Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RYR2
  • Mouse genes Ryr2
  • Rat genes Ryr2
  • Zfish genes ryr2a,ryr2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ryr2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005262	calcium channel activity	Ryr2	IDA		Mouse	MGI:MGI:1267127|PMID:9628868
Molecular Function	GO:0048763	calcium-induced calcium release activity	RYR2	IDA		Human	PMID:17921453
Molecular Function	GO:0048763	calcium-induced calcium release activity	Ryr2	IDA		Rat	PMID:18799678|RGD:7175259
Molecular Function	GO:0015278	calcium-release channel activity	RYR2	IDA		Human	PMID:17921453
Molecular Function	GO:0015278	calcium-release channel activity	Ryr2	IDA		Mouse	MGI:MGI:1345009|PMID:10473538
Molecular Function	GO:0005516	calmodulin binding	RYR2	IMP		Human	PMID:19220289
Molecular Function	GO:0005516	calmodulin binding	RYR2	IDA		Human	PMID:22067155
Molecular Function	GO:0005516	calmodulin binding	RYR2	IPI	UniProtKB:P0DP23	Human	PMID:23040497
Molecular Function	GO:0005516	calmodulin binding	RYR2	IPI	UniProtKB:P0DP24	Human	PMID:23040497
Molecular Function	GO:0005516	calmodulin binding	RYR2	IPI	UniProtKB:P0DP25	Human	PMID:23040497
Molecular Function	GO:0005516	calmodulin binding	RYR2	IDA		Human	PMID:26164367
Molecular Function	GO:0005516	calmodulin binding	RYR2	IDA		Human	PMID:27516456
Molecular Function	GO:0005516	calmodulin binding	Ryr2	IDA		Mouse	PMID:17431507
Molecular Function	GO:0019899	enzyme binding	RYR2	IPI	UniProtKB:Q08499	Human	PMID:16213210
Molecular Function	GO:0019899	enzyme binding	Ryr2	IPI	UniProtKB:Q9Z2I2	Mouse	MGI:MGI:4420848|PMID:20080623
Molecular Function	GO:0019899	enzyme binding	Ryr2	IPI	UniProtKB:Q01063|UniProtKB:Q9Z2I2	Mouse	MGI:MGI:3690823|PMID:16213210
Molecular Function	GO:0019899	enzyme binding	Ryr2	IPI	UniProtKB:P28161	Mouse	MGI:MGI:5431202|PMID:22406107
Molecular Function	GO:0042802	identical protein binding	RYR2	IPI	UniProtKB:Q92736	Human	PMID:10830164
Molecular Function	GO:0042802	identical protein binding	Ryr2	IPI	UniProtKB:E9Q401	Mouse	MGI:MGI:5644027|PMID:12324472
Molecular Function	GO:0042802	identical protein binding	Ryr2	IPI	UniProtKB:E9Q401	Mouse	MGI:MGI:5644020|PMID:20427316
Molecular Function	GO:0097159	organic cyclic compound binding	Ryr2	IPI	CHEBI:8925	Mouse	PMID:17431507
Molecular Function	GO:0005515	protein binding	RYR2	IPI	UniProtKB:P68106	Human	PMID:10830164
Molecular Function	GO:0005515	protein binding	RYR2	IPI	UniProtKB:Q13023	Human	PMID:10830164
Molecular Function	GO:0005515	protein binding	RYR2	IPI	UniProtKB:Q15257	Human	PMID:10830164
Molecular Function	GO:0005515	protein binding	RYR2	IPI	UniProtKB:P62942	Human	PMID:11237759
Molecular Function	GO:0005515	protein binding	RYR2	IPI	UniProtKB:P68106	Human	PMID:11237759
Molecular Function	GO:0005515	protein binding	RYR2	IPI	UniProtKB:P68106	Human	PMID:17921453
Molecular Function	GO:0005515	protein binding	RYR2	IPI	UniProtKB:Q00987	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	RYR2	IPI	UniProtKB:P68106	Human	PMID:23233753
Molecular Function	GO:0005515	protein binding	Ryr2	IPI	UniProtKB:P23327	Mouse	MGI:MGI:5619424|PMID:24805197
Molecular Function	GO:0005515	protein binding	Ryr2	IPI	UniProtKB:Q9Z2I2	Mouse	MGI:MGI:5438859|PMID:22939628
Molecular Function	GO:0005515	protein binding	Ryr2	IPI	UniProtKB:Q6PHZ2	Mouse	MGI:MGI:6189498|PMID:20479242
Molecular Function	GO:0005515	protein binding	Ryr2	IPI	UniProtKB:Q6PHZ2	Mouse	MGI:MGI:6189492|PMID:24952909
Molecular Function	GO:0005515	protein binding	Ryr2	IPI	UniProtKB:Q9Z2I2	Mouse	MGI:MGI:3620455|PMID:16481613
Molecular Function	GO:0005515	protein binding	Ryr2	IPI	UniProtKB:Q8K4S1	Mouse	MGI:MGI:5491968|PMID:23540699
Molecular Function	GO:0005515	protein binding	Ryr2	IPI	PR:Q9Z2I2	Mouse	PMID:21788490
Molecular Function	GO:0005515	protein binding	Ryr2	IPI	PR:Q01815	Mouse	PMID:16352659
Molecular Function	GO:0005515	protein binding	Ryr2	IPI	RGD:2738	Rat	PMID:15010472|RGD:1599256
Molecular Function	GO:0034236	protein kinase A catalytic subunit binding	RYR2	IDA		Human	PMID:10830164
Molecular Function	GO:0034237	protein kinase A regulatory subunit binding	RYR2	IDA		Human	PMID:10830164
Molecular Function	GO:0019901	protein kinase binding	Ryr2	IPI	UniProtKB:P15791|UniProtKB:Q6PHZ2	Mouse	MGI:MGI:3772026|PMID:12676814
Molecular Function	GO:0043621	protein self-association	Ryr2	IMP		Mouse	MGI:MGI:1345009|PMID:10473538
Molecular Function	GO:0005219	ryanodine-sensitive calcium-release channel activity	RYR2	IDA		Human	PMID:17921453
Molecular Function	GO:0005219	ryanodine-sensitive calcium-release channel activity	Ryr2	IDA		Mouse	PMID:17431507
Molecular Function	GO:0005219	ryanodine-sensitive calcium-release channel activity	Ryr2	IDA		Mouse	PMID:14593104
Molecular Function	GO:0005219	ryanodine-sensitive calcium-release channel activity	Ryr2	IDA		Rat	PMID:18799678|RGD:7175259
Molecular Function	GO:0005219	ryanodine-sensitive calcium-release channel activity	Ryr2	IMP		Rat	PMID:21807619|RGD:7175254
Molecular Function	GO:0097110	scaffold protein binding	Ryr2	IPI	UniProtKB:Q9WVC7	Rat	PMID:11590243|RGD:1599255
Molecular Function	GO:0043924	suramin binding	RYR2	IMP		Human	PMID:19220289
Cellular Component	GO:0031672	A band	Ryr2	IDA		Rat	PMID:17627991|RGD:7175261
Cellular Component	GO:0034704	calcium channel complex	RYR2	IDA		Human	PMID:10830164
Cellular Component	GO:0034704	calcium channel complex	RYR2	IDA		Human	PMID:16213210
Cellular Component	GO:0034704	calcium channel complex	Ryr2	IDA		Mouse	MGI:MGI:3690823|PMID:16213210
Cellular Component	GO:0005737	cytoplasm	Ryr2	IDA		Rat	PMID:20177054|RGD:7242274
Cellular Component	GO:0005783	endoplasmic reticulum	Ryr2	IDA		Rat	PMID:18799678|RGD:7175259
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	Ryr2	IDA		Rat	PMID:20177054|RGD:7242274
Cellular Component	GO:0016020	membrane	RYR2	IDA		Human	PMID:12443530
Cellular Component	GO:0016020	membrane	Ryr2	IDA		Mouse	PMID:17431507
Cellular Component	GO:0043005	neuron projection	Ryr2	IDA		Rat	PMID:16723744|RGD:1599250
Cellular Component	GO:0005635	nuclear envelope	Ryr2	IDA		Rat	PMID:11590243|RGD:1599255
Cellular Component	GO:0005886	plasma membrane	Ryr2	IDA		Rat	PMID:19116207|RGD:7242196
Cellular Component	GO:0032991	protein-containing complex	RYR2	IDA		Human	PMID:18468998
Cellular Component	GO:0032991	protein-containing complex	Ryr2	IDA		Rat	PMID:16306226|RGD:2312613
Cellular Component	GO:0042383	sarcolemma	Ryr2	IDA		Rat	PMID:21474431|RGD:7175530
Cellular Component	GO:0030017	sarcomere	Ryr2	IDA		Mouse	MGI:MGI:4442115|PMID:20226167
Cellular Component	GO:0016529	sarcoplasmic reticulum	RYR2	IDA		Human	PMID:10830164
Cellular Component	GO:0016529	sarcoplasmic reticulum	RYR2	IDA		Human	PMID:12919952
Cellular Component	GO:0016529	sarcoplasmic reticulum	Ryr2	IDA		Mouse	MGI:MGI:5431202|PMID:22406107
Cellular Component	GO:0016529	sarcoplasmic reticulum	Ryr2	IDA		Mouse	MGI:MGI:5486563|PMID:12919952
Cellular Component	GO:0016529	sarcoplasmic reticulum	Ryr2	IDA		Mouse	PMID:21788490
Cellular Component	GO:0016529	sarcoplasmic reticulum	Ryr2	IDA		Rat	PMID:11590243|RGD:1599255
Cellular Component	GO:0016529	sarcoplasmic reticulum	Ryr2	IDA		Rat	PMID:21807619|RGD:7175254
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	Ryr2	IDA		Mouse	PMID:16481613
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	Ryr2	IDA		Mouse	PMID:14592808
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	Ryr2	IDA		Rat	PMID:11053140|RGD:8554533
Cellular Component	GO:0005790	smooth endoplasmic reticulum	Ryr2	IDA		Mouse	PMID:23454728
Cellular Component	GO:0030018	Z disc	RYR2	IDA		Human	PMID:19131648
Cellular Component	GO:0030018	Z disc	Ryr2	IDA		Mouse	PMID:16204356
Cellular Component	GO:0030018	Z disc	Ryr2	IDA		Mouse	PMID:19383796
Cellular Component	GO:0030018	Z disc	Ryr2	IDA		Rat	PMID:15980179|RGD:1600288
Cellular Component	GO:0030018	Z disc	Ryr2	IDA		Rat	PMID:11053140|RGD:8554533
Cellular Component	GO:0030018	Z disc	Ryr2	IDA		Rat	PMID:15010472|RGD:1599256
Cellular Component	GO:0030018	Z disc	Ryr2	IDA		Rat	PMID:17627991|RGD:7175261
Biological Process	GO:0097553	calcium ion transmembrane import into cytosol	Ryr2	IMP	MGI:MGI:3713774	Mouse	PMID:17431507
Biological Process	GO:0070588	calcium ion transmembrane transport	Ryr2	IMP	MGI:MGI:3641338	Mouse	PMID:21673970
Biological Process	GO:0070588	calcium ion transmembrane transport	Ryr2	IMP		Rat	PMID:19116207|RGD:7242196
Biological Process	GO:0006816	calcium ion transport	RYR2	IDA		Human	PMID:17921453
Biological Process	GO:0006816	calcium ion transport	Ryr2	IMP		Mouse	MGI:MGI:1267127|PMID:9628868
Biological Process	GO:0006816	calcium ion transport	Ryr2	IDA		Mouse	MGI:MGI:1345009|PMID:10473538
Biological Process	GO:0006816	calcium ion transport	Ryr2	IPI	PR:Q61144	Mouse	PMID:16204356
Biological Process	GO:0006816	calcium ion transport	Ryr2	IDA		Mouse	PMID:14593104
Biological Process	GO:0060402	calcium ion transport into cytosol	RYR2	IDA		Human	PMID:17921453
Biological Process	GO:0019722	calcium-mediated signaling	Ryr2	IMP		Mouse	MGI:MGI:1267127|PMID:9628868
Biological Process	GO:0019722	calcium-mediated signaling	Ryr2	IDA		Mouse	MGI:MGI:3713015|PMID:17431507
Biological Process	GO:0035584	calcium-mediated signaling using intracellular calcium source	RYR2	IDA		Human	PMID:17921453
Biological Process	GO:0060048	cardiac muscle contraction	RYR2	IMP		Human	PMID:10830164
Biological Process	GO:0003300	cardiac muscle hypertrophy	Ryr2	IMP	MGI:MGI:3713774	Mouse	PMID:17431507
Biological Process	GO:0071313	cellular response to caffeine	RYR2	IDA		Human	PMID:12919952
Biological Process	GO:0071313	cellular response to caffeine	Ryr2	IDA		Mouse	MGI:MGI:5431202|PMID:22406107
Biological Process	GO:0071313	cellular response to caffeine	Ryr2	IDA		Mouse	MGI:MGI:1267127|PMID:9628868
Biological Process	GO:0071313	cellular response to caffeine	Ryr2	IDA		Mouse	PMID:12089338
Biological Process	GO:0071872	cellular response to epinephrine stimulus	Ryr2	IMP		Mouse	MGI:MGI:3820489|PMID:17872467
Biological Process	GO:0005513	detection of calcium ion	RYR2	IDA		Human	PMID:10830164
Biological Process	GO:0003143	embryonic heart tube morphogenesis	Ryr2	IMP		Mouse	MGI:MGI:1267127|PMID:9628868
Biological Process	GO:0051649	establishment of localization in cell	Ryr2	IMP		Mouse	PMID:12089338
Biological Process	GO:0072599	establishment of protein localization to endoplasmic reticulum	RYR2	IDA		Human	PMID:12443530
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Ryr2	IMP		Mouse	MGI:MGI:1267127|PMID:9628868
Biological Process	GO:0003220	left ventricular cardiac muscle tissue morphogenesis	Ryr2	IMP	MGI:MGI:3713774	Mouse	PMID:17431507
Biological Process	GO:0071421	manganese ion transmembrane transport	Ryr2	IMP		Rat	PMID:19116207|RGD:7242196
Biological Process	GO:0034220	monoatomic ion transmembrane transport	Ryr2	IMP		Rat	PMID:19116207|RGD:7242196
Biological Process	GO:0051481	negative regulation of cytosolic calcium ion concentration	Ryr2	IDA		Rat	PMID:18799678|RGD:7175259
Biological Process	GO:0021532	neural tube patterning	ryr2a	IMP	ZFIN:ZDB-GENO-190227-9	Zfish	PMID:29754802
Biological Process	GO:0021532	neural tube patterning	ryr2a	IGI	ZFIN:ZDB-GENE-020108-2,ZFIN:ZDB-GENE-041001-165	Zfish	PMID:29754802
Biological Process	GO:1901896	positive regulation of ATPase-coupled calcium transmembrane transporter activity	RYR2	IDA		Human	PMID:12443530
Biological Process	GO:0010460	positive regulation of heart rate	Ryr2	IMP		Mouse	PMID:12089338
Biological Process	GO:0010460	positive regulation of heart rate	Ryr2	IMP	MGI:MGI:2183509	Mouse	PMID:12089338
Biological Process	GO:0010460	positive regulation of heart rate	Ryr2	IMP	MGI:MGI:3713774	Mouse	PMID:17431507
Biological Process	GO:0051284	positive regulation of sequestering of calcium ion	RYR2	IDA		Human	PMID:12443530
Biological Process	GO:0051284	positive regulation of sequestering of calcium ion	RYR2	IDA		Human	PMID:12919952
Biological Process	GO:0098735	positive regulation of the force of heart contraction	RYR2	IMP		Human	PMID:15105296
Biological Process	GO:0086029	Purkinje myocyte to ventricular cardiac muscle cell signaling	Ryr2	IMP		Mouse	MGI:MGI:3820489|PMID:17872467
Biological Process	GO:0098910	regulation of atrial cardiac muscle cell action potential	RYR2	IMP		Human	PMID:17875969
Biological Process	GO:0098904	regulation of AV node cell action potential	RYR2	IMP		Human	PMID:17875969
Biological Process	GO:0055117	regulation of cardiac muscle contraction	RYR2	IMP		Human	PMID:11159936
Biological Process	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	RYR2	IMP		Human	PMID:17875969
Biological Process	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	Ryr2	IGI	UniProtKB:Q9Z2I2	Mouse	MGI:MGI:3621834|PMID:12837242
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	Ryr2	IMP		Rat	PMID:15870112|RGD:1599253
Biological Process	GO:0002027	regulation of heart rate	RYR2	IMP		Human	PMID:11159936
Biological Process	GO:0002027	regulation of heart rate	RYR2	IMP		Human	PMID:12919952
Biological Process	GO:0002027	regulation of heart rate	RYR2	IMP		Human	PMID:15197150
Biological Process	GO:0002027	regulation of heart rate	Ryr2	IMP		Mouse	MGI:MGI:3820489|PMID:17872467
Biological Process	GO:0098907	regulation of SA node cell action potential	RYR2	IMP		Human	PMID:17875969
Biological Process	GO:0098911	regulation of ventricular cardiac muscle cell action potential	RYR2	IMP		Human	PMID:17875969
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	RYR2	IDA		Human	PMID:12443530
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	RYR2	IDA		Human	PMID:17921453
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	Ryr2	IDA		Mouse	MGI:MGI:3713015|PMID:17431507
Biological Process	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	RYR2	IMP		Human	PMID:12919952
Biological Process	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	Ryr2	IDA		Mouse	MGI:MGI:4442115|PMID:20226167
Biological Process	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	Ryr2	IMP		Mouse	PMID:12089338
Biological Process	GO:0031000	response to caffeine	RYR2	IDA		Human	PMID:17921453
Biological Process	GO:0031000	response to caffeine	Ryr2	IDA		Mouse	MGI:MGI:1345009|PMID:10473538
Biological Process	GO:0031000	response to caffeine	Ryr2	IDA		Mouse	PMID:14593104
Biological Process	GO:0051592	response to calcium ion	Ryr2	IDA		Rat	PMID:17027851|RGD:1599247
Biological Process	GO:0001666	response to hypoxia	Ryr2	IDA		Mouse	MGI:MGI:3836482|PMID:19120137
Biological Process	GO:0032026	response to magnesium ion	Ryr2	IDA		Rat	PMID:16971497|RGD:1599254
Biological Process	GO:0014850	response to muscle activity	RYR2	IMP		Human	PMID:17875969
Biological Process	GO:0035994	response to muscle stretch	RYR2	IMP		Human	PMID:15105296
Biological Process	GO:0007584	response to nutrient	Ryr2	IEP		Rat	PMID:17224993|RGD:1599246
Biological Process	GO:0051775	response to redox state	RYR2	IDA		Human	PMID:19226252
Biological Process	GO:0009410	response to xenobiotic stimulus	Ryr2	IEP		Rat	PMID:15916736|RGD:1599252
Biological Process	GO:0070296	sarcoplasmic reticulum calcium ion transport	Ryr2	IMP		Rat	PMID:21807619|RGD:7175254
Biological Process	GO:0007224	smoothened signaling pathway	ryr2a	IGI	ZFIN:ZDB-GENE-020108-2,ZFIN:ZDB-GENE-041001-165	Zfish	PMID:29754802
Biological Process	GO:0007224	smoothened signaling pathway	ryr2a	IMP	ZFIN:ZDB-GENO-190227-9	Zfish	PMID:29754802
Biological Process	GO:0097050	type B pancreatic cell apoptotic process	RYR2	IMP		Human	PMID:15044459
Biological Process	GO:0097050	type B pancreatic cell apoptotic process	Ryr2	IMP		Mouse	MGI:MGI:3720302|PMID:15044459
Biological Process	GO:0086005	ventricular cardiac muscle cell action potential	Ryr2	IMP		Mouse	MGI:MGI:3820489|PMID:17872467

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern