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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Runx2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Runx2
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0043425bHLH transcription factor bindingRunx2IPIPR:Q64279MousePMID:19144722
Molecular FunctionGO:0043425bHLH transcription factor bindingRunx2IPIPR:Q61039MousePMID:19144722
Molecular FunctionGO:0003682chromatin bindingRunx2IDAMousePMID:18487609
Molecular FunctionGO:0003682chromatin bindingRunx2IDAMousePMID:15537544
Molecular FunctionGO:0031490chromatin DNA bindingRunx2IDAMousePMID:21930712
Molecular FunctionGO:0000987cis-regulatory region sequence-specific DNA bindingRunx2IMPMouseMGI:MGI:6453224|PMID:31545469
Molecular FunctionGO:0001228DNA-binding transcription activator activity, RNA polymerase II-specificRunx2IDAMouseMGI:MGI:892148|PMID:9182762
Molecular FunctionGO:0003700DNA-binding transcription factor activityRunx2IMPMouseMGI:MGI:6453224|PMID:31545469
Molecular FunctionGO:0003700DNA-binding transcription factor activityRunx2IDAMousePMID:20551513
Molecular FunctionGO:0003700DNA-binding transcription factor activityRunx2IDAMousePMID:15030764
Molecular FunctionGO:0003700DNA-binding transcription factor activityRunx2IDAMousePMID:12551949
Molecular FunctionGO:0003700DNA-binding transcription factor activityrunx2bIDAZfishPMID:16007341
Molecular FunctionGO:0140297DNA-binding transcription factor bindingRunx2IPIPR:P27782MousePMID:12551949
Molecular FunctionGO:0140297DNA-binding transcription factor bindingRunx2IPIRGD:621863RatPMID:18171674|RGD:9590341
Molecular FunctionGO:0140296general transcription initiation factor bindingRunx2IPIRGD:620720RatPMID:18171674|RGD:9590341
Molecular FunctionGO:0042826histone deacetylase bindingRunx2IPIRGD:619979RatPMID:20097749|RGD:9681006
Molecular FunctionGO:0042826histone deacetylase bindingRunx2IPIRGD:1562895RatPMID:25019367|RGD:13208813
Molecular FunctionGO:0042809nuclear vitamin D receptor bindingrunx2bIPIUniProtKB:Q9PTN2ZfishPMID:20236534
Molecular FunctionGO:0005515protein bindingRUNX2IPIUniProtKB:Q8WYB5HumanPMID:11965546
Molecular FunctionGO:0005515protein bindingRUNX2IPIUniProtKB:Q92794HumanPMID:11965546
Molecular FunctionGO:0005515protein bindingRUNX2IPIUniProtKB:Q9H7Z6HumanPMID:11965546
Molecular FunctionGO:0005515protein bindingRUNX2IPIUniProtKB:P12956HumanPMID:12145306
Molecular FunctionGO:0005515protein bindingRUNX2IPIUniProtKB:P13010HumanPMID:12145306
Molecular FunctionGO:0005515protein bindingRUNX2IPIUniProtKB:O43541HumanPMID:16299379
Molecular FunctionGO:0005515protein bindingRUNX2IPIUniProtKB:P17480HumanPMID:17251981
Molecular FunctionGO:0005515protein bindingRUNX2IPIUniProtKB:Q99JB6HumanPMID:17377532
Molecular FunctionGO:0005515protein bindingRUNX2IPIUniProtKB:P17480HumanPMID:20160071
Molecular FunctionGO:0005515protein bindingRUNX2IPIUniProtKB:O15297HumanPMID:22065775
Molecular FunctionGO:0005515protein bindingRUNX2IPIUniProtKB:Q13526HumanPMID:24113655
Molecular FunctionGO:0005515protein bindingRUNX2IPIUniProtKB:O15350HumanPMID:25331851
Molecular FunctionGO:0005515protein bindingRunx2IPIUniProtKB:Q6NZM9MouseMGI:MGI:3513625|PMID:15537544
Molecular FunctionGO:0005515protein bindingRunx2IPIUniProtKB:P25976MouseMGI:MGI:3698914|PMID:17251981
Molecular FunctionGO:0005515protein bindingRunx2IPIUniProtKB:Q6AYI1|UniProtKB:P17844MouseMGI:MGI:5315698|PMID:17960593
Molecular FunctionGO:0005515protein bindingRunx2IPIUniProtKB:Q9D030MouseMGI:MGI:4839410|PMID:20655471
Molecular FunctionGO:0005515protein bindingRunx2IPIUniProtKB:Q9R1E0MouseMGI:MGI:5430843|PMID:21471200
Molecular FunctionGO:0005515protein bindingRunx2IPIPR:Q8BUN5MousePMID:15990875
Molecular FunctionGO:0005515protein bindingRunx2IPIPR:Q91WL8MousePMID:18487609
Molecular FunctionGO:0005515protein bindingRunx2IPIPR:O88559MousePMID:15150273
Molecular FunctionGO:0005515protein bindingRunx2IPIPR:Q9Z2V6MousePMID:15990875
Molecular FunctionGO:0005515protein bindingRunx2IPIPR:Q8VI24MousePMID:16751105
Molecular FunctionGO:0005515protein bindingRunx2IPIPR:Q8R138MousePMID:21239498
Molecular FunctionGO:0005515protein bindingRunx2IPIUniProtKB:P25977RatPMID:17251981|RGD:13432326
Molecular FunctionGO:0005515protein bindingRunx2IPIUniProtKB:Q568Y7RatPMID:28062493|RGD:13441204
Molecular FunctionGO:0019904protein domain specific bindingRunx2IPIPR:P26687MousePMID:15030764
Molecular FunctionGO:0019904protein domain specific bindingRunx2IPIPR:Q9D030MousePMID:15030764
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingRunx2IDAMouseMGI:MGI:892148|PMID:9182762
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingRunx2IGIMGI:MGI:2679336MousePMID:16751105
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingRunx2IDAMousePMID:21324897
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingRunx2IDAMousePMID:12807883
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingRunx2IDAMousePMID:15107406
Molecular FunctionGO:1990837sequence-specific double-stranded DNA bindingRUNX2IDAHumanPMID:28473536
Molecular FunctionGO:0000976transcription cis-regulatory region bindingRunx2IDAMouseMGI:MGI:3822269|PMID:18804520
Molecular FunctionGO:0000976transcription cis-regulatory region bindingRunx2IDAMousePMID:12551949
Cellular ComponentGO:0000785chromatinRunx2IDAMouseMGI:MGI:3759198|PMID:17352693
Cellular ComponentGO:0005737cytoplasmRunx2IDAMousePMID:17182356
Cellular ComponentGO:0005654nucleoplasmRUNX2IDAHumanGO_REF:0000052
Cellular ComponentGO:0005634nucleusRUNX2IDAHumanPMID:28505335
Cellular ComponentGO:0005634nucleusRUNX2IDAHumanPMID:28738062
Cellular ComponentGO:0005634nucleusRunx2IDAMouseMGI:MGI:5574120|PMID:24391920
Cellular ComponentGO:0005634nucleusRunx2IDAMousePMID:19144722
Cellular ComponentGO:0005634nucleusRunx2IDAMousePMID:15565649
Cellular ComponentGO:0005634nucleusRunx2IDAMousePMID:17182356
Cellular ComponentGO:0005634nucleusRunx2IDAMousePMID:12434156
Cellular ComponentGO:0005634nucleusRunx2IDAMousePMID:31336344
Cellular ComponentGO:0005634nucleusRunx2IDAMousePMID:12551949
Cellular ComponentGO:0005634nucleusRunx2IDAMousePMID:15150273
Cellular ComponentGO:0005634nucleusRunx2IDARatPMID:25019367|RGD:13208813
Cellular ComponentGO:0005667transcription regulator complexRunx2IDAMousePMID:16751105
Biological ProcessGO:0030509BMP signaling pathwayRunx2IMPMouseMGI:MGI:5487530|PMID:20843790
Biological ProcessGO:0051216cartilage developmentrunx2bIMPZFIN:ZDB-MRPHLNO-061127-3ZfishPMID:17013873
Biological ProcessGO:0051216cartilage developmentrunx2bIMPZFIN:ZDB-MRPHLNO-061127-8ZfishPMID:17013873
Biological ProcessGO:0051216cartilage developmentrunx2bIMPZFIN:ZDB-MRPHLNO-061127-4ZfishPMID:17013873
Biological ProcessGO:0051216cartilage developmentrunx2bIMPZFIN:ZDB-MRPHLNO-061127-2ZfishPMID:17013873
Biological ProcessGO:0051216cartilage developmentrunx2bIMPZFIN:ZDB-MRPHLNO-061127-1ZfishPMID:17013873
Biological ProcessGO:0048469cell maturationRunx2IGIMGI:MGI:102672MousePMID:15107406
Biological ProcessGO:0048469cell maturationRunx2IMPMGI:MGI:2183833MousePMID:15389629
Biological ProcessGO:0008283cell population proliferationRunx2IGIMGI:MGI:97370MousePMID:22927960
Biological ProcessGO:0008283cell population proliferationRunx2IGIMGI:MGI:97801MousePMID:16476422
Biological ProcessGO:0008283cell population proliferationRunx2IMPMGI:MGI:2176465MousePMID:15668330
Biological ProcessGO:0071773cellular response to BMP stimulusRunx2IMPMouseMGI:MGI:5487530|PMID:20843790
Biological ProcessGO:0044344cellular response to fibroblast growth factor stimulusRunx2IEPRatPMID:12403780|RGD:1601650
Biological ProcessGO:0034224cellular response to zinc ion starvationRunx2IEPRatPMID:21893222|RGD:151667428
Biological ProcessGO:0002063chondrocyte developmentRunx2IMPMGI:MGI:2176466MousePMID:10213384
Biological ProcessGO:0002062chondrocyte differentiationRunx2IGIMGI:MGI:97801MousePMID:16476422
Biological ProcessGO:0002062chondrocyte differentiationRunx2IMPMGI:MGI:2176465MousePMID:10072783
Biological ProcessGO:0002062chondrocyte differentiationRunx2IGIMGI:MGI:102672MousePMID:22916278
Biological ProcessGO:0002062chondrocyte differentiationRunx2IMPMGI:MGI:2176466MousePMID:22916278
Biological ProcessGO:0002062chondrocyte differentiationrunx2bIMPZFIN:ZDB-MRPHLNO-061127-8ZfishPMID:17013873
Biological ProcessGO:0009953dorsal/ventral pattern formationrunx2bIGIZFIN:ZDB-MRPHLNO-061127-3,ZFIN:ZDB-MRPHLNO-111209-7ZfishPMID:22087291
Biological ProcessGO:0009953dorsal/ventral pattern formationrunx2bIGIZFIN:ZDB-MRPHLNO-061127-3,ZFIN:ZDB-MRPHLNO-111209-6ZfishPMID:22087291
Biological ProcessGO:0048701embryonic cranial skeleton morphogenesisRunx2IGIMGI:MGI:104685MousePMID:15030764
Biological ProcessGO:0048701embryonic cranial skeleton morphogenesisRunx2IGIMGI:MGI:98872MousePMID:15030764
Biological ProcessGO:0035115embryonic forelimb morphogenesisRunx2IMPMGI:MGI:2176466MousePMID:22916278
Biological ProcessGO:0001958endochondral ossificationRunx2IMPMGI:MGI:2176466MousePMID:10072783
Biological ProcessGO:0050673epithelial cell proliferationRunx2IMPMGI:MGI:2176465MousePMID:15668330
Biological ProcessGO:0010467gene expressionRunx2IDAMousePMID:31281513
Biological ProcessGO:0036076ligamentous ossificationRunx2IGIMGI:MGI:99829MousePMID:22927960
Biological ProcessGO:0036076ligamentous ossificationRunx2IGIMGI:MGI:97370MousePMID:22927960
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionRUNX2IDAHumanPMID:11965546
Biological ProcessGO:0045892negative regulation of DNA-templated transcriptionRunx2IDAMouseMGI:MGI:3822269|PMID:18804520
Biological ProcessGO:0045879negative regulation of smoothened signaling pathwayRunx2IMPMGI:MGI:2176465MousePMID:15668330
Biological ProcessGO:0042475odontogenesis of dentin-containing toothRunx2IMPMGI:MGI:2176465MousePMID:15668330
Biological ProcessGO:0042475odontogenesis of dentin-containing toothRunx2IMPMousePMID:15136142
Biological ProcessGO:0002076osteoblast developmentRunx2IGIMGI:MGI:1341800MousePMID:18986983
Biological ProcessGO:0001649osteoblast differentiationRUNX2IEPHumanPMID:20128911
Biological ProcessGO:0001649osteoblast differentiationRUNX2IGIRNAcentral:URS0000446722_9606HumanPMID:25012146
Biological ProcessGO:0001649osteoblast differentiationRunx2IGIMGI:MGI:1917649MousePMID:16099986
Biological ProcessGO:0001649osteoblast differentiationRunx2IGIMGI:MGI:88177MousePMID:15565649
Biological ProcessGO:0001649osteoblast differentiationRunx2IMPMGI:MGI:2183833MousePMID:15389629
Biological ProcessGO:0001649osteoblast differentiationRunx2IMPRatPMID:19940863|RGD:12880052
Biological ProcessGO:0002051osteoblast fate commitmentRunx2IGIMGI:MGI:1316736MousePMID:15150273
Biological ProcessGO:0008284positive regulation of cell population proliferationRunx2IGIMGI:MGI:97801MousePMID:16476422
Biological ProcessGO:0032332positive regulation of chondrocyte differentiationRunx2IMPMGI:MGI:2176465MousePMID:10072783
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionRUNX2IDAHumanPMID:11965546
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionRunx2IMPMouseMGI:MGI:6453224|PMID:31545469
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionRunx2IDAMousePMID:12551949
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionrunx2bIDAZfishPMID:18246063
Biological ProcessGO:0045893positive regulation of DNA-templated transcriptionrunx2bIDAZfishPMID:16007341
Biological ProcessGO:0050679positive regulation of epithelial cell proliferationRunx2IMPMGI:MGI:2176465MousePMID:15668330
Biological ProcessGO:0010628positive regulation of gene expressionRunx2IDAMousePMID:21324897
Biological ProcessGO:0045778positive regulation of ossificationRunx2IMPRatPMID:11784711|RGD:1601657
Biological ProcessGO:0045669positive regulation of osteoblast differentiationRUNX2IMPHumanPMID:28703881
Biological ProcessGO:0045669positive regulation of osteoblast differentiationRunx2IGIMGI:MGI:1316736MousePMID:15150273
Biological ProcessGO:0045669positive regulation of osteoblast differentiationRunx2IDAMousePMID:15175325
Biological ProcessGO:0045669positive regulation of osteoblast differentiationRunx2IGIMGI:MGI:1341800MousePMID:18986983
Biological ProcessGO:2000648positive regulation of stem cell proliferationRunx2IMPMGI:MGI:2176465MousePMID:15668330
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIRUNX2IMPHumanPMID:28505335
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIRUNX2IMPHumanPMID:28703881
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIRUNX2IMPHumanPMID:28738062
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIRunx2IDAMouseMGI:MGI:892148|PMID:9182762
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIRunx2IDAMousePMID:15030764
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIRunx2IDAMousePMID:19144722
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIRunx2IGIMGI:MGI:1316736MousePMID:15150273
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIRunx2IMPMousePMID:31336344
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIRunx2IGIMGI:MGI:1341884MousePMID:20628571
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIRunx2IGIMGI:MGI:104853MousePMID:20628571
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIRunx2IDAMousePMID:18487609
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIRunx2IGIMGI:MGI:2679336MousePMID:16751105
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIRunx2IDAMousePMID:15107406
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIRunx2IGIMGI:MGI:1931237MousePMID:18487609
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIRunx2IGIMGI:MGI:3036234MousePMID:15537544
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIRunx2IGIMGI:MGI:1917649MousePMID:16099986
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIRunx2IDAMousePMID:15150273
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIRunx2IDAMousePMID:12434156
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIRunx2IGIMGI:MGI:99414MousePMID:20628571
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IIRunx2IDAMousePMID:15990875
Biological ProcessGO:1901522positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulusRunx2IMPMouseMGI:MGI:5487530|PMID:20843790
Biological ProcessGO:0040036regulation of fibroblast growth factor receptor signaling pathwayRunx2IMPMousePMID:15136142
Biological ProcessGO:0010468regulation of gene expressionRunx2IDAMousePMID:24505141
Biological ProcessGO:0042487regulation of odontogenesis of dentin-containing toothRunx2IMPMGI:MGI:2176465MousePMID:14688224
Biological ProcessGO:0030278regulation of ossificationRunx2IMPMGI:MGI:2176466MousePMID:10213384
Biological ProcessGO:0045667regulation of osteoblast differentiationRunx2IDAMousePMID:21628588
Biological ProcessGO:0032868response to insulinRunx2IEPRatPMID:20818503|RGD:151667419
Biological ProcessGO:0033591response to L-ascorbic acidRunx2IMPMGI:MGI:2385534MousePMID:21930712
Biological ProcessGO:0033591response to L-ascorbic acidRunx2IDAMousePMID:21930712
Biological ProcessGO:0014070response to organic cyclic compoundRunx2IEPRatPMID:20818503|RGD:151667419
Biological ProcessGO:1904383response to sodium phosphateRunx2IDAMousePMID:23523568
Biological ProcessGO:0001501skeletal system developmentRunx2IMPMGI:MGI:2176466MousePMID:15050892
Biological ProcessGO:0001501skeletal system developmentRunx2IMPMGI:MGI:2176465MousePMID:14688224
Biological ProcessGO:0048705skeletal system morphogenesisRunx2IMPMGI:MGI:2176465MousePMID:15030764
Biological ProcessGO:0060395SMAD protein signal transductionRUNX2IGIRNAcentral:URS0000446722_9606HumanPMID:25012146
Biological ProcessGO:0007224smoothened signaling pathwayRunx2IMPMGI:MGI:2176465MousePMID:15668330
Biological ProcessGO:0048863stem cell differentiationRunx2IDAMousePMID:17693062
Biological ProcessGO:0072089stem cell proliferationRunx2IMPMGI:MGI:2176465MousePMID:15668330
Biological ProcessGO:0030217T cell differentiationRunx2IDAMousePMID:7862157

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory