Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Runx1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes RUNX1
- Mouse genes Runx1
- Rat genes Runx1
- Zfish genes runx1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Runx1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Runx1	IDA		Mouse	MGI:MGI:3690807\|PMID:7774816
Molecular Function	GO:0003677	DNA binding	Runx1	IDA		Mouse	PMID:12807883
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	RUNX1	IDA		Human	PMID:9199349
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	RUNX1	IMP		Human	PMID:9199349
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Runx1	IDA		Mouse	PMID:12807883
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Runx1	IPI	UniProtKB:P17433	Mouse	MGI:MGI:6284428\|PMID:29924977
Molecular Function	GO:0140297	DNA-binding transcription factor binding	Runx1	IPI	PR:P27782	Mouse	PMID:12551949
Molecular Function	GO:1990841	promoter-specific chromatin binding	Runx1	IDA		Rat	PMID:19342459\|RGD:11251715
Molecular Function	GO:0005515	protein binding	RUNX1	IPI	UniProtKB:P17947	Human	PMID:10207087
Molecular Function	GO:0005515	protein binding	RUNX1	IPI	UniProtKB:P32519	Human	PMID:10207087
Molecular Function	GO:0005515	protein binding	RUNX1	IPI	UniProtKB:Q99607	Human	PMID:10207087
Molecular Function	GO:0005515	protein binding	RUNX1	IPI	UniProtKB:Q8WYB5	Human	PMID:11965546
Molecular Function	GO:0005515	protein binding	RUNX1	IPI	UniProtKB:Q15723	Human	PMID:14970218
Molecular Function	GO:0005515	protein binding	RUNX1	IPI	UniProtKB:Q9H2X6	Human	PMID:16917507
Molecular Function	GO:0005515	protein binding	RUNX1	IPI	UniProtKB:Q9BZS1	Human	PMID:17377532
Molecular Function	GO:0005515	protein binding	RUNX1	IPI	UniProtKB:Q00534	Human	PMID:17431401
Molecular Function	GO:0005515	protein binding	RUNX1	IPI	UniProtKB:Q13951	Human	PMID:17431401
Molecular Function	GO:0005515	protein binding	RUNX1	IPI	UniProtKB:P46937	Human	PMID:18280240
Molecular Function	GO:0005515	protein binding	RUNX1	IPI	UniProtKB:P17542	Human	PMID:19497860
Molecular Function	GO:0005515	protein binding	RUNX1	IPI	UniProtKB:P17542	Human	PMID:21179004
Molecular Function	GO:0005515	protein binding	RUNX1	IPI	UniProtKB:P28906	Human	PMID:21873977
Molecular Function	GO:0005515	protein binding	RUNX1	IPI	UniProtKB:Q00534	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	RUNX1	IPI	UniProtKB:P46937	Human	PMID:25283809
Molecular Function	GO:0005515	protein binding	RUNX1	IPI	UniProtKB:Q13951	Human	PMID:25678665
Molecular Function	GO:0005515	protein binding	RUNX1	IPI	UniProtKB:Q13951	Human	PMID:2845103
Molecular Function	GO:0005515	protein binding	RUNX1	IPI	UniProtKB:Q92785	Human	PMID:28533407
Molecular Function	GO:0005515	protein binding	RUNX1	IPI	UniProtKB:P52926	Human	PMID:29391048
Molecular Function	GO:0005515	protein binding	RUNX1	IPI	UniProtKB:Q13951	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	Runx1	IPI	UniProtKB:P27577	Mouse	MGI:MGI:3690807\|PMID:7774816
Molecular Function	GO:0005515	protein binding	Runx1	IPI	UniProtKB:Q99JB6	Mouse	MGI:MGI:3710039\|PMID:17377532
Molecular Function	GO:0005515	protein binding	Runx1	IPI	UniProtKB:Q9JKD8	Mouse	MGI:MGI:4868293\|PMID:21151104
Molecular Function	GO:0005515	protein binding	Runx1	IPI	UniProtKB:Q9JIZ5	Mouse	MGI:MGI:5291878\|PMID:21873191
Molecular Function	GO:0005515	protein binding	Runx1	IPI	PR:Q9D030	Mouse	PMID:19090621
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	RUNX1	IDA		Human	PMID:17377532
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Runx1	IDA		Mouse	MGI:MGI:3710039\|PMID:17377532
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	runx1	IPI	ZFIN:ZDB-GENE-081028-51	Zfish	PMID:30045885
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	RUNX1	IDA		Human	PMID:9199349
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	RUNX1	IMP		Human	PMID:9199349
Molecular Function	GO:0043565	sequence-specific DNA binding	runx1	IPI	ZFIN:ZDB-GENE-020515-2	Zfish	PMID:19275935
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	Runx1	IDA		Rat	PMID:19342459\|RGD:11251715
Molecular Function	GO:0000976	transcription cis-regulatory region binding	RUNX1	IDA		Human	PMID:21873977
Cellular Component	GO:0005604	basement membrane	Runx1	IDA		Mouse	PMID:17011173
Cellular Component	GO:0000785	chromatin	Runx1	IDA		Rat	PMID:21678417\|RGD:6482841
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	RUNX1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	RUNX1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	RUNX1	IDA		Human	PMID:7862156
Cellular Component	GO:0005634	nucleus	Runx1	IDA		Mouse	MGI:MGI:3710039\|PMID:17377532
Cellular Component	GO:0005634	nucleus	Runx1	IDA		Mouse	PMID:24582971
Cellular Component	GO:0005634	nucleus	Runx1	IDA		Mouse	PMID:21464233
Cellular Component	GO:0005634	nucleus	Runx1	IDA		Rat	PMID:7969143\|RGD:634721
Biological Process	GO:0030183	B cell differentiation	runx1	IMP	ZFIN:ZDB-GENO-190917-4	Zfish	PMID:30045885
Biological Process	GO:0048266	behavioral response to pain	Runx1	IMP		Mouse	PMID:16446141
Biological Process	GO:0001568	blood vessel development	runx1	IMP	ZFIN:ZDB-MRPHLNO-060207-2	Zfish	PMID:11934867
Biological Process	GO:0001568	blood vessel development	runx1	IMP	ZFIN:ZDB-MRPHLNO-060207-1	Zfish	PMID:11934867
Biological Process	GO:0061026	cardiac muscle tissue regeneration	runx1	IMP		Zfish	PMID:32341028\|ZFIN:ZDB-PUB-200429-4
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Runx1	IDA		Mouse	PMID:23861879
Biological Process	GO:0007417	central nervous system development	Runx1	IMP	MGI:MGI:3043614	Mouse	PMID:16174759
Biological Process	GO:0060216	definitive hemopoiesis	Runx1	IMP	MGI:MGI:1857580	Mouse	PMID:10207104
Biological Process	GO:0060216	definitive hemopoiesis	runx1	IMP	ZFIN:ZDB-MRPHLNO-051102-3,ZFIN:ZDB-MRPHLNO-051102-4	Zfish	PMID:19168679
Biological Process	GO:0060216	definitive hemopoiesis	runx1	IMP	ZFIN:ZDB-MRPHLNO-100813-4	Zfish	PMID:18927441
Biological Process	GO:0060216	definitive hemopoiesis	runx1	IMP	ZFIN:ZDB-GENO-091020-2	Zfish	PMID:19168679
Biological Process	GO:0035162	embryonic hemopoiesis	Runx1	IMP	MGI:MGI:3043614	Mouse	PMID:16174759
Biological Process	GO:0035162	embryonic hemopoiesis	runx1	IMP	ZFIN:ZDB-MRPHLNO-051102-3,ZFIN:ZDB-MRPHLNO-051102-4	Zfish	PMID:16166372
Biological Process	GO:0035162	embryonic hemopoiesis	runx1	IMP	ZFIN:ZDB-MRPHLNO-060207-2	Zfish	PMID:11934867
Biological Process	GO:0098508	endothelial to hematopoietic transition	runx1	IMP	ZFIN:ZDB-MRPHLNO-051102-3,ZFIN:ZDB-MRPHLNO-051102-4	Zfish	PMID:24046317
Biological Process	GO:0031069	hair follicle morphogenesis	Runx1	IMP	MGI:MGI:3043614	Mouse	PMID:17011173
Biological Process	GO:0030097	hemopoiesis	RUNX1	IDA		Human	PMID:21873977
Biological Process	GO:0030097	hemopoiesis	runx1	IMP	ZFIN:ZDB-GENO-091020-2	Zfish	PMID:20154212
Biological Process	GO:0030097	hemopoiesis	runx1	IMP	ZFIN:ZDB-MRPHLNO-050726-3	Zfish	PMID:17559829
Biological Process	GO:0030097	hemopoiesis	runx1	IMP	ZFIN:ZDB-MRPHLNO-050726-3	Zfish	PMID:15737934
Biological Process	GO:0001701	in utero embryonic development	Runx1	IMP	MGI:MGI:3043614	Mouse	PMID:16174759
Biological Process	GO:0001889	liver development	Runx1	IMP	MGI:MGI:3043614	Mouse	PMID:16174759
Biological Process	GO:0030099	myeloid cell differentiation	runx1	IGI	ZFIN:ZDB-GENO-120220-7	Zfish	PMID:22132109
Biological Process	GO:0030099	myeloid cell differentiation	runx1	IMP	ZFIN:ZDB-MRPHLNO-060207-1	Zfish	PMID:19275935
Biological Process	GO:0002573	myeloid leukocyte differentiation	RUNX1	IMP		Human	PMID:28111278
Biological Process	GO:0002573	myeloid leukocyte differentiation	runx1	IMP		Zfish	PMID:27751705
Biological Process	GO:0002318	myeloid progenitor cell differentiation	Runx1	IMP		Mouse	PMID:19182774
Biological Process	GO:0043371	negative regulation of CD4-positive, alpha-beta T cell differentiation	Runx1	IDA		Mouse	MGI:MGI:3772948\|PMID:18258917
Biological Process	GO:0008285	negative regulation of cell population proliferation	Runx1	IMP		Mouse	PMID:24582971
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Runx1	IDA		Mouse	MGI:MGI:3710039\|PMID:17377532
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Runx1	IDA		Mouse	MGI:MGI:3772948\|PMID:18258917
Biological Process	GO:0007399	nervous system development	runx1	IMP	ZFIN:ZDB-MRPHLNO-060207-1	Zfish	PMID:11934867
Biological Process	GO:0007399	nervous system development	runx1	IMP	ZFIN:ZDB-MRPHLNO-060207-2	Zfish	PMID:11934867
Biological Process	GO:0048666	neuron development	Runx1	IMP		Mouse	PMID:16446141
Biological Process	GO:0030182	neuron differentiation	Runx1	IMP	MGI:MGI:2668479	Mouse	PMID:15240886
Biological Process	GO:0048663	neuron fate commitment	Runx1	IMP		Mouse	PMID:25834056
Biological Process	GO:0030223	neutrophil differentiation	runx1	IGI	ZFIN:ZDB-GENE-020111-2	Zfish	PMID:27751705
Biological Process	GO:0030728	ovulation	Runx1	IEP		Rat	PMID:23239112\|RGD:9831388
Biological Process	GO:0045766	positive regulation of angiogenesis	Runx1	IMP		Mouse	MGI:MGI:1860995\|PMID:10943840
Biological Process	GO:0043378	positive regulation of CD8-positive, alpha-beta T cell differentiation	Runx1	IDA		Mouse	MGI:MGI:3772948\|PMID:18258917
Biological Process	GO:1903431	positive regulation of cell maturation	Runx1	IMP		Mouse	PMID:24582971
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	runx1	IMP		Zfish	PMID:32341028\|ZFIN:ZDB-PUB-200429-4
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	RUNX1	IDA		Human	PMID:10207087
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	RUNX1	IDA		Human	PMID:14970218
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Runx1	IDA		Mouse	MGI:MGI:4868293\|PMID:21151104
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Runx1	IMP		Rat	PMID:19342459\|RGD:11251715
Biological Process	GO:1903055	positive regulation of extracellular matrix organization	runx1	IMP		Zfish	PMID:32341028\|ZFIN:ZDB-PUB-200429-4
Biological Process	GO:0010628	positive regulation of gene expression	runx1	IGI	ZFIN:ZDB-GENE-010611-1,ZFIN:ZDB-GENE-980526-164	Zfish	PMID:19275935
Biological Process	GO:0010628	positive regulation of gene expression	runx1	IMP	ZFIN:ZDB-MRPHLNO-060207-1	Zfish	PMID:19275935
Biological Process	GO:0030854	positive regulation of granulocyte differentiation	RUNX1	IMP		Human	PMID:9199349
Biological Process	GO:0032743	positive regulation of interleukin-2 production	RUNX1	IMP		Human	PMID:17377532
Biological Process	GO:0032743	positive regulation of interleukin-2 production	Runx1	IMP		Mouse	MGI:MGI:3710039\|PMID:17377532
Biological Process	GO:0045660	positive regulation of neutrophil differentiation	runx1	IMP	ZFIN:ZDB-GENO-091020-2	Zfish	PMID:22493295
Biological Process	GO:2000872	positive regulation of progesterone secretion	Runx1	IMP		Rat	PMID:16675540\|RGD:6482842
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	RUNX1	IDA		Human	PMID:10207087
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	RUNX1	IDA		Human	PMID:14970218
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	RUNX1	IMP		Human	PMID:20972335
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	RUNX1	IDA		Human	PMID:21873977
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	RUNX1	IDA		Human	PMID:9199349
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	RUNX1	IMP		Human	PMID:9199349
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Runx1	IDA		Mouse	PMID:19090621
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Runx1	IMP		Rat	PMID:21678417\|RGD:6482841
Biological Process	GO:0032729	positive regulation of type II interferon production	Runx1	IDA		Mouse	MGI:MGI:3710039\|PMID:17377532
Biological Process	GO:0060043	regulation of cardiac muscle cell proliferation	runx1	IMP		Zfish	PMID:32341028\|ZFIN:ZDB-PUB-200429-4
Biological Process	GO:1905203	regulation of connective tissue replacement	runx1	IMP		Zfish	PMID:32341028\|ZFIN:ZDB-PUB-200429-4
Biological Process	GO:0006355	regulation of DNA-templated transcription	Runx1	IMP		Mouse	MGI:MGI:6284428\|PMID:29924977
Biological Process	GO:0006355	regulation of DNA-templated transcription	Runx1	IDA		Mouse	PMID:12807883
Biological Process	GO:0071336	regulation of hair follicle cell proliferation	Runx1	IMP	MGI:MGI:3711451,MGI:MGI:3711451	Mouse	PMID:21464233
Biological Process	GO:0045637	regulation of myeloid cell differentiation	runx1	IMP	ZFIN:ZDB-GENO-091020-2	Zfish	PMID:22493295
Biological Process	GO:0045658	regulation of neutrophil differentiation	runx1	IGI	ZFIN:ZDB-GENO-140321-1	Zfish	PMID:22493295
Biological Process	GO:0010755	regulation of plasminogen activation	runx1	IMP		Zfish	PMID:32341028\|ZFIN:ZDB-PUB-200429-4
Biological Process	GO:0009966	regulation of signal transduction	Runx1	IMP	MGI:MGI:3711451,MGI:MGI:3711451	Mouse	PMID:21464233
Biological Process	GO:0002667	regulation of T cell anergy	Runx1	IMP		Mouse	MGI:MGI:3710039\|PMID:17377532
Biological Process	GO:0014894	response to denervation involved in regulation of muscle adaptation	Runx1	IEP		Rat	PMID:7969143\|RGD:634721
Biological Process	GO:0032526	response to retinoic acid	Runx1	IDA		Mouse	MGI:MGI:3799604\|PMID:18439490
Biological Process	GO:0001501	skeletal system development	Runx1	IMP	MGI:MGI:2668479	Mouse	PMID:15389629

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.