Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SCAP
  • Mouse genes Scap
  • Rat genes Scap
  • Zfish genes scap
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Scap

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SCAP	IPI	UniProtKB:Q9Y5U4	Human	PMID:17428920
Molecular Function	GO:0005515	protein binding	SCAP	IPI	UniProtKB:Q8WU17	Human	PMID:19706601
Molecular Function	GO:0005515	protein binding	SCAP	IPI	UniProtKB:Q9H741	Human	PMID:32111832
Molecular Function	GO:0005515	protein binding	Scap	IPI	PR:Q91WG1	Mouse	PMID:12242332
Molecular Function	GO:0005515	protein binding	Scap	IPI	PR:Q8BGI3	Mouse	PMID:12242332
Molecular Function	GO:0044877	protein-containing complex binding	Scap	IPI	RGD:728328|RGD:1350460	Rat	PMID:19158095|RGD:2308803
Cellular Component	GO:0005789	endoplasmic reticulum membrane	SCAP	IDA		Human	PMID:32111832
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Scap	IDA		Mouse	PMID:12242332
Cellular Component	GO:0000139	Golgi membrane	SCAP	IDA		Human	PMID:32111832
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Scap	IDA		Rat	PMID:19158095|RGD:2308803
Cellular Component	GO:0032991	protein-containing complex	Scap	IDA		Rat	PMID:19158095|RGD:2308803
Biological Process	GO:0007568	aging	Scap	IEP		Rat	PMID:16741953|RGD:1581819
Biological Process	GO:0044255	cellular lipid metabolic process	Scap	IMP	MGI:MGI:2148743	Mouse	PMID:22337502
Biological Process	GO:0008203	cholesterol metabolic process	Scap	IDA		Mouse	PMID:11358865
Biological Process	GO:0006955	immune response	Scap	IMP	MGI:MGI:2148743	Mouse	PMID:22337502
Biological Process	GO:0006629	lipid metabolic process	scap	IMP	ZFIN:ZDB-MRPHLNO-110425-1	Zfish	PMID:19127516
Biological Process	GO:0006629	lipid metabolic process	scap	IMP		Zfish	PMID:14612568
Biological Process	GO:0019915	lipid storage	scap	IMP	ZFIN:ZDB-MRPHLNO-110425-1	Zfish	PMID:14612568
Biological Process	GO:0045542	positive regulation of cholesterol biosynthetic process	SCAP	IDA		Human	PMID:32322062
Biological Process	GO:0045540	regulation of cholesterol biosynthetic process	Scap	IMP	MGI:MGI:2148743,MGI:MGI:2180899	Mouse	PMID:16054043
Biological Process	GO:0042304	regulation of fatty acid biosynthetic process	Scap	IMP	MGI:MGI:2148743,MGI:MGI:2180899	Mouse	PMID:16054043
Biological Process	GO:0019217	regulation of fatty acid metabolic process	Scap	IDA		Mouse	PMID:11358865
Biological Process	GO:0001666	response to hypoxia	Scap	IMP	MGI:MGI:2148743,MGI:MGI:2176073	Mouse	PMID:17666524
Biological Process	GO:0032868	response to insulin	Scap	IMP	MGI:MGI:2148743,MGI:MGI:2180899	Mouse	PMID:16054043
Biological Process	GO:0032933	SREBP signaling pathway	SCAP	IMP		Human	PMID:11726962
Biological Process	GO:0032933	SREBP signaling pathway	SCAP	IDA		Human	PMID:32322062

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern