Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SCN11A
  • Mouse genes Scn11a
  • Rat genes Scn11a
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Scn11a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	Scn11a	IPI	PR:P61329	Mouse	PMID:11376006
Molecular Function	GO:0005515	protein binding	Scn11a	IPI	RGD:620163	Rat	PMID:11376006|RGD:632803
Molecular Function	GO:0005515	protein binding	Scn11a	IPI	UniProtKB:P61150	Rat	PMID:12401812|RGD:6484231
Molecular Function	GO:0005248	voltage-gated sodium channel activity	Scn11a	IDA		Mouse	PMID:16029194
Cellular Component	GO:0030424	axon	Scn11a	IDA		Mouse	PMID:22641814
Cellular Component	GO:0030424	axon	Scn11a	IDA		Mouse	PMID:16029194
Cellular Component	GO:0030424	axon	Scn11a	IDA		Rat	PMID:21118538|RGD:15090835
Cellular Component	GO:0044295	axonal growth cone	Scn11a	IDA		Mouse	PMID:22641814
Cellular Component	GO:0044299	C-fiber	Scn11a	IDA		Mouse	PMID:16029194
Cellular Component	GO:0044297	cell body	Scn11a	IDA		Mouse	PMID:31534133
Cellular Component	GO:0070062	extracellular exosome	SCN11A	HDA		Human	PMID:19056867
Cellular Component	GO:0098978	glutamatergic synapse	Scn11a	IDA		Rat	PMID:19162133|RGD:13702365
Cellular Component	GO:0043025	neuronal cell body	Scn11a	IDA		Mouse	PMID:17363266
Cellular Component	GO:0043025	neuronal cell body	Scn11a	IMP	MGI:MGI:3695487	Mouse	PMID:23596386
Cellular Component	GO:0005886	plasma membrane	Scn11a	IDA		Mouse	PMID:16029194
Cellular Component	GO:0042734	presynaptic membrane	Scn11a	IDA		Rat	PMID:19162133|RGD:13702365
Biological Process	GO:0001508	action potential	Scn11a	IMP		Mouse	PMID:30395542
Biological Process	GO:0099610	action potential initiation	Scn11a	IMP	MGI:MGI:5608917	Mouse	PMID:18270172
Biological Process	GO:0099610	action potential initiation	Scn11a	IMP	MGI:MGI:5608917	Mouse	PMID:25959819
Biological Process	GO:0099610	action potential initiation	Scn11a	IMP	MGI:MGI:6415024	Mouse	PMID:30557356
Biological Process	GO:0099610	action potential initiation	Scn11a	IMP	MGI:MGI:6415027	Mouse	PMID:30557356
Biological Process	GO:0099610	action potential initiation	Scn11a	IMP	MGI:MGI:6392908	Mouse	PMID:27224030
Biological Process	GO:0099610	action potential initiation	Scn11a	IMP	MGI:MGI:5608917	Mouse	PMID:31534133
Biological Process	GO:0002526	acute inflammatory response	Scn11a	IMP	MGI:MGI:5608917	Mouse	PMID:31534133
Biological Process	GO:0060840	artery development	Scn11a	IMP	MGI:MGI:5608917	Mouse	PMID:31534133
Biological Process	GO:0007409	axonogenesis	Scn11a	IMP	MGI:MGI:3818305	Mouse	PMID:22641814
Biological Process	GO:0007409	axonogenesis	Scn11a	IMP		Mouse	PMID:22641814
Biological Process	GO:0061367	behavioral response to acetic acid induced pain	Scn11a	IMP	MGI:MGI:3528983	Mouse	PMID:19931571
Biological Process	GO:0061368	behavioral response to formalin induced pain	Scn11a	IMP	MGI:MGI:3528983	Mouse	PMID:19931571
Biological Process	GO:0048266	behavioral response to pain	Scn11a	IMP	MGI:MGI:3528983	Mouse	PMID:19931571
Biological Process	GO:1990408	calcitonin gene-related peptide receptor signaling pathway	Scn11a	IMP	MGI:MGI:5608917	Mouse	PMID:31534133
Biological Process	GO:1990408	calcitonin gene-related peptide receptor signaling pathway	Scn11a	IMP	MGI:MGI:5558025	Mouse	PMID:32817686
Biological Process	GO:0070588	calcium ion transmembrane transport	Scn11a	IMP		Mouse	PMID:22641814
Biological Process	GO:0070588	calcium ion transmembrane transport	Scn11a	IMP	MGI:MGI:3818305	Mouse	PMID:22641814
Biological Process	GO:0048870	cell motility	Scn11a	IMP	MGI:MGI:3695487	Mouse	PMID:23596386
Biological Process	GO:0070417	cellular response to cold	Scn11a	IMP	MGI:MGI:5608917	Mouse	PMID:25959819
Biological Process	GO:0007635	chemosensory behavior	Scn11a	IMP		Mouse	PMID:30395542
Biological Process	GO:0002544	chronic inflammatory response	Scn11a	IMP	MGI:MGI:5608917	Mouse	PMID:31534133
Biological Process	GO:0007623	circadian rhythm	Scn11a	IMP	MGI:MGI:3818305	Mouse	PMID:25101983
Biological Process	GO:0050974	detection of mechanical stimulus involved in sensory perception	Scn11a	IMP	MGI:MGI:3818305	Mouse	PMID:25101983
Biological Process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	Scn11a	IMP	MGI:MGI:5608917	Mouse	PMID:31534133
Biological Process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	Scn11a	IMP	MGI:MGI:5608917	Mouse	PMID:31534133
Biological Process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	Scn11a	IMP	MGI:MGI:3818305	Mouse	PMID:25101983
Biological Process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	Scn11a	IMP	MGI:MGI:5608917	Mouse	PMID:25959819
Biological Process	GO:0051649	establishment of localization in cell	Scn11a	IDA		Mouse	PMID:16029194
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Scn11a	IMP	MGI:MGI:3818305	Mouse	PMID:18096591
Biological Process	GO:0006954	inflammatory response	Scn11a	IMP		Mouse	PMID:17167076
Biological Process	GO:0006954	inflammatory response	Scn11a	IMP	MGI:MGI:3604572	Mouse	PMID:19146922
Biological Process	GO:0006954	inflammatory response	Scn11a	IMP	MGI:MGI:5608917	Mouse	PMID:18270172
Biological Process	GO:0006954	inflammatory response	Scn11a	IMP	MGI:MGI:3695487	Mouse	PMID:23596386
Biological Process	GO:0006954	inflammatory response	Scn11a	IMP	MGI:MGI:5558025	Mouse	PMID:32817686
Biological Process	GO:0043303	mast cell degranulation	Scn11a	IMP	MGI:MGI:5608917	Mouse	PMID:31534133
Biological Process	GO:0060073	micturition	Scn11a	IMP	MGI:MGI:3604572	Mouse	PMID:19146922
Biological Process	GO:0019228	neuronal action potential	Scn11a	IMP		Mouse	PMID:17167076
Biological Process	GO:0021554	optic nerve development	Scn11a	IEP		Rat	PMID:22473424|RGD:10411906
Biological Process	GO:0010737	protein kinase A signaling	Scn11a	IMP	MGI:MGI:5608917	Mouse	PMID:31534133
Biological Process	GO:0060004	reflex	Scn11a	IMP	MGI:MGI:3604572	Mouse	PMID:17363266
Biological Process	GO:0042391	regulation of membrane potential	Scn11a	IMP	MGI:MGI:6415024	Mouse	PMID:30557356
Biological Process	GO:0051930	regulation of sensory perception of pain	Scn11a	IMP		Mouse	MGI:MGI:5553040|PMID:24036948
Biological Process	GO:0010996	response to auditory stimulus	Scn11a	IMP	MGI:MGI:5608917	Mouse	PMID:31534133
Biological Process	GO:0009409	response to cold	Scn11a	IMP	MGI:MGI:6392908	Mouse	PMID:27224030
Biological Process	GO:1902518	response to cyclophosphamide	Scn11a	IMP	MGI:MGI:3604572	Mouse	PMID:19146922
Biological Process	GO:0009408	response to heat	Scn11a	IMP	MGI:MGI:6392908	Mouse	PMID:27224030
Biological Process	GO:0009644	response to high light intensity	Scn11a	IMP	MGI:MGI:5608917	Mouse	PMID:31534133
Biological Process	GO:0071731	response to nitric oxide	Scn11a	IMP	MGI:MGI:5608917	Mouse	PMID:31534133
Biological Process	GO:0048265	response to pain	Scn11a	IMP		Mouse	PMID:17167076
Biological Process	GO:0048265	response to pain	Scn11a	IMP	MGI:MGI:3604572	Mouse	PMID:17363266
Biological Process	GO:0048265	response to pain	Scn11a	IMP	MGI:MGI:6415027	Mouse	PMID:30557356
Biological Process	GO:0048265	response to pain	Scn11a	IMP	MGI:MGI:6415024	Mouse	PMID:30557356
Biological Process	GO:0048265	response to pain	Scn11a	IMP	MGI:MGI:6392908	Mouse	PMID:27224030
Biological Process	GO:0034695	response to prostaglandin E	Scn11a	IMP	MGI:MGI:3604572	Mouse	PMID:19146922
Biological Process	GO:0009636	response to toxic substance	Scn11a	IMP	MGI:MGI:3818305	Mouse	PMID:18096591
Biological Process	GO:0009410	response to xenobiotic stimulus	Scn11a	IMP	MGI:MGI:5608917	Mouse	PMID:25959819
Biological Process	GO:0009410	response to xenobiotic stimulus	Scn11a	IMP	MGI:MGI:5608917	Mouse	PMID:31534133
Biological Process	GO:0160025	sensory perception of itch	Scn11a	IMP		Mouse	PMID:30395542
Biological Process	GO:0160025	sensory perception of itch	Scn11a	IMP	MGI:MGI:5558025	Mouse	PMID:32817686
Biological Process	GO:0060538	skeletal muscle organ development	Scn11a	IMP	MGI:MGI:5558025	Mouse	PMID:32817686
Biological Process	GO:1990770	small intestine smooth muscle contraction	Scn11a	IMP	MGI:MGI:5558025	Mouse	PMID:32817686
Biological Process	GO:0035725	sodium ion transmembrane transport	Scn11a	IMP	MGI:MGI:3818305	Mouse	PMID:18096591
Biological Process	GO:0035725	sodium ion transmembrane transport	Scn11a	IMP		Mouse	PMID:24719102
Biological Process	GO:0035725	sodium ion transmembrane transport	Scn11a	IMP	MGI:MGI:5608917	Mouse	PMID:18270172
Biological Process	GO:0006814	sodium ion transport	Scn11a	IDA		Mouse	PMID:16029194
Biological Process	GO:0040040	thermosensory behavior	Scn11a	IMP	MGI:MGI:6392908	Mouse	PMID:27224030
Biological Process	GO:0001966	thigmotaxis	Scn11a	IMP	MGI:MGI:5608917	Mouse	PMID:31534133
Biological Process	GO:0019226	transmission of nerve impulse	Scn11a	IMP	MGI:MGI:3604572	Mouse	PMID:15964986

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern