Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse S1pr1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes S1PR1
- Mouse genes S1pr1
- Rat genes S1pr1
- Zfish genes s1pr1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set S1pr1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	S1pr1	IMP		Rat	PMID:11557736\|RGD:1581747
Molecular Function	GO:0001664	G protein-coupled receptor binding	S1PR1	IPI	UniProtKB:O95136	Human	PMID:24851274
Molecular Function	GO:0070915	lysophosphatidic acid receptor activity	s1pr1	IDA		Zfish	PMID:11112429\|ZFIN:ZDB-PUB-001221-12
Molecular Function	GO:0005515	protein binding	S1PR1	IPI	UniProtKB:Q07108	Human	PMID:16525420
Molecular Function	GO:0046625	sphingolipid binding	S1pr1	IDA		Rat	PMID:9765227\|RGD:1581785
Molecular Function	GO:0038036	sphingosine-1-phosphate receptor activity	S1PR1	IDA		Human	PMID:22344443
Molecular Function	GO:0038036	sphingosine-1-phosphate receptor activity	S1pr1	IMP		Mouse	MGI:MGI:2151313\|PMID:11032855
Cellular Component	GO:0009897	external side of plasma membrane	S1pr1	IMP	MGI:MGI:3818509	Mouse	PMID:18836449
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	S1PR1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	S1PR1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	S1PR1	IDA		Human	PMID:22344443
Biological Process	GO:0031532	actin cytoskeleton reorganization	S1pr1	IMP		Mouse	MGI:MGI:3703727\|PMID:11726541
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	S1pr1	IDA		Mouse	PMID:11443127
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	S1pr1	IMP		Rat	PMID:9765227\|RGD:1581785
Biological Process	GO:0001525	angiogenesis	S1pr1	IDA		Mouse	PMID:15371328
Biological Process	GO:0001955	blood vessel maturation	S1pr1	IMP		Mouse	MGI:MGI:2151313\|PMID:11032855
Biological Process	GO:0007420	brain development	S1pr1	IMP	MGI:MGI:2158346	Mouse	PMID:16314531
Biological Process	GO:0003245	cardiac muscle tissue growth involved in heart morphogenesis	S1pr1	IMP		Mouse	MGI:MGI:5049789\|PMID:21668976
Biological Process	GO:0016477	cell migration	S1pr1	IMP		Mouse	MGI:MGI:3839226\|PMID:19204730
Biological Process	GO:0042074	cell migration involved in gastrulation	s1pr1	IMP	ZFIN:ZDB-MRPHLNO-081222-1	Zfish	PMID:18701549
Biological Process	GO:0042074	cell migration involved in gastrulation	s1pr1	IGI	ZFIN:ZDB-MRPHLNO-070911-3,ZFIN:ZDB-MRPHLNO-081222-1	Zfish	PMID:18701549
Biological Process	GO:0008283	cell population proliferation	S1pr1	IMP	MGI:MGI:2158346	Mouse	PMID:16314531
Biological Process	GO:0006935	chemotaxis	S1pr1	IMP		Mouse	MGI:MGI:2151313\|PMID:11032855
Biological Process	GO:0006935	chemotaxis	S1pr1	IMP		Mouse	MGI:MGI:3703727\|PMID:11726541
Biological Process	GO:0045446	endothelial cell differentiation	S1pr1	IEP		Rat	PMID:7959012\|RGD:61573
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	S1pr1	IMP		Rat	PMID:11557736\|RGD:1581747
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	s1pr1	IDA		Zfish	PMID:11112429\|ZFIN:ZDB-PUB-001221-12
Biological Process	GO:0007507	heart development	s1pr1	IGI	ZFIN:ZDB-GENE-991124-7	Zfish	PMID:29922649
Biological Process	GO:0007507	heart development	s1pr1	IMP		Zfish	PMID:29922649
Biological Process	GO:0061384	heart trabecula morphogenesis	S1pr1	IMP		Mouse	MGI:MGI:5049789\|PMID:21668976
Biological Process	GO:0030032	lamellipodium assembly	S1pr1	IMP		Mouse	MGI:MGI:3703727\|PMID:11726541
Biological Process	GO:0030595	leukocyte chemotaxis	S1pr1	IDA		Mouse	PMID:25348153
Biological Process	GO:0008078	mesodermal cell migration	s1pr1	IGI	ZFIN:ZDB-GENO-070911-1,ZFIN:ZDB-MRPHLNO-081222-1	Zfish	PMID:18701549
Biological Process	GO:0016525	negative regulation of angiogenesis	s1pr1	IMP	ZFIN:ZDB-MRPHLNO-121026-2	Zfish	PMID:22951644
Biological Process	GO:0051497	negative regulation of stress fiber assembly	S1pr1	IDA		Rat	PMID:11094076\|RGD:1581790
Biological Process	GO:0030182	neuron differentiation	S1pr1	IEP		Rat	PMID:7959012\|RGD:61573
Biological Process	GO:0030335	positive regulation of cell migration	S1pr1	IDA		Rat	PMID:11557736\|RGD:1581747
Biological Process	GO:0030335	positive regulation of cell migration	s1pr1	IGI	ZFIN:ZDB-MRPHLNO-070911-3,ZFIN:ZDB-MRPHLNO-081222-1	Zfish	PMID:18701549
Biological Process	GO:0030335	positive regulation of cell migration	s1pr1	IMP	ZFIN:ZDB-MRPHLNO-081222-1	Zfish	PMID:18701549
Biological Process	GO:0008284	positive regulation of cell population proliferation	S1pr1	IMP	MGI:MGI:2158346	Mouse	PMID:16314531
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	S1pr1	IMP		Rat	PMID:9765227\|RGD:1581785
Biological Process	GO:0043547	positive regulation of GTPase activity	S1pr1	IDA		Rat	PMID:14711826\|RGD:1304283
Biological Process	GO:0050927	positive regulation of positive chemotaxis	S1pr1	IDA		Rat	PMID:11094076\|RGD:1581790
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	S1pr1	IDA		Rat	PMID:11557736\|RGD:1581747
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	S1pr1	IMP		Rat	PMID:14711826\|RGD:1304283
Biological Process	GO:0060312	regulation of blood vessel remodeling	s1pr1	IMP	ZFIN:ZDB-MRPHLNO-121026-2	Zfish	PMID:22951644
Biological Process	GO:0030500	regulation of bone mineralization	S1pr1	IMP		Mouse	MGI:MGI:3839226\|PMID:19204730
Biological Process	GO:0045124	regulation of bone resorption	S1pr1	IMP		Mouse	MGI:MGI:3839226\|PMID:19204730
Biological Process	GO:0030155	regulation of cell adhesion	S1pr1	IDA		Mouse	PMID:15371328
Biological Process	GO:0003376	sphingosine-1-phosphate receptor signaling pathway	S1PR1	IDA		Human	PMID:22344443
Biological Process	GO:0003376	sphingosine-1-phosphate receptor signaling pathway	S1pr1	IMP		Mouse	MGI:MGI:2151313\|PMID:11032855
Biological Process	GO:0002040	sprouting angiogenesis	s1pr1	IMP	ZFIN:ZDB-MRPHLNO-121026-2	Zfish	PMID:22951644
Biological Process	GO:0072678	T cell migration	S1pr1	IMP		Mouse	MGI:MGI:3040577\|PMID:14732704
Biological Process	GO:0019226	transmission of nerve impulse	S1pr1	IEP		Rat	PMID:7959012\|RGD:61573
Biological Process	GO:0001944	vasculature development	s1pr1	IGI	ZFIN:ZDB-MRPHLNO-090423-1,ZFIN:ZDB-MRPHLNO-121026-2	Zfish	PMID:23229546
Biological Process	GO:0001944	vasculature development	s1pr1	IGI	ZFIN:ZDB-MRPHLNO-070911-3,ZFIN:ZDB-MRPHLNO-121026-2	Zfish	PMID:23229546
Biological Process	GO:0001944	vasculature development	s1pr1	IMP	ZFIN:ZDB-MRPHLNO-121026-2	Zfish	PMID:23229546
Biological Process	GO:0001944	vasculature development	s1pr1	IMP	ZFIN:ZDB-MRPHLNO-130307-2	Zfish	PMID:23229546

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.