Source |
Alliance of Genome Resources |
Category | ID | Classification term | Gene | Evidence | Inferred from | Organism | Reference |
---|---|---|---|---|---|---|---|
Molecular Function | GO:0005262 | calcium channel activity | Ryr2 | IDA | Mouse | MGI:MGI:1267127|PMID:9628868 | |
Molecular Function | GO:0048763 | calcium-induced calcium release activity | RYR2 | IDA | Human | PMID:17921453 | |
Molecular Function | GO:0048763 | calcium-induced calcium release activity | Ryr2 | IDA | Rat | PMID:18799678|RGD:7175259 | |
Molecular Function | GO:0015278 | calcium-release channel activity | RYR2 | IDA | Human | PMID:17921453 | |
Molecular Function | GO:0015278 | calcium-release channel activity | Ryr2 | IDA | Mouse | MGI:MGI:1345009|PMID:10473538 | |
Molecular Function | GO:0005516 | calmodulin binding | RYR2 | IMP | Human | PMID:19220289 | |
Molecular Function | GO:0005516 | calmodulin binding | RYR2 | IDA | Human | PMID:22067155 | |
Molecular Function | GO:0005516 | calmodulin binding | RYR2 | IPI | UniProtKB:P0DP23 | Human | PMID:23040497 |
Molecular Function | GO:0005516 | calmodulin binding | RYR2 | IPI | UniProtKB:P0DP24 | Human | PMID:23040497 |
Molecular Function | GO:0005516 | calmodulin binding | RYR2 | IPI | UniProtKB:P0DP25 | Human | PMID:23040497 |
Molecular Function | GO:0005516 | calmodulin binding | RYR2 | IDA | Human | PMID:26164367 | |
Molecular Function | GO:0005516 | calmodulin binding | RYR2 | IDA | Human | PMID:27516456 | |
Molecular Function | GO:0005516 | calmodulin binding | Ryr2 | IDA | Mouse | PMID:17431507 | |
Molecular Function | GO:0019899 | enzyme binding | RYR2 | IPI | UniProtKB:Q08499 | Human | PMID:16213210 |
Molecular Function | GO:0019899 | enzyme binding | Ryr2 | IPI | UniProtKB:Q9Z2I2 | Mouse | MGI:MGI:4420848|PMID:20080623 |
Molecular Function | GO:0019899 | enzyme binding | Ryr2 | IPI | UniProtKB:Q01063|UniProtKB:Q9Z2I2 | Mouse | MGI:MGI:3690823|PMID:16213210 |
Molecular Function | GO:0019899 | enzyme binding | Ryr2 | IPI | UniProtKB:P28161 | Mouse | MGI:MGI:5431202|PMID:22406107 |
Molecular Function | GO:0042802 | identical protein binding | RYR2 | IPI | UniProtKB:Q92736 | Human | PMID:10830164 |
Molecular Function | GO:0042802 | identical protein binding | Ryr2 | IPI | UniProtKB:E9Q401 | Mouse | MGI:MGI:5644027|PMID:12324472 |
Molecular Function | GO:0042802 | identical protein binding | Ryr2 | IPI | UniProtKB:E9Q401 | Mouse | MGI:MGI:5644020|PMID:20427316 |
Molecular Function | GO:0097159 | organic cyclic compound binding | Ryr2 | IPI | CHEBI:8925 | Mouse | PMID:17431507 |
Molecular Function | GO:0005515 | protein binding | RYR2 | IPI | UniProtKB:P68106 | Human | PMID:10830164 |
Molecular Function | GO:0005515 | protein binding | RYR2 | IPI | UniProtKB:Q13023 | Human | PMID:10830164 |
Molecular Function | GO:0005515 | protein binding | RYR2 | IPI | UniProtKB:Q15257 | Human | PMID:10830164 |
Molecular Function | GO:0005515 | protein binding | RYR2 | IPI | UniProtKB:P62942 | Human | PMID:11237759 |
Molecular Function | GO:0005515 | protein binding | RYR2 | IPI | UniProtKB:P68106 | Human | PMID:11237759 |
Molecular Function | GO:0005515 | protein binding | RYR2 | IPI | UniProtKB:P68106 | Human | PMID:17921453 |
Molecular Function | GO:0005515 | protein binding | RYR2 | IPI | UniProtKB:Q00987 | Human | PMID:20195357 |
Molecular Function | GO:0005515 | protein binding | RYR2 | IPI | UniProtKB:P68106 | Human | PMID:23233753 |
Molecular Function | GO:0005515 | protein binding | Ryr2 | IPI | UniProtKB:P23327 | Mouse | MGI:MGI:5619424|PMID:24805197 |
Molecular Function | GO:0005515 | protein binding | Ryr2 | IPI | UniProtKB:Q9Z2I2 | Mouse | MGI:MGI:5438859|PMID:22939628 |
Molecular Function | GO:0005515 | protein binding | Ryr2 | IPI | UniProtKB:Q6PHZ2 | Mouse | MGI:MGI:6189498|PMID:20479242 |
Molecular Function | GO:0005515 | protein binding | Ryr2 | IPI | UniProtKB:Q6PHZ2 | Mouse | MGI:MGI:6189492|PMID:24952909 |
Molecular Function | GO:0005515 | protein binding | Ryr2 | IPI | UniProtKB:Q9Z2I2 | Mouse | MGI:MGI:3620455|PMID:16481613 |
Molecular Function | GO:0005515 | protein binding | Ryr2 | IPI | UniProtKB:Q8K4S1 | Mouse | MGI:MGI:5491968|PMID:23540699 |
Molecular Function | GO:0005515 | protein binding | Ryr2 | IPI | PR:Q9Z2I2 | Mouse | PMID:21788490 |
Molecular Function | GO:0005515 | protein binding | Ryr2 | IPI | PR:Q01815 | Mouse | PMID:16352659 |
Molecular Function | GO:0005515 | protein binding | Ryr2 | IPI | RGD:2738 | Rat | PMID:15010472|RGD:1599256 |
Molecular Function | GO:0034236 | protein kinase A catalytic subunit binding | RYR2 | IDA | Human | PMID:10830164 | |
Molecular Function | GO:0034237 | protein kinase A regulatory subunit binding | RYR2 | IDA | Human | PMID:10830164 | |
Molecular Function | GO:0019901 | protein kinase binding | Ryr2 | IPI | UniProtKB:P15791|UniProtKB:Q6PHZ2 | Mouse | MGI:MGI:3772026|PMID:12676814 |
Molecular Function | GO:0043621 | protein self-association | Ryr2 | IMP | Mouse | MGI:MGI:1345009|PMID:10473538 | |
Molecular Function | GO:0005219 | ryanodine-sensitive calcium-release channel activity | RYR2 | IDA | Human | PMID:17921453 | |
Molecular Function | GO:0005219 | ryanodine-sensitive calcium-release channel activity | Ryr2 | IDA | Mouse | PMID:17431507 | |
Molecular Function | GO:0005219 | ryanodine-sensitive calcium-release channel activity | Ryr2 | IDA | Mouse | PMID:14593104 | |
Molecular Function | GO:0005219 | ryanodine-sensitive calcium-release channel activity | Ryr2 | IDA | Rat | PMID:18799678|RGD:7175259 | |
Molecular Function | GO:0005219 | ryanodine-sensitive calcium-release channel activity | Ryr2 | IMP | Rat | PMID:21807619|RGD:7175254 | |
Molecular Function | GO:0097110 | scaffold protein binding | Ryr2 | IPI | UniProtKB:Q9WVC7 | Rat | PMID:11590243|RGD:1599255 |
Molecular Function | GO:0043924 | suramin binding | RYR2 | IMP | Human | PMID:19220289 | |
Cellular Component | GO:0031672 | A band | Ryr2 | IDA | Rat | PMID:17627991|RGD:7175261 | |
Cellular Component | GO:0034704 | calcium channel complex | RYR2 | IDA | Human | PMID:10830164 | |
Cellular Component | GO:0034704 | calcium channel complex | RYR2 | IDA | Human | PMID:16213210 | |
Cellular Component | GO:0034704 | calcium channel complex | Ryr2 | IDA | Mouse | MGI:MGI:3690823|PMID:16213210 | |
Cellular Component | GO:0005737 | cytoplasm | Ryr2 | IDA | Rat | PMID:20177054|RGD:7242274 | |
Cellular Component | GO:0005783 | endoplasmic reticulum | Ryr2 | IDA | Rat | PMID:18799678|RGD:7175259 | |
Cellular Component | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane | Ryr2 | IDA | Rat | PMID:20177054|RGD:7242274 | |
Cellular Component | GO:0016020 | membrane | RYR2 | IDA | Human | PMID:12443530 | |
Cellular Component | GO:0016020 | membrane | Ryr2 | IDA | Mouse | PMID:17431507 | |
Cellular Component | GO:0043005 | neuron projection | Ryr2 | IDA | Rat | PMID:16723744|RGD:1599250 | |
Cellular Component | GO:0005635 | nuclear envelope | Ryr2 | IDA | Rat | PMID:11590243|RGD:1599255 | |
Cellular Component | GO:0005886 | plasma membrane | Ryr2 | IDA | Rat | PMID:19116207|RGD:7242196 | |
Cellular Component | GO:0032991 | protein-containing complex | RYR2 | IDA | Human | PMID:18468998 | |
Cellular Component | GO:0032991 | protein-containing complex | Ryr2 | IDA | Rat | PMID:16306226|RGD:2312613 | |
Cellular Component | GO:0042383 | sarcolemma | Ryr2 | IDA | Rat | PMID:21474431|RGD:7175530 | |
Cellular Component | GO:0030017 | sarcomere | Ryr2 | IDA | Mouse | MGI:MGI:4442115|PMID:20226167 | |
Cellular Component | GO:0016529 | sarcoplasmic reticulum | RYR2 | IDA | Human | PMID:10830164 | |
Cellular Component | GO:0016529 | sarcoplasmic reticulum | RYR2 | IDA | Human | PMID:12919952 | |
Cellular Component | GO:0016529 | sarcoplasmic reticulum | Ryr2 | IDA | Mouse | MGI:MGI:5431202|PMID:22406107 | |
Cellular Component | GO:0016529 | sarcoplasmic reticulum | Ryr2 | IDA | Mouse | MGI:MGI:5486563|PMID:12919952 | |
Cellular Component | GO:0016529 | sarcoplasmic reticulum | Ryr2 | IDA | Mouse | PMID:21788490 | |
Cellular Component | GO:0016529 | sarcoplasmic reticulum | Ryr2 | IDA | Rat | PMID:11590243|RGD:1599255 | |
Cellular Component | GO:0016529 | sarcoplasmic reticulum | Ryr2 | IDA | Rat | PMID:21807619|RGD:7175254 | |
Cellular Component | GO:0033017 | sarcoplasmic reticulum membrane | Ryr2 | IDA | Mouse | PMID:16481613 | |
Cellular Component | GO:0033017 | sarcoplasmic reticulum membrane | Ryr2 | IDA | Mouse | PMID:14592808 | |
Cellular Component | GO:0033017 | sarcoplasmic reticulum membrane | Ryr2 | IDA | Rat | PMID:11053140|RGD:8554533 | |
Cellular Component | GO:0005790 | smooth endoplasmic reticulum | Ryr2 | IDA | Mouse | PMID:23454728 | |
Cellular Component | GO:0030018 | Z disc | RYR2 | IDA | Human | PMID:19131648 | |
Cellular Component | GO:0030018 | Z disc | Ryr2 | IDA | Mouse | PMID:16204356 | |
Cellular Component | GO:0030018 | Z disc | Ryr2 | IDA | Mouse | PMID:19383796 | |
Cellular Component | GO:0030018 | Z disc | Ryr2 | IDA | Rat | PMID:15980179|RGD:1600288 | |
Cellular Component | GO:0030018 | Z disc | Ryr2 | IDA | Rat | PMID:11053140|RGD:8554533 | |
Cellular Component | GO:0030018 | Z disc | Ryr2 | IDA | Rat | PMID:15010472|RGD:1599256 | |
Cellular Component | GO:0030018 | Z disc | Ryr2 | IDA | Rat | PMID:17627991|RGD:7175261 | |
Biological Process | GO:0097553 | calcium ion transmembrane import into cytosol | Ryr2 | IMP | MGI:MGI:3713774 | Mouse | PMID:17431507 |
Biological Process | GO:0070588 | calcium ion transmembrane transport | Ryr2 | IMP | MGI:MGI:3641338 | Mouse | PMID:21673970 |
Biological Process | GO:0070588 | calcium ion transmembrane transport | Ryr2 | IMP | Rat | PMID:19116207|RGD:7242196 | |
Biological Process | GO:0006816 | calcium ion transport | RYR2 | IDA | Human | PMID:17921453 | |
Biological Process | GO:0006816 | calcium ion transport | Ryr2 | IMP | Mouse | MGI:MGI:1267127|PMID:9628868 | |
Biological Process | GO:0006816 | calcium ion transport | Ryr2 | IDA | Mouse | MGI:MGI:1345009|PMID:10473538 | |
Biological Process | GO:0006816 | calcium ion transport | Ryr2 | IPI | PR:Q61144 | Mouse | PMID:16204356 |
Biological Process | GO:0006816 | calcium ion transport | Ryr2 | IDA | Mouse | PMID:14593104 | |
Biological Process | GO:0060402 | calcium ion transport into cytosol | RYR2 | IDA | Human | PMID:17921453 | |
Biological Process | GO:0019722 | calcium-mediated signaling | Ryr2 | IMP | Mouse | MGI:MGI:1267127|PMID:9628868 | |
Biological Process | GO:0019722 | calcium-mediated signaling | Ryr2 | IDA | Mouse | MGI:MGI:3713015|PMID:17431507 | |
Biological Process | GO:0035584 | calcium-mediated signaling using intracellular calcium source | RYR2 | IDA | Human | PMID:17921453 | |
Biological Process | GO:0060048 | cardiac muscle contraction | RYR2 | IMP | Human | PMID:10830164 | |
Biological Process | GO:0003300 | cardiac muscle hypertrophy | Ryr2 | IMP | MGI:MGI:3713774 | Mouse | PMID:17431507 |
Biological Process | GO:0071313 | cellular response to caffeine | RYR2 | IDA | Human | PMID:12919952 | |
Biological Process | GO:0071313 | cellular response to caffeine | Ryr2 | IDA | Mouse | MGI:MGI:5431202|PMID:22406107 | |
Biological Process | GO:0071313 | cellular response to caffeine | Ryr2 | IDA | Mouse | MGI:MGI:1267127|PMID:9628868 | |
Biological Process | GO:0071313 | cellular response to caffeine | Ryr2 | IDA | Mouse | PMID:12089338 | |
Biological Process | GO:0071872 | cellular response to epinephrine stimulus | Ryr2 | IMP | Mouse | MGI:MGI:3820489|PMID:17872467 | |
Biological Process | GO:0005513 | detection of calcium ion | RYR2 | IDA | Human | PMID:10830164 | |
Biological Process | GO:0003143 | embryonic heart tube morphogenesis | Ryr2 | IMP | Mouse | MGI:MGI:1267127|PMID:9628868 | |
Biological Process | GO:0051649 | establishment of localization in cell | Ryr2 | IMP | Mouse | PMID:12089338 | |
Biological Process | GO:0072599 | establishment of protein localization to endoplasmic reticulum | RYR2 | IDA | Human | PMID:12443530 | |
Biological Process | GO:0006874 | intracellular calcium ion homeostasis | Ryr2 | IMP | Mouse | MGI:MGI:1267127|PMID:9628868 | |
Biological Process | GO:0003220 | left ventricular cardiac muscle tissue morphogenesis | Ryr2 | IMP | MGI:MGI:3713774 | Mouse | PMID:17431507 |
Biological Process | GO:0071421 | manganese ion transmembrane transport | Ryr2 | IMP | Rat | PMID:19116207|RGD:7242196 | |
Biological Process | GO:0034220 | monoatomic ion transmembrane transport | Ryr2 | IMP | Rat | PMID:19116207|RGD:7242196 | |
Biological Process | GO:0051481 | negative regulation of cytosolic calcium ion concentration | Ryr2 | IDA | Rat | PMID:18799678|RGD:7175259 | |
Biological Process | GO:0021532 | neural tube patterning | ryr2a | IMP | ZFIN:ZDB-GENO-190227-9 | Zfish | PMID:29754802 |
Biological Process | GO:0021532 | neural tube patterning | ryr2a | IGI | ZFIN:ZDB-GENE-020108-2,ZFIN:ZDB-GENE-041001-165 | Zfish | PMID:29754802 |
Biological Process | GO:1901896 | positive regulation of ATPase-coupled calcium transmembrane transporter activity | RYR2 | IDA | Human | PMID:12443530 | |
Biological Process | GO:0010460 | positive regulation of heart rate | Ryr2 | IMP | Mouse | PMID:12089338 | |
Biological Process | GO:0010460 | positive regulation of heart rate | Ryr2 | IMP | MGI:MGI:2183509 | Mouse | PMID:12089338 |
Biological Process | GO:0010460 | positive regulation of heart rate | Ryr2 | IMP | MGI:MGI:3713774 | Mouse | PMID:17431507 |
Biological Process | GO:0051284 | positive regulation of sequestering of calcium ion | RYR2 | IDA | Human | PMID:12443530 | |
Biological Process | GO:0051284 | positive regulation of sequestering of calcium ion | RYR2 | IDA | Human | PMID:12919952 | |
Biological Process | GO:0098735 | positive regulation of the force of heart contraction | RYR2 | IMP | Human | PMID:15105296 | |
Biological Process | GO:0086029 | Purkinje myocyte to ventricular cardiac muscle cell signaling | Ryr2 | IMP | Mouse | MGI:MGI:3820489|PMID:17872467 | |
Biological Process | GO:0098910 | regulation of atrial cardiac muscle cell action potential | RYR2 | IMP | Human | PMID:17875969 | |
Biological Process | GO:0098904 | regulation of AV node cell action potential | RYR2 | IMP | Human | PMID:17875969 | |
Biological Process | GO:0055117 | regulation of cardiac muscle contraction | RYR2 | IMP | Human | PMID:11159936 | |
Biological Process | GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling | RYR2 | IMP | Human | PMID:17875969 | |
Biological Process | GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | Ryr2 | IGI | UniProtKB:Q9Z2I2 | Mouse | MGI:MGI:3621834|PMID:12837242 |
Biological Process | GO:0051480 | regulation of cytosolic calcium ion concentration | Ryr2 | IMP | Rat | PMID:15870112|RGD:1599253 | |
Biological Process | GO:0002027 | regulation of heart rate | RYR2 | IMP | Human | PMID:11159936 | |
Biological Process | GO:0002027 | regulation of heart rate | RYR2 | IMP | Human | PMID:12919952 | |
Biological Process | GO:0002027 | regulation of heart rate | RYR2 | IMP | Human | PMID:15197150 | |
Biological Process | GO:0002027 | regulation of heart rate | Ryr2 | IMP | Mouse | MGI:MGI:3820489|PMID:17872467 | |
Biological Process | GO:0098907 | regulation of SA node cell action potential | RYR2 | IMP | Human | PMID:17875969 | |
Biological Process | GO:0098911 | regulation of ventricular cardiac muscle cell action potential | RYR2 | IMP | Human | PMID:17875969 | |
Biological Process | GO:0051209 | release of sequestered calcium ion into cytosol | RYR2 | IDA | Human | PMID:12443530 | |
Biological Process | GO:0051209 | release of sequestered calcium ion into cytosol | RYR2 | IDA | Human | PMID:17921453 | |
Biological Process | GO:0051209 | release of sequestered calcium ion into cytosol | Ryr2 | IDA | Mouse | MGI:MGI:3713015|PMID:17431507 | |
Biological Process | GO:0014808 | release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | RYR2 | IMP | Human | PMID:12919952 | |
Biological Process | GO:0014808 | release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | Ryr2 | IDA | Mouse | MGI:MGI:4442115|PMID:20226167 | |
Biological Process | GO:0014808 | release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | Ryr2 | IMP | Mouse | PMID:12089338 | |
Biological Process | GO:0031000 | response to caffeine | RYR2 | IDA | Human | PMID:17921453 | |
Biological Process | GO:0031000 | response to caffeine | Ryr2 | IDA | Mouse | MGI:MGI:1345009|PMID:10473538 | |
Biological Process | GO:0031000 | response to caffeine | Ryr2 | IDA | Mouse | PMID:14593104 | |
Biological Process | GO:0051592 | response to calcium ion | Ryr2 | IDA | Rat | PMID:17027851|RGD:1599247 | |
Biological Process | GO:0001666 | response to hypoxia | Ryr2 | IDA | Mouse | MGI:MGI:3836482|PMID:19120137 | |
Biological Process | GO:0032026 | response to magnesium ion | Ryr2 | IDA | Rat | PMID:16971497|RGD:1599254 | |
Biological Process | GO:0014850 | response to muscle activity | RYR2 | IMP | Human | PMID:17875969 | |
Biological Process | GO:0035994 | response to muscle stretch | RYR2 | IMP | Human | PMID:15105296 | |
Biological Process | GO:0007584 | response to nutrient | Ryr2 | IEP | Rat | PMID:17224993|RGD:1599246 | |
Biological Process | GO:0051775 | response to redox state | RYR2 | IDA | Human | PMID:19226252 | |
Biological Process | GO:0009410 | response to xenobiotic stimulus | Ryr2 | IEP | Rat | PMID:15916736|RGD:1599252 | |
Biological Process | GO:0070296 | sarcoplasmic reticulum calcium ion transport | Ryr2 | IMP | Rat | PMID:21807619|RGD:7175254 | |
Biological Process | GO:0007224 | smoothened signaling pathway | ryr2a | IGI | ZFIN:ZDB-GENE-020108-2,ZFIN:ZDB-GENE-041001-165 | Zfish | PMID:29754802 |
Biological Process | GO:0007224 | smoothened signaling pathway | ryr2a | IMP | ZFIN:ZDB-GENO-190227-9 | Zfish | PMID:29754802 |
Biological Process | GO:0097050 | type B pancreatic cell apoptotic process | RYR2 | IMP | Human | PMID:15044459 | |
Biological Process | GO:0097050 | type B pancreatic cell apoptotic process | Ryr2 | IMP | Mouse | MGI:MGI:3720302|PMID:15044459 | |
Biological Process | GO:0086005 | ventricular cardiac muscle cell action potential | Ryr2 | IMP | Mouse | MGI:MGI:3820489|PMID:17872467 |
EXP Inferred from experiment |
IDA Inferred from direct assay |
IEP Inferred from expression pattern |
IGI Inferred from genetic interaction |
IMP Inferred from mutant phenotype |
IPI Inferred from physical interaction |
HTP Inferred from High Throughput Experiment |
HDA Inferred from High Throughput Direct Assay |
HMP Inferred from High Throughput Mutant Phenotype |
HGI Inferred from High Throughput Genetic Interaction |
HEP Inferred from High Throughput Expression Pattern |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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