Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RTN4
  • Mouse genes Rtn4
  • Rat genes Rtn4
  • Zfish genes rtn4a,rtn4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rtn4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	RTN4	HDA		Human	PMID:25468996
Molecular Function	GO:0005515	protein binding	RTN4	IPI	UniProtKB:P10415	Human	PMID:11126360
Molecular Function	GO:0005515	protein binding	RTN4	IPI	UniProtKB:Q07817	Human	PMID:11126360
Molecular Function	GO:0005515	protein binding	RTN4	IPI	UniProtKB:P56817	Human	PMID:15286784
Molecular Function	GO:0005515	protein binding	RTN4	IPI	UniProtKB:Q9Y5P4	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	RTN4	IPI	UniProtKB:O43639	Human	PMID:16752908
Molecular Function	GO:0005515	protein binding	RTN4	IPI	UniProtKB:Q6PST4	Human	PMID:19665976
Molecular Function	GO:0005515	protein binding	RTN4	IPI	UniProtKB:Q8WXF7	Human	PMID:19665976
Molecular Function	GO:0005515	protein binding	RTN4	IPI	UniProtKB:Q9NRS6	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	RTN4	IPI	UniProtKB:Q13596	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RTN4	IPI	UniProtKB:Q15041	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RTN4	IPI	UniProtKB:Q17RD7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RTN4	IPI	UniProtKB:Q9BQ24	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RTN4	IPI	UniProtKB:Q9NRS6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	RTN4	IPI	UniProtKB:Q8WVE7	Human	PMID:26906412
Molecular Function	GO:0005515	protein binding	RTN4	IPI	UniProtKB:Q17RD7	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	RTN4	IPI	UniProtKB:Q9Y5P4	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	RTN4	IPI	UniProtKB:Q17RD7	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	RTN4	IPI	UniProtKB:Q9Y5P4	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	Rtn4	IPI	UniProtKB:O35704	Mouse	MGI:MGI:5749304|PMID:26301690
Molecular Function	GO:0005515	protein binding	Rtn4	IPI	UniProtKB:P52592	Mouse	MGI:MGI:5563306|PMID:24453941
Molecular Function	GO:0005515	protein binding	Rtn4	IPI	UniProtKB:Q60870|UniProtKB:Q60870	Mouse	MGI:MGI:6401630|PMID:32075961
Molecular Function	GO:0005515	protein binding	Rtn4	IPI	UniProtKB:P48722	Mouse	MGI:MGI:5521246|PMID:23909438
Molecular Function	GO:0005515	protein binding	Rtn4	IPI	UniProtKB:Q8CB44	Mouse	MGI:MGI:6274965|PMID:25917084
Molecular Function	GO:0005515	protein binding	Rtn4	IPI	PR:Q99PI8	Mouse	PMID:11201742
Molecular Function	GO:0005515	protein binding	Rtn4	IPI	PR:Q8BH75	Mouse	PMID:18986647
Molecular Function	GO:0005515	protein binding	Rtn4	IPI	UniProtKB:Q99M75	Rat	PMID:15673660|RGD:12790657
Molecular Function	GO:0005515	protein binding	Rtn4	IPI	RGD:1310526	Rat	PMID:19386232|RGD:2314926
Molecular Function	GO:0005515	protein binding	Rtn4	IPI	RGD:1321479	Rat	PMID:19386232|RGD:2314926
Molecular Function	GO:0005515	protein binding	Rtn4	IPI	UniProtKB:Q6PST4	Rat	PMID:19665976|RGD:8554793
Molecular Function	GO:0005515	protein binding	Rtn4	IPI	UniProtKB:Q8WXF7	Rat	PMID:19665976|RGD:8554793
Molecular Function	GO:0005515	protein binding	Rtn4	IPI	UniProtKB:P48722	Rat	PMID:23909438|RGD:10047346
Molecular Function	GO:0005515	protein binding	Rtn4	IPI	UniProtKB:O95136	Rat	PMID:24453941|RGD:13432243
Molecular Function	GO:0005515	protein binding	Rtn4	IPI	UniProtKB:P52592	Rat	PMID:24453941|RGD:13432243
Molecular Function	GO:0005515	protein binding	rtn4a	IPI	ZFIN:ZDB-GENE-040310-2	Zfish	PMID:24466042
Molecular Function	GO:0005515	protein binding	rtn4a	IPI	ZFIN:ZDB-GENE-040310-1	Zfish	PMID:24466042
Molecular Function	GO:0005515	protein binding	rtn4a	IPI	ZFIN:ZDB-GENE-040310-4	Zfish	PMID:24466042
Molecular Function	GO:0044877	protein-containing complex binding	Rtn4	IDA		Rat	PMID:15640160|RGD:2314968
Molecular Function	GO:0003723	RNA binding	RTN4	HDA		Human	PMID:22658674
Molecular Function	GO:0031625	ubiquitin protein ligase binding	RTN4	IPI	UniProtKB:Q9H4P4	Human	PMID:27353365
Cellular Component	GO:0042995	cell projection	Rtn4	IDA		Mouse	PMID:15121177
Cellular Component	GO:0005737	cytoplasm	Rtn4	IDA		Rat	PMID:19386232|RGD:2314926
Cellular Component	GO:0005783	endoplasmic reticulum	RTN4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	RTN4	HDA		Human	PMID:16791210
Cellular Component	GO:0005783	endoplasmic reticulum	Rtn4	IDA		Mouse	PMID:31006538
Cellular Component	GO:0005783	endoplasmic reticulum	Rtn4	IDA		Mouse	PMID:12225863
Cellular Component	GO:0005783	endoplasmic reticulum	Rtn4	IDA		Rat	PMID:16469703|RGD:2314964
Cellular Component	GO:0005789	endoplasmic reticulum membrane	RTN4	IDA		Human	PMID:10667797
Cellular Component	GO:0005789	endoplasmic reticulum membrane	RTN4	IDA		Human	PMID:25612671
Cellular Component	GO:0005789	endoplasmic reticulum membrane	RTN4	IDA		Human	PMID:26906412
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Rtn4	IDA		Mouse	MGI:MGI:5749304|PMID:26301690
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Rtn4	IDA		Mouse	MGI:MGI:6274949|PMID:27786289
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Rtn4	IDA		Rat	PMID:10231557|RGD:633934
Cellular Component	GO:0071782	endoplasmic reticulum tubular network	RTN4	IDA		Human	PMID:27353365
Cellular Component	GO:0098826	endoplasmic reticulum tubular network membrane	RTN4	IDA		Human	PMID:27619977
Cellular Component	GO:0098978	glutamatergic synapse	Rtn4	IDA		Mouse	PMID:30040841
Cellular Component	GO:0098978	glutamatergic synapse	Rtn4	EXP		Mouse	PMID:30040841
Cellular Component	GO:0098978	glutamatergic synapse	Rtn4	IMP		Mouse	PMID:30040841
Cellular Component	GO:0098978	glutamatergic synapse	Rtn4	IDA		Rat	PMID:24966370|RGD:13702375
Cellular Component	GO:0043209	myelin sheath	Rtn4	IDA		Rat	PMID:19524873|RGD:2314925
Cellular Component	GO:0043005	neuron projection	Rtn4	IDA		Rat	PMID:19386232|RGD:2314926
Cellular Component	GO:0043025	neuronal cell body	Rtn4	IDA		Rat	PMID:19386232|RGD:2314926
Cellular Component	GO:0005635	nuclear envelope	RTN4	IDA		Human	PMID:11126360
Cellular Component	GO:0005886	plasma membrane	Rtn4	IDA		Rat	PMID:19236864|RGD:2314931
Cellular Component	GO:0098794	postsynapse	Rtn4	IMP		Mouse	PMID:30040841
Cellular Component	GO:0098794	postsynapse	Rtn4	IDA		Mouse	PMID:30040841
Cellular Component	GO:0098794	postsynapse	Rtn4	IDA		Rat	PMID:12853107|RGD:155230733
Cellular Component	GO:0014069	postsynaptic density	Rtn4	IDA		Mouse	PMID:17114649
Cellular Component	GO:0098839	postsynaptic density membrane	Rtn4	IDA		Rat	PMID:24966370|RGD:13702375
Cellular Component	GO:0032991	protein-containing complex	Rtn4	IDA		Rat	PMID:15640160|RGD:2314968
Biological Process	GO:0007568	aging	Rtn4	IEP		Rat	PMID:16738487|RGD:2314960
Biological Process	GO:0007411	axon guidance	rtn4a	IGI	ZFIN:ZDB-MRPHLNO-100202-3,ZFIN:ZDB-MRPHLNO-100202-6	Zfish	PMID:19041397
Biological Process	GO:0007411	axon guidance	rtn4a	IMP	ZFIN:ZDB-MRPHLNO-100202-6	Zfish	PMID:19041397
Biological Process	GO:0031103	axon regeneration	rtn4b	IMP	ZFIN:ZDB-MRPHLNO-140923-6	Zfish	PMID:25888884
Biological Process	GO:0031103	axon regeneration	rtn4b	IMP	ZFIN:ZDB-MRPHLNO-140922-6	Zfish	PMID:25888884
Biological Process	GO:0007413	axonal fasciculation	Rtn4	IMP		Mouse	MGI:MGI:4830045|PMID:20573699
Biological Process	GO:0007413	axonal fasciculation	Rtn4	IDA		Rat	PMID:20573699|RGD:8554113
Biological Process	GO:0007409	axonogenesis	rtn4a	IDA		Zfish	PMID:20007473
Biological Process	GO:0001825	blastocyst formation	Rtn4	IMP		Mouse	PMID:27869233
Biological Process	GO:0007420	brain development	rtn4a	IMP	ZFIN:ZDB-MRPHLNO-140923-1	Zfish	PMID:24755266
Biological Process	GO:0007420	brain development	rtn4a	IMP	ZFIN:ZDB-MRPHLNO-140923-1,ZFIN:ZDB-MRPHLNO-140923-3,ZFIN:ZDB-MRPHLNO-140923-7	Zfish	PMID:24755266
Biological Process	GO:0007420	brain development	rtn4b	IMP	ZFIN:ZDB-MRPHLNO-140923-6	Zfish	PMID:24755266
Biological Process	GO:0043010	camera-type eye development	rtn4a	IMP	ZFIN:ZDB-MRPHLNO-140923-1	Zfish	PMID:24755266
Biological Process	GO:0043010	camera-type eye development	rtn4a	IMP	ZFIN:ZDB-MRPHLNO-140923-1,ZFIN:ZDB-MRPHLNO-140923-3,ZFIN:ZDB-MRPHLNO-140923-7	Zfish	PMID:24755266
Biological Process	GO:0043010	camera-type eye development	rtn4b	IMP	ZFIN:ZDB-MRPHLNO-140923-6	Zfish	PMID:24755266
Biological Process	GO:0060317	cardiac epithelial to mesenchymal transition	Rtn4	IMP		Mouse	PMID:19156209
Biological Process	GO:0035441	cell migration involved in vasculogenesis	Rtn4	IMP		Mouse	MGI:MGI:5492189|PMID:23625008
Biological Process	GO:0071456	cellular response to hypoxia	Rtn4	IDA		Mouse	MGI:MGI:6274961|PMID:27763637
Biological Process	GO:0007417	central nervous system development	rtn4b	IMP	ZFIN:ZDB-MRPHLNO-140923-6	Zfish	PMID:24755266
Biological Process	GO:0022009	central nervous system vasculogenesis	Rtn4	IMP		Mouse	MGI:MGI:5492189|PMID:23625008
Biological Process	GO:0021801	cerebral cortex radial glia-guided migration	Rtn4	IMP		Mouse	MGI:MGI:4461842|PMID:20093372
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	rtn4b	IMP	ZFIN:ZDB-MRPHLNO-140923-6	Zfish	PMID:24755266
Biological Process	GO:0071787	endoplasmic reticulum tubular network formation	RTN4	IDA		Human	PMID:24262037
Biological Process	GO:0071787	endoplasmic reticulum tubular network formation	RTN4	IDA		Human	PMID:25612671
Biological Process	GO:1990809	endoplasmic reticulum tubular network membrane organization	RTN4	IMP		Human	PMID:27619977
Biological Process	GO:0071786	endoplasmic reticulum tubular network organization	RTN4	IMP		Human	PMID:18779370
Biological Process	GO:0071786	endoplasmic reticulum tubular network organization	RTN4	IMP		Human	PMID:26906412
Biological Process	GO:0030900	forebrain development	rtn4b	IMP	ZFIN:ZDB-MRPHLNO-140923-6	Zfish	PMID:24755266
Biological Process	GO:0090156	intracellular sphingolipid homeostasis	Rtn4	IMP		Mouse	MGI:MGI:5749304|PMID:26301690
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	Rtn4	IMP		Mouse	MGI:MGI:4941402|PMID:21183689
Biological Process	GO:0060231	mesenchymal to epithelial transition	rtn4a	IGI	ZFIN:ZDB-MIRNAG-090929-187	Zfish	PMID:28701377
Biological Process	GO:0060231	mesenchymal to epithelial transition	rtn4a	IGI	ZFIN:ZDB-GENE-020102-1	Zfish	PMID:28701377
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Rtn4	EXP		Mouse	PMID:30040841
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Rtn4	IDA		Mouse	PMID:30040841
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Rtn4	IMP		Mouse	PMID:30040841
Biological Process	GO:0008045	motor neuron axon guidance	rtn4b	IMP	ZFIN:ZDB-MRPHLNO-140923-6	Zfish	PMID:24755266
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	RTN4	IDA		Human	PMID:15286784
Biological Process	GO:0030517	negative regulation of axon extension	RTN4	IDA		Human	PMID:10667797
Biological Process	GO:0030517	negative regulation of axon extension	Rtn4	IMP		Mouse	MGI:MGI:4830045|PMID:20573699
Biological Process	GO:0030517	negative regulation of axon extension	Rtn4	IDA		Rat	PMID:20573699|RGD:8554113
Biological Process	GO:0050771	negative regulation of axonogenesis	Rtn4	IDA		Rat	PMID:10667796|RGD:628417
Biological Process	GO:0050771	negative regulation of axonogenesis	Rtn4	IMP		Rat	PMID:18973596|RGD:2314943
Biological Process	GO:0030308	negative regulation of cell growth	RTN4	IMP		Human	PMID:20463223
Biological Process	GO:0045665	negative regulation of neuron differentiation	Rtn4	IDA		Rat	PMID:19379790|RGD:2314929
Biological Process	GO:0010977	negative regulation of neuron projection development	Rtn4	IDA		Rat	PMID:19386232|RGD:2314926
Biological Process	GO:0070571	negative regulation of neuron projection regeneration	Rtn4	IMP		Rat	PMID:18973596|RGD:2314943
Biological Process	GO:2001213	negative regulation of vasculogenesis	Rtn4	IMP		Mouse	MGI:MGI:5492189|PMID:23625008
Biological Process	GO:0007399	nervous system development	Rtn4	IDA		Mouse	PMID:12225863
Biological Process	GO:0048884	neuromast development	rtn4a	IMP	ZFIN:ZDB-MRPHLNO-140923-1	Zfish	PMID:24755266
Biological Process	GO:0048884	neuromast development	rtn4b	IMP	ZFIN:ZDB-MRPHLNO-140923-6	Zfish	PMID:24755266
Biological Process	GO:0051292	nuclear pore complex assembly	RTN4	IMP		Human	PMID:26906412
Biological Process	GO:0021557	oculomotor nerve development	rtn4b	IMP	ZFIN:ZDB-MRPHLNO-140923-6	Zfish	PMID:24755266
Biological Process	GO:0021553	olfactory nerve development	Rtn4	IEP		Rat	PMID:16262653|RGD:2314966
Biological Process	GO:0048709	oligodendrocyte differentiation	Rtn4	IEP		Rat	PMID:19236864|RGD:2314931
Biological Process	GO:0021554	optic nerve development	rtn4a	IMP	ZFIN:ZDB-MRPHLNO-140923-1	Zfish	PMID:24755266
Biological Process	GO:0021554	optic nerve development	rtn4b	IMP	ZFIN:ZDB-MRPHLNO-140923-6	Zfish	PMID:24755266
Biological Process	GO:0007422	peripheral nervous system development	rtn4b	IMP	ZFIN:ZDB-MRPHLNO-140923-6	Zfish	PMID:24755266
Biological Process	GO:0048936	peripheral nervous system neuron axonogenesis	rtn4a	IMP	ZFIN:ZDB-MRPHLNO-100202-6	Zfish	PMID:19041397
Biological Process	GO:0045766	positive regulation of angiogenesis	Rtn4	IMP		Mouse	MGI:MGI:4366092|PMID:19805174
Biological Process	GO:1905653	positive regulation of artery morphogenesis	Rtn4	IMP		Mouse	MGI:MGI:4366092|PMID:19805174
Biological Process	GO:0033603	positive regulation of dopamine secretion	Rtn4	IMP		Rat	PMID:19112410|RGD:2314933
Biological Process	GO:0010634	positive regulation of epithelial cell migration	RTN4	IMP		Human	PMID:27353365
Biological Process	GO:1905580	positive regulation of ERBB3 signaling pathway	RTN4	IMP		Human	PMID:27353365
Biological Process	GO:0045687	positive regulation of glial cell differentiation	Rtn4	IDA		Rat	PMID:19379790|RGD:2314929
Biological Process	GO:2000347	positive regulation of hepatocyte proliferation	Rtn4	IMP		Mouse	MGI:MGI:6282933|PMID:23299899
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Rtn4	IMP		Mouse	MGI:MGI:4366092|PMID:19805174
Biological Process	GO:1905523	positive regulation of macrophage migration	Rtn4	IMP		Mouse	MGI:MGI:4366092|PMID:19805174
Biological Process	GO:0033601	positive regulation of mammary gland epithelial cell proliferation	RTN4	IMP		Human	PMID:27353365
Biological Process	GO:1902624	positive regulation of neutrophil migration	Rtn4	IMP		Mouse	MGI:MGI:4941402|PMID:21183689
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	RTN4	IMP		Human	PMID:27353365
Biological Process	GO:1905552	positive regulation of protein localization to endoplasmic reticulum	RTN4	IDA		Human	PMID:27353365
Biological Process	GO:0035022	positive regulation of Rac protein signal transduction	Rtn4	IMP		Mouse	MGI:MGI:4366092|PMID:19805174
Biological Process	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway	Rtn4	IMP		Mouse	MGI:MGI:6274965|PMID:25917084
Biological Process	GO:0048916	posterior lateral line development	rtn4a	IGI	ZFIN:ZDB-MRPHLNO-140521-2,ZFIN:ZDB-MRPHLNO-140521-4	Zfish	PMID:24466042
Biological Process	GO:0048922	posterior lateral line neuromast deposition	rtn4a	IGI	ZFIN:ZDB-MRPHLNO-140521-2,ZFIN:ZDB-MRPHLNO-140521-4	Zfish	PMID:24466042
Biological Process	GO:0061462	protein localization to lysosome	Rtn4	IMP		Mouse	MGI:MGI:6274965|PMID:25917084
Biological Process	GO:0050821	protein stabilization	RTN4	IMP		Human	PMID:27353365
Biological Process	GO:0050821	protein stabilization	Rtn4	IMP		Mouse	MGI:MGI:5883191|PMID:27353365
Biological Process	GO:2000172	regulation of branching morphogenesis of a nerve	Rtn4	IMP		Mouse	MGI:MGI:4830045|PMID:20573699
Biological Process	GO:2000172	regulation of branching morphogenesis of a nerve	Rtn4	IDA		Rat	PMID:20573699|RGD:8554113
Biological Process	GO:0051960	regulation of nervous system development	Rtn4	IMP		Mouse	MGI:MGI:4830045|PMID:20573699
Biological Process	GO:0051930	regulation of sensory perception of pain	Rtn4	IDA		Rat	PMID:17720311|RGD:2314948
Biological Process	GO:0014823	response to activity	Rtn4	IEP		Rat	PMID:18093178|RGD:2314945
Biological Process	GO:0061053	somite development	rtn4a	IGI	ZFIN:ZDB-GENE-020102-1	Zfish	PMID:28701377
Biological Process	GO:0061053	somite development	rtn4a	IGI	ZFIN:ZDB-MIRNAG-090929-187	Zfish	PMID:28701377
Biological Process	GO:0002040	sprouting angiogenesis	rtn4a	IMP	ZFIN:ZDB-MRPHLNO-111209-5	Zfish	PMID:20813898
Biological Process	GO:0002040	sprouting angiogenesis	rtn4a	IMP	ZFIN:ZDB-MRPHLNO-111209-4	Zfish	PMID:20813898
Biological Process	GO:0021558	trochlear nerve development	rtn4b	IMP	ZFIN:ZDB-MRPHLNO-140923-6	Zfish	PMID:24755266

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern