Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RYK
  • Mouse genes Ryk
  • Rat genes Ryk
  • Zfish genes ryk
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ryk

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005109	frizzled binding	Ryk	IPI	UniProtKB:Q61091	Mouse	MGI:MGI:3510085|PMID:15454084
Molecular Function	GO:0005515	protein binding	RYK	IPI	UniProtKB:O14640	Human	PMID:15454084
Molecular Function	GO:0005515	protein binding	Ryk	IPI	UniProtKB:P35222	Mouse	MGI:MGI:5586590|PMID:24960609
Molecular Function	GO:0005515	protein binding	Ryk	IPI	UniProtKB:P54753	Mouse	PMID:10932185
Molecular Function	GO:0005515	protein binding	Ryk	IPI	UniProtKB:P29323	Mouse	PMID:10932185
Molecular Function	GO:0005515	protein binding	Ryk	IPI	UniProtKB:Q15375	Mouse	PMID:10932185
Molecular Function	GO:0005515	protein binding	Ryk	IPI	PR:P51141	Mouse	PMID:15454084
Molecular Function	GO:0005515	protein binding	Ryk	IPI	PR:Q61091	Mouse	PMID:15454084
Molecular Function	GO:0004888	transmembrane signaling receptor activity	RYK	IDA		Human	PMID:10454588
Molecular Function	GO:0042813	Wnt receptor activity	Ryk	IPI	PR:P04426	Mouse	PMID:15454084
Molecular Function	GO:0042813	Wnt receptor activity	Ryk	IPI	PR:P27467	Mouse	PMID:15454084
Molecular Function	GO:0017147	Wnt-protein binding	Ryk	IPI	UniProtKB:P17553	Mouse	MGI:MGI:3822212|PMID:19000841
Molecular Function	GO:0017147	Wnt-protein binding	Ryk	IPI	PR:P27467	Mouse	PMID:15454084
Molecular Function	GO:0017147	Wnt-protein binding	Ryk	IPI	PR:P04426	Mouse	PMID:15454084
Molecular Function	GO:0017147	Wnt-protein binding	Ryk	IPI	PR:P22725	Mouse	PMID:16723543
Molecular Function	GO:0017147	Wnt-protein binding	ryk	IDA		Zfish	PMID:20660632
Cellular Component	GO:0005737	cytoplasm	Ryk	IDA		Mouse	MGI:MGI:3822212|PMID:19000841
Cellular Component	GO:0016020	membrane	Ryk	IDA		Mouse	MGI:MGI:3822212|PMID:19000841
Cellular Component	GO:0016020	membrane	Ryk	IDA		Mouse	PMID:10030667
Cellular Component	GO:0016020	membrane	Ryk	IDA		Mouse	PMID:8394755
Cellular Component	GO:0005634	nucleus	Ryk	IDA		Mouse	MGI:MGI:3822212|PMID:19000841
Cellular Component	GO:0005886	plasma membrane	Ryk	IDA		Mouse	PMID:7822791
Cellular Component	GO:0005886	plasma membrane	ryk	IDA		Zfish	PMID:20660632
Biological Process	GO:0048846	axon extension involved in axon guidance	Ryk	IGI	MGI:MGI:98958	Mouse	PMID:16723543
Biological Process	GO:0007411	axon guidance	Ryk	IDA		Mouse	MGI:MGI:4887339|PMID:16116452
Biological Process	GO:0007411	axon guidance	Ryk	IMP		Mouse	MGI:MGI:3625635|PMID:16723543
Biological Process	GO:0007409	axonogenesis	Ryk	IGI	MGI:MGI:98956	Mouse	PMID:15454084
Biological Process	GO:0007409	axonogenesis	Ryk	IGI	UniProtKB:P22725	Rat	PMID:23517308|RGD:11054651
Biological Process	GO:0042074	cell migration involved in gastrulation	ryk	IMP	ZFIN:ZDB-MRPHLNO-100805-1	Zfish	PMID:20660632
Biological Process	GO:0033278	cell proliferation in midbrain	Ryk	IMP		Rat	PMID:23517308|RGD:11054651
Biological Process	GO:0036518	chemorepulsion of dopaminergic neuron axon	Ryk	IGI	UniProtKB:P22725	Mouse	MGI:MGI:5707582|PMID:23517308
Biological Process	GO:0071679	commissural neuron axon guidance	Ryk	IMP	MGI:MGI:2667542	Mouse	PMID:16723543
Biological Process	GO:0060026	convergent extension	ryk	IGI	ZFIN:ZDB-MRPHLNO-041217-10,ZFIN:ZDB-MRPHLNO-120905-2	Zfish	PMID:22773843
Biological Process	GO:0060028	convergent extension involved in axis elongation	ryk	IMP	ZFIN:ZDB-MRPHLNO-100805-1	Zfish	PMID:20660632
Biological Process	GO:0060028	convergent extension involved in axis elongation	ryk	IMP	ZFIN:ZDB-MRPHLNO-120905-1	Zfish	PMID:22773843
Biological Process	GO:0060028	convergent extension involved in axis elongation	ryk	IGI	ZFIN:ZDB-MRPHLNO-090915-1,ZFIN:ZDB-MRPHLNO-100805-1	Zfish	PMID:20660632
Biological Process	GO:0022038	corpus callosum development	Ryk	IMP		Mouse	MGI:MGI:3625635|PMID:16723543
Biological Process	GO:0060030	dorsal convergence	ryk	IMP	ZFIN:ZDB-MRPHLNO-090915-1,ZFIN:ZDB-MRPHLNO-100805-1	Zfish	PMID:20660632
Biological Process	GO:0060030	dorsal convergence	ryk	IMP	ZFIN:ZDB-MRPHLNO-100805-1	Zfish	PMID:20660632
Biological Process	GO:1904948	midbrain dopaminergic neuron differentiation	Ryk	IMP		Mouse	MGI:MGI:5707582|PMID:23517308
Biological Process	GO:0050919	negative chemotaxis	Ryk	IGI	MGI:MGI:98958	Mouse	PMID:16723543
Biological Process	GO:0048843	negative regulation of axon extension involved in axon guidance	Ryk	IGI	MGI:MGI:98958	Mouse	PMID:16723543
Biological Process	GO:0030182	neuron differentiation	Ryk	IDA		Mouse	MGI:MGI:3822212|PMID:19000841
Biological Process	GO:0031175	neuron projection development	Ryk	IMP		Mouse	MGI:MGI:3510085|PMID:15454084
Biological Process	GO:1904938	planar cell polarity pathway involved in axon guidance	Ryk	IGI	UniProtKB:P22725	Mouse	MGI:MGI:5707582|PMID:23517308
Biological Process	GO:0043410	positive regulation of MAPK cascade	RYK	IDA		Human	PMID:10454588
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	ryk	IMP	ZFIN:ZDB-MRPHLNO-100805-1	Zfish	PMID:20660632
Biological Process	GO:0048705	skeletal system morphogenesis	Ryk	IMP	MGI:MGI:2667542	Mouse	PMID:10932185
Biological Process	GO:0016055	Wnt signaling pathway	Ryk	IDA		Mouse	MGI:MGI:3510085|PMID:15454084
Biological Process	GO:0016055	Wnt signaling pathway	Ryk	IGI	MGI:MGI:98958	Mouse	PMID:16723543
Biological Process	GO:1904953	Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	Ryk	IGI	UniProtKB:P22725	Rat	PMID:23517308|RGD:11054651
Biological Process	GO:0007223	Wnt signaling pathway, calcium modulating pathway	ryk	IMP	ZFIN:ZDB-MRPHLNO-100805-1	Zfish	PMID:20660632

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern