Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RTN4R
  • Mouse genes Rtn4r
  • Rat genes Rtn4r
  • Zfish genes rtn4r
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rtn4r

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0035374	chondroitin sulfate binding	Rtn4r	IDA		Mouse	MGI:MGI:5461303|PMID:22406547
Molecular Function	GO:1905573	ganglioside GM1 binding	RTN4R	IDA		Human	PMID:18411262
Molecular Function	GO:1905576	ganglioside GT1b binding	RTN4R	IDA		Human	PMID:18411262
Molecular Function	GO:0008201	heparin binding	Rtn4r	IDA		Mouse	MGI:MGI:5461303|PMID:22406547
Molecular Function	GO:0038131	neuregulin receptor activity	Rtn4r	IDA		Mouse	MGI:MGI:5688832|PMID:22923615
Molecular Function	GO:0005515	protein binding	RTN4R	IPI	UniProtKB:O95970	Human	PMID:20463223
Molecular Function	GO:0005515	protein binding	RTN4R	IPI	UniProtKB:Q9P0K1	Human	PMID:20463223
Molecular Function	GO:0005515	protein binding	RTN4R	IPI	UniProtKB:Q8IZA0	Human	PMID:20697954
Molecular Function	GO:0005515	protein binding	RTN4R	IPI	UniProtKB:P32242	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	RTN4R	IPI	UniProtKB:P49639	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Rtn4r	IPI	PR:Q8R555	Mouse	PMID:21817055
Molecular Function	GO:0005515	protein binding	Rtn4r	IPI	PR:Q99P72	Mouse	PMID:11201742
Molecular Function	GO:0005515	protein binding	Rtn4r	IPI	PR:P20917	Mouse	PMID:12839991
Molecular Function	GO:0005515	protein binding	Rtn4r	IPI	UniProtKB:Q96FE5	Rat	PMID:14966521|RGD:14697714
Molecular Function	GO:0005515	protein binding	Rtn4r	IPI	UniProtKB:P07722	Rat	PMID:15673660|RGD:12790657
Molecular Function	GO:0005515	protein binding	Rtn4r	IPI	UniProtKB:Q9JK11	Rat	PMID:15673660|RGD:12790657
Molecular Function	GO:0005515	protein binding	Rtn4r	IPI	UniProtKB:P07722	Rat	PMID:19420245|RGD:12050099
Molecular Function	GO:0005515	protein binding	rtn4r	IPI	ZFIN:ZDB-GENE-030710-1	Zfish	PMID:24466042
Molecular Function	GO:0044877	protein-containing complex binding	Rtn4r	IPI	RGD:631413|RGD:3177	Rat	PMID:23613963|RGD:14390159
Molecular Function	GO:0038023	signaling receptor activity	Rtn4r	IMP		Rat	PMID:15673660|RGD:12790657
Cellular Component	GO:0044295	axonal growth cone	Rtn4r	IDA		Mouse	MGI:MGI:5688832|PMID:22923615
Cellular Component	GO:0009986	cell surface	RTN4R	IDA		Human	PMID:16712417
Cellular Component	GO:0009986	cell surface	RTN4R	IDA		Human	PMID:18411262
Cellular Component	GO:0009986	cell surface	RTN4R	IDA		Human	PMID:20463223
Cellular Component	GO:0009986	cell surface	Rtn4r	IDA		Mouse	MGI:MGI:5315189|PMID:22325200
Cellular Component	GO:0009986	cell surface	Rtn4r	IDA		Rat	PMID:15673660|RGD:12790657
Cellular Component	GO:0009986	cell surface	Rtn4r	IDA		Rat	PMID:22325200|RGD:12790647
Cellular Component	GO:0043198	dendritic shaft	Rtn4r	IDA		Mouse	MGI:MGI:5315189|PMID:22325200
Cellular Component	GO:0005783	endoplasmic reticulum	RTN4R	IDA		Human	GO_REF:0000054
Cellular Component	GO:0009897	external side of plasma membrane	RTN4R	IMP		Human	PMID:16712417
Cellular Component	GO:0070062	extracellular exosome	RTN4R	HDA		Human	PMID:23533145
Cellular Component	GO:0098978	glutamatergic synapse	Rtn4r	IDA		Rat	PMID:24966370|RGD:13702375
Cellular Component	GO:0030426	growth cone	Rtn4r	IDA		Mouse	PMID:21817055
Cellular Component	GO:0045121	membrane raft	Rtn4r	IDA		Rat	PMID:15673660|RGD:12790657
Cellular Component	GO:0043005	neuron projection	Rtn4r	IDA		Mouse	MGI:MGI:5688832|PMID:22923615
Cellular Component	GO:0043025	neuronal cell body	Rtn4r	IDA		Mouse	MGI:MGI:5688832|PMID:22923615
Cellular Component	GO:0005886	plasma membrane	Rtn4r	IDA		Mouse	MGI:MGI:5688832|PMID:22923615
Cellular Component	GO:0005886	plasma membrane	Rtn4r	IDA		Mouse	PMID:11201742
Cellular Component	GO:0098793	presynapse	Rtn4r	IDA		Rat	PMID:24966370|RGD:13702375
Biological Process	GO:0007411	axon guidance	rtn4r	IGI	ZFIN:ZDB-MRPHLNO-100202-3,ZFIN:ZDB-MRPHLNO-100202-6	Zfish	PMID:19041397
Biological Process	GO:0007411	axon guidance	rtn4r	IMP	ZFIN:ZDB-MRPHLNO-100323-5	Zfish	PMID:19041397
Biological Process	GO:0007411	axon guidance	rtn4r	IMP	ZFIN:ZDB-MRPHLNO-100202-3	Zfish	PMID:19041397
Biological Process	GO:0007409	axonogenesis	Rtn4r	IDA		Mouse	PMID:11201742
Biological Process	GO:0007166	cell surface receptor signaling pathway	Rtn4r	IMP		Rat	PMID:15673660|RGD:12790657
Biological Process	GO:0022038	corpus callosum development	Rtn4r	IMP		Mouse	MGI:MGI:5824191|PMID:27339102
Biological Process	GO:0030517	negative regulation of axon extension	Rtn4r	IDA		Mouse	MGI:MGI:5688832|PMID:22923615
Biological Process	GO:0048681	negative regulation of axon regeneration	Rtn4r	IMP		Mouse	MGI:MGI:5461303|PMID:22406547
Biological Process	GO:0010977	negative regulation of neuron projection development	Rtn4r	IMP		Mouse	MGI:MGI:5461303|PMID:22406547
Biological Process	GO:0010977	negative regulation of neuron projection development	Rtn4r	IMP		Mouse	MGI:MGI:3513958|PMID:15504325
Biological Process	GO:0010977	negative regulation of neuron projection development	Rtn4r	IMP		Rat	PMID:15673660|RGD:12790657
Biological Process	GO:0023041	neuronal signal transduction	Rtn4r	IDA		Mouse	MGI:MGI:5688832|PMID:22923615
Biological Process	GO:0048936	peripheral nervous system neuron axonogenesis	rtn4r	IMP	ZFIN:ZDB-MRPHLNO-100202-3	Zfish	PMID:19041397
Biological Process	GO:0048936	peripheral nervous system neuron axonogenesis	rtn4r	IGI	ZFIN:ZDB-MRPHLNO-100202-3,ZFIN:ZDB-MRPHLNO-100202-6	Zfish	PMID:19041397
Biological Process	GO:0048936	peripheral nervous system neuron axonogenesis	rtn4r	IMP	ZFIN:ZDB-MRPHLNO-100323-5	Zfish	PMID:19041397
Biological Process	GO:0043547	positive regulation of GTPase activity	Rtn4r	IDA		Mouse	MGI:MGI:5688832|PMID:22923615
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction	RTN4R	IMP		Human	PMID:16712417

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern