Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes S100A6
  • Mouse genes S100a6
  • Rat genes S100a6
  • Zfish genes icn,icn2,s100s,s100t
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set S100a6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	S100A6	IDA		Human	PMID:11937060
Molecular Function	GO:0005509	calcium ion binding	S100a6	IDA		Mouse	MGI:MGI:3687445|PMID:2358072
Molecular Function	GO:0005509	calcium ion binding	S100a6	IDA		Rat	PMID:12000747|RGD:633924
Molecular Function	GO:0048306	calcium-dependent protein binding	S100A6	IDA		Human	PMID:10913138
Molecular Function	GO:0015075	monoatomic ion transmembrane transporter activity	S100a6	IDA		Rat	PMID:12000747|RGD:633924
Molecular Function	GO:0005515	protein binding	S100A6	IPI	UniProtKB:P04271	Human	PMID:10913138
Molecular Function	GO:0005515	protein binding	S100A6	IPI	UniProtKB:P50995	Human	PMID:12577318
Molecular Function	GO:0005515	protein binding	S100A6	IPI	UniProtKB:P07355	Human	PMID:19724273
Molecular Function	GO:0005515	protein binding	S100A6	IPI	UniProtKB:P50995	Human	PMID:19724273
Molecular Function	GO:0005515	protein binding	S100A6	IPI	UniProtKB:P26882	Human	PMID:20188096
Molecular Function	GO:0005515	protein binding	S100A6	IPI	UniProtKB:Q02790	Human	PMID:20188096
Molecular Function	GO:0005515	protein binding	S100A6	IPI	UniProtKB:P04637	Human	PMID:20591429
Molecular Function	GO:0005515	protein binding	S100A6	IPI	UniProtKB:Q00987	Human	PMID:20591429
Molecular Function	GO:0005515	protein binding	S100A6	IPI	UniProtKB:P52292	Human	PMID:20965181
Molecular Function	GO:0005515	protein binding	S100A6	IPI	UniProtKB:P50542	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	S100A6	IPI	UniProtKB:P04271	Human	PMID:29997244
Molecular Function	GO:0005515	protein binding	S100A6	IPI	UniProtKB:O95684	Human	PMID:31837246
Molecular Function	GO:0005515	protein binding	S100A6	IPI	UniProtKB:P04637	Human	PMID:31837246
Molecular Function	GO:0005515	protein binding	S100A6	IPI	UniProtKB:P35579	Human	PMID:31837246
Molecular Function	GO:0005515	protein binding	S100A6	IPI	UniProtKB:Q8TD43	Human	PMID:31837246
Molecular Function	GO:0005515	protein binding	S100A6	IPI	UniProtKB:Q9HB71	Human	PMID:31837246
Molecular Function	GO:0005515	protein binding	S100A6	IPI	UniProtKB:B3EWG5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	S100a6	IPI	UniProtKB:Q9CXW3	Mouse	MGI:MGI:5486571|PMID:12042313
Molecular Function	GO:0005515	protein binding	S100a6	IPI	PR:Q9CXW3	Mouse	PMID:9572262
Molecular Function	GO:0042803	protein homodimerization activity	S100A6	IDA		Human	PMID:10913138
Molecular Function	GO:0042803	protein homodimerization activity	S100A6	IPI	UniProtKB:P06703	Human	PMID:11937060
Molecular Function	GO:0044548	S100 protein binding	S100A6	IPI	UniProtKB:P04271	Human	PMID:10913138
Molecular Function	GO:0005523	tropomyosin binding	S100A6	IDA		Human	PMID:19724273
Molecular Function	GO:0008270	zinc ion binding	S100a6	IDA		Mouse	MGI:MGI:3687445|PMID:2358072
Cellular Component	GO:0062023	collagen-containing extracellular matrix	S100A6	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	S100A6	HDA		Human	PMID:28675934
Cellular Component	GO:0062023	collagen-containing extracellular matrix	S100a6	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0005737	cytoplasm	S100A6	IDA		Human	PMID:10913138
Cellular Component	GO:0005737	cytoplasm	S100A6	IDA		Human	PMID:12601007
Cellular Component	GO:0005829	cytosol	S100A6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	S100A6	IDA		Human	PMID:19724273
Cellular Component	GO:0070062	extracellular exosome	S100A6	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	S100A6	HDA		Human	PMID:19199708
Cellular Component	GO:0005576	extracellular region	S100A6	HDA		Human	PMID:27068509
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	S100A6	IDA		Human	PMID:19724273
Cellular Component	GO:0005635	nuclear envelope	S100A6	IDA		Human	PMID:12601007
Cellular Component	GO:0005635	nuclear envelope	S100A6	IDA		Human	PMID:12805373
Cellular Component	GO:0005634	nucleus	S100A6	IDA		Human	PMID:10913138
Cellular Component	GO:0048471	perinuclear region of cytoplasm	S100A6	IDA		Human	PMID:12118070
Cellular Component	GO:0005886	plasma membrane	S100A6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0001726	ruffle	S100A6	IDA		Human	PMID:10913138
Biological Process	GO:0021782	glial cell development	icn2	IMP	ZFIN:ZDB-CRISPR-191009-37,ZFIN:ZDB-CRISPR-191009-38	Zfish	PMID:30924555
Biological Process	GO:0060041	retina development in camera-type eye	icn2	IMP	ZFIN:ZDB-CRISPR-191009-37,ZFIN:ZDB-CRISPR-191009-38	Zfish	PMID:30924555

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern