Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SCARB2
  • Mouse genes Scarb2
  • Rat genes Scarb2
  • Zfish genes scarb2a,scarb2b,scarb2c
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Scarb2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0038024	cargo receptor activity	SCARB2	IMP		Human	PMID:18022370
Molecular Function	GO:0038024	cargo receptor activity	Scarb2	IMP		Mouse	MGI:MGI:3773765|PMID:18022370
Molecular Function	GO:0015485	cholesterol binding	Scarb2	IDA		Mouse	MGI:MGI:6112073|PMID:29199275
Molecular Function	GO:0019899	enzyme binding	SCARB2	IPI	UniProtKB:P17439	Human	PMID:18022370
Molecular Function	GO:0019899	enzyme binding	SCARB2	IPI	UniProtKB:P04062	Human	PMID:25202012
Molecular Function	GO:0019899	enzyme binding	Scarb2	IPI	UniProtKB:P17439	Mouse	MGI:MGI:3773765|PMID:18022370
Molecular Function	GO:0031210	phosphatidylcholine binding	Scarb2	IDA		Mouse	MGI:MGI:6112073|PMID:29199275
Molecular Function	GO:0001786	phosphatidylserine binding	Scarb2	IDA		Mouse	MGI:MGI:6112073|PMID:29199275
Molecular Function	GO:0005515	protein binding	SCARB2	IPI	UniProtKB:P04062	Human	PMID:24162852
Molecular Function	GO:0005515	protein binding	SCARB2	IPI	UniProtKB:O60883	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SCARB2	IPI	UniProtKB:P31937	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SCARB2	IPI	UniProtKB:Q86VI4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SCARB2	IPI	UniProtKB:Q8N6F1-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SCARB2	IPI	UniProtKB:Q8TED1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SCARB2	IPI	UniProtKB:Q9Y282	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Scarb2	IPI	UniProtKB:P17439	Mouse	MGI:MGI:6274951|PMID:27789271
Molecular Function	GO:0042803	protein homodimerization activity	SCARB2	IPI	UniProtKB:Q14108	Human	PMID:29199275
Molecular Function	GO:0042803	protein homodimerization activity	Scarb2	IPI	UniProtKB:O35114	Mouse	MGI:MGI:6112073|PMID:29199275
Molecular Function	GO:0051087	protein-folding chaperone binding	Scarb2	IPI	UniProtKB:Q61696	Mouse	MGI:MGI:6274951|PMID:27789271
Molecular Function	GO:0005044	scavenger receptor activity	Scarb2	IDA		Mouse	MGI:MGI:6112073|PMID:29199275
Cellular Component	GO:0030666	endocytic vesicle membrane	Scarb2	IDA		Mouse	MGI:MGI:6112073|PMID:29199275
Cellular Component	GO:0070062	extracellular exosome	SCARB2	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	SCARB2	HDA		Human	PMID:23533145
Cellular Component	GO:0005925	focal adhesion	SCARB2	HDA		Human	PMID:21423176
Cellular Component	GO:0043202	lysosomal lumen	Scarb2	IDA		Mouse	MGI:MGI:3773765|PMID:18022370
Cellular Component	GO:0005765	lysosomal membrane	SCARB2	HDA		Human	PMID:17897319
Cellular Component	GO:0005765	lysosomal membrane	Scarb2	IDA		Mouse	MGI:MGI:3773765|PMID:18022370
Cellular Component	GO:0016020	membrane	SCARB2	HDA		Human	PMID:19946888
Cellular Component	GO:0005886	plasma membrane	Scarb2	IDA		Mouse	MGI:MGI:6112073|PMID:29199275
Biological Process	GO:0015917	aminophospholipid transport	Scarb2	IDA		Mouse	MGI:MGI:6112073|PMID:29199275
Biological Process	GO:0010467	gene expression	Scarb2	IMP	MGI:MGI:2654430	Mouse	PMID:16901941
Biological Process	GO:0030903	notochord development	scarb2a	IMP		Zfish	PMID:26743566
Biological Process	GO:0010976	positive regulation of neuron projection development	Scarb2	IDA		Rat	PMID:23825416|RGD:8655547
Biological Process	GO:0006622	protein targeting to lysosome	SCARB2	IMP		Human	PMID:18022370
Biological Process	GO:0006622	protein targeting to lysosome	Scarb2	IMP		Mouse	MGI:MGI:3773765|PMID:18022370
Biological Process	GO:0006898	receptor-mediated endocytosis	Scarb2	IDA		Mouse	MGI:MGI:6112073|PMID:29199275
Biological Process	GO:0043470	regulation of carbohydrate catabolic process	SCARB2	IMP		Human	PMID:18022370
Biological Process	GO:0043470	regulation of carbohydrate catabolic process	Scarb2	IMP		Mouse	MGI:MGI:3773765|PMID:18022370
Biological Process	GO:1905123	regulation of glucosylceramidase activity	Scarb2	IMP		Mouse	MGI:MGI:5609206|PMID:25316793
Biological Process	GO:0007605	sensory perception of sound	Scarb2	IMP	MGI:MGI:2654430	Mouse	PMID:16901941

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern