biological Process	GO:1904535	positive regulation of telomeric loop disassembly	Rtel1	IDA		Mouse	MGI:MGI:5645200|PMID:22579284
Biological Process	GO:0010569	regulation of double-strand break repair via homologous recombination	RTEL1	IMP		Human	PMID:18957201
Biological Process	GO:0031297	replication fork processing	Rtel1	IDA		Mouse	MGI:MGI:5522574|PMID:24115439
Biological Process	GO:0000732	strand displacement	Rtel1	IDA		Mouse	MGI:MGI:5645200|PMID:22579284
Biological Process	GO:0000723	telomere maintenance	RTEL1	IMP		Human	PMID:23453664
Biological Process	GO:0000723	telomere maintenance	Rtel1	IMP	MGI:MGI:3052235	Mouse	PMID:15210109
Biological Process	GO:0043247	telomere maintenance in response to DNA damage	Rtel1	IMP		Mouse	MGI:MGI:5645200|PMID:22579284
Biological Process	GO:0090657	telomeric loop disassembly	RTEL1	IMP		Human	PMID:25620558
Biological Process	GO:0090657	telomeric loop disassembly	Rtel1	IDA		Mouse	MGI:MGI:5645200|PMID:22579284
Biological Process	GO:0090657	telomeric loop disassembly	Rtel1	IMP		Mouse	MGI:MGI:5522574|PMID:24115439

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern