Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RYR1
  • Mouse genes Ryr1
  • Rat genes Ryr1
  • Zfish genes ryr1a,ryr1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ryr1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005262	calcium channel activity	Ryr1	IMP		Mouse	MGI:MGI:3764002|PMID:18003898
Molecular Function	GO:0048763	calcium-induced calcium release activity	RYR1	IMP		Human	PMID:26115329
Molecular Function	GO:0019899	enzyme binding	Ryr1	IPI	UniProtKB:P26883	Mouse	MGI:MGI:3837615|PMID:19198614
Molecular Function	GO:0002020	protease binding	Ryr1	IPI	UniProtKB:P16259	Mouse	MGI:MGI:3811664|PMID:18676612
Molecular Function	GO:0005515	protein binding	Ryr1	IPI	UniProtKB:P26883	Mouse	MGI:MGI:3775502|PMID:18268335
Molecular Function	GO:0005515	protein binding	Ryr1	IPI	UniProtKB:O55108|UniProtKB:P49070	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Ryr1	IPI	UniProtKB:P26883	Mouse	MGI:MGI:5438859|PMID:22939628
Molecular Function	GO:0005515	protein binding	Ryr1	IPI	RGD:619856	Rat	PMID:16176928|RGD:7327230
Molecular Function	GO:0005515	protein binding	ryr1b	IPI	ZFIN:ZDB-GENE-040801-248	Zfish	PMID:23736855
Molecular Function	GO:0005219	ryanodine-sensitive calcium-release channel activity	RYR1	IMP		Human	PMID:11741831
Molecular Function	GO:0005219	ryanodine-sensitive calcium-release channel activity	RYR1	IMP		Human	PMID:16163667
Molecular Function	GO:0005219	ryanodine-sensitive calcium-release channel activity	RYR1	IDA		Human	PMID:22480578
Molecular Function	GO:0005219	ryanodine-sensitive calcium-release channel activity	RYR1	IMP		Human	PMID:26115329
Molecular Function	GO:0005219	ryanodine-sensitive calcium-release channel activity	Ryr1	IMP		Mouse	MGI:MGI:74313|PMID:7621815
Molecular Function	GO:0005219	ryanodine-sensitive calcium-release channel activity	Ryr1	IDA		Rat	PMID:11316255|RGD:12903237
Molecular Function	GO:0005219	ryanodine-sensitive calcium-release channel activity	Ryr1	IDA		Rat	PMID:19116207|RGD:7242196
Molecular Function	GO:0005219	ryanodine-sensitive calcium-release channel activity	Ryr1	IDA		Rat	PMID:19230144|RGD:7175256
Molecular Function	GO:0005219	ryanodine-sensitive calcium-release channel activity	ryr1b	IMP	ZFIN:ZDB-GENO-070928-2	Zfish	PMID:17596281
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Ryr1	IDA		Mouse	MGI:MGI:3764002|PMID:18003898
Molecular Function	GO:0005245	voltage-gated calcium channel activity	Ryr1	IDA		Mouse	PMID:12954602
Cellular Component	GO:0005938	cell cortex	RYR1	IDA		Human	PMID:11206130
Cellular Component	GO:0005737	cytoplasm	RYR1	IDA		Human	PMID:11206130
Cellular Component	GO:0070062	extracellular exosome	RYR1	HDA		Human	PMID:19056867
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	Ryr1	IDA		Rat	PMID:20177054|RGD:7242274
Cellular Component	GO:0031674	I band	RYR1	IDA		Human	PMID:11206130
Cellular Component	GO:0030314	junctional membrane complex	Ryr1	IDA		Mouse	PMID:10444070
Cellular Component	GO:0016020	membrane	Ryr1	IDA		Mouse	PMID:12704193
Cellular Component	GO:0016020	membrane	Ryr1	IDA		Mouse	PMID:7832748
Cellular Component	GO:0005886	plasma membrane	RYR1	IDA		Human	PMID:11206130
Cellular Component	GO:0032991	protein-containing complex	Ryr1	IDA		Mouse	MGI:MGI:3811664|PMID:18676612
Cellular Component	GO:0042383	sarcolemma	Ryr1	IDA		Rat	PMID:21474431|RGD:7175530
Cellular Component	GO:0016529	sarcoplasmic reticulum	Ryr1	IDA		Mouse	PMID:8943043
Cellular Component	GO:0016529	sarcoplasmic reticulum	Ryr1	IDA		Mouse	PMID:7832748
Cellular Component	GO:0016529	sarcoplasmic reticulum	Ryr1	IDA		Mouse	PMID:15536090
Cellular Component	GO:0016529	sarcoplasmic reticulum	Ryr1	IDA		Mouse	PMID:11784029
Cellular Component	GO:0016529	sarcoplasmic reticulum	Ryr1	IDA		Mouse	PMID:12954602
Cellular Component	GO:0016529	sarcoplasmic reticulum	Ryr1	IDA		Rat	PMID:19230144|RGD:7175256
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	RYR1	IDA		Human	PMID:7556644
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	Ryr1	IDA		Mouse	MGI:MGI:3764002|PMID:18003898
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	Ryr1	IDA		Mouse	PMID:14592808
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	Ryr1	IDA		Rat	PMID:11316255|RGD:12903237
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	Ryr1	IDA		Rat	PMID:21454501|RGD:8554079
Cellular Component	GO:0005790	smooth endoplasmic reticulum	Ryr1	IDA		Mouse	PMID:23454728
Cellular Component	GO:0030315	T-tubule	Ryr1	IDA		Mouse	PMID:23695157
Cellular Component	GO:0030315	T-tubule	Ryr1	IDA		Mouse	PMID:15536090
Cellular Component	GO:0030315	T-tubule	Ryr1	IDA		Mouse	PMID:8943043
Cellular Component	GO:0030315	T-tubule	Ryr1	IDA		Mouse	PMID:22355118
Cellular Component	GO:0014802	terminal cisterna	Ryr1	IDA		Rat	PMID:11316255|RGD:12903237
Biological Process	GO:0006816	calcium ion transport	Ryr1	IDA		Mouse	PMID:12954602
Biological Process	GO:0006816	calcium ion transport	Ryr1	IDA		Rat	PMID:19116207|RGD:7242196
Biological Process	GO:0071318	cellular response to ATP	Ryr1	IDA		Rat	PMID:11316255|RGD:12903237
Biological Process	GO:0071313	cellular response to caffeine	RYR1	IMP		Human	PMID:16163667
Biological Process	GO:0071313	cellular response to caffeine	RYR1	IMP		Human	PMID:26115329
Biological Process	GO:0071313	cellular response to caffeine	Ryr1	IMP		Mouse	MGI:MGI:74313|PMID:7621815
Biological Process	GO:0034599	cellular response to oxidative stress	ryr1b	IMP		Zfish	PMID:22418739
Biological Process	GO:1990791	dorsal root ganglion development	ryr1a	IMP	ZFIN:ZDB-MRPHLNO-090108-5,ZFIN:ZDB-MRPHLNO-090109-2	Zfish	PMID:29754802
Biological Process	GO:1990791	dorsal root ganglion development	ryr1a	IGI	ZFIN:ZDB-GENE-041001-165	Zfish	PMID:29754802
Biological Process	GO:0048484	enteric nervous system development	ryr1a	IMP	ZFIN:ZDB-MRPHLNO-090108-5,ZFIN:ZDB-MRPHLNO-090109-2	Zfish	PMID:29754802
Biological Process	GO:0048484	enteric nervous system development	ryr1a	IGI	ZFIN:ZDB-GENE-041001-165	Zfish	PMID:29754802
Biological Process	GO:0031443	fast-twitch skeletal muscle fiber contraction	ryr1b	IMP	ZFIN:ZDB-MRPHLNO-110822-2	Zfish	PMID:22075003
Biological Process	GO:0031443	fast-twitch skeletal muscle fiber contraction	ryr1b	IMP	ZFIN:ZDB-GENO-200723-2	Zfish	PMID:31383689
Biological Process	GO:0031443	fast-twitch skeletal muscle fiber contraction	ryr1b	IMP	ZFIN:ZDB-GENO-070928-2	Zfish	PMID:17596281
Biological Process	GO:0008345	larval locomotory behavior	ryr1b	IMP		Zfish	PMID:22418739
Biological Process	GO:0006936	muscle contraction	Ryr1	IMP		Mouse	MGI:MGI:67115|PMID:7515481
Biological Process	GO:0006936	muscle contraction	Ryr1	IDA		Mouse	PMID:12954602
Biological Process	GO:0006936	muscle contraction	Ryr1	IMP	MGI:MGI:2152826	Mouse	PMID:12704193
Biological Process	GO:0021532	neural tube patterning	ryr1a	IGI	ZFIN:ZDB-GENE-071001-1,ZFIN:ZDB-GENE-041001-165	Zfish	PMID:29754802
Biological Process	GO:0021532	neural tube patterning	ryr1a	IMP	ZFIN:ZDB-GENO-190227-9	Zfish	PMID:29754802
Biological Process	GO:0043931	ossification involved in bone maturation	Ryr1	IMP		Mouse	MGI:MGI:3764002|PMID:18003898
Biological Process	GO:0003151	outflow tract morphogenesis	Ryr1	IMP		Mouse	MGI:MGI:3764002|PMID:18003898
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	Ryr1	IDA		Rat	PMID:19116207|RGD:7242196
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	RYR1	IMP		Human	PMID:11741831
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	RYR1	IMP		Human	PMID:16163667
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	Ryr1	IMP	MGI:MGI:2152826	Mouse	PMID:12704193
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	Ryr1	IDA		Rat	PMID:19116207|RGD:7242196
Biological Process	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	Ryr1	IMP		Mouse	MGI:MGI:3764002|PMID:18003898
Biological Process	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	Ryr1	IDA		Rat	PMID:11316255|RGD:12903237
Biological Process	GO:0031000	response to caffeine	Ryr1	IDA		Rat	PMID:19116207|RGD:7242196
Biological Process	GO:0032355	response to estradiol	Ryr1	IEP		Rat	PMID:19593990|RGD:13782367
Biological Process	GO:0001666	response to hypoxia	RYR1	IDA		Human	PMID:19120137
Biological Process	GO:0070296	sarcoplasmic reticulum calcium ion transport	Ryr1	IDA		Rat	PMID:19230144|RGD:7175256
Biological Process	GO:0003009	skeletal muscle contraction	ryr1a	IMP	ZFIN:ZDB-GENO-200729-3	Zfish	PMID:31383689
Biological Process	GO:0003009	skeletal muscle contraction	ryr1b	IMP	ZFIN:ZDB-GENO-200729-3	Zfish	PMID:31383689
Biological Process	GO:0048741	skeletal muscle fiber development	Ryr1	IMP		Mouse	MGI:MGI:3764002|PMID:18003898
Biological Process	GO:0048741	skeletal muscle fiber development	ryr1a	IMP	ZFIN:ZDB-GENO-190227-2	Zfish	PMID:29754802
Biological Process	GO:0048741	skeletal muscle fiber development	ryr1a	IGI	ZFIN:ZDB-GENE-070705-417,ZFIN:ZDB-GENE-041001-165	Zfish	PMID:29754802
Biological Process	GO:0048741	skeletal muscle fiber development	ryr1b	IMP	ZFIN:ZDB-MRPHLNO-090108-5,ZFIN:ZDB-MRPHLNO-090109-2	Zfish	PMID:29754802
Biological Process	GO:0048741	skeletal muscle fiber development	ryr1b	IMP	ZFIN:ZDB-GENO-190227-2	Zfish	PMID:29754802
Biological Process	GO:0048741	skeletal muscle fiber development	ryr1a	IMP	ZFIN:ZDB-MRPHLNO-090108-5,ZFIN:ZDB-MRPHLNO-090109-2	Zfish	PMID:29754802
Biological Process	GO:0048741	skeletal muscle fiber development	ryr1b	IGI	ZFIN:ZDB-GENE-020108-2,ZFIN:ZDB-GENE-041001-165	Zfish	PMID:29754802
Biological Process	GO:0043588	skin development	Ryr1	IMP		Mouse	MGI:MGI:3764002|PMID:18003898
Biological Process	GO:0031444	slow-twitch skeletal muscle fiber contraction	ryr1b	IMP	ZFIN:ZDB-GENO-200723-2	Zfish	PMID:31383689
Biological Process	GO:0007224	smoothened signaling pathway	ryr1a	IGI	ZFIN:ZDB-GENE-071001-1,ZFIN:ZDB-GENE-041001-165	Zfish	PMID:29754802
Biological Process	GO:0007224	smoothened signaling pathway	ryr1a	IMP	ZFIN:ZDB-MRPHLNO-090108-5,ZFIN:ZDB-MRPHLNO-090109-2	Zfish	PMID:29754802
Biological Process	GO:0007224	smoothened signaling pathway	ryr1b	IGI	ZFIN:ZDB-GENE-020108-2,ZFIN:ZDB-GENE-041001-165	Zfish	PMID:29754802
Biological Process	GO:0007224	smoothened signaling pathway	ryr1a	IGI	ZFIN:ZDB-GENE-041001-165	Zfish	PMID:29754802
Biological Process	GO:0007224	smoothened signaling pathway	ryr1a	IMP	ZFIN:ZDB-GENO-190227-9	Zfish	PMID:29754802
Biological Process	GO:0007224	smoothened signaling pathway	ryr1a	IMP	ZFIN:ZDB-GENO-190227-2	Zfish	PMID:29754802
Biological Process	GO:0007224	smoothened signaling pathway	ryr1a	IGI	ZFIN:ZDB-GENE-070705-417,ZFIN:ZDB-GENE-041001-165	Zfish	PMID:29754802
Biological Process	GO:0007224	smoothened signaling pathway	ryr1b	IMP	ZFIN:ZDB-GENO-190227-2	Zfish	PMID:29754802

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern