Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes S100A8
  • Mouse genes S100a8
  • Rat genes S100a8
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set S100a8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	S100A8	IPI	UniProtKB:P06702	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	S100A8	IPI	UniProtKB:P04406	Human	PMID:25417112
Molecular Function	GO:0005515	protein binding	S100A8	IPI	UniProtKB:P06702	Human	PMID:25417112
Molecular Function	GO:0005515	protein binding	S100A8	IPI	UniProtKB:Q8TD43	Human	PMID:31837246
Molecular Function	GO:0005515	protein binding	S100A8	IPI	UniProtKB:P06702	Human	PMID:9867828
Cellular Component	GO:0062023	collagen-containing extracellular matrix	S100A8	HDA		Human	PMID:28344315
Cellular Component	GO:0062023	collagen-containing extracellular matrix	S100A8	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	S100A8	HDA		Human	PMID:28675934
Cellular Component	GO:0005829	cytosol	S100A8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	S100A8	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	S100A8	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	S100A8	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	S100A8	HDA		Human	PMID:27068509
Cellular Component	GO:0005615	extracellular space	S100A8	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	S100A8	IDA		Human	PMID:21805676
Cellular Component	GO:0005615	extracellular space	S100A8	HDA		Human	PMID:22664934
Cellular Component	GO:0005615	extracellular space	S100a8	IDA		Rat	PMID:15221771|RGD:2316912
Cellular Component	GO:0045111	intermediate filament cytoskeleton	S100A8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	S100A8	HDA		Human	PMID:21630459
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	S100A8	IDA		Human	PMID:19935772
Biological Process	GO:0002526	acute inflammatory response	S100a8	IEP		Rat	PMID:15221771|RGD:2316912
Biological Process	GO:0014002	astrocyte development	S100a8	IGI	MGI:MGI:1338947	Mouse	PMID:22577135
Biological Process	GO:0035425	autocrine signaling	S100a8	IGI	UniProtKB:Q4FZY1	Rat	PMID:27312849|RGD:13838801
Biological Process	GO:0006914	autophagy	S100A8	IDA		Human	PMID:19935772
Biological Process	GO:0002544	chronic inflammatory response	S100a8	IEP		Rat	PMID:8343166|RGD:633930
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	S100A8	IDA		Human	PMID:12626582
Biological Process	GO:0070488	neutrophil aggregation	S100A8	IDA		Human	PMID:12626582
Biological Process	GO:0030593	neutrophil chemotaxis	S100A8	IDA		Human	PMID:12626582
Biological Process	GO:0002790	peptide secretion	S100a8	IDA		Mouse	PMID:18820689
Biological Process	GO:0002790	peptide secretion	S100a8	IMP		Mouse	PMID:18820689
Biological Process	GO:0018119	peptidyl-cysteine S-nitrosylation	S100A8	IMP		Human	PMID:25417112
Biological Process	GO:0050729	positive regulation of inflammatory response	S100A8	IDA		Human	PMID:12626582
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	S100A8	IDA		Human	PMID:19935772
Biological Process	GO:0002793	positive regulation of peptide secretion	S100a8	IMP		Mouse	PMID:18820689
Biological Process	GO:0002793	positive regulation of peptide secretion	S100a8	IDA		Mouse	PMID:18820689
Biological Process	GO:0045471	response to ethanol	S100a8	IEP		Rat	PMID:17207109|RGD:2316908
Biological Process	GO:0032496	response to lipopolysaccharide	S100a8	IEP		Rat	PMID:17207109|RGD:2316908
Biological Process	GO:0010043	response to zinc ion	S100a8	IEP		Rat	PMID:19111725|RGD:2316905
Biological Process	GO:0042060	wound healing	S100a8	IEP		Rat	PMID:15943814|RGD:2316909

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern