Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RUNX3
  • Mouse genes Runx3
  • Rat genes Runx3
  • Zfish genes runx3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Runx3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Runx3	IDA		Mouse	PMID:12807883
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Runx3	IDA		Mouse	MGI:MGI:3759198|PMID:17352693
Molecular Function	GO:0005515	protein binding	RUNX3	IPI	UniProtKB:Q99JB6	Human	PMID:17377532
Molecular Function	GO:0005515	protein binding	RUNX3	IPI	UniProtKB:P35222	Human	PMID:18772112
Molecular Function	GO:0005515	protein binding	RUNX3	IPI	UniProtKB:Q9NQB0	Human	PMID:18772112
Molecular Function	GO:0005515	protein binding	RUNX3	IPI	UniProtKB:P06239	Human	PMID:20100835
Molecular Function	GO:0005515	protein binding	RUNX3	IPI	UniProtKB:P06241	Human	PMID:20100835
Molecular Function	GO:0005515	protein binding	RUNX3	IPI	UniProtKB:P12931	Human	PMID:20100835
Molecular Function	GO:0005515	protein binding	RUNX3	IPI	UniProtKB:Q15911	Human	PMID:20599712
Molecular Function	GO:0005515	protein binding	RUNX3	IPI	UniProtKB:P25440	Human	PMID:24229708
Molecular Function	GO:0005515	protein binding	RUNX3	IPI	UniProtKB:P56524	Human	PMID:24229708
Molecular Function	GO:0005515	protein binding	RUNX3	IPI	UniProtKB:Q09472	Human	PMID:24229708
Molecular Function	GO:0005515	protein binding	RUNX3	IPI	UniProtKB:Q9UQL6	Human	PMID:24229708
Molecular Function	GO:0005515	protein binding	RUNX3	IPI	UniProtKB:P16371	Human	PMID:9751710
Molecular Function	GO:0005515	protein binding	RUNX3	IPI	UniProtKB:Q04724	Human	PMID:9751710
Molecular Function	GO:0005515	protein binding	Runx3	IPI	UniProtKB:Q9JKD8	Mouse	MGI:MGI:4868293|PMID:21151104
Molecular Function	GO:0005515	protein binding	Runx3	IPI	PR:P23772	Mouse	PMID:20399120
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Runx3	IDA		Mouse	MGI:MGI:3759198|PMID:17352693
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	RUNX3	IDA		Human	PMID:28473536
Molecular Function	GO:0001222	transcription corepressor binding	RUNX3	IPI	UniProtKB:Q04724	Human	PMID:9751710
Cellular Component	GO:0000785	chromatin	Runx3	IDA		Mouse	MGI:MGI:3759198|PMID:17352693
Cellular Component	GO:0005737	cytoplasm	RUNX3	IDA		Human	PMID:20100835
Cellular Component	GO:0005737	cytoplasm	RUNX3	IDA		Human	PMID:20599712
Cellular Component	GO:0005829	cytosol	RUNX3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	RUNX3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	RUNX3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	RUNX3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	RUNX3	IDA		Human	PMID:20100835
Cellular Component	GO:0005634	nucleus	RUNX3	IDA		Human	PMID:20599712
Cellular Component	GO:0005634	nucleus	Runx3	IDA		Mouse	PMID:15514019
Biological Process	GO:0007411	axon guidance	Runx3	IMP	MGI:MGI:2179229	Mouse	PMID:12352981
Biological Process	GO:0051216	cartilage development	runx3	IMP	ZFIN:ZDB-MRPHLNO-061127-5	Zfish	PMID:17013873
Biological Process	GO:0048469	cell maturation	Runx3	IGI	MGI:MGI:99829	Mouse	PMID:15107406
Biological Process	GO:0002062	chondrocyte differentiation	Runx3	IGI	MGI:MGI:99829	Mouse	PMID:22916278
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	runx3	IMP	ZFIN:ZDB-MRPHLNO-061127-5	Zfish	PMID:23209659
Biological Process	GO:0031069	hair follicle morphogenesis	Runx3	IMP	MGI:MGI:2183399	Mouse	PMID:15937937
Biological Process	GO:0030097	hemopoiesis	runx3	IMP	ZFIN:ZDB-GENO-980202-118	Zfish	PMID:14579373
Biological Process	GO:0030097	hemopoiesis	runx3	IEP		Zfish	PMID:14579373
Biological Process	GO:0043371	negative regulation of CD4-positive, alpha-beta T cell differentiation	Runx3	IMP		Mouse	MGI:MGI:3772948|PMID:18258917
Biological Process	GO:0045786	negative regulation of cell cycle	Runx3	IMP		Mouse	MGI:MGI:2177980|PMID:11955451
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Runx3	IMP		Mouse	MGI:MGI:2177980|PMID:11955451
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Runx3	IDA		Mouse	MGI:MGI:3759198|PMID:17352693
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Runx3	IDA		Mouse	MGI:MGI:3772948|PMID:18258917
Biological Process	GO:0031175	neuron projection development	Runx3	IMP	MGI:MGI:2179229	Mouse	PMID:12352981
Biological Process	GO:0043378	positive regulation of CD8-positive, alpha-beta T cell differentiation	Runx3	IMP		Mouse	MGI:MGI:3772948|PMID:18258917
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	RUNX3	IDA		Human	PMID:20599712
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	Runx3	IMP	MGI:MGI:2179229	Mouse	PMID:11955451
Biological Process	GO:0006468	protein phosphorylation	RUNX3	IDA		Human	PMID:20100835
Biological Process	GO:0071559	response to transforming growth factor beta	RUNX3	IDA		Human	PMID:20599712
Biological Process	GO:0032609	type II interferon production	Runx3	IDA		Mouse	PMID:20399120

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern